292171f62ffb3305ed38797d27b951cc pmc_34294142.pdf 0cdfddf361bb74d7ad8daa5c0b30a9152ea803e2 pmc_34294142.pdf 4e59749235827d027bb26603d6b5d93e9014793aa5334e28eee3d4084737c10b pmc_34294142.pdf Title: Dexibuprofen ameliorates peripheral and central risk factors associated with Alzheimer’s disease in metabolically stressed APPswe/PS1dE9 mice Subject: Cell & Bioscience, https://doi.org/10.1186/s13578-021-00646-w Keywords: APPswe/PS1dE9,Alzheimer´s disease,Dexibuprofen,Unfolded protein response,neuroinflammation,Synapsis,Cognitive deficits,High fat diet,Metabolic alterations,βA plaques Author: Miren Ettcheto Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Wed Jul 21 02:26:02 2021 CEST ModDate: Thu Jul 22 11:12:02 2021 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 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Language: EN Outlines: Item: Title: Dexibuprofen ameliorates peripheral and central risk factors associated with Alzheimer’s disease in metabolically stressed APPswePS1dE9 mice Children: Item: Title: Abstract Children: Item: Title: Background: Item: Title: Results: Item: Title: Conclusions: Item: Title: Background Item: Title: Methods Children: Item: Title: Animals and treatment Item: Title: Glucose and insulin tolerance test Item: Title: Cognitive test Children: Item: Title: Morris water maze Item: Title: Novel object recognition test Item: Title: Immunofluorescence, S-thioflavin staining and enzymatic immunohistochemistry Item: Title: Immunoblot analysis Item: Title: Real time PCR Item: Title: Statistical analysis Item: Title: Results Children: Item: Title: DXI treatment ameliorates HFD-related peripheral alterations in APPPS1 mice Item: Title: DXI treatment improves cognitive decline observed in both APPPS1 mice fed with conventional chow and obesogenic diet Item: Title: DXI reduces Aβ-plaque burden in APPPS1 mice fed with conventional chow and obesogenic diet Item: Title: DXI treatment reduces the neuroinflammatory response in APPPS1 fed with conventional chow and obesogenic diet Item: Title: DXI reduces endoplasmic reticulum stress Item: Title: DXI improves insulin signaling pathway APPPS1 mice hippocampus Item: Title: Discussion Item: Title: Conclusions Item: Title: Acknowledgements Item: Title: References Info: Title: Dexibuprofen ameliorates peripheral and central risk factors associated with Alzheimer’s disease in metabolically stressed APPswe/PS1dE9 mice Author: Miren Ettcheto Subject: Cell & Bioscience, https://doi.org/10.1186/s13578-021-00646-w Keywords: APPswe/PS1dE9,Alzheimer´s disease,Dexibuprofen,Unfolded protein response,neuroinflammation,Synapsis,Cognitive deficits,High fat diet,Metabolic alterations,βA plaques Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed 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peripheral and central risk factors associated with Alzheimer’s disease in metabolically stressed APPswe/PS1dE9 mice Miren Ettcheto Elena Sánchez-Lopez Amanda Cano Marina Carrasco Katherine Herrera Patricia R. 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