2a9d22247ff4a4bdb95b26d74c2784b1 pmc_34122329.pdf 81a1ca61f29ee54a9111a00cc1616d4709c91ea0 pmc_34122329.pdf 17953f53ee576c9198484a35760a6e9b67ee8c975070eb774761229853ec8e8a pmc_34122329.pdf Title: Crosstalk Between LXR and Caveolin-1 Signaling Supports Cholesterol Efflux and Anti-Inflammatory Pathways in Macrophages Subject: Macrophages are immune cells that play crucial roles in host defense against pathogens by triggering their exceptional phagocytic and inflammatory functions Keywords: gene expression, caveolin-1, cholesterol efflux, inflammation, LXR, macrophage Author: Cristina M. Ramírez; Marta Torrecilla-Parra; Virginia Pardo-Marqués; Mario Fernández de-Frutos; Ana Pérez-García; Carlos Tabraue; Juan Vladimir de la Rosa; Patricia Martín-Rodriguez; Mercedes Díaz-Sarmiento; Uxue Nuñez; Marta C. Orizaola; Paqui G. Través; Marta Camps; Lisardo Boscá ; Antonio Castrillo Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Mon May 24 09:46:50 2021 CEST ModDate: Mon May 24 09:47:22 2021 CEST Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 10616236 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ILGEJD+AdvOT6e5d2ec0+fb Type 1C Custom yes yes yes 520 0 ILGEMD+AdvOT6601a1b9.BI Type 1C WinAnsi yes yes no 546 0 ILGEGJ+AdvOT34fe1490.B Type 1C WinAnsi yes yes no 522 0 ILGEGK+AdvOT34fe1490.B+fb Type 1C Custom yes yes yes 523 0 ILGEGL+AdvOT01861455.I Type 1C WinAnsi yes yes no 524 0 ILGEGM+AdvOT01861455.I+01 Type 1C MacRoman yes yes no 525 0 ILGEGN+AdvPSA18C Type 1C WinAnsi yes yes no 526 0 ILGEHN+AdvOT1deab444.I Type 1C WinAnsi yes yes no 527 0 ILGEHO+AdvPSA323 Type 1C WinAnsi yes yes no 528 0 ILGEHP+AdvOT1deab444.I+01 Type 1C MacRoman yes yes no 529 0 ILGEIA+AdvOT1deab444.I+20 Type 1C WinAnsi yes yes no 530 0 ILGEIB+AdvOT1deab444.I+fb Type 1C Custom yes yes yes 531 0 ILGEIC+AdvOT6e5d2ec0 Type 1C WinAnsi yes yes no 532 0 ILGFDB+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 310 0 ILGFDC+AdvOT3f84ef53 Type 1C WinAnsi yes yes no 323 0 ILGFDD+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 292 0 ILGFEE+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 305 0 ILGFEF+AdvOT1ef757c0+20 Type 1C Custom yes yes yes 303 0 ILGFFF+AdvOT1ef757c0+22 Type 1C Custom yes yes no 293 0 ILGFFG+AdvOT1ef757c0+01 Type 1C MacRoman yes yes no 315 0 ILGFFH+AdvTT58d178b9+03 Type 1C Custom yes yes yes 309 0 ILGFGI+AdvOT6e5d2ec0+01 Type 1C MacRoman yes yes no 316 0 ILGFHI+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 326 0 ILGFKI+AdvOT94be8fa4.B Type 1C WinAnsi yes yes no 330 0 ILGFKJ+AdvOT2f02755f.I Type 1C WinAnsi yes yes no 329 0 ILGHCB+HelveticaNeueLTStd-Bd Type 1C WinAnsi yes yes no 333 0 ILGNOF+AdvOT7d6df7ab.I+22 Type 1C Custom yes yes no 334 0 ILHDHC+AdvOTb65e897d.B+fb Type 1C Custom yes yes yes 336 0 ILHDHD+AdvOT7d6df7ab.I+01 Type 1C MacRoman yes yes no 335 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:14:17 CEST RepresentationInformation: pmc_34122329.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:14:10 CEST Size: 10616236 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 618 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Crosstalk Between LXR and Caveolin-1 Signaling Supports Cholesterol Efflux and Anti-Inflammatory Pathways in Macrophages Destination: bmark_1193277371 Children: Item: Title: Introduction Destination: s1 Item: Title: Material and Methods Destination: s2 Children: Item: Title: Animal Procedures Destination: s2_1 Item: Title: Antibodies Destination: s2_2 Item: Title: Cell Culture and Treatments Destination: s2_3 Item: Title: Transfections Destination: s2_4 Item: Title: Total Protein Extracts and Microsomal Purification Destination: s2_5 Item: Title: Detergent-Free Caveolae Extraction Destination: s2_6 Item: Title: Protein Analysis by Western Blotting and Bioplex ELISA Destination: s2_7 Item: Title: RNA Isolation and Gene Expression Destination: s2_8 Item: Title: Immunofluorescence Microscopy Destination: s2_9 Item: Title: Electron-Microscopy Procedures Destination: s2_10 Item: Title: Cholesterol Efflux Assays Destination: s2_11 Item: Title: Results Destination: s3 Children: Item: Title: Caveolin-1 Expression Modulates Inflammatory Responses and ABCA1 Expression in RAW264.7 Cells Destination: s3_1 Item: Title: Caveolin-1 Expression Is Reduced in LXRαβ-/- Mouse Peritoneal Macrophages and Liver Destination: s3_2 Item: Title: Subcellular Distribution Caveolin-1 and ABCA1 Is Controlled by LXR activity Destination: s3_3 Item: Title: Cav-1 and ABCA1 Co-Localize in Mouse Peritoneal Macrophages Destination: s3_4 Item: Title: The Anti-Inflammatory Actions of LXR Agonists Are Decreased in Cav-1-/- Macrophages Destination: s3_5 Item: Title: Cholesterol Efflux to ApoAI and HDL Is Impaired in Cav-1 Deficient Macrophages Destination: s3_6 Item: Title: Discussion Destination: s4 Item: Title: Data Availability Statement Destination: s5 Item: Title: Ethics Statement Destination: s6 Item: Title: Author Contributions Destination: s7 Item: Title: Acknowledgments Destination: bmark_-366698314 Item: Title: Supplementary Material Destination: bmark_386646472 Item: Title: References Destination: bmark_2090415954 Info: Title: Crosstalk Between LXR and Caveolin-1 Signaling Supports Cholesterol Efflux and Anti-Inflammatory Pathways in Macrophages Author: Cristina M. Ramírez; Marta Torrecilla-Parra; Virginia Pardo-Marqués; Mario Fernández de-Frutos; Ana Pérez-García; Carlos Tabraue; Juan Vladimir de la Rosa; Patricia Martín-Rodriguez; Mercedes Díaz-Sarmiento; Uxue Nuñez; Marta C. Orizaola; Paqui G. Través; Marta Camps; Lisardo Boscá ; Antonio Castrillo Subject: Macrophages are immune cells that play crucial roles in host defense against pathogens by triggering their exceptional phagocytic and inflammatory functions Keywords: gene expression, caveolin-1, cholesterol efflux, inflammation, LXR, macrophage Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Mon May 24 09:46:50 CEST 2021 ModDate: Mon May 24 09:47:22 CEST 2021 ID: 0x58008833d8fbd3cf35e7cce294ed40eb, 0x3fd9259dcfb210489bde420a55ceb3be Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2362 ImageHeight: 2037 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2362 ImageHeight: 2049 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png 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Anti-Inflammatory Pathways in Macrophages Cristina M. Ramírez; Marta Torrecilla-Parra; Virginia Pardo-Marqués; Mario Fernández de-Frutos; Ana Pérez-García; Carlos Tabraue; Juan Vladimir de la Rosa; Patricia Martín-Rodriguez; Mercedes Díaz-Sarmiento; Uxue Nuñez; Marta C. Orizaola; Paqui G. 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CRC32 Checksum: 2a9d22247ff4a4bdb95b26d74c2784b1 Type: MD5 Checksum: 81a1ca61f29ee54a9111a00cc1616d4709c91ea0 Type: SHA-1 Checksum: 17953f53ee576c9198484a35760a6e9b67ee8c975070eb774761229853ec8e8a Type: SHA-256