8c15e18241ce8871384eb3c0a258f0db pmc_34209680.pdf 7c4b82917365ce166e86fb069e846873d57ad94b pmc_34209680.pdf 67ece0fffb3229360d451e97f1f064eece5885ce4190291cf6d72afcc37e70a8 pmc_34209680.pdf Title: Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study Subject: (1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: Prospective, population-based nationwide registry. Adult patients diagnosed with IBD—Crohn’s disease (CD), ulcerative colitis (UC) or IBD unclassified (IBD-U)—during 2017 in Spain were included and were followed-up for 1 year. (3) Results: We identified 3611 incident cases of IBD diagnosed during 2017 in 108 hospitals covering over 22 million inhabitants. The overall incidence (cases/100,000 person-years) was 16 for IBD, 7.5 for CD, 8 for UC, and 0.5 for IBD-U; 53% of patients were male and median age was 43 years (interquartile range = 31–56 years). During a median 12-month follow-up, 34% of patients were treated with systemic steroids, 25% with immunomodulators, 15% with biologics and 5.6% underwent surgery. The percentage of patients under these treatments was significantly higher in CD than UC and IBD-U. Use of systemic steroids and biologics was significantly higher in hospitals with high resources. In total, 28% of patients were hospitalized (35% CD and 22% UC patients, p < 0.01). (4) Conclusion: The incidence of IBD in Spain is rather high and similar to that reported in Northern Europe. IBD patients require substantial therapeutic resources, which are greater in CD and in hospitals with high resources, and much higher than previously reported. One third of patients are hospitalized in the first year after diagnosis and a relevant proportion undergo surgery. Keywords: epidemiology; incidence; inflammatory bowel disease; Crohn’s disease; ulcerative colitis Author: María Chaparro, Ana Garre, Andrea Núñez Ortiz, María Teresa Diz-Lois Palomares, Cristina Rodríguez, Sabino Riestra, Milagros Vela, José Manuel Benítez, Estela Fernández Salgado, Eugenia Sánchez Rodríguez, Vicent Hernández, Rocío Ferreiro-Iglesias, Ángel Ponferrada Díaz, Jesús Barrio, José María Huguet, Beatriz Sicilia, María Dolores Martín-Arranz, Xavier Calvet, Daniel Ginard, Inmaculada Alonso-Abreu, Luis Fernández-Salazar, Pilar Varela Trastoy, Montserrat Rivero, Isabel Vera-Mendoza, Pablo Vega, Pablo Navarro, Mónica Sierra, José Luis Cabriada, Mariam Aguas, Raquel Vicente, Mercè Navarro-Llavat, Ana Echarri, Fernando Gomollón, Elena Guerra del Río, Concepción Piñero, María José Casanova, Katerina Spicakova, Jone Ortiz de Zarate, Emilio Torrella Cortés, Ana Gutiérrez, Horacio Alonso-Galán, Álvaro Hernández-Martínez, José Miguel Marrero, Rufo Lorente Poyatos, Margalida Calafat, Lidia Martí Romero, Pilar Robledo, Orencio Bosch, Nuria Jiménez, María Esteve Comas, José María Duque, Ana María Fuentes Coronel, Manuela Josefa Sampedro, Eva Sesé Abizanda, Belén Herreros Martínez, Liliana Pozzati, Hipólito Fernández Rosáenz, Belén Crespo Suarez, Pilar López Serrano, Alfredo J. Lucendo, Margarita Muñoz Vicente, Fernando Bermejo, José Joaquín Ramírez Palanca, Margarita Menacho, Amalia Carmona, Raquel Camargo, Sandra Torra Alsina, Nuria Maroto, Juan Nerín de la Puerta, Elena Castro, Ignacio Marín-Jiménez, Belén Botella, Amparo Sapiña, Noelia Cruz, José Luis F. Forcelledo, Abdel Bouhmidi, Carlos Castaño-Milla, Verónica Opio, Isabel Nicolás, Marcos Kutz, Alfredo Abraldes Bechiarelli, Jordi Gordillo, Yolanda Ber, Yolanda Torres Domínguez, María Teresa Novella Durán, Silvia Rodríguez Mondéjar, Francisco J. Martínez-Cerezo, Lilyan Kolle, Miriam Sabat, Cesar Ledezma, Eduardo Iyo, Óscar Roncero, Rebeca Irisarri, Laia Lluis, Isabel Blázquez Gómez, Eva María Zapata, María José Alcalá, Cristina Martínez Pascual, María Montealegre, Laura Mata, Ana Monrobel, Alejandro Hernández Camba, Luis Hernández, María Tejada, Alberto Mir, María Luisa Galve, Marta Soler, Daniel Hervías, José Antonio Gómez-Valero, Manuel Barreiro-de Acosta, Fernando Rodríguez-Artalejo, Esther García-Esquinas, Javier P. Gisbert and on behalf of the EpidemIBD study group of GETECCU Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Jun 30 03:16:48 2021 CEST ModDate: Wed Jun 30 03:29:00 2021 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 19 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1366811 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IYDCBB+VnURWPalladioL Type 1 Custom yes yes no 10 0 JYJOMY+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 RBISDP+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 NJSWDA+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 OFOJGC+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 36 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 39 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 61 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 65 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 69 0 PDTLUH+CMSY10 Type 1 Builtin yes yes no 93 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 100 0 JLZORU+EURM10 Type 1 Builtin yes yes no 104 0 HTXPSE+ArialMT TrueType WinAnsi yes yes yes 129 0 LHYIWW+Calibri TrueType WinAnsi yes yes yes 133 0 ULHSBP+ArialMT TrueType WinAnsi yes yes yes 161 0 DJQUXX+Calibri TrueType WinAnsi yes yes yes 165 0 ZAGZSF+ArialMT TrueType WinAnsi yes yes yes 189 0 IYPBON+Calibri TrueType WinAnsi yes yes yes 193 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:11:52 CEST RepresentationInformation: pmc_34209680.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:14:24 CEST Size: 1366811 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 373 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Methods Destination: section.2 Children: Item: Title: Study Design Destination: subsection.2.1 Item: Title: Study Population Destination: subsection.2.2 Item: Title: Recruitment and Patient Follow-Up Destination: subsection.2.3 Item: Title: Definitions Destination: subsection.2.4 Item: Title: Data Collection and Follow-Up Destination: subsection.2.5 Item: Title: Statistical Analysis Destination: subsection.2.6 Item: Title: Results Destination: section.3 Children: Item: Title: Incidence of IBD Destination: subsection.3.1 Item: Title: Patients’ Characteristics Destination: subsection.3.2 Item: Title: Drug Treatment and Surgery during the First 12 Months after Diagnosis Destination: subsection.3.3 Item: Title: Hospitalizations Destination: subsection.3.4 Item: Title: Drug Treatments, Surgery and Hospitalizations during the First 12 Months Based on Hospital Category Destination: subsection.3.5 Item: Title: Discussion Destination: section.4 Item: Title: References Destination: section.4 Info: Title: Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study Author: María Chaparro, Ana Garre, Andrea Núñez Ortiz, María Teresa Diz-Lois Palomares, Cristina Rodríguez, Sabino Riestra, Milagros Vela, José Manuel Benítez, Estela Fernández Salgado, Eugenia Sánchez Rodríguez, Vicent Hernández, Rocío Ferreiro-Iglesias, Ángel Ponferrada Díaz, Jesús Barrio, José María Huguet, Beatriz Sicilia, María Dolores Martín-Arranz, Xavier Calvet, Daniel Ginard, Inmaculada Alonso-Abreu, Luis Fernández-Salazar, Pilar Varela Trastoy, Montserrat Rivero, Isabel Vera-Mendoza, Pablo Vega, Pablo Navarro, Mónica Sierra, José Luis Cabriada, Mariam Aguas, Raquel Vicente, Mercè Navarro-Llavat, Ana Echarri, Fernando Gomollón, Elena Guerra del Río, Concepción Piñero, María José Casanova, Katerina Spicakova, Jone Ortiz de Zarate, Emilio Torrella Cortés, Ana Gutiérrez, Horacio Alonso-Galán, Álvaro Hernández-Martínez, José Miguel Marrero, Rufo Lorente Poyatos, Margalida Calafat, Lidia Martí Romero, Pilar Robledo, Orencio Bosch, Nuria Jiménez, María Esteve Comas, José María Duque, Ana María Fuentes Coronel, Manuela Josefa Sampedro, Eva Sesé Abizanda, Belén Herreros Martínez, Liliana Pozzati, Hipólito Fernández Rosáenz, Belén Crespo Suarez, Pilar López Serrano, Alfredo J. Lucendo, Margarita Muñoz Vicente, Fernando Bermejo, José Joaquín Ramírez Palanca, Margarita Menacho, Amalia Carmona, Raquel Camargo, Sandra Torra Alsina, Nuria Maroto, Juan Nerín de la Puerta, Elena Castro, Ignacio Marín-Jiménez, Belén Botella, Amparo Sapiña, Noelia Cruz, José Luis F. Forcelledo, Abdel Bouhmidi, Carlos Castaño-Milla, Verónica Opio, Isabel Nicolás, Marcos Kutz, Alfredo Abraldes Bechiarelli, Jordi Gordillo, Yolanda Ber, Yolanda Torres Domínguez, María Teresa Novella Durán, Silvia Rodríguez Mondéjar, Francisco J. Martínez-Cerezo, Lilyan Kolle, Miriam Sabat, Cesar Ledezma, Eduardo Iyo, Óscar Roncero, Rebeca Irisarri, Laia Lluis, Isabel Blázquez Gómez, Eva María Zapata, María José Alcalá, Cristina Martínez Pascual, María Montealegre, Laura Mata, Ana Monrobel, Alejandro Hernández Camba, Luis Hernández, María Tejada, Alberto Mir, María Luisa Galve, Marta Soler, Daniel Hervías, José Antonio Gómez-Valero, Manuel Barreiro-de Acosta, Fernando Rodríguez-Artalejo, Esther García-Esquinas, Javier P. Gisbert and on behalf of the EpidemIBD study group of GETECCU Subject: (1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: Prospective, population-based nationwide registry. Adult patients diagnosed with IBD Crohn’s disease (CD), ulcerative colitis (UC) or IBD unclassified (IBD-U) during 2017 in Spain were included and were followed-up for 1 year. (3) Results: We identified 3611 incident cases of IBD diagnosed during 2017 in 108 hospitals covering over 22 million inhabitants. The overall incidence (cases/100,000 person-years) was 16 for IBD, 7.5 for CD, 8 for UC, and 0.5 for IBD-U; 53% of patients were male and median age was 43 years (interquartile range = 31 56 years). During a median 12-month follow-up, 34% of patients were treated with systemic steroids, 25% with immunomodulators, 15% with biologics and 5.6% underwent surgery. The percentage of patients under these treatments was significantly higher in CD than UC and IBD-U. Use of systemic steroids and biologics was significantly higher in hospitals with high resources. In total, 28% of patients were hospitalized (35% CD and 22% UC patients, p < 0.01). (4) Conclusion: The incidence of IBD in Spain is rather high and similar to that reported in Northern Europe. IBD patients require substantial therapeutic resources, which are greater in CD and in hospitals with high resources, and much higher than previously reported. One third of patients are hospitalized in the first year after diagnosis and a relevant proportion undergo surgery. 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