97f7cd14ae91422e868c886c9d748f2b pmc_34135307.pdf c28c916797e4272ff13fee9ee5794112d23a03e7 pmc_34135307.pdf 3a0772cdf1ebd00fa97924ac353667d5f948f011f1248976f870cadc4366bc4b pmc_34135307.pdf Title: Prophylaxis with intrathecal or high-dose methotrexate in diffuse large B-cell lymphoma and high risk of CNS relapse Subject: Blood Cancer Journal, doi:10.1038/s41408-021-00506-3 Keywords: Author: Sabela Bobillo Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Wed Jun 16 13:39:03 2021 CEST ModDate: Wed Jun 16 15:27:20 2021 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 6 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 804608 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- COGHJJ+AdvOTa20b42a7 Type 1C WinAnsi yes yes no 387 0 COGHIH+AdvOT65f8a23b.I Type 1C WinAnsi yes yes no 18 0 COGHII+AdvOT3b30f6db.B Type 1C WinAnsi yes yes no 20 0 COGHIJ+AdvOT46dcae81+20 Type 1C WinAnsi yes yes no 21 0 COGGFI+AdvTT5afe5d37.B Type 1C WinAnsi yes yes no 388 0 Arial-BoldMT Type 1C WinAnsi yes no no 389 0 COGGKI+AdvOT46dcae81 Type 1C WinAnsi yes yes no 23 0 COGGKJ+AdvTT6780a46b Type 1C WinAnsi yes yes no 25 0 COGHIF+AdvTT2876772e+27 Type 1C Custom yes yes yes 390 0 COGHIG+AdvOT46dcae81+fb Type 1C Custom yes yes yes 28 0 COGHNJ+AdvTTab7e17fd Type 1C WinAnsi yes yes no 19 0 COGIGJ+AdvOT7d2ebc01 Type 1C WinAnsi yes yes no 22 0 COGIHJ+AdvMyriad_R Type 1C WinAnsi yes yes no 24 0 Calibri-Light Type 1C Custom yes no yes 26 0 COGIFI+AdvOT919a0533.B Type 1C WinAnsi yes yes no 27 0 COGIJL+AdvTT6780a46b+22 Type 1C Custom yes yes yes 49 0 COGIIK+AdvTT6780a46b+20 Type 1C WinAnsi yes yes no 50 0 COGIJK+AdvOTd0125be5.BI Type 1C WinAnsi yes yes no 51 0 COGMOC+AdvOT3b30f6db.B+20 Type 1C WinAnsi yes yes no 170 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-09-21 02:30:59 CEST RepresentationInformation: pmc_34135307.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 12:14:11 CEST Size: 804608 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR10' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR10' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR14' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR19' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR20' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR21' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR21' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR19' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR15' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR20' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR22' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR23' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR23' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR10' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR10' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR22' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR22' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR14' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR16' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR24' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR14' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR16' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR17' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR18' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR19' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR20' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR16' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR16' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR22' cannot be found Offset: 397175 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR10' cannot be found Offset: 397175 MIMEtype: application/pdf PDFMetadata: Objects: 481 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Prophylaxis with intrathecal or high-dose methotrexate in diffuse large B-cell lymphoma and high risk of CNS relapse Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Patients and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Children: Item: Title: Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Children: Item: Title: Patient characteristics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: CNS prophylaxis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: CNS relapse and the effect of prophylaxis on CNS relapse Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: ADDITIONAL INFORMATION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Info: Title: Prophylaxis with intrathecal or high-dose methotrexate in diffuse large B-cell lymphoma and high risk of CNS relapse Author: Sabela Bobillo Subject: Blood Cancer Journal, doi:10.1038/s41408-021-00506-3 Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Wed Jun 16 14:09:03 CEST 2021 ModDate: Wed Jun 16 15:27:20 CEST 2021 ID: 0x4ceff7cbccb4b5c4e3b470b4de1b96f2, 0x5111062e9472c2fb5a24325df4210502 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 951 ImageHeight: 1424 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 950 ImageHeight: 556 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 950 ImageHeight: 596 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 954 ImageHeight: 604 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 952 ImageHeight: 603 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Fonts: Type1: Font: BaseFont: COGHJJ+AdvOTa20b42a7 FontSubset: true FirstChar: 48 LastChar: 121 FontDescriptor: FontName: COGHJJ+AdvOTa20b42a7 Flags: Serif, Nonsymbolic FontBBox: -72, -239, 979, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: COGGFI+AdvTT5afe5d37.B FontSubset: true FirstChar: 65 LastChar: 84 FontDescriptor: FontName: COGGFI+AdvTT5afe5d37.B Flags: Nonsymbolic FontBBox: -31, -250, 895, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Arial-BoldMT FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: COGHIF+AdvTT2876772e+27 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: COGHIF+AdvTT2876772e+27 Flags: Symbolic FontBBox: 0, -197, 968, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: COGMOC+AdvOT3b30f6db.B+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: COGMOC+AdvOT3b30f6db.B+20 Flags: Nonsymbolic FontBBox: -10, -197, 1250, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: COGIJL+AdvTT6780a46b+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: COGIJL+AdvTT6780a46b+22 Flags: Symbolic FontBBox: 0, -250, 875, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: COGHIH+AdvOT65f8a23b.I FontSubset: true FirstChar: 45 LastChar: 117 FontDescriptor: FontName: COGHIH+AdvOT65f8a23b.I Flags: Nonsymbolic FontBBox: -104, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: COGIIK+AdvTT6780a46b+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: COGIIK+AdvTT6780a46b+20 Flags: Nonsymbolic FontBBox: 0, -114, 1156, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: COGHNJ+AdvTTab7e17fd FontSubset: true FirstChar: 61 LastChar: 61 FontDescriptor: FontName: COGHNJ+AdvTTab7e17fd Flags: Nonsymbolic FontBBox: -156, -250, 1072, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: COGIJK+AdvOTd0125be5.BI FontSubset: true FirstChar: 110 LastChar: 112 FontDescriptor: FontName: COGIJK+AdvOTd0125be5.BI Flags: Nonsymbolic FontBBox: -93, -250, 927, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: COGHII+AdvOT3b30f6db.B FontSubset: true FirstChar: 37 LastChar: 121 FontDescriptor: FontName: COGHII+AdvOT3b30f6db.B Flags: Nonsymbolic FontBBox: -31, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: COGHIJ+AdvOT46dcae81+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: COGHIJ+AdvOT46dcae81+20 Flags: Nonsymbolic FontBBox: 0, -197, 1125, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: COGIGJ+AdvOT7d2ebc01 FontSubset: true FirstChar: 50 LastChar: 54 FontDescriptor: FontName: COGIGJ+AdvOT7d2ebc01 Flags: Nonsymbolic FontBBox: -31, -208, 958, 916 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: COGGKI+AdvOT46dcae81 FontSubset: true FirstChar: 35 LastChar: 243 FontDescriptor: FontName: COGGKI+AdvOT46dcae81 Flags: Nonsymbolic FontBBox: -41, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: COGIHJ+AdvMyriad_R FontSubset: true FirstChar: 35 LastChar: 117 FontDescriptor: FontName: COGIHJ+AdvMyriad_R Flags: Nonsymbolic FontBBox: -41, -239, 1125, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: COGGKJ+AdvTT6780a46b FontSubset: true FirstChar: 37 LastChar: 122 FontDescriptor: FontName: COGGKJ+AdvTT6780a46b Flags: Nonsymbolic FontBBox: -41, -250, 875, 843 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Calibri-Light FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Calibri-Light Flags: Serif, Symbolic FontBBox: -511, -269, 1208, 952 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: COGIFI+AdvOT919a0533.B FontSubset: true FirstChar: 46 LastChar: 108 FontDescriptor: FontName: COGIFI+AdvOT919a0533.B Flags: Nonsymbolic FontBBox: -31, -250, 656, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: COGHIG+AdvOT46dcae81+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: COGHIG+AdvOT46dcae81+fb Flags: Symbolic FontBBox: 0, 0, 739, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: application/pdf doi:10.1038/s41408-021-00506-3 Prophylaxis with intrathecal or high-dose methotrexate in diffuse large B-cell lymphoma and high risk of CNS relapse Sabela Bobillo Erel Joffe David Sermer Patrizia Mondello Paola Ghione Philip C. Caron Audrey Hamilton Paul A. Hamlin Steven M. Horwitz Anita Kumar Matthew J. Matasar Connie L. Batlevi Alison Moskowitz Ariela Noy Collette N. Owens M. Lia Palomba David Straus Gottfried Keudell Ahmet Dogan Andrew D. Zelenetz Venkatraman E. Seshan Anas Younes Springer US Blood Cancer Journal, doi:10.1038/s41408-021-00506-3 10.1038/s41408-021-00506-3 http://dx.doi.org/10.1038/s41408-021-00506-3 journal Blood Cancer Journal © 2021, The Author(s) 2044-5385 10.1038/s41408-021-00506-3 springer.com springerlink.com 2010-04-23 True 10.1038/s41408-021-00506-3 springer.com springerlink.com Springer 2021-06-16T15:27:20+02:00 2021-06-16T17:09:03+05:30 2021-06-16T15:27:20+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) VoR uuid:b846ff76-2fa0-4ac6-b0c6-7c099d1b3d7c uuid:7f83b6c7-09df-4504-a73d-dd073b19aa9d default 1 converted uuid:05008c74-10ac-4467-a24d-5b1336805030 converted to PDF/A-2b pdfToolbox 2021-06-16T17:09:48+05:30 2 B Erel Joffe http://orcid.org/0000-0002-7883-289X Patrizia Mondello http://orcid.org/0000-0002-0355-3757 Connie L. Batlevi http://orcid.org/0000-0002-9036-9463 Ariela Noy http://orcid.org/0000-0002-3001-4898 M. Lia Palomba http://orcid.org/0000-0001-5099-9156 Ahmet Dogan http://orcid.org/0000-0001-6576-5256 Venkatraman E. Seshan http://orcid.org/0000-0002-9258-2698 Anas Younes http://orcid.org/0000-0002-0001-4133 http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://springernature.com/ns/xmpExtensions/2.0/ sn Springer Nature ORCID Schema external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. authorInfo Bag AuthorInformation Specifies the types of author information: name and ORCID of an author. http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author AuthorInformation Gives the name of an author. name Text Gives the ORCID of an author. orcid URI http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 478, 689, 480, 721 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 478, 695, 534, 727 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 534, 695, 549, 705 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 534, 695, 549, 705 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 144, 628, 145, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 144, 628, 145, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 154, 628, 156, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 147, 628, 154, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 154, 628, 154, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 291, 628, 292, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 291, 628, 292, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 301, 628, 303, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 294, 628, 301, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 301, 628, 301, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 406, 617, 407, 626 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 406, 617, 407, 626 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 416, 617, 419, 626 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 409, 617, 416, 626 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 416, 617, 417, 626 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 76, 606, 77, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 76, 606, 77, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 86, 606, 88, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 78, 606, 86, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 86, 606, 86, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 237, 606, 239, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 237, 606, 239, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 247, 606, 250, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 240, 606, 247, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 247, 606, 248, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 475, 606, 476, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 475, 606, 476, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 485, 606, 488, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 478, 606, 485, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 485, 606, 485, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 216, 595, 217, 604 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 216, 595, 217, 604 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 226, 595, 229, 604 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 219, 595, 226, 604 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 226, 595, 227, 604 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 301, 595, 302, 604 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 301, 595, 302, 604 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 310, 595, 313, 604 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 595, 310, 604 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 310, 595, 311, 604 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 152, 310, 157, 319 Flags: Print AppearanceDictionary: true Destination: 96 Annotation: Subtype: Link Rect: 260, 270, 265, 279 Flags: Print AppearanceDictionary: true Destination: 96 Annotation: Subtype: Link Rect: 38, 181, 42, 190 Flags: Print AppearanceDictionary: true Destination: 96 Annotation: Subtype: Link Rect: 85, 161, 89, 170 Flags: Print AppearanceDictionary: true Destination: 96 Annotation: Subtype: Link Rect: 94, 161, 98, 170 Flags: Print AppearanceDictionary: true Destination: 96 Annotation: Subtype: Link Rect: 264, 141, 269, 150 Flags: Print AppearanceDictionary: true Destination: 96 Annotation: Subtype: Link Rect: 275, 141, 279, 150 Flags: Print AppearanceDictionary: true Destination: 96 Annotation: Subtype: Link Rect: 495, 320, 504, 329 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 343, 251, 348, 259 Flags: Print AppearanceDictionary: true Destination: 96 Annotation: Subtype: Link Rect: 354, 251, 363, 259 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 368, 251, 377, 259 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 457, 211, 466, 220 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 470, 211, 479, 220 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 442, 181, 451, 190 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 194, 80, 284, 87 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 476, 749, 549, 757 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 250, 234, 258, 242 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 550, 523, 555, 532 Flags: Print AppearanceDictionary: true Destination: 3 Annotation: Subtype: Link Rect: 430, 443, 439, 452 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 335, 337, 339, 346 Flags: Print AppearanceDictionary: true Destination: 43 Thumb: true Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 103, 118, 107, 127 Flags: Print AppearanceDictionary: true Destination: 62 Thumb: true Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 151, 315, 155, 324 Flags: Print AppearanceDictionary: true Destination: 62 Annotation: Subtype: Link Rect: 216, 255, 220, 264 Flags: Print AppearanceDictionary: true Destination: 62 Annotation: Subtype: Link Rect: 154, 215, 159, 224 Flags: Print AppearanceDictionary: true Destination: 62 Annotation: Subtype: Link Rect: 278, 145, 282, 154 Flags: Print AppearanceDictionary: true Destination: 62 Annotation: Subtype: Link Rect: 347, 153, 351, 162 Flags: Print AppearanceDictionary: true Destination: 96 Annotation: Subtype: Link Rect: 356, 153, 360, 162 Flags: Print AppearanceDictionary: true Destination: 96 Annotation: Subtype: Link Rect: 496, 124, 500, 133 Flags: Print AppearanceDictionary: true Destination: 96 Annotation: Subtype: Link Rect: 505, 124, 510, 133 Flags: Print AppearanceDictionary: true Destination: 96 Annotation: Subtype: Link Rect: 515, 124, 520, 133 Flags: Print AppearanceDictionary: true Destination: 96 Annotation: Subtype: Link Rect: 527, 84, 536, 93 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 541, 84, 550, 93 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 63, 723, 72, 732 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 77, 723, 86, 732 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 90, 723, 100, 732 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 104, 723, 113, 732 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 118, 723, 127, 732 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 74, 693, 84, 702 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 252, 683, 261, 692 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 161, 573, 170, 582 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 174, 573, 183, 582 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 188, 573, 197, 582 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 78, 494, 87, 503 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 226, 464, 235, 473 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 199, 374, 208, 383 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 213, 374, 222, 383 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 244, 324, 253, 333 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 257, 304, 266, 313 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 270, 304, 279, 313 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 68, 284, 77, 293 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 83, 284, 92, 293 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 182, 245, 191, 254 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 228, 195, 237, 204 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 270, 135, 279, 144 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 77, 95, 86, 104 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 462, 643, 472, 652 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 478, 643, 488, 652 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 353, 484, 363, 493 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 347, 332, 475, 339 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 488, 296, 559, 303 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 311, 287, 333, 294 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 487, 135, 559, 142 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 311, 126, 368, 133 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 874c4aac Type: CRC32 Checksum: 97f7cd14ae91422e868c886c9d748f2b Type: MD5 Checksum: c28c916797e4272ff13fee9ee5794112d23a03e7 Type: SHA-1