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Keywords: Romani, whole-exome sequences, clinically relevant variants, drug-response variants, local ancestry inference, Eurocentric bias Author: David Comas Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Thu Jun 10 13:36:06 2021 CEST ModDate: Thu Jun 10 13:36:06 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 582512 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ALKUXX+MinionPro-Regular Type 1 Custom yes yes no 24 0 KKOAAV+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 25 0 WRIAGC+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 26 0 CCVXXJ+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 31 0 YEMBRK+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 32 0 HBGONA+HelveticaNeueLTStd-MdIt Type 1 Custom yes yes no 33 0 VXWSEY+RBLMI Type 1 Builtin yes yes no 153 0 OOWUTY+MinionPro-It Type 1 Custom yes yes no 154 0 ZCLZAZ+MTSYN Type 1 Builtin yes yes no 155 0 YFCPZQ+MinionPro-Bold Type 1 Custom yes yes no 167 0 CMERJW+MTGU Type 1 Builtin yes yes no 882 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-09-11 03:02:47 CEST RepresentationInformation: pmc_34220960.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-07-12 03:34:50 CEST Size: 582512 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 1050 FreeObjects: 72 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Admixture Has Shaped Romani Genetic Diversity in Clinically Relevant Variants Children: Item: Title: Introduction Item: Title: Materials and Methods Children: Item: Title: Data Item: Title: Local Ancestry Inference Item: Title: Genetic Portability Item: Title: Gene Enrichment Analyses Item: Title: Screening of Known Disease-Associated Variants Item: Title: Screening Beyond Disease-Associated Variants Item: Title: Results Children: Item: Title: Initial Assessment of Functional Variants as a First Evidence of Inter-Population Variability Item: Title: A Genome-Wide Screening Does Not Support an Increased Susceptibility for Genetic Disorders Item: Title: Many Drug-Response Variants in Roma Are Related to Metabolic and Cardiovascular Disorders Item: Title: Discussion Item: Title: Data Availability Statement Item: Title: Ethics Statement Item: Title: Author Contributions Item: Title: Funding Item: Title: Acknowledgments Item: Title: Supplementary Material Item: Title: References Info: Title: Admixture Has Shaped Romani Genetic Diversity in Clinically Relevant Variants Author: David Comas Subject: Genetic patterns of inter-population variation are a result of different demographic and adaptive histories, which gradually shape the frequency distribution of the variants. Keywords: Romani, whole-exome sequences, clinically relevant variants, drug-response variants, local ancestry inference, Eurocentric bias Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Thu Jun 10 14:06:06 CEST 2021 ModDate: Thu Jun 10 14:06:06 CEST 2021 ID: 0x9e76cda9eeb6a8aae9e14cd293856834, 0x9e76cda9eeb6a8aae9e14cd293856834 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: YEMBRK+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 2 LastChar: 242 FontDescriptor: FontName: YEMBRK+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -165, -214, 1099, 951 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: HBGONA+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 233 FontDescriptor: FontName: HBGONA+HelveticaNeueLTStd-MdIt Flags: Symbolic FontBBox: -165, -218, 1125, 947 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: CMERJW+MTGU FontSubset: true FirstChar: 98 LastChar: 98 FontDescriptor: FontName: CMERJW+MTGU Flags: Symbolic FontBBox: 25, -213, 839, 683 FontFile: true Font: BaseFont: YFCPZQ+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 121 FontDescriptor: FontName: YFCPZQ+MinionPro-Bold Flags: Symbolic FontBBox: -318, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: ALKUXX+MinionPro-Regular FontSubset: true FirstChar: 1 LastChar: 253 FontDescriptor: FontName: ALKUXX+MinionPro-Regular Flags: Symbolic FontBBox: -289, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: KKOAAV+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 44 LastChar: 150 FontDescriptor: FontName: KKOAAV+HelveticaNeueLTStd-Bd Flags: Symbolic FontBBox: -166, -218, 1078, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: VXWSEY+RBLMI FontSubset: true FirstChar: 49 LastChar: 62 FontDescriptor: FontName: VXWSEY+RBLMI Flags: Symbolic FontBBox: -11, -230, 987, 750 FontFile: true Font: BaseFont: WRIAGC+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 2 LastChar: 193 FontDescriptor: FontName: WRIAGC+HelveticaNeueLTStd-Lt Flags: Symbolic FontBBox: -166, -214, 1050, 967 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: OOWUTY+MinionPro-It FontSubset: true FirstChar: 40 LastChar: 233 FontDescriptor: FontName: OOWUTY+MinionPro-It Flags: Symbolic FontBBox: -201, -360, 1684, 919 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: ZCLZAZ+MTSYN FontSubset: true FirstChar: 3 LastChar: 67 FontDescriptor: FontName: ZCLZAZ+MTSYN Flags: Symbolic FontBBox: 0, -954, 1043, 900 FontFile: true Font: BaseFont: CCVXXJ+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: CCVXXJ+HelveticaNeueLTStd-BdIt Flags: Symbolic FontBBox: -166, -218, 1129, 975 FontFile: true EncodingDictionary: Differences: true XMP: Romani, whole-exome sequences, clinically relevant variants, drug-response variants, local ancestry inference, Eurocentric bias pdfTeX-1.40.15 1.5 application/pdf Admixture Has Shaped Romani Genetic Diversity in Clinically Relevant Variants Genetic patterns of inter-population variation are a result of different demographic and adaptive histories, which gradually shape the frequency distribution of the variants. 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