d7711ba4535deb1579d6847a1a0a7e28 pmc_34249838.pdf 2ba1552ab7f6ebe73033a3ab13d8e100d86ea4af pmc_34249838.pdf 74210192e04999c70c6ecf218e5da226f348d819f3fefa490f002a487380c4e8 pmc_34249838.pdf Title: The Current Situation Regarding Long-Acting Insulin Analogues Including Biosimilars Among African, Asian, European, and South American Countries; Findings and Implications for the Future Subject: Background: Diabetes mellitus rates continue to rise, which coupled with increasing costs of associated complications has appreciably increased global expenditure in recent years. Keywords: Africa, biosimilars, cross-national study, drug utilisation, Europe, health policy, insulin glargine, prices Author: Brian Godman Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Tue Jun 22 13:58:08 2021 CEST ModDate: Tue Jun 22 14:06:59 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 21 Encrypted: no Page size: 595.26 x 779.52 pts Page rot: 0 File size: 636812 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ODVLLD+HelveticaNeueLTStd-Bd Type 1C WinAnsi yes yes no 33 0 YODTGO+HelveticaNeueLTStd-Lt Type 1C Custom yes yes no 38 0 PVCLLY+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes no 51 0 JHSCTV+HelveticaNeueLTStd-LtIt Type 1C Custom yes yes no 53 0 BWLFOX+HelveticaNeueLTStd-MdIt Type 1C Custom yes yes no 66 0 ACWPCF+MinionPro-Regular Type 1C Custom yes yes no 122 0 ORALEN+MTSY Type 1C Custom yes yes yes 140 0 MQLYNT+MinionPro-Bold Type 1C Custom yes yes no 267 0 GYRZGH+HelveticaNeueLTStd-Md Type 1C WinAnsi yes yes no 275 0 UVCDXQ+HelveticaNeueLTStd-Roman Type 1C WinAnsi yes yes no 408 0 VUOOEL+MinionPro-It Type 1C Custom yes yes no 526 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-09-11 03:01:48 CEST RepresentationInformation: pmc_34249838.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-07-19 03:35:06 CEST Size: 636812 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 828 FreeObjects: 26 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: The Current Situation Regarding Long-Acting Insulin Analogues Including Biosimilars Among African, Asian, European, and South 䄀洀攀爀椀挀愀渀 䌀漀甀渀琀爀椀攀猀㬀 䘀椀渀搀椀渀最猀 愀渀搀 䤀洀瀀氀椀挀愀琀椀漀渀猀 昀漀爀 琀栀攀 䘀甀琀甀爀攩㸾൥湤潢樍㘠〠潢樍㰼⽐慲敮琠㔠〠刯乥硴‷‰⁒⽄敳琯獥捴楯渪⸲⽁捴楯港䝯呯⽔楴汥⣾＀䤀渀琀爀漀搀甀挀琀椀漀温㸾൥湤潢樍㈵‰扪഼㰯偡牥湴‵‰⁒⽄敳琯獥捴楯渪⸲㐯䅣瑩潮⽇潔漯偲敶′㐠〠刯呩瑬攨References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Methodology Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Children: Item: Title: General Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Africa Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Children: Item: Title: African Countries Where Long-Acting Analogues Are Not Funded in the Public Healthcare System Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: African Countries Where Long-Acting Analogues Are Funded in the Public Healthcare System Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: South America Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Asia Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Children: Item: Title: Bangladesh Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: India Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Korea, Malaysia and Pakistan Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Europe Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Suggestions for the Future to Increase the Utilisation of Insulin Glargine Biosimilars Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Data Availability Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Info: Title: The Current Situation Regarding Long-Acting Insulin Analogues Including Biosimilars Among African, Asian, European, and South American Countries; Findings and Implications for the Future Author: Brian Godman Subject: Background: Diabetes mellitus rates continue to rise, which coupled with increasing costs of associated complications has appreciably increased global expenditure in recent years. Keywords: Africa, biosimilars, cross-national study, drug utilisation, Europe, health policy, insulin glargine, prices Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Tue Jun 22 14:28:08 CEST 2021 ModDate: Tue Jun 22 14:36:59 CEST 2021 ID: 0x5dd3911297a57a0abad1434db0d96941, 0x09814025063e8e43b7b9c5e975db46f9 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 279 ImageHeight: 279 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 992 ImageHeight: 636 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Fonts: Type1: Font: BaseFont: ODVLLD+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 36 LastChar: 151 FontDescriptor: FontName: ODVLLD+HelveticaNeueLTStd-Bd Flags: Serif, Nonsymbolic FontBBox: -19, -214, 925, 808 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BWLFOX+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 19 LastChar: 252 FontDescriptor: FontName: BWLFOX+HelveticaNeueLTStd-MdIt Flags: Symbolic FontBBox: -133, -205, 995, 731 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: PVCLLY+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 134 FontDescriptor: FontName: PVCLLY+HelveticaNeueLTStd-BdIt Flags: Nonsymbolic FontBBox: -63, -182, 744, 731 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GYRZGH+HelveticaNeueLTStd-Md FontSubset: true FirstChar: 44 LastChar: 121 FontDescriptor: FontName: GYRZGH+HelveticaNeueLTStd-Md Flags: Nonsymbolic FontBBox: 0, -205, 938, 731 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHSCTV+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 0 LastChar: 243 FontDescriptor: FontName: JHSCTV+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -137, -206, 978, 781 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: YODTGO+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 0 LastChar: 174 FontDescriptor: FontName: YODTGO+HelveticaNeueLTStd-Lt Flags: Symbolic FontBBox: -30, -214, 904, 807 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: UVCDXQ+HelveticaNeueLTStd-Roman FontSubset: true FirstChar: 40 LastChar: 124 FontDescriptor: FontName: UVCDXQ+HelveticaNeueLTStd-Roman Flags: Serif, Nonsymbolic FontBBox: -10, -214, 791, 786 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ACWPCF+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: ACWPCF+MinionPro-Regular Flags: Symbolic FontBBox: -26, -257, 956, 715 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: MQLYNT+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 120 FontDescriptor: FontName: MQLYNT+MinionPro-Bold Flags: Symbolic FontBBox: 0, -244, 660, 703 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: ORALEN+MTSY FontSubset: true FirstChar: 0 LastChar: 112 FontDescriptor: FontName: ORALEN+MTSY Flags: Symbolic FontBBox: 0, -954, 944, 679 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: VUOOEL+MinionPro-It FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: VUOOEL+MinionPro-It Flags: Symbolic FontBBox: -142, -257, 1003, 810 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true XMP: 2021-06-22T17:28:08+05:30 LaTeX with hyperref package + hypdvips 2021-06-22T17:36:59+05:30 2021-06-22T17:36:59+05:30 application/pdf Background: Diabetes mellitus rates continue to rise, which coupled with increasing costs of associated complications has appreciably increased global expenditure in recent years. 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Subtype: Link Rect: 47, 468, 58, 479 Destination: External Annotation: Subtype: Link Rect: 61, 468, 72, 479 Destination: External Annotation: Subtype: Link Rect: 263, 433, 279, 445 Destination: External Annotation: Subtype: Link Rect: 197, 319, 208, 330 Destination: External Annotation: Subtype: Link Rect: 214, 319, 225, 330 Destination: External Annotation: Subtype: Link Rect: 159, 135, 174, 147 Destination: External Annotation: Subtype: Link Rect: 177, 135, 192, 147 Destination: External Annotation: Subtype: Link Rect: 389, 697, 405, 708 Destination: External Annotation: Subtype: Link Rect: 440, 559, 451, 571 Destination: External Annotation: Subtype: Link Rect: 307, 514, 323, 525 Destination: External Annotation: Subtype: Link Rect: 515, 433, 526, 445 Destination: External Annotation: Subtype: Link Rect: 434, 399, 445, 410 Destination: External Annotation: Subtype: Link Rect: 447, 399, 458, 410 Destination: External Annotation: Subtype: Link Rect: 461, 376, 472, 388 Destination: External Annotation: Subtype: Link Rect: 476, 376, 491, 388 Destination: External Annotation: Subtype: Link Rect: 307, 307, 323, 319 Destination: External Annotation: Subtype: Link Rect: 335, 296, 346, 307 Destination: External Annotation: Subtype: Link Rect: 307, 250, 318, 261 Destination: External Annotation: Subtype: Link Rect: 320, 250, 336, 261 Destination: External Annotation: Subtype: Link Rect: 43, 30, 120, 37 Annotation: Subtype: Link Rect: 123, 29, 183, 37 Annotation: Subtype: Link Rect: 434, 29, 551, 38 Page: Label: 9 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 116, 502, 146, 511 Destination: External Annotation: Subtype: Link Rect: 181, 456, 192, 468 Destination: External Annotation: Subtype: Link Rect: 80, 388, 91, 399 Destination: External Annotation: Subtype: Link Rect: 93, 388, 109, 399 Destination: External Annotation: Subtype: Link Rect: 111, 388, 127, 399 Destination: External Annotation: Subtype: Link Rect: 198, 307, 228, 316 Destination: External Annotation: Subtype: Link Rect: 274, 250, 285, 261 Destination: External Annotation: Subtype: Link Rect: 71, 181, 87, 193 Destination: External Annotation: Subtype: Link Rect: 240, 112, 274, 121 Destination: External Annotation: Subtype: Link Rect: 279, 113, 285, 121 Destination: External Annotation: Subtype: Link Rect: 171, 78, 202, 87 Destination: External Annotation: Subtype: Link Rect: 479, 708, 509, 717 Destination: External Annotation: Subtype: Link Rect: 404, 639, 434, 648 Destination: External Annotation: Subtype: Link Rect: 370, 617, 400, 625 Destination: External Annotation: Subtype: Link Rect: 315, 525, 345, 533 Destination: External Annotation: Subtype: Link Rect: 390, 204, 420, 213 Destination: External Annotation: Subtype: Link Rect: 516, 181, 527, 193 Destination: External Annotation: Subtype: Link Rect: 43, 30, 120, 37 Annotation: Subtype: Link Rect: 123, 29, 183, 37 Annotation: Subtype: Link Rect: 434, 29, 551, 38 Page: Label: 10 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 370, 709, 380, 719 Destination: External Annotation: Subtype: Link Rect: 190, 177, 201, 188 Destination: External Annotation: Subtype: Link Rect: 204, 177, 219, 188 Destination: External Annotation: Subtype: Link Rect: 222, 177, 237, 188 Destination: External Annotation: Subtype: Link Rect: 270, 119, 285, 130 Destination: External Annotation: Subtype: Link Rect: 307, 383, 323, 395 Destination: External Annotation: Subtype: Link Rect: 441, 360, 457, 372 Destination: External Annotation: Subtype: Link Rect: 462, 360, 477, 372 Destination: External Annotation: Subtype: Link Rect: 534, 269, 546, 280 Destination: External Annotation: Subtype: Link Rect: 343, 177, 358, 188 Destination: External Annotation: Subtype: Link Rect: 307, 154, 323, 165 Destination: External Annotation: Subtype: Link Rect: 325, 154, 341, 165 Destination: External Annotation: Subtype: Link Rect: 307, 97, 331, 105 Destination: External Annotation: Subtype: Link Rect: 461, 74, 485, 82 Destination: External Annotation: Subtype: Link Rect: 43, 30, 120, 37 Annotation: Subtype: Link Rect: 123, 29, 183, 37 Annotation: Subtype: Link Rect: 434, 29, 551, 38 Page: Label: 11 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 118, 410, 133, 422 Destination: External Annotation: Subtype: Link Rect: 138, 410, 154, 422 Destination: External Annotation: Subtype: Link Rect: 182, 250, 193, 261 Destination: External Annotation: Subtype: Link Rect: 195, 250, 211, 261 Destination: External Annotation: Subtype: Link Rect: 214, 250, 229, 261 Destination: External Annotation: Subtype: Link Rect: 213, 216, 225, 227 Destination: External Annotation: Subtype: Link Rect: 47, 67, 62, 78 Destination: External Annotation: Subtype: Link Rect: 449, 454, 484, 464 Destination: External Annotation: Subtype: Link Rect: 538, 330, 549, 342 Destination: External Annotation: Subtype: Link Rect: 304, 319, 319, 330 Destination: External Annotation: Subtype: Link Rect: 339, 227, 369, 236 Destination: External Annotation: Subtype: Link Rect: 506, 158, 536, 167 Destination: External Annotation: Subtype: Link Rect: 43, 30, 120, 37 Annotation: Subtype: Link Rect: 123, 29, 183, 37 Annotation: Subtype: Link Rect: 434, 29, 551, 38 Page: Label: 12 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 83, 552, 98, 563 Destination: External Annotation: Subtype: Link Rect: 104, 552, 120, 563 Destination: External Annotation: Subtype: Link Rect: 143, 518, 158, 529 Destination: External Annotation: Subtype: Link Rect: 161, 518, 177, 529 Destination: External Annotation: Subtype: Link Rect: 213, 403, 224, 414 Destination: External Annotation: Subtype: Link Rect: 227, 403, 242, 414 Destination: External Annotation: Subtype: Link Rect: 245, 403, 261, 414 Destination: External Annotation: Subtype: Link Rect: 47, 311, 77, 320 Destination: External Annotation: Subtype: Link Rect: 159, 197, 189, 205 Destination: External Annotation: Subtype: Link Rect: 188, 82, 218, 91 Destination: External Annotation: Subtype: Link Rect: 267, 71, 278, 82 Destination: External Annotation: Subtype: Link Rect: 468, 255, 493, 263 Destination: External Annotation: Subtype: Link Rect: 513, 127, 548, 137 Destination: External Annotation: Subtype: Link Rect: 43, 30, 120, 37 Annotation: Subtype: Link Rect: 123, 29, 183, 37 Annotation: Subtype: Link Rect: 434, 29, 551, 38 Page: Label: 13 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 61, 429, 71, 438 Destination: External Annotation: Subtype: Link Rect: 73, 429, 83, 438 Destination: External Annotation: Subtype: Link Rect: 84, 429, 94, 438 Destination: External Annotation: Subtype: Link Rect: 267, 408, 281, 417 Destination: External Annotation: Subtype: Link Rect: 282, 408, 296, 417 Destination: External Annotation: Subtype: Link Rect: 363, 387, 372, 396 Destination: External Annotation: Subtype: Link Rect: 374, 387, 384, 396 Destination: External Annotation: Subtype: Link Rect: 385, 387, 399, 396 Destination: External Annotation: Subtype: Link Rect: 462, 366, 476, 376 Destination: External Annotation: Subtype: Link Rect: 478, 366, 491, 376 Destination: External Annotation: Subtype: Link Rect: 479, 357, 493, 366 Destination: External Annotation: Subtype: Link Rect: 495, 357, 509, 366 Destination: External Annotation: Subtype: Link Rect: 287, 347, 300, 357 Destination: External Annotation: Subtype: Link Rect: 493, 347, 507, 357 Destination: External Annotation: Subtype: Link Rect: 135, 326, 149, 336 Destination: External Annotation: Subtype: Link Rect: 96, 177, 112, 189 Destination: External Annotation: Subtype: Link Rect: 117, 177, 132, 189 Destination: External Annotation: Subtype: Link Rect: 148, 120, 159, 131 Destination: External Annotation: Subtype: Link Rect: 165, 120, 176, 131 Destination: External Annotation: Subtype: Link Rect: 181, 120, 197, 131 Destination: External Annotation: Subtype: Link Rect: 202, 120, 218, 131 Destination: External Annotation: Subtype: Link Rect: 211, 97, 242, 105 Destination: External Annotation: Subtype: Link Rect: 315, 154, 339, 162 Destination: External Annotation: Subtype: Link Rect: 43, 30, 120, 37 Annotation: Subtype: Link Rect: 123, 29, 183, 37 Annotation: Subtype: Link Rect: 434, 29, 551, 38 Page: Label: 14 Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 390, 663, 399, 673 Destination: External Annotation: Subtype: Link Rect: 473, 593, 487, 602 Destination: External Annotation: Subtype: Link Rect: 488, 593, 502, 602 Destination: External Annotation: Subtype: Link Rect: 277, 563, 287, 572 Destination: External Annotation: Subtype: Link Rect: 526, 563, 540, 572 Destination: External Annotation: Subtype: Link Rect: 187, 462, 201, 471 Destination: External Annotation: Subtype: Link Rect: 198, 441, 208, 451 Destination: External Annotation: Subtype: Link Rect: 210, 441, 219, 451 Destination: External Annotation: Subtype: Link Rect: 331, 432, 345, 441 Destination: External Annotation: Subtype: Link Rect: 346, 432, 360, 441 Destination: External Annotation: Subtype: Link Rect: 315, 422, 324, 432 Destination: External Annotation: Subtype: Link Rect: 100, 363, 110, 373 Destination: External Annotation: Subtype: Link Rect: 112, 363, 125, 373 Destination: External Annotation: Subtype: Link Rect: 127, 363, 141, 373 Destination: External Annotation: Subtype: Link Rect: 69, 354, 83, 363 Destination: External Annotation: Subtype: Link Rect: 85, 354, 98, 363 Destination: External Annotation: Subtype: Link Rect: 231, 344, 256, 351 Destination: External Annotation: Subtype: Link Rect: 84, 335, 98, 344 Destination: External Annotation: Subtype: Link Rect: 99, 335, 113, 344 Destination: External Annotation: Subtype: Link Rect: 222, 254, 233, 265 Destination: External Annotation: Subtype: Link Rect: 237, 254, 248, 265 Destination: External Annotation: Subtype: Link Rect: 251, 254, 266, 265 Destination: External Annotation: Subtype: Link Rect: 270, 254, 285, 265 Destination: External Annotation: Subtype: Link Rect: 148, 220, 164, 231 Destination: External Annotation: Subtype: Link Rect: 166, 220, 181, 231 Destination: External Annotation: Subtype: Link Rect: 307, 254, 318, 265 Destination: External Annotation: Subtype: Link Rect: 495, 242, 525, 251 Destination: External Annotation: Subtype: Link Rect: 307, 151, 331, 159 Destination: External Annotation: Subtype: Link Rect: 363, 128, 379, 139 Destination: External Annotation: Subtype: Link Rect: 384, 128, 400, 139 Destination: External Annotation: Subtype: Link Rect: 405, 128, 421, 139 Destination: External Annotation: Subtype: Link Rect: 427, 128, 442, 139 Destination: External Annotation: Subtype: Link Rect: 307, 82, 323, 93 Destination: External Annotation: Subtype: Link Rect: 325, 82, 341, 93 Destination: External Annotation: Subtype: Link Rect: 418, 59, 429, 71 Destination: External Annotation: Subtype: Link Rect: 433, 59, 444, 71 Destination: External Annotation: Subtype: Link Rect: 447, 59, 463, 71 Destination: External Annotation: Subtype: Link Rect: 43, 30, 120, 37 Annotation: Subtype: Link Rect: 123, 29, 183, 37 Annotation: Subtype: Link Rect: 434, 29, 551, 38 Page: Label: 15 Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 257, 662, 287, 671 Destination: External Annotation: Subtype: Link Rect: 150, 582, 180, 591 Destination: External Annotation: Subtype: Link Rect: 156, 546, 191, 556 Destination: External Annotation: Subtype: Link Rect: 195, 548, 226, 556 Destination: External Annotation: Subtype: Link Rect: 133, 456, 148, 468 Destination: External Annotation: Subtype: Link Rect: 263, 433, 287, 441 Destination: External Annotation: Subtype: Link Rect: 47, 422, 58, 433 Destination: External Annotation: Subtype: Link Rect: 47, 330, 62, 342 Destination: External Annotation: Subtype: Link Rect: 65, 330, 80, 342 Destination: External Annotation: Subtype: Link Rect: 55, 319, 79, 327 Destination: External Annotation: Subtype: Link Rect: 243, 135, 267, 144 Destination: External Annotation: Subtype: Link Rect: 335, 525, 346, 536 Destination: External Annotation: Subtype: Link Rect: 43, 30, 120, 37 Annotation: Subtype: Link Rect: 123, 29, 183, 37 Annotation: Subtype: Link Rect: 434, 29, 551, 38 Page: Label: 16 Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 188, 490, 289, 499 Annotation: Subtype: Link Rect: 118, 472, 179, 480 Annotation: Subtype: Link Rect: 172, 433, 251, 442 Annotation: Subtype: Link Rect: 111, 386, 204, 395 Annotation: Subtype: Link Rect: 174, 348, 266, 357 Annotation: Subtype: Link Rect: 114, 319, 185, 329 Annotation: Subtype: Link Rect: 115, 293, 197, 300 Annotation: Subtype: Link Rect: 145, 255, 234, 262 Annotation: Subtype: Link Rect: 115, 216, 214, 225 Annotation: Subtype: Link Rect: 108, 179, 167, 187 Annotation: Subtype: Link Rect: 90, 151, 175, 158 Annotation: Subtype: Link Rect: 158, 103, 243, 111 Annotation: Subtype: Link Rect: 430, 520, 515, 527 Annotation: Subtype: Link Rect: 345, 462, 444, 471 Annotation: Subtype: Link Rect: 552, 413, 320, 434 Annotation: Subtype: Link Rect: 357, 368, 446, 376 Annotation: Subtype: Link Rect: 375, 329, 468, 338 Annotation: Subtype: Link Rect: 412, 300, 501, 310 Annotation: Subtype: Link Rect: 375, 264, 436, 272 Annotation: Subtype: Link Rect: 530, 234, 551, 243 Annotation: Subtype: Link Rect: 321, 225, 534, 234 Annotation: Subtype: Link Rect: 321, 215, 461, 225 Annotation: Subtype: Link Rect: 510, 196, 551, 206 Annotation: Subtype: Link Rect: 321, 187, 539, 196 Annotation: Subtype: Link Rect: 321, 177, 550, 187 Annotation: Subtype: Link Rect: 388, 111, 551, 120 Annotation: Subtype: Link Rect: 321, 102, 368, 111 Annotation: Subtype: Link Rect: 434, 92, 551, 102 Annotation: Subtype: Link Rect: 321, 83, 436, 92 Annotation: Subtype: Link Rect: 43, 29, 120, 36 Annotation: Subtype: Link Rect: 123, 28, 183, 36 Annotation: Subtype: Link Rect: 434, 28, 551, 37 Page: Label: 17 Sequence: 17 Annotations: Annotation: Subtype: Link Rect: 137, 697, 291, 706 Annotation: Subtype: Link Rect: 61, 687, 147, 697 Annotation: Subtype: Link Rect: 85, 642, 173, 649 Annotation: Subtype: Link Rect: 107, 602, 198, 612 Annotation: Subtype: Link Rect: 112, 564, 200, 573 Annotation: Subtype: Link Rect: 97, 528, 182, 536 Annotation: Subtype: Link Rect: 85, 481, 170, 488 Annotation: Subtype: Link Rect: 85, 434, 170, 441 Annotation: Subtype: Link Rect: 140, 413, 291, 422 Annotation: Subtype: Link Rect: 61, 404, 228, 413 Annotation: Subtype: Link Rect: 111, 367, 199, 375 Annotation: Subtype: Link Rect: 80, 337, 291, 347 Annotation: Subtype: Link Rect: 61, 330, 84, 336 Annotation: Subtype: Link Rect: 92, 281, 164, 290 Annotation: Subtype: Link Rect: 81, 244, 180, 252 Annotation: Subtype: Link Rect: 292, 168, 60, 186 Annotation: Subtype: Link Rect: 136, 129, 229, 138 Annotation: Subtype: Link Rect: 292, 92, 60, 111 Annotation: Subtype: Link Rect: 361, 697, 440, 706 Annotation: Subtype: Link Rect: 334, 659, 427, 668 Annotation: Subtype: Link Rect: 368, 621, 427, 631 Annotation: Subtype: Link Rect: 382, 566, 467, 573 Annotation: Subtype: Link Rect: 345, 527, 455, 536 Annotation: Subtype: Link Rect: 432, 498, 538, 508 Annotation: Subtype: Link Rect: 365, 462, 464, 469 Annotation: Subtype: Link Rect: 432, 442, 551, 451 Annotation: Subtype: Link Rect: 321, 432, 544, 441 Annotation: Subtype: Link Rect: 321, 424, 330, 431 Annotation: Subtype: Link Rect: 442, 404, 551, 413 Annotation: Subtype: Link Rect: 321, 394, 463, 403 Annotation: Subtype: Link Rect: 426, 366, 533, 375 Annotation: Subtype: Link Rect: 346, 339, 393, 346 Annotation: Subtype: Link Rect: 361, 309, 440, 318 Annotation: Subtype: Link Rect: 415, 290, 469, 299 Annotation: Subtype: Link Rect: 432, 262, 519, 271 Annotation: Subtype: Link Rect: 430, 243, 551, 252 Annotation: Subtype: Link Rect: 321, 233, 414, 243 Annotation: Subtype: Link Rect: 368, 195, 463, 205 Annotation: Subtype: Link Rect: 368, 157, 463, 167 Annotation: Subtype: Link Rect: 510, 148, 551, 157 Annotation: Subtype: Link Rect: 321, 139, 545, 148 Annotation: Subtype: Link Rect: 321, 129, 337, 136 Annotation: Subtype: Link Rect: 436, 112, 505, 119 Annotation: Subtype: Link Rect: 552, 73, 320, 92 Annotation: Subtype: Link Rect: 43, 30, 120, 37 Annotation: Subtype: Link Rect: 123, 29, 183, 37 Annotation: Subtype: Link Rect: 434, 29, 551, 38 Page: Label: 18 Sequence: 18 Annotations: Annotation: Subtype: Link Rect: 179, 680, 240, 687 Annotation: Subtype: Link Rect: 164, 642, 253, 649 Annotation: Subtype: Link Rect: 85, 585, 170, 592 Annotation: Subtype: Link Rect: 148, 538, 209, 545 Annotation: Subtype: Link Rect: 89, 489, 169, 498 Annotation: Subtype: Link Rect: 180, 462, 250, 469 Annotation: Subtype: Link Rect: 267, 442, 291, 451 Annotation: Subtype: Link Rect: 61, 432, 273, 441 Annotation: Subtype: Link Rect: 61, 422, 229, 432 Annotation: Subtype: Link Rect: 85, 377, 144, 384 Annotation: Subtype: Link Rect: 168, 339, 268, 346 Annotation: Subtype: Link Rect: 292, 291, 60, 309 Annotation: Subtype: Link Rect: 147, 262, 291, 271 Annotation: Subtype: Link Rect: 61, 252, 265, 261 Annotation: Subtype: Link Rect: 61, 244, 92, 251 Annotation: Subtype: Link Rect: 93, 224, 291, 233 Annotation: Subtype: Link Rect: 61, 214, 179, 224 Annotation: Subtype: Link Rect: 153, 187, 223, 195 Annotation: Subtype: Link Rect: 101, 150, 185, 157 Annotation: Subtype: Link Rect: 93, 112, 179, 119 Annotation: Subtype: Link Rect: 466, 688, 545, 697 Annotation: Subtype: Link Rect: 552, 650, 320, 669 Annotation: Subtype: Link Rect: 365, 613, 449, 621 Annotation: Subtype: Link Rect: 436, 574, 519, 583 Annotation: Subtype: Link Rect: 341, 546, 428, 555 Annotation: Subtype: Link Rect: 413, 527, 551, 536 Annotation: Subtype: Link Rect: 321, 517, 536, 526 Annotation: Subtype: Link Rect: 321, 509, 359, 517 Annotation: Subtype: Link Rect: 435, 489, 551, 498 Annotation: Subtype: Link Rect: 321, 479, 535, 489 Annotation: Subtype: Link Rect: 345, 443, 434, 450 Annotation: Subtype: Link Rect: 368, 396, 468, 403 Annotation: Subtype: Link Rect: 357, 347, 437, 356 Annotation: Subtype: Link Rect: 345, 311, 430, 318 Annotation: Subtype: Link Rect: 420, 290, 492, 299 Annotation: Subtype: Link Rect: 354, 252, 551, 261 Annotation: Subtype: Link Rect: 321, 243, 347, 252 Annotation: Subtype: Link Rect: 469, 214, 549, 224 Annotation: Subtype: Link Rect: 354, 177, 433, 186 Annotation: Subtype: Link Rect: 475, 139, 530, 148 Annotation: Subtype: Link Rect: 450, 102, 528, 110 Annotation: Subtype: Link Rect: 43, 30, 120, 37 Annotation: Subtype: Link Rect: 123, 29, 183, 37 Annotation: Subtype: Link Rect: 434, 29, 551, 38 Page: Label: 19 Sequence: 19 Annotations: Annotation: Subtype: Link Rect: 215, 697, 270, 706 Annotation: Subtype: Link Rect: 85, 651, 180, 659 Annotation: Subtype: Link Rect: 252, 640, 291, 649 Annotation: Subtype: Link Rect: 61, 631, 199, 640 Annotation: Subtype: Link Rect: 292, 583, 60, 603 Annotation: Subtype: Link Rect: 101, 536, 184, 545 Annotation: Subtype: Link Rect: 88, 489, 168, 498 Annotation: Subtype: Link Rect: 88, 460, 291, 470 Annotation: Subtype: Link Rect: 61, 451, 241, 460 Annotation: Subtype: Link Rect: 292, 412, 60, 433 Annotation: Subtype: Link Rect: 164, 356, 248, 366 Annotation: Subtype: Link Rect: 97, 319, 177, 328 Annotation: Subtype: Link Rect: 97, 281, 177, 290 Annotation: Subtype: Link Rect: 292, 232, 60, 253 Annotation: Subtype: Link Rect: 74, 187, 173, 195 Annotation: Subtype: Link Rect: 292, 130, 60, 149 Annotation: Subtype: Link Rect: 114, 101, 207, 110 Annotation: Subtype: Link Rect: 552, 698, 320, 717 Annotation: Subtype: Link Rect: 357, 661, 442, 668 Annotation: Subtype: Link Rect: 345, 621, 432, 631 Annotation: Subtype: Link Rect: 552, 582, 320, 603 Annotation: Subtype: Link Rect: 442, 536, 551, 545 Annotation: Subtype: Link Rect: 321, 527, 429, 536 Annotation: Subtype: Link Rect: 429, 489, 508, 498 Annotation: Subtype: Link Rect: 375, 441, 468, 451 Annotation: Subtype: Link Rect: 335, 413, 551, 422 Annotation: Subtype: Link Rect: 321, 404, 349, 413 Annotation: Subtype: Link Rect: 456, 385, 551, 394 Annotation: Subtype: Link Rect: 321, 376, 530, 384 Annotation: Subtype: Link Rect: 321, 366, 419, 375 Annotation: Subtype: Link Rect: 416, 339, 515, 346 Annotation: Subtype: Link Rect: 400, 309, 551, 318 Annotation: Subtype: Link Rect: 321, 299, 410, 309 Annotation: Subtype: Link Rect: 440, 271, 497, 280 Annotation: Subtype: Link Rect: 386, 233, 467, 243 Annotation: Subtype: Link Rect: 436, 205, 510, 214 Annotation: Subtype: Link Rect: 390, 169, 489, 176 Annotation: Subtype: Link Rect: 435, 148, 551, 157 Annotation: Subtype: Link Rect: 437, 101, 551, 110 Annotation: Subtype: Link Rect: 321, 91, 421, 101 Annotation: Subtype: Link Rect: 43, 30, 120, 37 Annotation: Subtype: Link Rect: 123, 29, 183, 37 Annotation: Subtype: Link Rect: 434, 29, 551, 38 Page: Label: 20 Sequence: 20 Annotations: Annotation: Subtype: Link Rect: 85, 697, 169, 706 Annotation: Subtype: Link Rect: 114, 659, 207, 668 Annotation: Subtype: Link Rect: 169, 621, 240, 631 Annotation: Subtype: Link Rect: 152, 593, 240, 602 Annotation: Subtype: Link Rect: 159, 564, 291, 574 Annotation: Subtype: Link Rect: 61, 557, 140, 564 Annotation: Subtype: Link Rect: 81, 536, 155, 545 Annotation: Subtype: Link Rect: 150, 517, 291, 526 Annotation: Subtype: Link Rect: 61, 509, 129, 517 Annotation: Subtype: Link Rect: 150, 490, 236, 498 Annotation: Subtype: Link Rect: 158, 470, 291, 479 Annotation: Subtype: Link Rect: 61, 460, 113, 470 Annotation: Subtype: Link Rect: 220, 441, 291, 451 Annotation: Subtype: Link Rect: 61, 432, 283, 441 Annotation: Subtype: Link Rect: 61, 422, 128, 432 Annotation: Subtype: Link Rect: 171, 404, 291, 413 Annotation: Subtype: Link Rect: 61, 394, 244, 403 Annotation: Subtype: Link Rect: 171, 366, 291, 375 Annotation: Subtype: Link Rect: 61, 356, 277, 366 Annotation: Subtype: Link Rect: 124, 328, 241, 337 Annotation: Subtype: Link Rect: 132, 281, 228, 290 Annotation: Subtype: Link Rect: 111, 244, 196, 252 Annotation: Subtype: Link Rect: 292, 194, 60, 215 Annotation: Subtype: Link Rect: 104, 157, 191, 167 Annotation: Subtype: Link Rect: 85, 130, 184, 138 Annotation: Subtype: Link Rect: 131, 110, 291, 119 Annotation: Subtype: Link Rect: 61, 101, 281, 110 Annotation: Subtype: Link Rect: 61, 91, 185, 101 Annotation: Subtype: Link Rect: 354, 697, 433, 706 Annotation: Subtype: Link Rect: 451, 678, 551, 687 Annotation: Subtype: Link Rect: 321, 669, 546, 678 Annotation: Subtype: Link Rect: 321, 660, 357, 668 Annotation: Subtype: Link Rect: 345, 613, 444, 621 Annotation: Subtype: Link Rect: 552, 565, 320, 584 Annotation: Subtype: Link Rect: 345, 517, 432, 526 Annotation: Subtype: Link Rect: 368, 490, 457, 498 Annotation: Subtype: Link Rect: 345, 452, 405, 460 Annotation: Subtype: Link Rect: 337, 423, 551, 432 Annotation: Subtype: Link Rect: 321, 413, 536, 422 Annotation: Subtype: Link Rect: 321, 404, 392, 413 Annotation: Subtype: Link Rect: 510, 394, 551, 403 Annotation: Subtype: Link Rect: 321, 385, 426, 394 Annotation: Subtype: Link Rect: 387, 366, 486, 375 Annotation: Subtype: Link Rect: 418, 319, 497, 328 Annotation: Subtype: Link Rect: 419, 299, 551, 309 Annotation: Subtype: Link Rect: 321, 290, 535, 299 Annotation: Subtype: Link Rect: 321, 282, 346, 290 Annotation: Subtype: Link Rect: 527, 262, 551, 271 Annotation: Subtype: Link Rect: 321, 252, 540, 261 Annotation: Subtype: Link Rect: 321, 243, 548, 252 Annotation: Subtype: Link Rect: 389, 205, 477, 214 Annotation: Subtype: Link Rect: 400, 186, 551, 195 Annotation: Subtype: Link Rect: 368, 140, 457, 148 Annotation: Subtype: Link Rect: 530, 120, 551, 129 Annotation: Subtype: Link Rect: 321, 110, 540, 119 Annotation: Subtype: Link Rect: 321, 101, 542, 110 Annotation: Subtype: Link Rect: 43, 30, 120, 37 Annotation: Subtype: Link Rect: 123, 29, 183, 37 Annotation: Subtype: Link Rect: 434, 29, 551, 38 Annotation: Subtype: Link Rect: 398, 72, 551, 82 Page: Label: 21 Sequence: 21 Annotations: Annotation: Subtype: Link Rect: 61, 706, 269, 716 Annotation: Subtype: Link Rect: 61, 697, 110, 706 Annotation: Subtype: Link Rect: 104, 659, 184, 668 Annotation: Subtype: Link Rect: 104, 621, 164, 631 Annotation: Subtype: Link Rect: 166, 576, 265, 583 Annotation: Subtype: Link Rect: 104, 528, 190, 536 Annotation: Subtype: Link Rect: 108, 489, 193, 498 Annotation: Subtype: Link Rect: 108, 452, 193, 460 Annotation: Subtype: Link Rect: 81, 405, 166, 413 Annotation: Subtype: Link Rect: 194, 377, 284, 384 Annotation: Subtype: Link Rect: 169, 347, 291, 356 Annotation: Subtype: Link Rect: 61, 337, 233, 347 Annotation: Subtype: Link Rect: 104, 299, 184, 309 Annotation: Subtype: Link Rect: 85, 262, 145, 271 Annotation: Subtype: Link Rect: 115, 225, 193, 233 Annotation: Subtype: Link Rect: 81, 186, 178, 195 Annotation: Subtype: Link Rect: 341, 697, 397, 706 Annotation: Subtype: Link Rect: 425, 661, 521, 668 Annotation: Subtype: Link Rect: 345, 632, 457, 640 Annotation: Subtype: Link Rect: 552, 584, 320, 603 Annotation: Subtype: Link Rect: 341, 555, 551, 564 Annotation: Subtype: Link Rect: 321, 546, 538, 555 Annotation: Subtype: Link Rect: 321, 537, 378, 545 Annotation: Subtype: Link Rect: 432, 318, 516, 327 Annotation: Subtype: Link Rect: 492, 216, 519, 222 Annotation: Subtype: Link Rect: 519, 216, 551, 222 Annotation: Subtype: Link Rect: 304, 206, 339, 214 Annotation: Subtype: Link Rect: 339, 206, 362, 213 Annotation: Subtype: Link Rect: 362, 205, 390, 214 Annotation: Subtype: Link Rect: 43, 30, 120, 37 Annotation: Subtype: Link Rect: 123, 29, 183, 37 Annotation: Subtype: Link Rect: 434, 29, 551, 38 Checksum: 0bda6baa Type: CRC32 Checksum: d7711ba4535deb1579d6847a1a0a7e28 Type: MD5 Checksum: 2ba1552ab7f6ebe73033a3ab13d8e100d86ea4af Type: SHA-1