078110e9625cc54ef371289bd3369a62 pmc_34064314.pdf cbaeaa4fc5eaf27f3bdccd6e150f467939d18ec4 pmc_34064314.pdf 7f1a3e22dcb74184e8135d792c21ecb4564921e3ed27cd5ba3e66faa09fe1b9f pmc_34064314.pdf Title: Risk of SARS-CoV-2 Infection in Previously Infected and Non-Infected Cohorts of Health Workers at High Risk of Exposure Subject: The objective of this study is to assess the risk of newly acquired RNA detection-proven SARS-CoV-2 infection after previous SARS-CoV-2 infection. This is a prospective study conducted from March to September 2020 in Barcelona, Spain. Healthcare workers caring for SARS-CoV-2 infected patients were divided in two cohorts: (a) previously RNA-proven SARS-CoV-2 infected cohort with mild symptoms (IC) and (b) healthy cohort (HC). Weekly SARS-CoV-2 RNA detection assays from nasopharyngeal swabs were performed. Serology status was assessed at the beginning and at the end of the study. Twenty participants were included in each group. The median age was 30 (IQR 27–34.75) years, and 55% were female. The median time of follow up was 49 (IQR 49–51) days. Fifteen out of 246 (6%) nasopharyngeal swab samples were positive for SARS-CoV-2, all in the IC. The percentage of participants in the IC with a probable newly acquired SARS-CoV-2 RNA-proven infection was 20% (95% IC 5.7–43.6%) at the end of the 7-week follow up period. The incidence reinfection rate was 28.6 (95% IC 7.8–73.2) cases per 1000 person-week. Despite detectable IgG antibodies against SARS-CoV-2 participants highly exposed to SARS-CoV-2 may develop a newly acquired SARS-CoV-2 RNA detection episode during the first months after the initial infection. Keywords: reinfection; SARS-CoV-2; natural immunity; genome amplification diagnostic assays; serology Author: Adrián Sánchez-Montalvá, Candela Fernández-Naval, Andrés Antón, Xavier Durà, Alba Vimes, Aroa Silgado, Fernando Velásquez-Orozco, Juan Espinosa-Pereiro, Fernando Salvador, Tomás Pumarola, Benito Almirante and Juliana Esperalba Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed May 12 11:17:12 2021 CEST ModDate: Wed May 12 11:17:12 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1298710 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- CTICOG+URWPalladioL-Ital Type 1 Custom yes yes no 112 0 PGRIFP+URWPalladioL-Bold Type 1 Custom yes yes no 113 0 UJJGOP+VnURWPalladioL-Bold Type 1 Custom yes yes no 114 0 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Date: 2021-09-11 03:15:52 CEST RepresentationInformation: pmc_34064314.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-06-07 03:39:10 CEST Size: 1298710 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: きちぴづひどちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰こぴふつべぜ〴ぜ〰こづぴぴどのでぜ〴ぜ〰ちのつぜ〴ぜ〰ぐはばふぬちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰こぴふつべぜ〴ぜ〰ぐひはっづつふひづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴ぜ〰ちのつぜ〴ぜ〰こちねばぬづぜ〴ぜ〰こどぺづぜ〴ぜ〰ぃちぬっふぬちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰こぴふつべぜ〴ぜ〰くぶづひびどでとぴぜ〴ぜ〰ちのつぜ〴ぜ〰ぅぴとどっちぬぜ〴ぜ〰こぴちぴづねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰きどっひはぢどはぬはでべぜ〴ぜ〰ぐひはっづつふひづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸵⸱ Children: Item: Title: こぴふつべぜ〴ぜ〰こづぴぴどのでぜ〴ぜ〰ちのつぜ〴ぜ〰ぐはばふぬちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰こぴふつべぜ〴ぜ〰ぐひはっづつふひづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴ぜ〰ちのつぜ〴ぜ〰こちねばぬづぜ〴ぜ〰こどぺづぜ〴ぜ〰ぃちぬっふぬちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰こぴふつべぜ〴ぜ〰くぶづひびどでとぴぜ〴ぜ〰ちのつぜ〴ぜ〰ぅぴとどっちぬぜ〴ぜ〰こぴちぴづねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰きどっひはぢどはぬはでべぜ〴ぜ〰ぐひはっづつふひづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸵⸱ Item: Title: こぴふつべぜ〴ぜ〰ぐひはっづつふひづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴ぜ〰ちのつぜ〴ぜ〰こちねばぬづぜ〴ぜ〰こどぺづぜ〴ぜ〰ぃちぬっふぬちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰こぴふつべぜ〴ぜ〰くぶづひびどでとぴぜ〴ぜ〰ちのつぜ〴ぜ〰ぅぴとどっちぬぜ〴ぜ〰こぴちぴづねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰きどっひはぢどはぬはでべぜ〴ぜ〰ぐひはっづつふひづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸵⸱ Item: Title: こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴ぜ〰ちのつぜ〴ぜ〰こちねばぬづぜ〴ぜ〰こどぺづぜ〴ぜ〰ぃちぬっふぬちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰こぴふつべぜ〴ぜ〰くぶづひびどでとぴぜ〴ぜ〰ちのつぜ〴ぜ〰ぅぴとどっちぬぜ〴ぜ〰こぴちぴづねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰きどっひはぢどはぬはでべぜ〴ぜ〰ぐひはっづつふひづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸵⸱ Item: Title: こぴふつべぜ〴ぜ〰くぶづひびどでとぴぜ〴ぜ〰ちのつぜ〴ぜ〰ぅぴとどっちぬぜ〴ぜ〰こぴちぴづねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰きどっひはぢどはぬはでべぜ〴ぜ〰ぐひはっづつふひづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸵⸱ Item: Title: きどっひはぢどはぬはでべぜ〴ぜ〰ぐひはっづつふひづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸵⸱ Children: Item: Title: こぁげこ〭ぃはざ〭〲ぜ〴ぜ〰げぎぁぜ〴ぜ〰つづぴづっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸵⸲ Item: Title: いづぴづひねどのちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰えふねはひちぬぜ〴ぜ〰ぉねねふのづぜ〴ぜ〰げづびばはのびづぜ〴ぜ〰ちでちどのびぴぜ〴ぜ〰こぁげこ〭ぃはざ〭〲ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: げづびふぬぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぐはばふぬちぴどはのぜ〴ぜ〰いづびっひどばぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰こぁげこ〭ぃはざ〭〲ぜ〴ぜ〰げぎぁぜ〴ぜ〰いづぴづっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰こづひはぬはでべぜ〴ぜ〰げづびふぬぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Children: Item: Title: ぐはばふぬちぴどはのぜ〴ぜ〰いづびっひどばぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰こぁげこ〭ぃはざ〭〲ぜ〴ぜ〰げぎぁぜ〴ぜ〰いづぴづっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰こづひはぬはでべぜ〴ぜ〰げづびふぬぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: 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