7500743d02a088aa642dd8998b7bb9a6 pmc_34071275.pdf 2be1b74e4b0e92986708abe8ea97b47a6eeb357d pmc_34071275.pdf 3237fa3a14d130a9de8254f4e235663eeb19dbc745f11cb195e2a00cc3cd5700 pmc_34071275.pdf Title: Assessment of EULAR/ACR-2019, SLICC-2012 and ACR-1997 Classification Criteria in SLE with Longstanding Disease Subject: Background: Different classification criteria for systemic lupus erythematosus (SLE) have been launched over the years. Our aim was to evaluate the performance of the EULAR/ACR-2019, SLICC-2012 and ACR-1997 classification criteria in a cohort of SLE patients with longstanding disease. Methods: Descriptive observational study in 79 patients with established and longstanding SLE. The three classification criteria sets were applied to those patients. Results: Of the 79 patients, 70 were women (88.6%), with a mean age of 51.8 14 years and a mean disease duration of 15.2 11.5 years. The sensitivity of the different criteria were: 51.9%, 87.3% and 86.1% for ACR-1997, SLICC-2012 and EULAR/ACR-2019, respectively. In total, 68 out of 79 patients (53.7%) met all three classification criteria; 11.4% did not meet any classification criteria and were characterized by low SLEDAI (0.6 0.9), low SLICC/ACR Damage Index (0.88 0.56) and fulfilling only skin domains, antiphospholipid antibodies or hypocomplementemia. To fulfill EULAR/ACR-2019 criteria was associated with low complement levels (p < 0.04), high anti-dsDNA levels (p < 0.001), presence of lupus nephritis III-IV (p < 0.05) and arthritis (p < 0.001). Conclusion: The EULAR/ACR-2019 classification criteria showed high sensitivity, similar to SLICC-2012, in SLE patients with longstanding disease. Patients with serological, articular or renal involvement are more likely to fulfill SLICC-2012 or EULAR/ACR-2019 criteria. Keywords: SLE; classification criteria; EULAR/ACR-2019; SLICC-2012; ACR-1997; longstanding lupus Author: Berta Magallares, David Lobo-Prat, Ivan Castellví, Patricia Moya, Ignasi Gich, Laura Martinez-Martinez, Hye Park, Ana Milena Millán, Ana Laiz, César Díaz-Torné, Susana Fernandez and Hèctor Corominas Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri May 28 10:16:34 2021 CEST ModDate: Fri May 28 10:16:34 2021 CEST Custom Metadata: yes Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 473276 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- RWBGLD+URWPalladioL-Ital Type 1 Custom yes yes no 85 0 HNZCRW+URWPalladioL-Bold Type 1 Custom yes yes no 86 0 DPDBQY+VnURWPalladioL-Bold Type 1 Custom yes yes no 87 0 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