f79ccde02a8e2a8ce734b6cdeae7bcb6 pmc_34300271.pdf 7c9d9d9c507ef47785bd5245140374124ace5f47 pmc_34300271.pdf 86484537777b2e0f69ddfdb210210c87cc974a6d2893a1c9aaad8d7836dd03f8 pmc_34300271.pdf Title: Evaluating Routine Blood Tests According to Clinical Symptoms and Diagnostic Criteria in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Subject: There is a lack of research regarding blood tests within individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and between patients and healthy controls. We aimed to compare results of routine blood tests between patients and healthy controls. Data from 149 patients diagnosed with ME/CFS based on clinical and psychiatric evaluation as well as on the DePaul Symptom Questionnaire, and data from 264 healthy controls recruited from blood donors were compared. One-way ANCOVA was conducted to examine differences between ME/CFS patients and healthy controls, adjusting for age and gender. Patients had higher sedimentation rate (mean difference: 1.38, 95% CI: 0.045 to 2.714), leukocytes (mean difference: 0.59, 95% CI: 0.248 to 0.932), lymphocytes (mean difference: 0.27, 95% CI: 0.145 to 0.395), neutrophils (mean difference: 0.34, 95% CI: 0.0 89 to 0.591), monocytes (mean difference: 0.34, 95% CI: 0.309 to 0.371), ferritin (mean difference: 28.13, 95% CI: -1.41 to 57.672), vitamin B12 (mean difference: 83.43, 95% CI: 62.89 to 124.211), calcium (mean difference: 0.02, 95% CI: -0.02 to 0.06), alanine transaminase (mean difference: 3.30, 95% CI: -1.37 to -7.971), low-density lipoproteins (mean difference: 0.45, 95% CI: 0.104 to 0.796), and total proteins (mean difference: 1.53, 95% CI: -0.945 to 4.005) than control subjects. The patients had lower potassium levels (mean difference: 0.11, 95% CI: 0.056 to 0.164), creatinine (mean difference: 2.60, 95% CI: 0.126 to 5.074) and creatine kinase (CK) (mean difference: 37.57, 95% CI: -0.282 to 75.422) compared to the healthy controls. Lower CK and creatinine levels may suggest muscle damage and metabolic abnormalities in ME/CFS patients. Keywords: myalgic encephalomyelitis/chronic fatigue syndrome; routine blood tests; diagnostic criteria; functional status; creatinine; creatine kinase Author: Ingrid H. Baklund, Toril Dammen, Torbjørn Åge Moum, Wenche Kristiansen, Daysi Sosa Duarte, Jesus Castro-Marrero, Ingrid Bergliot Helland and Elin Bolle Strand Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Mon Jul 19 10:46:14 2021 CEST ModDate: Mon Jul 19 13:08:14 2021 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 301357 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- BMWNIW+VnURWPalladioL Type 1 Custom yes yes no 10 0 CMGZSR+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 LUYAVS+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 APYARF+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 JDUPKS+CMSY10 Type 1 Builtin yes yes no 28 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 36 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 39 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 61 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 65 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 69 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 90 0 MDIKPC+CMBSY10 Type 1 Builtin yes yes no 97 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:10:10 CEST RepresentationInformation: pmc_34300271.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:14:36 CEST Size: 301357 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 326 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Participants Destination: subsection.2.1 Item: Title: ME/CFS Assessment and Diagnosis Destination: subsection.2.2 Item: Title: Measures Destination: subsection.2.3 Item: Title: Patient Groupings: Functional Status, Illness Duration, and Diagnostic Criteria Destination: subsection.2.4 Item: Title: Blood Collection and Processing Destination: subsection.2.5 Item: Title: Ethics Destination: subsection.2.6 Item: Title: Statistical Analysis Destination: subsection.2.7 Item: Title: Results Destination: section.3 Children: Item: Title: Study Population Characteristics Destination: subsection.3.1 Item: Title: Comparing Patients and Healthy Controls Destination: subsection.3.2 Item: Title: Comparing Subgroups of Patients between Blood Tests, Clinical Characteristics, and Case Criteria for ME/CFS Destination: subsection.3.3 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.5 Info: Title: Evaluating Routine Blood Tests According to Clinical Symptoms and Diagnostic Criteria in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Author: Ingrid H. Baklund, Toril Dammen, Torbjørn Åge Moum, Wenche Kristiansen, Daysi Sosa Duarte, Jesus Castro-Marrero, Ingrid Bergliot Helland and Elin Bolle Strand Subject: There is a lack of research regarding blood tests within individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and between patients and healthy controls. We aimed to compare results of routine blood tests between patients and healthy controls. Data from 149 patients diagnosed with ME/CFS based on clinical and psychiatric evaluation as well as on the DePaul Symptom Questionnaire, and data from 264 healthy controls recruited from blood donors were compared. One-way ANCOVA was conducted to examine differences between ME/CFS patients and healthy controls, adjusting for age and gender. Patients had higher sedimentation rate (mean difference: 1.38, 95% CI: 0.045 to 2.714), leukocytes (mean difference: 0.59, 95% CI: 0.248 to 0.932), lymphocytes (mean difference: 0.27, 95% CI: 0.145 to 0.395), neutrophils (mean difference: 0.34, 95% CI: 0.0 89 to 0.591), monocytes (mean difference: 0.34, 95% CI: 0.309 to 0.371), ferritin (mean difference: 28.13, 95% CI: -1.41 to 57.672), vitamin B12 (mean difference: 83.43, 95% CI: 62.89 to 124.211), calcium (mean difference: 0.02, 95% CI: -0.02 to 0.06), alanine transaminase (mean difference: 3.30, 95% CI: -1.37 to -7.971), low-density lipoproteins (mean difference: 0.45, 95% CI: 0.104 to 0.796), and total proteins (mean difference: 1.53, 95% CI: -0.945 to 4.005) than control subjects. The patients had lower potassium levels (mean difference: 0.11, 95% CI: 0.056 to 0.164), creatinine (mean difference: 2.60, 95% CI: 0.126 to 5.074) and creatine kinase (CK) (mean difference: 37.57, 95% CI: -0.282 to 75.422) compared to the healthy controls. Lower CK and creatinine levels may suggest muscle damage and metabolic abnormalities in ME/CFS patients. Keywords: myalgic encephalomyelitis/chronic fatigue syndrome; routine blood tests; diagnostic criteria; functional status; creatinine; creatine kinase Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Mon Jul 19 10:46:14 CEST 2021 ModDate: Mon Jul 19 13:08:14 CEST 2021 ID: 0xe40046fe0f441c059815abf75ef48332, 0xe40046fe0f441c059815abf75ef48332 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: MDIKPC+CMBSY10 FontSubset: true FirstChar: 6 LastChar: 6 FontDescriptor: FontName: MDIKPC+CMBSY10 Flags: Symbolic FontBBox: -26, -940, 1332, 825 FontFile: true Font: BaseFont: LUYAVS+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 248 FontDescriptor: FontName: LUYAVS+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: APYARF+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: APYARF+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 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