52d433730dcbbb778c61cb60a8ca5060 pmc_34199265.pdf cf6971db5d9ed6a0337b1c5fd85de2d3c5ba1a16 pmc_34199265.pdf cdbf28e40ab344d28df4e3ee687ba8f0ff156c7e4b40f7514a043e81f2907d2a pmc_34199265.pdf Title: Lifetime Weight Course as a Phenotypic Marker of Severity and Therapeutic Response in Patients with Eating Disorders Subject: The association between lifetime weight fluctuations and clinical characteristics has been widely studied in populations with eating disorders (ED). However, there is a lack of literature examining the potential role of weight course as a transdiagnostic factor in ED so far. Therefore, the aim of this study is to compare ED severity and treatment outcomes among four specific BMI profiles based on BMI-trajectories across the lifespan: (a) persistent obesity (OB-OB; (n = 74)), (b) obesity in the past but currently in a normal weight range (OB-NW; n = 156), (c) normal weight throughout the lifespan (NW-NW; n = 756), and (d) current obesity but previously at normal weight (NW-OB; n = 314). Lifetime obesity is associated with greater general psychopathology and personality traits such as low persistence and self-directedness, and high reward dependence. Additionally, greater extreme weight changes (NW-OB and OB-NW) were associated with higher psychopathology but not with greater ED severity. Higher dropout rates were found in the OB-OB group. These results shed new light on the BMI trajectory as a transdiagnostic feature playing a pivotal role in the severity and treatment outcome in patients with ED. Keywords: body mass index (BMI) profiles; eating disorders; obesity; treatment outcome Author: Zaida Agüera, Cristina Vintró-Alcaraz, Isabel Baenas, Roser Granero, Isabel Sánchez, Jéssica Sánchez-González, José M. Menchón, Susana Jiménez-Murcia, Janet Treasure and Fernando Fernández-Aranda Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Jun 15 11:39:14 2021 CEST ModDate: Tue Jun 15 12:31:58 2021 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1297648 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HKBJPQ+VnURWPalladioL Type 1 Custom yes yes no 10 0 KOJCWM+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 KHEPKH+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 WIMYBB+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 ZZTQUO+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 HGMNRX+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 36 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 58 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 62 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 66 0 ZIPEAN+EURM10 Type 1 Builtin yes yes no 81 0 FXXUVH+CMSY10 Type 1 Builtin yes yes no 92 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 100 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 104 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 108 0 BCDHEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 112 0 Arial-BoldMT TrueType WinAnsi no no no 120 0 ArialMT TrueType WinAnsi no no no 123 0 URYLRZ+URWPalladioL-BoldItal Type 1 Custom yes yes no 129 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 144 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 148 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 152 0 BCDHEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 156 0 BCDIEE+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 163 0 BCDJEE+PalatinoLinotype-BoldItalic TrueType WinAnsi yes yes no 170 0 Arial-BoldMT TrueType WinAnsi no no no 175 0 ArialMT TrueType WinAnsi no no no 178 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 200 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 204 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 208 0 BCDHEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 212 0 BCDJEE+PalatinoLinotype-BoldItalic TrueType WinAnsi yes yes no 219 0 Arial-BoldMT TrueType WinAnsi no no no 224 0 ArialMT TrueType WinAnsi no no no 227 0 CRUZTT+VnURWPalladioL-Italic Type 1 Custom yes yes no 243 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:12:57 CEST RepresentationInformation: pmc_34199265.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:14:17 CEST Size: 1297648 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 472 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Participants Destination: subsection.2.1 Item: Title: Assessment Destination: subsection.2.2 Item: Title: Treatment Destination: subsection.2.3 Item: Title: Statistical Analyses Destination: subsection.2.4 Item: Title: Results Destination: section.3 Children: Item: Title: Comparison between the Groups for Sociodemographics, BMI, and Motivational Measures Destination: subsection.3.1 Item: Title: Comparison between the Groups for Clinical Measures Destination: subsection.3.2 Item: Title: Comparison between the Groups for Impulsive Behaviors Destination: subsection.3.3 Item: Title: Association between Age of Onset of ED and Age of Maximum BMI Destination: subsection.3.4 Item: Title: Comparison of the CBT Outcomes between the BMI Profiles Destination: subsection.3.5 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.5 Info: Title: Lifetime Weight Course as a Phenotypic Marker of Severity and Therapeutic Response in Patients with Eating Disorders Author: Zaida Agüera, Cristina Vintró-Alcaraz, Isabel Baenas, Roser Granero, Isabel Sánchez, Jéssica Sánchez-González, José M. Menchón, Susana Jiménez-Murcia, Janet Treasure and Fernando Fernández-Aranda Subject: The association between lifetime weight fluctuations and clinical characteristics has been widely studied in populations with eating disorders (ED). However, there is a lack of literature examining the potential role of weight course as a transdiagnostic factor in ED so far. Therefore, the aim of this study is to compare ED severity and treatment outcomes among four specific BMI profiles based on BMI-trajectories across the lifespan: (a) persistent obesity (OB-OB; (n = 74)), (b) obesity in the past but currently in a normal weight range (OB-NW; n = 156), (c) normal weight throughout the lifespan (NW-NW; n = 756), and (d) current obesity but previously at normal weight (NW-OB; n = 314). Lifetime obesity is associated with greater general psychopathology and personality traits such as low persistence and self-directedness, and high reward dependence. Additionally, greater extreme weight changes (NW-OB and OB-NW) were associated with higher psychopathology but not with greater ED severity. Higher dropout rates were found in the OB-OB group. These results shed new light on the BMI trajectory as a transdiagnostic feature playing a pivotal role in the severity and treatment outcome in patients with ED. 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