73f75bce7a17e94823ca98f62c20847a pmc_34069240.pdf 48ff3fb70cd09b5d3783fc9f3c87351d2ec3cbf4 pmc_34069240.pdf e614be2a9de3484bd98bc42254e353121887e903fe74911c26dda73f5c731be9 pmc_34069240.pdf Title: Limited Liver or Lung Colorectal Cancer Metastases. Systemic Treatment, Surgery, Ablation or SBRT Subject: The prognosis for oligometastatic colorectal cancer has improved in recent years, mostly because of recent advances in new techniques and approaches to the treatment of oligometastases, including new surgical procedures, better systemic treatments, percutaneous ablation, and stereotactic body radiation therapy (SBRT). There are several factors to consider when deciding on the better approach for each patient: tumor factors (metachronous or synchronous metastases, RAS mutation, BRAF mutation, disease-free interval, size and number of metastases), patient factors (age, frailty, comorbidities, patient preferences), and physicians’ factors (local expertise). These advances have presented major challenges and opportunities for oncologic multidisciplinary teams to treat patients with limited liver and lung metastases from colorectal cancer with a curative intention. In this review, we describe the different treatment options in patients with limited liver and lung metastases from colorectal cancer, and the possible combination of three approaches: systemic treatment, surgery, and local ablative treatments. Keywords: oligometastasis; colorectal cancer; ablation; stereotactic body radiation therapy; liver metastases; lung metastases Author: Meritxell Molla, Julen Fernandez-Plana, Santiago Albiol, Constantino Fondevila, Ivan Vollmer, Carla Cases, Angeles Garcia-Criado, Jaume Capdevila, Carles Conill, Yliam Fundora, Carlos Fernandez-Martos and Estela Pineda Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri May 14 14:53:51 2021 CEST ModDate: Fri May 14 14:53:51 2021 CEST Custom Metadata: yes Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 3356629 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- PYEQNY+URWPalladioL-Ital Type 1 Custom yes yes no 118 0 RLPUSZ+URWPalladioL-Bold Type 1 Custom yes yes no 119 0 RLZHRS+URWPalladioL-Roma Type 1 Custom yes yes no 120 0 OXNQRR+VnURWPalladioL Type 1 Custom yes yes no 123 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 131 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 132 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 151 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 152 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 153 0 SKVKGL+CMSY10 Type 1 Builtin yes yes no 174 0 MKONDC+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 251 0 MKONDE+PalatinoLinotype TrueType WinAnsi yes yes no 252 0 MKONDG+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 253 0 RIJDHR+CMBSY10 Type 1 Builtin yes yes no 310 0 MKONDC+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 363 0 MKONDE+PalatinoLinotype TrueType WinAnsi yes yes no 364 0 MKONDG+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 365 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:15:29 CEST RepresentationInformation: pmc_34069240.pdf 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