8fb8d0f0943c57a0549a9bb7f0502cdc pmc_34210055.pdf 08ea5d80de586bbb22e8ea658bc376c64aa33173 pmc_34210055.pdf 4c65027aada8fb04ba802b6a5b1ca1099ebe6d4d35b1949f942d2bd4fbdd7abc pmc_34210055.pdf Title: Predictive Role of Leptin Receptor (Ob-R) Overexpression in Patients with Early Breast Cancer Receiving Neoadjuvant Systemic Treatment Subject: The primary aim of this retrospective study was to investigate the correlation between the immunohistochemical expression of Ob-R (leptin receptor) with pCR (pathological complete response) in early breast cancer patients receiving neoadjuvant systemic treatment (NST). A total of 100 women with breast cancer receiving NST (2017–2020) followed by surgical resection were retrospectively obtained. Demographic parameters and clinicopathological factors (e.g., treatment modalities, immunohistochemistry (IHC), and cancer subtype) were obtained from the patient’s clinical records. In the analyzed breast cancer cohort, high expression of Ob-R was found in 52% of tumors and there was a significantly higher incidence in the HER2+ and TNBC subgroups. Overall, a significantly greater percentage of patients with Ob-R positive tumors achieved pCR compared with Ob-R negative patients (57.7% vs. 27.1%; p = 0.002). This result was observed in most breast cancer subtypes. In patients with HER2+ breast cancer, there was no difference in Ob-R expression in relation to the HR status. Ob-R cell positivity was significantly higher in younger breast cancer patients (p = 0.008), those who were premenopausal (p = 0.011), and in those with a BMI > 25 kg/m2 (p = 0.019). A significantly greater percentage of early breast cancer patients with Ob-R positive tumors achieved pCR compared with Ob-R negative patients. Furthermore, breast cancer patients with positive Ob-R expression were significantly younger than those with negative Ob-R expression. This association was not explained by differences in BMI between young and old patients. Keywords: leptin receptor; Ob-R; breast cancer; predictive biomarker Author: Laura García-Estévez, Isabel Calvo, Silvia Pérez, Isabel Gallegos, Eva Díaz, Miguel Sampayo-Cordero, Sara S Oltra and Gema Moreno-Bueno Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Jun 29 15:33:02 2021 CEST ModDate: Tue Jun 29 17:17:06 2021 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1890629 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OPZDHV+VnURWPalladioL Type 1 Custom yes yes no 10 0 AGWZOR+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 IMRVGS+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 HBYMOL+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 YSPQJI+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 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PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Material and Methods Destination: section.2 Children: Item: Title: Study Design Destination: subsection.2.1 Item: Title: Patient Population and Treatment Destination: subsection.2.2 Item: Title: Procedures Destination: subsection.2.3 Item: Title: Ob-R Expression by Immunohistochemical Analysis Destination: subsection.2.4 Item: Title: Endpoints and Definitions Destination: subsection.2.5 Item: Title: Statistical Methods Destination: subsection.2.6 Item: Title: Results Destination: section.3 Children: Item: Title: Patient Characteristics Destination: subsection.3.1 Item: Title: Ob-R Overexpression Is a Significant Predictive Factor for pCR in the Global Breast Cancer Population Destination: subsection.3.2 Item: Title: HER2 and TNBC Breast Cancer Show High Levels of Ob-R Destination: subsection.3.3 Item: Title: The Correlation between Ob-R Overexpression and pCR Rate Depends on the Breast Cancer Subtype Destination: subsection.3.4 Item: Title: Ob-R Overexpression Is Highly Correlated to Age and Menopausal Status in Breast Cancer Destination: subsection.3.5 Item: Title: Ob-R Overexpression Is Significantly Associated with BMI in Breast Cancer Patients Destination: subsection.3.6 Item: Title: Ob-R Overexpression Showed Not Association with Mammographic Breast Density (MBD) Destination: subsection.3.7 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.5 Info: Title: Predictive Role of Leptin Receptor (Ob-R) Overexpression in Patients with Early Breast Cancer Receiving Neoadjuvant Systemic Treatment Author: Laura García-Estévez, Isabel Calvo, Silvia Pérez, Isabel Gallegos, Eva Díaz, Miguel Sampayo-Cordero, Sara S Oltra and Gema Moreno-Bueno Subject: The primary aim of this retrospective study was to investigate the correlation between the immunohistochemical expression of Ob-R (leptin receptor) with pCR (pathological complete response) in early breast cancer patients receiving neoadjuvant systemic treatment (NST). A total of 100 women with breast cancer receiving NST (2017 2020) followed by surgical resection were retrospectively obtained. Demographic parameters and clinicopathological factors (e.g., treatment modalities, immunohistochemistry (IHC), and cancer subtype) were obtained from the patient’s clinical records. In the analyzed breast cancer cohort, high expression of Ob-R was found in 52% of tumors and there was a significantly higher incidence in the HER2+ and TNBC subgroups. Overall, a significantly greater percentage of patients with Ob-R positive tumors achieved pCR compared with Ob-R negative patients (57.7% vs. 27.1%; p = 0.002). This result was observed in most breast cancer subtypes. In patients with HER2+ breast cancer, there was no difference in Ob-R expression in relation to the HR status. Ob-R cell positivity was significantly higher in younger breast cancer patients (p = 0.008), those who were premenopausal (p = 0.011), and in those with a BMI > 25 kg/m2 (p = 0.019). A significantly greater percentage of early breast cancer patients with Ob-R positive tumors achieved pCR compared with Ob-R negative patients. Furthermore, breast cancer patients with positive Ob-R expression were significantly younger than those with negative Ob-R expression. This association was not explained by differences in BMI between young and old patients. 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