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PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 1274 FreeObjects: 1 IncrementalUpdates: 3 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome Destination: bmark_1600680688 Children: Item: Title: Overview Destination: s1 Children: Item: Title: Genetics of DS Destination: s1_1 Item: Title: Worldwide Prevalence of DS Destination: s1_2 Item: Title: Changes in Lifespan of Individuals With DS Destination: s1_3 Item: Title: Infectious Diseases in Adults With DS Destination: s2 Children: Item: Title: Respiratory Tract Infections Destination: s2_1 Children: Item: Title: Respiratory Syncytial Virus (RSV) Destination: s2_1_1 Item: Title: Influenza Virus Destination: s2_1_2 Item: Title: SARS-CoV-2 Destination: s2_1_3 Item: Title: Infectious Diseases in DS: Hospitalization Rate and Length Destination: s2_2 Item: Title: Interplay Between Immune Dysregulation and Infectious Diseases in DS Destination: s3 Children: Item: Title: Dysregulation of Innate Immunity in DS Destination: s3_1 Children: Item: Title: Dysregulation of Innate Immune Cell Types in DS Destination: s3_1_1 Children: Item: Title: Granulocytes Destination: s3_1_1_1 Item: Title: Monocytes Destination: s3_1_1_2 Item: Title: Natural Killer Cells Destination: s3_1_1_3 Item: Title: Differences in Toll-Like Receptor Signaling Destination: s3_1_2 Item: Title: Anomalies in FcγR Receptor Signaling Destination: s3_1_3 Item: Title: Interferon Hyperactivity Destination: s3_1_4 Item: Title: Dysregulation of the Complement Cascade Destination: s3_1_5 Item: Title: Dysregulation of Adaptive Immunity in DS Destination: s3_2 Children: Item: Title: Dysregulation of the T Cell Lineage Destination: s3_2_1 Item: Title: B Cell Dysfunction in DS Destination: s3_2_2 Item: Title: Dendritic Cells in DS Destination: s3_2_3 Item: Title: Aberrant Cytokine and Chemokine Signaling in DS Destination: s3_3 Item: Title: Implications for Vaccine Efficacy in DS Destination: s3_4 Item: Title: Genetic Basis for Immune Dysregulation and Increased Burden of Infections in DS Destination: s4 Item: Title: The Immunosenescent Phenotype of DS Destination: s5 Item: Title: Concluding Remarks Destination: s6 Item: Title: Author Contributions Destination: s7 Item: Title: Acknowledgments Destination: bmark_-366698314 Item: Title: References Destination: bmark_2090415954 Info: Title: Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome Author: Tomer Illouz Subject: The risk of severe outcomes following respiratory tract infections is significantly increased in individuals over 60 years, especially in those with chronic medical conditions, i.e., hypertension, diabetes, cardiovascular disease, dementia, chronic respi Keywords: Down syndrome, immune dysregulation, 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immune dysregulation, hospitalization, respiratory tract infections, interferon, COVID-19 2021-06-22T20:53:34+08:00 2021-06-22T20:02:29+08:00 Arbortext Advanced Print Publisher 10.0.1306/W Unicode 2021-06-22T20:53:34+08:00 application/pdf The risk of severe outcomes following respiratory tract infections is significantly increased in individuals over 60 years, especially in those with chronic medical conditions, i.e., hypertension, diabetes, cardiovascular disease, dementia, chronic respi Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome Tomer Illouz Arya Biragyn Maria Florencia Iulita Lisi Flores-Aguilar Mara Dierssen Ilario De Toma Stylianos E. Antonarakis Eugene Yu Yann Herault Marie-Claude Potier Alexandra Botté Randall Roper Benjamin Sredni Jacqueline London William Mobley Andre Strydom Eitan Okun the T21RS COVID-19 Initiative Down syndrome immune dysregulation hospitalization respiratory tract infections interferon COVID-19 uuid:76b39e53-8a0c-4b97-944e-cf8522726fbf uuid:93032dcf-2397-4797-b5d5-8269c0b5674e Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 175, 568, 480, 589 Annotation: Subtype: Link Rect: 175, 545, 505, 566 Annotation: Subtype: Link Rect: 175, 522, 529, 543 Annotation: Subtype: Link Rect: 175, 499, 431, 520 Annotation: Subtype: Link Rect: 175, 476, 391, 497 Annotation: Subtype: Link Rect: 45, 29, 116, 36 Annotation: Subtype: Link Rect: 125, 29, 183, 36 Annotation: Subtype: Link Rect: 425, 29, 549, 36 Annotation: Subtype: Link Rect: 87, 464, 158, 472 Annotation: Subtype: Link Rect: 100, 305, 158, 312 Annotation: Subtype: Link Rect: 57, 64, 158, 71 Annotation: Subtype: Link Rect: 522, 736, 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