09ab10f6f4c4a0ef26ca126d5ff1d526 pmc_34209585.pdf 79227bbc4c9a1bec070d580114d312ed94237746 pmc_34209585.pdf 6819bd5270c37195d7df2b701ee94d1017c933656061ed5b0962f70adfd416ce pmc_34209585.pdf Title: A New Classification of the Severity of Psoriasis: What’s Moderate Psoriasis? Subject: The purpose of this study is to propose a ranking system for the severity of psoriasis. The consensus method of selecting the indices to include and the classification of real patient profiles by an expert panel to create a gold standard of severity were used. The performance of potential cut-offs was evaluated to create a ranking algorithm. The combined use of PASI, BSA, and sPGA may allow the classification of the severity of psoriatic patients. The final algorithm identifies severe patients in a single step (2 out 3 are met: PASI 11 or BSA 10 or sPGA 3), while two steps are required for mild ((2 out 3 are met: PASI 3 or BSA 5 or sPGA 2) and DLQI < 5) and moderate forms (the patient does not meet 2 out 3 (PASI 11 or BSA 10 or sPGA 3) but has a DLQI 5. A ranking algorithm is presented, consisting of different measures of disease which classifies psoriatic patients into three categories: mild, moderate, and severe. Keywords: psoriasis; severity; classification; moderate; discrimination; cut-offs Author: Laura Salgado-Boquete, José Manuel Carrascosa, Mar Llamas-Velasco, Ricardo Ruiz-Villaverde, Pablo de la Cueva and Isabel Belinchón Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Jun 29 09:38:28 2021 CEST ModDate: Tue Jun 29 09:42:11 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 919434 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DRZUJM+VnURWPalladioL Type 1 Custom yes yes no 10 0 DBIYTU+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 IFVWWI+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 PEDSPV+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 IKKWKP+CMSY10 Type 1 Builtin yes yes no 28 0 HJOMHV+VnURWPalladioL-Bold Type 1 Custom yes yes no 32 0 PJCGLK+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 41 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 63 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 67 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 71 0 URYLRZ+URWPalladioL-BoldItal Type 1 Custom yes yes no 92 0 TTFQJI+CMBSY10 Type 1 Builtin yes yes no 96 0 MPDJPD+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 110 0 MPDKAE+PalatinoLinotype CID TrueType Identity-H yes yes yes 113 0 MPDKAF+PalatinoLinotype TrueType WinAnsi yes yes no 119 0 MPDKAH+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 122 0 MPDMGJ+Arial CID TrueType Identity-H yes yes yes 125 0 MPDJPD+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 138 0 MPDKAE+PalatinoLinotype CID TrueType Identity-H yes yes yes 141 0 MPDKAF+PalatinoLinotype TrueType WinAnsi yes yes no 147 0 MPDKAH+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 150 0 MPDMGJ+Arial CID TrueType Identity-H yes yes yes 153 0 MPDJPD+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 170 0 MPDKAE+PalatinoLinotype CID TrueType Identity-H yes yes yes 173 0 MPDKAF+PalatinoLinotype TrueType WinAnsi yes yes no 179 0 MPDKAH+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 182 0 MPDMGJ+Arial CID TrueType Identity-H yes yes yes 185 0 KGSZMU+VnURWPalladioL-Italic Type 1 Custom yes yes no 201 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-07-28 02:42:34 CEST RepresentationInformation: pmc_34209585.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 12:14:24 CEST Size: 919434 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 320 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Expert Panels Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Selection of Indices to Be Included in the Proposal Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Patient Profiles and Gold Standard Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Statistical Analysis, Definitions, and Diagnostic Performance Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Children: Item: Title: Selection of Indices to Be Included in the Definition: Delphi Study Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Patient Profiles Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Strength of Association Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Cut-off Points Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Models and Performance: ROC Curves Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Info: Title: A New Classification of the Severity of Psoriasis: What’s Moderate Psoriasis? Author: Laura Salgado-Boquete, José Manuel Carrascosa, Mar Llamas-Velasco, Ricardo Ruiz-Villaverde, Pablo de la Cueva and Isabel Belinchón Subject: The purpose of this study is to propose a ranking system for the severity of psoriasis. The consensus method of selecting the indices to include and the classification of real patient profiles by an expert panel to create a gold standard of severity were used. The performance of potential cut-offs was evaluated to create a ranking algorithm. The combined use of PASI, BSA, and sPGA may allow the classification of the severity of psoriatic patients. The final algorithm identifies severe patients in a single step (2 out 3 are met: PASI 11 or BSA 10 or sPGA 3), while two steps are required for mild ((2 out 3 are met: PASI 3 or BSA 5 or sPGA 2) and DLQI < 5) and moderate forms (the patient does not meet 2 out 3 (PASI 11 or BSA 10 or sPGA 3) but has a DLQI 5. A ranking algorithm is presented, consisting of different measures of disease which classifies psoriatic patients into three categories: mild, moderate, and severe. 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