eec056ac0ba4be8df04aeeea47d72d9d pmc_34072889.pdf e7197e15578733bd4e938cfaea7ffd9794d3339c pmc_34072889.pdf 4e1534b5c0b4e4d4e3dba68e96de42bca2257711986924a850c2554b491197c9 pmc_34072889.pdf Title: Effect of Edema Disease Vaccination on Mortality and Growth Parameters in Nursery Pigs in a Shiga Toxin 2e Positive Commercial Farm Subject: Diseases caused by Escherichia coli are recognized as major problems in the swine industry, one of them being edema disease (ED). Importantly, the current decrease in antibiotic use may cause difficulties in controlling the disorders caused by E. coli. Therefore, this study assessed the efficacy of a commercial vaccine against ED in nursery pigs from a farm with previous history of ED. A total of 1344 pigs were monitored; half of them were randomly assigned to a vaccinated group (VG) and the other half to a non-vaccinated group (NVG). The vaccine was administered at 7 days of age. Animals received a pre-starter feed with 2500 ppm of zinc oxide (ZnO) for 2 weeks and a starter feed without ZnO for another 3 weeks. Pen-group weights were recorded at 28 (weaning), 42 (end of pre-starter phase), and 63 days of life (end of nursery phase). Death/culling rates, average daily gain (ADG), and average daily feed intake (ADFI) were calculated for each group at each phase. The overall relative risk of dying/being culled for a pig in the NVG was 5 times higher than that of the VG group but increased to 12 times higher during the starter period. ADG and ADFI were also significantly higher in the VG group for that period. Vaccination against ED significantly reduced pig losses and improved ADG and ADFI, particularly when ZnO was not used. Keywords: edema disease; vaccination; antibiotic reduction; productive parameters Author: Susana Mesonero-Escuredo, Joaquín Morales, Raúl Carlos Mainar-Jaime, Gonzalo Díaz, José Luís Arnal, Carlos Casanovas, Sergio Barrabés and Joaquim Segalés Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Jun 1 09:02:57 2021 CEST ModDate: Tue Jun 1 09:05:24 2021 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 7 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 263665 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- CIQLLF+VnURWPalladioL Type 1 Custom yes yes no 10 0 GFCGJO+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 DDJUBB+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 XUULRV+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 NBDQEL+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 55 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 59 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 63 0 PTGIIY+URWPalladioL-BoldItal Type 1 Custom yes yes no 78 0 CZKGAS+CMR10 Type 1 Builtin yes yes no 82 0 DVCMRV+CMSY10 Type 1 Builtin yes yes no 86 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:15:05 CEST RepresentationInformation: pmc_34072889.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:14:05 CEST Size: 263665 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 190 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Farm Description Destination: subsection.2.1 Item: Title: Study Design Destination: subsection.2.2 Item: Title: Data Collection Destination: subsection.2.3 Item: Title: Statistical Analyses Destination: subsection.2.4 Item: Title: Results Destination: section.3 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.5 Info: Title: Effect of Edema Disease Vaccination on Mortality and Growth Parameters in Nursery Pigs in a Shiga Toxin 2e Positive Commercial Farm Author: Susana Mesonero-Escuredo, Joaquín Morales, Raúl Carlos Mainar-Jaime, Gonzalo Díaz, José Luís Arnal, Carlos Casanovas, Sergio Barrabés and Joaquim Segalés Subject: Diseases caused by Escherichia coli are recognized as major problems in the swine industry, one of them being edema disease (ED). Importantly, the current decrease in antibiotic use may cause difficulties in controlling the disorders caused by E. coli. Therefore, this study assessed the efficacy of a commercial vaccine against ED in nursery pigs from a farm with previous history of ED. A total of 1344 pigs were monitored; half of them were randomly assigned to a vaccinated group (VG) and the other half to a non-vaccinated group (NVG). The vaccine was administered at 7 days of age. Animals received a pre-starter feed with 2500 ppm of zinc oxide (ZnO) for 2 weeks and a starter feed without ZnO for another 3 weeks. Pen-group weights were recorded at 28 (weaning), 42 (end of pre-starter phase), and 63 days of life (end of nursery phase). Death/culling rates, average daily gain (ADG), and average daily feed intake (ADFI) were calculated for each group at each phase. The overall relative risk of dying/being culled for a pig in the NVG was 5 times higher than that of the VG group but increased to 12 times higher during the starter period. ADG and ADFI were also significantly higher in the VG group for that period. Vaccination against ED significantly reduced pig losses and improved ADG and ADFI, particularly when ZnO was not used. 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