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Background Destination: 1 Item: Title: 2. Methods/design Destination: 1 Children: Item: Title: 2.1. Objectives Destination: 1 Item: Title: 2.2. Study design Destination: 1 Item: Title: 2.3. Study population Destination: 1 Item: Title: 2.4. Recruitment procedure Destination: 1 Item: Title: 2.5. Follow-up procedure Destination: 1 Children: Item: Title: 2.5.1. Participants withdrawal Destination: 1 Item: Title: 2.5.2. Randomization and blinding Destination: 1 Item: Title: 2.6. Trial interventions Destination: 1 Item: Title: 2.7. Harms Destination: 1 Item: Title: 2.8. Outcomes Destination: 1 Children: Item: Title: 2.8.1. Primary outcome Destination: 1 Item: Title: 2.8.2. Secondary outcomes Destination: 1 Item: Title: 2.9. Data collection and processing Destination: 1 Item: Title: 2.10. Funding source Destination: 1 Item: Title: 2.11. Statistical analysis Destination: 1 Item: Title: 2.12. Sample size Destination: 1 Item: Title: 2.13. Data management and protection Destination: 1 Children: Item: Title: 2.13.1. Data safety monitoring Destination: 1 Item: Title: 2.13.2. Auditing of the participating medical centers Destination: 1 Item: Title: 2.14. Ethical approval Destination: 1 Item: Title: 3. Discussion Destination: 1 Children: Item: Title: Availability of the protocol Destination: 1 Item: Title: Trial status Destination: 1 Item: Title: Contributors Destination: 1 Item: Title: References Destination: 1 Info: Title: Efficacy and safety of preoperative preparation with Lugol's iodine solution in euthyroid patients with Graves’ disease (LIGRADIS Trial): Study protocol for a multicenter randomized trial Author: José Luis Muñoz de Nova Subject: Contemporary Clinical Trials Communications, 22 (2021) 100806. doi:10.1016/j.conctc.2021.100806 Keywords: Thyroid surgery,Graves' disease,Lugol's solution,Hyperthyroidism Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Sat Jun 19 05:06:37 CEST 2021 ModDate: Sat Jun 19 05:22:31 CEST 2021 ID: 0xb11f83e441724d86b427b665f114bc76, 0xf263c722ba101454c9a5eb115e575c35 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 228 ImageHeight: 296 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1442 ImageHeight: 1817 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: VLKIAP+STIX-Regular FontSubset: true FirstChar: 32 LastChar: 255 FontDescriptor: FontName: VLKIAP+STIX-Regular Flags: Symbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: MacRomanEncoding Differences: true ToUnicode: true TrueType: Font: BaseFont: PXAAAA+CharisSIL FontSubset: true FirstChar: 1 LastChar: 96 FontDescriptor: FontName: CharisSIL Flags: Symbolic FontBBox: -692, -533, 3000, 1269 FontFile2: true ToUnicode: true Font: BaseFont: PXAAAC+CharisSIL-Italic FontSubset: true FirstChar: 32 LastChar: 255 FontDescriptor: FontName: CharisSIL-Italic Flags: Nonsymbolic, Italic FontBBox: -716, -533, 3057, 1269 FontFile2: true Encoding: MacRomanEncoding Font: BaseFont: PXAAAD+CharisSIL-Bold FontSubset: true FirstChar: 32 LastChar: 255 FontDescriptor: FontName: CharisSIL-Bold Flags: Nonsymbolic FontBBox: -720, -533, 3000, 1269 FontFile2: true Encoding: MacRomanEncoding XMP: http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf 10.1016/j.conctc.2021.100806 Elsevier Inc. Contemporary Clinical Trials Communications, 22 (2021) 100806. doi:10.1016/j.conctc.2021.100806 Thyroid surgery Graves' disease Lugol's solution Hyperthyroidism Efficacy and safety of preoperative preparation with Lugol's iodine solution in euthyroid patients with Graves’ disease (LIGRADIS Trial): Study protocol for a multicenter randomized trial José Luis Muñoz de Nova Guzmán Franch-Arcas Gina Paola Mejía-Abril María Eugenia Flores-Ruiz Nuria Muñoz-Pérez Elena Pintos-Sánchez Francisco Javier Guadarrama González Álvaro Valdés de Anca Enrique Mercader-Cidoncha Aitor de la Quintana-Basarrate Irene Osorio-Silla Susana Ros-López Lander Gallego-Otaegui Elena Santos-Molina Concepción Martínez-Nieto Elena Gamborino-Caramés Mariano Artés-Caselles Leyre Lorente-Poch Maitane García-Carrillo Pablo Moreno-Llorente Consuelo Marín-Velarde Joaquín Ortega-Serrano Juan Manuel Martos-Martínez Oscar Vidal-Pérez Patricia Luengo-Pierrard Jesús María Villar-del-Moral VoR 19th June 2021 Acrobat Distiller 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