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Title:           Exome sequencing of early-onset patients supports genetic heterogeneity in colorectal cancer
Subject:         Scientific Reports, https://doi.org/10.1038/s41598-021-90590-z
Author:          C. Fernández-Rozadilla 
Creator:         Springer
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      Title: Exome sequencing of early-onset patients supports genetic heterogeneity in colorectal cancer
      Children: 
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Patient description and sequencing. 
         Item: 
          Title: Variant prioritization. 
         Item: 
          Title: Data analysis. 
          Children: 
           Item: 
            Title: Variant and gene-based analysis. 
           Item: 
            Title: Pathway-based analysis. 
         Item: 
          Title: Candidate gene selection. 
         Item: 
          Title: Candidate gene resequencing. 
          Children: 
           Item: 
            Title: Replication cohort. 
           Item: 
            Title: Candidate-gene variants. 
           Item: 
            Title: TCGA germline variants in the candidate genes. 
       Item: 
        Title: Discussion
       Item: 
        Title: Materials and methods
        Children: 
         Item: 
          Title: Study patients: discovery cohort. 
         Item: 
          Title: Whole-exome sequencing (WES). 
         Item: 
          Title: Variant prioritization. 
          Children: 
           Item: 
            Title: Variant-based analysis. 
         Item: 
          Title: Gene and pathway-based analyses. 
         Item: 
          Title: Gene prioritization and candidate-gene selecion for replication. 
         Item: 
          Title: Candidate-gene resequencing. 
          Children: 
           Item: 
            Title: Replication cohort. 
           Item: 
            Title: Candidate gene sequencing. 
           Item: 
            Title: Variant validation. 
         Item: 
          Title: TCGA germline variants on candidate genes. 
          Children: 
           Item: 
            Title: TCGA second hit validation and somatic mutation profiles. 
         Item: 
          Title: TDG immunohistochemistry. 
       Item: 
        Title: Conclusions
       Item: 
        Title: References
       Item: 
        Title: Acknowledgements
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  Checksum: 8d6f03e9
   Type: CRC32
  Checksum: fb080e5bb99ccc97016967000e974b9c
   Type: MD5
  Checksum: 1b611fcdbf5558f0ff30940d7d6d823ee2793e8d
   Type: SHA-1
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   Type: SHA-256