7de2e9cce3aefafba62a4bc4f0d9d97d pmc_34177765.pdf 4d1964b80498327edd8c5ebcfa94043302b55dc3 pmc_34177765.pdf 8e42954022a47026afa8a9210cc546a958539dce69be3507f86234091d5b9831 pmc_34177765.pdf Title: Platelet Derived Growth Factor-AA Correlates With Muscle Function Tests and Quantitative Muscle Magnetic Resonance in Dystrophinopathies Subject: Introduction: Duchenne (DMD) and Becker (BMD) muscular dystrophy are X-linked muscular disorders produced by mutations in the DMD gene which encodes the protein dystrophin. Keywords: PDGF, MRI, biomarker, Duchenne, Becker, dystrophinopathy Author: Jordi Dı́az-Manera Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Thu Jun 10 11:07:23 2021 CEST ModDate: Thu Jun 10 12:13:54 2021 CEST Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.26 x 779.52 pts Page rot: 0 File size: 1017188 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NRRHYK+HelveticaNeueLTStd-Bd Type 1C Custom yes yes no 35 0 ISOGDC+HelveticaNeueLTStd-Lt Type 1C Custom yes yes no 40 0 PIAOFJ+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes no 53 0 VFTZFI+HelveticaNeueLTStd-LtIt Type 1C Custom yes yes no 55 0 BVYVJG+HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes yes no 60 0 WFYTDZ+MTGU Type 1C Custom yes yes no 62 0 UJBOMI+MinionPro-Regular Type 1C Custom yes yes no 70 0 XQPXXR+MinionPro-It Type 1C Custom yes yes no 72 0 ARNWRS+MTSY Type 1C Custom yes yes yes 99 0 GBAUGV+RMTMI Type 1C WinAnsi yes yes no 101 0 JILSVQ+MinionPro-Bold Type 1C Custom yes yes no 112 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:13:29 CEST RepresentationInformation: pmc_34177765.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:14:14 CEST Size: 1017188 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 318 FreeObjects: 16 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Platelet Derived Growth Factor-AA Correlates With Muscle Function Tests and Quantitative Muscle Magnetic Resonance in Dystrophinopathies Destination: ariclecounter.1 Children: Item: Title: Introduction Destination: section*.2 Item: Title: Materials and Methods Destination: section*.3 Children: Item: Title: Study Design and Participants Destination: section*.4 Item: Title: Functional Assessment Destination: section*.5 Item: Title: Quantification of Growth Factors in Serum Samples Destination: section*.6 Item: Title: Muscle MRI Destination: section*.7 Item: Title: RNA Extraction and Reverse Transcription Destination: section*.8 Item: Title: Real-Time Quantitative PCR Analysis Destination: section*.9 Item: Title: Immunohistochemistry Destination: section*.10 Item: Title: Data Analysis Destination: section*.11 Item: Title: Results Destination: section*.12 Children: Item: Title: Cohort Description Destination: section*.13 Item: Title: Growth Factor Serum Levels Comparison Between DMD, BMD, and Age Matched Controls Destination: section*.14 Item: Title: Correlation of Growth Factor Serum Samples With Muscle Function Test Results Destination: section*.15 Item: Title: PDGF-AA Expression in Skeletal Muscle Biopsies of DMD and BMD Patients Destination: section*.16 Item: Title: Discussion Destination: section*.17 Item: Title: Data Availability Statement Destination: section*.18 Item: Title: Ethics Statement Destination: section*.19 Item: Title: Author Contributions Destination: section*.20 Item: Title: Funding Destination: section*.21 Item: Title: Acknowledgments Destination: section*.22 Item: Title: References Destination: section*.23 Info: Title: Platelet Derived Growth Factor-AA Correlates With Muscle Function Tests and Quantitative Muscle Magnetic Resonance in Dystrophinopathies Author: Jordi Dı́az-Manera Subject: Introduction: Duchenne (DMD) and Becker (BMD) muscular dystrophy are X-linked muscular disorders produced by mutations in the DMD gene which encodes the protein dystrophin. Keywords: PDGF, MRI, biomarker, Duchenne, Becker, dystrophinopathy Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Thu Jun 10 11:37:23 CEST 2021 ModDate: Thu Jun 10 12:43:54 CEST 2021 ID: 0x5dc328b8499aa5b30b8fa4c99c6e0e33, 0x1ebc30d6e7451f4d99a5b2c3bee5a06d Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 279 ImageHeight: 279 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1559 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1963 ImageHeight: 2480 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 872 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Fonts: Type1: Font: BaseFont: JILSVQ+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 117 FontDescriptor: FontName: JILSVQ+MinionPro-Bold Flags: Symbolic FontBBox: 0, -244, 717, 703 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: NRRHYK+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 0 LastChar: 124 FontDescriptor: FontName: NRRHYK+HelveticaNeueLTStd-Bd Flags: Symbolic FontBBox: -9, -214, 848, 786 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: ARNWRS+MTSY FontSubset: true FirstChar: 0 LastChar: 68 FontDescriptor: FontName: ARNWRS+MTSY Flags: Symbolic FontBBox: 0, -209, 944, 679 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: PIAOFJ+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: PIAOFJ+HelveticaNeueLTStd-BdIt Flags: Nonsymbolic FontBBox: -63, -182, 717, 731 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GBAUGV+RMTMI FontSubset: true FirstChar: 60 LastChar: 60 FontDescriptor: FontName: GBAUGV+RMTMI Flags: Nonsymbolic, AllCap FontBBox: 0, 0, 682, 455 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: UJBOMI+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: UJBOMI+MinionPro-Regular Flags: Symbolic FontBBox: -26, -257, 956, 811 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: VFTZFI+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 0 LastChar: 246 FontDescriptor: FontName: VFTZFI+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -137, -206, 978, 729 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: ISOGDC+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 0 LastChar: 233 FontDescriptor: FontName: ISOGDC+HelveticaNeueLTStd-Lt Flags: Symbolic FontBBox: -30, -214, 904, 786 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: XQPXXR+MinionPro-It FontSubset: true FirstChar: 2 LastChar: 243 FontDescriptor: FontName: XQPXXR+MinionPro-It Flags: Symbolic FontBBox: -142, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: BVYVJG+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 243 FontDescriptor: FontName: BVYVJG+HelveticaNeueLTStd-MdIt Flags: Symbolic FontBBox: -49, -205, 891, 731 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: WFYTDZ+MTGU FontSubset: true FirstChar: 97 LastChar: 114 FontDescriptor: FontName: WFYTDZ+MTGU Flags: Symbolic FontBBox: 0, -196, 607, 683 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true XMP: 2021-06-10T14:37:23+05:30 LaTeX with hyperref package + hypdvips 2021-06-10T15:43:54+05:30 2021-06-10T15:43:54+05:30 application/pdf Introduction: Duchenne (DMD) and Becker (BMD) muscular dystrophy are X-linked muscular disorders produced by mutations in the DMD gene which encodes the protein dystrophin. Jordi Dı́az-Manera Platelet Derived Growth Factor-AA Correlates With Muscle Function Tests and Quantitative Muscle Magnetic Resonance in Dystrophinopathies PDGF MRI biomarker Duchenne Becker dystrophinopathy PDGF, MRI, biomarker, Duchenne, Becker, dystrophinopathy dvips + MiKTeX GPL Ghostscript 9.0 uuid:594e554d-f7bc-47aa-bd8b-4c3c6240dbca uuid:db7d5e72-28da-40a4-b368-32c3a7e811d4 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 43, 719, 144, 755 Annotation: Subtype: Link Rect: 474, 736, 551, 744 Annotation: Subtype: Link Rect: 474, 728, 517, 736 Annotation: Subtype: Link Rect: 517, 729, 533, 736 Annotation: Subtype: Link Rect: 533, 728, 551, 736 Annotation: Subtype: Link Rect: 451, 720, 551, 728 Annotation: Subtype: Link Rect: 521, 678, 551, 709 Annotation: Subtype: Link Rect: 43, 30, 111, 38 Annotation: Subtype: Link Rect: 114, 30, 174, 38 Annotation: Subtype: Link Rect: 431, 29, 551, 38 Annotation: Subtype: Link Rect: 87, 545, 160, 555 Annotation: Subtype: Link Rect: 53, 397, 160, 406 Annotation: Subtype: Link Rect: 74, 70, 160, 78 Annotation: Subtype: Link Rect: 176, 517, 551, 630 Page: Label: 2 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 222, 550, 228, 562 Destination: External Annotation: Subtype: Link Rect: 86, 504, 93, 516 Destination: External Annotation: Subtype: Link Rect: 246, 493, 252, 504 Destination: External Annotation: Subtype: Link Rect: 279, 459, 285, 470 Destination: External Annotation: Subtype: Link Rect: 152, 401, 159, 413 Destination: External Annotation: Subtype: Link Rect: 93, 332, 99, 343 Destination: External Annotation: Subtype: Link Rect: 101, 332, 108, 343 Destination: External Annotation: Subtype: Link Rect: 277, 309, 284, 320 Destination: External Annotation: Subtype: Link Rect: 105, 228, 111, 239 Destination: External Annotation: Subtype: Link Rect: 114, 228, 125, 239 Destination: External Annotation: Subtype: Link Rect: 220, 194, 232, 205 Destination: External Annotation: Subtype: Link Rect: 235, 194, 246, 205 Destination: External Annotation: Subtype: Link Rect: 188, 125, 199, 136 Destination: External Annotation: Subtype: Link Rect: 202, 125, 213, 136 Destination: External Annotation: Subtype: Link Rect: 375, 180, 386, 192 Destination: External Annotation: Subtype: Link Rect: 415, 123, 426, 134 Destination: External Annotation: Subtype: Link Rect: 387, 89, 398, 100 Destination: External Annotation: Subtype: Link Rect: 43, 28, 111, 36 Annotation: Subtype: Link Rect: 114, 28, 174, 36 Annotation: Subtype: Link Rect: 431, 28, 551, 37 Page: Label: 3 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 101, 640, 112, 651 Destination: External Annotation: Subtype: Link Rect: 521, 651, 532, 662 Destination: External Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 431, 29, 551, 38 Page: Label: 4 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 83, 304, 113, 312 Destination: External Annotation: Subtype: Link Rect: 205, 168, 240, 178 Destination: External Annotation: Subtype: Link Rect: 198, 145, 239, 155 Destination: External Annotation: Subtype: Link Rect: 181, 64, 235, 75 Destination: External Annotation: Subtype: Link Rect: 362, 449, 392, 458 Destination: External Annotation: Subtype: Link Rect: 403, 390, 437, 400 Destination: External Annotation: Subtype: Link Rect: 307, 344, 358, 354 Destination: External Annotation: Subtype: Link Rect: 473, 122, 514, 132 Destination: External Annotation: Subtype: Link Rect: 521, 124, 532, 135 Destination: External Annotation: Subtype: Link Rect: 534, 124, 546, 135 Destination: External Annotation: Subtype: Link Rect: 422, 99, 462, 109 Destination: External Annotation: Subtype: Link Rect: 370, 64, 411, 75 Destination: External Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 431, 29, 551, 38 Page: Label: 5 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 431, 29, 551, 38 Page: Label: 6 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 282, 165, 289, 176 Destination: External Annotation: Subtype: Link Rect: 43, 153, 54, 165 Destination: External Annotation: Subtype: Link Rect: 59, 153, 70, 165 Destination: External Annotation: Subtype: Link Rect: 47, 107, 58, 119 Destination: External Annotation: Subtype: Link Rect: 61, 107, 73, 119 Destination: External Annotation: Subtype: Link Rect: 507, 392, 518, 403 Destination: External Annotation: Subtype: Link Rect: 326, 357, 337, 369 Destination: External Annotation: Subtype: Link Rect: 446, 323, 458, 335 Destination: External Annotation: Subtype: Link Rect: 460, 323, 472, 335 Destination: External Annotation: Subtype: Link Rect: 327, 312, 338, 323 Destination: External Annotation: Subtype: Link Rect: 418, 300, 429, 312 Destination: External Annotation: Subtype: Link Rect: 432, 300, 443, 312 Destination: External Annotation: Subtype: Link Rect: 400, 243, 411, 254 Destination: External Annotation: Subtype: Link Rect: 369, 186, 380, 197 Destination: External Annotation: Subtype: Link Rect: 383, 186, 394, 197 Destination: External Annotation: Subtype: Link Rect: 520, 174, 532, 186 Destination: External Annotation: Subtype: Link Rect: 534, 174, 546, 186 Destination: External Annotation: Subtype: Link Rect: 377, 140, 388, 151 Destination: External Annotation: Subtype: Link Rect: 473, 117, 484, 128 Destination: External Annotation: Subtype: Link Rect: 534, 82, 546, 94 Destination: External Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 431, 29, 551, 38 Page: Label: 7 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 431, 29, 551, 38 Page: Label: 8 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 217, 433, 228, 444 Destination: External Annotation: Subtype: Link Rect: 274, 387, 285, 398 Destination: External Annotation: Subtype: Link Rect: 116, 330, 127, 341 Destination: External Annotation: Subtype: Link Rect: 131, 330, 142, 341 Destination: External Annotation: Subtype: Link Rect: 263, 295, 275, 307 Destination: External Annotation: Subtype: Link Rect: 277, 295, 289, 307 Destination: External Annotation: Subtype: Link Rect: 43, 284, 54, 295 Destination: External Annotation: Subtype: Link Rect: 164, 227, 175, 238 Destination: External Annotation: Subtype: Link Rect: 179, 227, 190, 238 Destination: External Annotation: Subtype: Link Rect: 193, 227, 204, 238 Destination: External Annotation: Subtype: Link Rect: 96, 204, 107, 215 Destination: External Annotation: Subtype: Link Rect: 113, 204, 124, 215 Destination: External Annotation: Subtype: Link Rect: 123, 181, 134, 192 Destination: External Annotation: Subtype: Link Rect: 246, 146, 257, 158 Destination: External Annotation: Subtype: Link Rect: 260, 146, 271, 158 Destination: External Annotation: Subtype: Link Rect: 521, 295, 532, 307 Destination: External Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 431, 29, 551, 38 Page: Label: 9 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 106, 548, 117, 559 Destination: External Annotation: Subtype: Link Rect: 120, 548, 131, 559 Destination: External Annotation: Subtype: Link Rect: 87, 514, 98, 525 Destination: External Annotation: Subtype: Link Rect: 144, 342, 155, 353 Destination: External Annotation: Subtype: Link Rect: 158, 342, 169, 353 Destination: External Annotation: Subtype: Link Rect: 231, 284, 242, 296 Destination: External Annotation: Subtype: Link Rect: 245, 284, 256, 296 Destination: External Annotation: Subtype: Link Rect: 338, 97, 437, 106 Annotation: Subtype: Link Rect: 341, 68, 464, 77 Annotation: Subtype: Link Rect: 43, 28, 111, 36 Annotation: Subtype: Link Rect: 114, 28, 174, 36 Annotation: Subtype: Link Rect: 431, 28, 551, 37 Page: Label: 10 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 108, 678, 232, 687 Annotation: Subtype: Link Rect: 126, 659, 204, 668 Annotation: Subtype: Link Rect: 81, 632, 156, 640 Annotation: Subtype: Link Rect: 108, 602, 175, 611 Annotation: Subtype: Link Rect: 143, 576, 232, 583 Annotation: Subtype: Link Rect: 77, 538, 138, 545 Annotation: Subtype: Link Rect: 292, 497, 56, 518 Annotation: Subtype: Link Rect: 190, 470, 273, 479 Annotation: Subtype: Link Rect: 81, 422, 164, 432 Annotation: Subtype: Link Rect: 77, 386, 153, 394 Annotation: Subtype: Link Rect: 81, 348, 146, 356 Annotation: Subtype: Link Rect: 81, 311, 135, 318 Annotation: Subtype: Link Rect: 129, 282, 175, 289 Annotation: Subtype: Link Rect: 81, 254, 151, 261 Annotation: Subtype: Link Rect: 190, 224, 273, 233 Annotation: Subtype: Link Rect: 126, 178, 207, 185 Annotation: Subtype: Link Rect: 150, 150, 253, 157 Annotation: Subtype: Link Rect: 104, 110, 186, 119 Annotation: Subtype: Link Rect: 199, 83, 287, 91 Annotation: Subtype: Link Rect: 368, 678, 426, 687 Annotation: Subtype: Link Rect: 372, 650, 437, 659 Annotation: Subtype: Link Rect: 368, 612, 451, 621 Annotation: Subtype: Link Rect: 475, 584, 540, 592 Annotation: Subtype: Link Rect: 463, 555, 542, 564 Annotation: Subtype: Link Rect: 361, 518, 427, 526 Annotation: Subtype: Link Rect: 341, 481, 428, 488 Annotation: Subtype: Link Rect: 368, 443, 453, 450 Annotation: Subtype: Link Rect: 372, 405, 462, 413 Annotation: Subtype: Link Rect: 473, 366, 535, 375 Annotation: Subtype: Link Rect: 451, 328, 533, 337 Annotation: Subtype: Link Rect: 341, 290, 403, 299 Annotation: Subtype: Link Rect: 365, 252, 447, 261 Annotation: Subtype: Link Rect: 552, 215, 316, 234 Annotation: Subtype: Link Rect: 408, 195, 498, 205 Annotation: Subtype: Link Rect: 341, 157, 429, 167 Annotation: Subtype: Link Rect: 345, 129, 435, 138 Annotation: Subtype: Link Rect: 341, 101, 431, 110 Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 431, 29, 551, 38 Page: Label: 11 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 129, 697, 187, 706 Annotation: Subtype: Link Rect: 196, 678, 281, 687 Annotation: Subtype: Link Rect: 104, 642, 158, 649 Annotation: Subtype: Link Rect: 81, 612, 168, 621 Annotation: Subtype: Link Rect: 124, 576, 209, 583 Annotation: Subtype: Link Rect: 202, 555, 280, 564 Annotation: Subtype: Link Rect: 122, 536, 206, 545 Annotation: Subtype: Link Rect: 77, 498, 148, 508 Annotation: Subtype: Link Rect: 81, 471, 141, 479 Annotation: Subtype: Link Rect: 146, 432, 212, 441 Annotation: Subtype: Link Rect: 147, 396, 232, 403 Annotation: Subtype: Link Rect: 292, 357, 56, 376 Annotation: Subtype: Link Rect: 126, 329, 211, 337 Annotation: Subtype: Link Rect: 104, 299, 201, 309 Annotation: Subtype: Link Rect: 132, 262, 225, 271 Annotation: Subtype: Link Rect: 386, 687, 468, 697 Annotation: Subtype: Link Rect: 552, 640, 316, 660 Annotation: Subtype: Link Rect: 430, 604, 529, 611 Annotation: Subtype: Link Rect: 358, 566, 429, 573 Annotation: Subtype: Link Rect: 341, 527, 406, 536 Annotation: Subtype: Link Rect: 367, 500, 460, 508 Annotation: Subtype: Link Rect: 354, 462, 443, 469 Annotation: Subtype: Link Rect: 405, 310, 431, 317 Annotation: Subtype: Link Rect: 431, 310, 463, 317 Annotation: Subtype: Link Rect: 463, 310, 499, 318 Annotation: Subtype: Link Rect: 499, 310, 522, 317 Annotation: Subtype: Link Rect: 522, 309, 549, 318 Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 431, 29, 551, 38 Checksum: 9538e1be Type: CRC32 Checksum: 7de2e9cce3aefafba62a4bc4f0d9d97d Type: MD5 Checksum: 4d1964b80498327edd8c5ebcfa94043302b55dc3 Type: SHA-1 Checksum: 8e42954022a47026afa8a9210cc546a958539dce69be3507f86234091d5b9831 Type: SHA-256