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Title:           New candidate blood biomarkers potentially associated with white matter hyperintensities progression
Subject:         Scientific Reports, https://doi.org/10.1038/s41598-021-93498-w
Author:          Joan Jiménez-Balado 
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      Title: New candidate blood biomarkers potentially associated with white matter hyperintensities progression
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        Title: Methods
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         Item: 
          Title: Setting. 
         Item: 
          Title: Case and control definitions. 
         Item: 
          Title: Subjects in the discovery and replication studies:. 
         Item: 
          Title: Sample processing. 
          Children: 
           Item: 
            Title: Discovery phase. 
           Item: 
            Title: Replication phase. 
         Item: 
          Title: Covariables. 
         Item: 
          Title: Statistics. 
          Children: 
           Item: 
            Title: Discovery phase. 
           Item: 
            Title: Replication phase. 
         Item: 
          Title: Data sharing. 
       Item: 
        Title: Results
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         Item: 
          Title: Discovery phase. 
          Children: 
           Item: 
            Title: Differentially expressed proteins. 
           Item: 
            Title: Differentially expressed pathways. 
         Item: 
          Title: Replication phase. 
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           Item: 
            Title: Descriptive analysis. 
           Item: 
            Title: Validation of SOMAscan technique. 
           Item: 
            Title: Longitudinal analysis. 
       Item: 
        Title: Discussion
       Item: 
        Title: Conclusions
       Item: 
        Title: References
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                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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               <rdf:li rdf:parseType="Resource">
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                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
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                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://iptc.org/std/Iptc4xmpExt/2008-02-29/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>Iptc4xmpExt</pdfaSchema:prefix>
                  <pdfaSchema:schema>IPTC Extension</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>A set of metadata about artwork or an object in the item.</pdfaProperty:description>
                           <pdfaProperty:name>ArtworkOrObject</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag ArtworkOrObjectDetails</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The location the content of the item was created.</pdfaProperty:description>
                           <pdfaProperty:name>LocationCreated</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag LocationDetails</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>A location the content of the item is about. For photos that is a location shown in the image.</pdfaProperty:description>
                           <pdfaProperty:name>LocationShown</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag LocationDetails</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Both a Registry Item Id and a Registry Organisation Id to record any registration of this item with a registry.</pdfaProperty:description>
                           <pdfaProperty:name>RegistryId</pdfaProperty:name>
                           <pdfaProperty:valueType>RegistryEntryDetails</pdfaProperty:valueType>
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                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>A structured datatype for details about artwork or an object in an image</pdfaType:description>
                           <pdfaType:namespaceURI>http://iptc.org/std/Iptc4xmpExt/2008-02-29/</pdfaType:namespaceURI>
                           <pdfaType:prefix>Iptc4xmpExt</pdfaType:prefix>
                           <pdfaType:type>ArtworkOrObjectDetails</pdfaType:type>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>A structured datatype for details of a location</pdfaType:description>
                           <pdfaType:namespaceURI>http://iptc.org/std/Iptc4xmpExt/2008-02-29/</pdfaType:namespaceURI>
                           <pdfaType:prefix>Iptc4xmpExt</pdfaType:prefix>
                           <pdfaType:type>LocationDetails</pdfaType:type>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>A structured datatype for an entry in a registry, includes the id issued by the registry and the registry's id.</pdfaType:description>
                           <pdfaType:namespaceURI>http://iptc.org/std/Iptc4xmpExt/2008-02-29/</pdfaType:namespaceURI>
                           <pdfaType:prefix>Iptc4xmpExt</pdfaType:prefix>
                           <pdfaType:type>RegistryEntryDetails</pdfaType:type>
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                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.useplus.org/ldf/xmp/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>plus</pdfaSchema:prefix>
                  <pdfaSchema:schema>PLUS LDF Version 1.2.0</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Owner or owners of the copyright in the licensed image.</pdfaProperty:description>
                           <pdfaProperty:name>CopyrightOwner</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq CopyrightOwnerDetail</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Creator/s of the image.</pdfaProperty:description>
                           <pdfaProperty:name>ImageCreator</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq ImageCreatorDetail</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Party providing the image to the Licensor or to the Licensee on behalf of the Licensor.</pdfaProperty:description>
                           <pdfaProperty:name>ImageSupplier</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq ImageSupplierDetail</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Party or parties granting the license to the Licensee.</pdfaProperty:description>
                           <pdfaProperty:name>Licensor</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq LicensorDetail</pdfaProperty:valueType>
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                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>&lt;DESCRIPTION&gt;</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.useplus.org/ldf/xmp/1.0/</pdfaType:namespaceURI>
                           <pdfaType:prefix>plus</pdfaType:prefix>
                           <pdfaType:type>CopyrightOwnerDetail</pdfaType:type>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>&lt;DESCRIPTION&gt;</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.useplus.org/ldf/xmp/1.0/</pdfaType:namespaceURI>
                           <pdfaType:prefix>plus</pdfaType:prefix>
                           <pdfaType:type>ImageCreatorDetail</pdfaType:type>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>&lt;DESCRIPTION&gt;</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.useplus.org/ldf/xmp/1.0/</pdfaType:namespaceURI>
                           <pdfaType:prefix>plus</pdfaType:prefix>
                           <pdfaType:type>ImageSupplierDetail</pdfaType:type>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>&lt;DESCRIPTION&gt;</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.useplus.org/ldf/xmp/1.0/</pdfaType:namespaceURI>
                           <pdfaType:prefix>plus</pdfaType:prefix>
                           <pdfaType:type>LicensorDetail</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
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               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/t/pg/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpTPg</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Paged-Text</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).</pdfaProperty:description>
                           <pdfaProperty:name>PlateNames</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
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                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
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                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
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                  </pdfaSchema:property>
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