2b3694c6768e226075331172c84877ad pmc_34150764.pdf 597cd1266f0ffc1fe25e3b5b1a0e0a875a9fa344 pmc_34150764.pdf 6a60e2aafa39d9c28578fec596a7520adf317177e2bd2126294ca9a1d70ddc71 pmc_34150764.pdf Title: Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma Subject: The invasive tumor front (the tumor–host interface) is vitally important in malignant cell progression and metastasis. Keywords: tumor-host interface, tumor microenvironment, extracellular matrix, reticular fibers, immune cells, gene expression, epigenetic profiles Author: Rosa Noguera and Xavier Matias-Guiu Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Wed Jun 2 10:19:42 2021 CEST ModDate: Wed Jun 2 11:58:55 2021 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 19 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 7002477 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JYUBBW+MinionPro-Regular Type 1 Custom yes yes no 965 0 UTOGYQ+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 968 0 VQDHRS+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 971 0 CCVXXJ+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 974 0 BPWXLX+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 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Title: Patients, Sample Description, and Case Selection Item: Title: Selection of Regions of Interest Item: Title: Histomorphometric Analysis of Reticular Fibers Item: Title: Multiplex Immunofluorescence Cell Phenotype Item: Title: Transcriptomic Profiling Item: Title: Genome-Wide DNA Methylation Analysis Item: Title: Results Children: Item: Title: Reticulin Fiber Scaffolding in uLMS and uADC Is Similar Item: Title: Heterogeneous Immune Environment at the ITF Item: Title: Transcriptional Profiling Reveals a Possible Role for Antimicrobial Peptides in Immune Response at the ITF of uADC Item: Title: Genome-Wide DNA Methylation Analysis Identifies an Epigenetic Signature of ITF Related to Cell Adhesion and Extracellular Matrix Item: Title: Gene Expression Profiling and DNA Methylation Identify a 20-Gene Epigenetic Signature Characteristic of ITF Item: Title: Discussion Item: Title: Conclusion Item: Title: Data Availability Statement Item: Title: Ethics Statement Item: Title: Author 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malignant cell progression and metastasis. Rosa Noguera and Xavier Matias-Guiu tumor-host interface tumor microenvironment extracellular matrix reticular fibers immune cells gene expression epigenetic profiles 2021-06-02T13:49:42+05:30 2021-06-02T13:49:42+05:30 2021-06-02T15:28:55+05:30 2021-06-02T15:28:55+05:30 LaTeX with hyperref package uuid:c41d7fd7-fd13-495f-abb1-dc959b1339bb uuid:589a1c95-470c-441f-9d22-b331501f729c Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 43, 718, 270, 754 Annotation: Subtype: Link Rect: 474, 736, 551, 745 Annotation: Subtype: Link Rect: 474, 727, 551, 737 Annotation: Subtype: Link Rect: 454, 718, 551, 729 Annotation: Subtype: Link Rect: 86, 505, 160, 515 Annotation: Subtype: Link Rect: 76, 67, 160, 74 Annotation: Subtype: Link Rect: 521, 677, 551, 707 Annotation: Subtype: Link Rect: 176, 577, 551, 667 Annotation: Subtype: Link Rect: 43, 29, 176, 38 Annotation: Subtype: Link Rect: 179, 29, 239, 38 Annotation: Subtype: Link Rect: 434, 29, 551, 38 Page: Sequence: 2 Annotations: 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