0a441bbdaff85ba5edbac8aac90e7482 pmc_34101091.pdf 5760797553dfeec4eeeaa7ccdda807515ba5feaa pmc_34101091.pdf 3c46cb6ed4b1ba3eba2cdf4e23673b2c4a23c904b34cfd1df6a1bb542b9391d9 pmc_34101091.pdf Title: Harnessing Type I IFN Immunity Against SARS-CoV-2 with Early Administration of IFN-β Subject: J Clin Immunol, doi:10.1007/s10875-021-01068-6 Keywords: Author: Donald C. Vinh Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Tue Jun 8 15:15:00 2021 CEST ModDate: Tue Jun 8 15:20:01 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 18 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 459961 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KGGOAH+AdvTT99c4c969 Type 1C WinAnsi yes yes no 637 0 KGGOOL+AdvTT3713a231+03 Type 1C Custom yes yes yes 655 0 KGGOPM+AdvTT4ff65459 Type 1C WinAnsi yes yes no 661 0 KGGOJF+AdvTT577c760c Type 1C WinAnsi yes yes no 640 0 KGGOKG+AdvTT577c760c+03 Type 1C Custom yes yes yes 648 0 KGGOKH+AdvP0005 Type 1C WinAnsi yes yes no 649 0 KGGONH+AdvTTc488b0e6 Type 1C WinAnsi yes yes no 650 0 KGGONI+AdvPi3 Type 1C WinAnsi yes yes no 651 0 KGGONJ+AdvTTb8864ccf.B Type 1C WinAnsi yes yes no 645 0 KGGONK+AdvTT3713a231 Type 1C WinAnsi yes yes no 644 0 KGGOOK+AdvTT3713a231+20 Type 1C WinAnsi yes yes no 659 0 KGGPJJ+AdvTTaf7f9f4f.B Type 1C WinAnsi yes yes no 238 0 KGHBLN+AdvTTb8864ccf.B+03 Type 1C Custom yes yes yes 243 0 KGHDCF+AdvTTaf7f9f4f.B+03 Type 1C Custom yes yes yes 326 0 KGHDND+AdvTT50a2f13e.I Type 1C WinAnsi yes yes no 333 0 KGHIBK+AdvTT50a2f13e.I+20 Type 1C WinAnsi yes yes no 384 0 KGHICL+AdvTTa351d857.B Type 1C WinAnsi yes yes no 385 0 KGHLGI+AdvTT577c760c+20 Type 1C WinAnsi yes yes no 386 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-09-11 03:10:48 CEST RepresentationInformation: pmc_34101091.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-06-14 03:35:04 CEST Size: 459961 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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referenced object 'CR45' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR46' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR47' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR48' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR49' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR50' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR51' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR52' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR53' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR54' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR60' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR61' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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referenced object 'CR118' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR123' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR126' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR127' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR128' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR129' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR130' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR131' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR16' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR132' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR133' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR134' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR135' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR136' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR137' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR139' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR140' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR129' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR130' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR130' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR141' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR143' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR144' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR145' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR134' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR133' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR132' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR134' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR131' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR146' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR147' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR148' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR149' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR150' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR151' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR152' cannot be found Offset: 414463 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Convalescent Plasma and mAbs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Anti-inflammatory Drugs: Intravenous Immunoglobulin (IVIG), Corticosteroids, and Anti-IL6R Antagonists Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Anti-inflammatory Agents that Interfere with Type I IFNs: JAK Inhibitors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: B Cell and Plasmablast Depletion and BTK Inhibition: How About COVID? Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Therapeutic Plasma Exchange (TPE): Past and Present Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Type I IFN: Almost 50 Years of Therapy with IFN-α and IFN-β in Various Diseases Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: IFN-α2 in Past and Current COVID Trials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: IFN-β in COVID-19 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: A Proposal: Early IFN-β in the Outpatient Setting Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Type III IFN: IFN-λ Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Conclusion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Info: Title: Harnessing Type I IFN Immunity Against SARS-CoV-2 with Early Administration of IFN-β Author: Donald C. 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