bf3ca2724b3a1e313f1be53fe1890ec6 pmc_34200304.pdf a7ee526e54e9ce2477111ac82da8b82b5a424a31 pmc_34200304.pdf 593d39df626006877a7eb3c673aca1db6fb5caa730ec0e60f8b3a3a64615451c pmc_34200304.pdf Title: Maternal Supplementation with Polyphenols and Omega-3 Fatty Acids during Pregnancy: Prenatal Effects on Growth and Metabolism Subject: Maternal supplementation with antioxidants and n-3 PUFAs may be a promising strategy to reduce the risk of intrauterine growth restriction and preterm delivery, which may diminish the appearance of low-birth-neonates. A previous studies showed beneficial outcomes of the combination of hydroxytyrosol and linoleic acid, but there is no data of its prenatal effects. The present study aimed to determine the possible prenatal implications of such maternal supplementation at prenatal stages in swine, a model of IUGR pregnancies. Results showed effects on litter size, with treated sows having larger litters and, therefore, smaller fetuses. However, the brain/head weight ratio showed a positive effect of the treatment in development, as well as in some other major organs like lungs, spleen, or kidneys. On the other hand, treated piglets showed better glycemic and lipidemic profiles, which could explain postnatal effects. However, further research on the implications of the treatment on litter size and prenatal and postnatal development must be done before practical recommendation can be given. Keywords: antioxidants; fatty-acids; intrauterine-growth-restriction; pregnancy; swine-model Author: Ana Heras-Molina, José Luis Pesántez-Pacheco, Consolación Garcia-Contreras, Marta Vázquez-Gómez, Adrián López, Rita Benítez, Yolanda Núñez, Susana Astiz, Cristina Óvilo, Beatriz Isabel and Antonio González-Bulnes Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Jun 8 05:20:35 2021 CEST ModDate: Tue Jun 8 05:36:45 2021 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1061288 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WRQCWE+VnURWPalladioL Type 1 Custom yes yes no 10 0 GRFEHY+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 XAFMUO+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 YGEELW+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 MMXMSZ+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 SZMRXJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 36 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 58 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 62 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 66 0 ZXDKIP+EURM10 Type 1 Builtin yes yes no 78 0 XEYJZU+CMSY10 Type 1 Builtin yes yes no 85 0 ABCDEE+Palatino Linotype,Bold TrueType WinAnsi yes yes no 103 0 ABCDEE+Palatino Linotype TrueType WinAnsi yes yes no 107 0 ABCDEE+Palatino Linotype,Italic TrueType WinAnsi yes yes no 111 0 ABCDEE+Palatino Linotype CID TrueType Identity-H yes yes yes 115 0 ABCDEE+Palatino Linotype,Bold TrueType WinAnsi yes yes no 132 0 ABCDEE+Palatino Linotype TrueType WinAnsi yes yes no 136 0 ABCDEE+Palatino Linotype,Italic TrueType WinAnsi yes yes no 140 0 ABCDEE+Palatino Linotype CID TrueType Identity-H yes yes yes 144 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:12:45 CEST RepresentationInformation: pmc_34200304.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:14:18 CEST Size: 1061288 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 340 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Ethic Statement Destination: subsection.2.1 Item: Title: Animals and Experimental Procedures Destination: subsection.2.2 Item: Title: Sampling of Fetuses and Placentas Destination: subsection.2.3 Item: Title: Evaluation of Maternal and Fetal Anti/Prooxidant and Metabolic Status Destination: subsection.2.4 Item: Title: Statistical Analysis Destination: subsection.2.5 Item: Title: Results Destination: section.3 Children: Item: Title: Effects of Dietary Hydroxytyrosol and n-3 PUFA on the Sows Destination: subsection.3.1 Item: Title: Effects of Dietary Hydroxytyrosol and n-3 PUFA on the Fetuses Destination: subsection.3.2 Children: Item: Title: Effects on Litter Features Destination: subsubsection.3.2.1 Item: Title: Effects on Body Weight, Size, and Composition Destination: subsubsection.3.2.2 Item: Title: Effects on Fetal Pro-Antioxidant and Metabolic Status Destination: subsubsection.3.2.3 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.5 Info: Title: Maternal Supplementation with Polyphenols and Omega-3 Fatty Acids during Pregnancy: Prenatal Effects on Growth and Metabolism Author: Ana Heras-Molina, José Luis Pesántez-Pacheco, Consolación Garcia-Contreras, Marta Vázquez-Gómez, Adrián López, Rita Benítez, Yolanda Núñez, Susana Astiz, Cristina Óvilo, Beatriz Isabel and Antonio González-Bulnes Subject: Maternal supplementation with antioxidants and n-3 PUFAs may be a promising strategy to reduce the risk of intrauterine growth restriction and preterm delivery, which may diminish the appearance of low-birth-neonates. A previous studies showed beneficial outcomes of the combination of hydroxytyrosol and linoleic acid, but there is no data of its prenatal effects. The present study aimed to determine the possible prenatal implications of such maternal supplementation at prenatal stages in swine, a model of IUGR pregnancies. Results showed effects on litter size, with treated sows having larger litters and, therefore, smaller fetuses. However, the brain/head weight ratio showed a positive effect of the treatment in development, as well as in some other major organs like lungs, spleen, or kidneys. On the other hand, treated piglets showed better glycemic and lipidemic profiles, which could explain postnatal effects. However, further research on the implications of the treatment on litter size and prenatal and postnatal development must be done before practical recommendation can be given. 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