da746037601c2e526f574318c40e9594 pmc_34316017.pdf 4cf1f52bd3447b1384d2be50148b4b2642a57127 pmc_34316017.pdf 3f94cc28db75ae6b6107f3627ed4afa56806aee92cc2637b5112e598a8e90f01 pmc_34316017.pdf Title: Molecular landscape and prognostic impact of FLT3-ITD insertion site in acute myeloid leukemia: RATIFY study results Author: Frank G. Rücker, Ling Du, Tamara J. Luck, Axel Benner, Julia Krzykalla, Insa Gathmann, Maria Teresa Voso, Sergio Amadori, Thomas W. Prior, Joseph M. Brandwein, Frederick R. Appelbaum, Bruno C. Medeiros, Martin S. Tallman, Lynn Savoie, Jorge Sierra, Celine Pallaud, Miguel A. Sanz, Joop H. Jansen, Dietger Niederwieser, Thomas Fischer, Gerhard Ehninger, Michael Heuser, Arnold Ganser, Lars Bullinger, Richard A. Larson, Clara D. Bloomfield, Richard M. Stone, Hartmut Döhner, Christian Thiede, Konstanze Döhner Creator: AH Formatter V7.2 MR1 for Linux64 : 7.2.2.53984 (2021-10-18T16:29+09) Producer: Antenna House PDF Output Library 7.2.1712 CreationDate: Thu Jan 6 07:59:41 2022 CET ModDate: Thu Jan 6 07:59:41 2022 CET Custom Metadata: no Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 23 Encrypted: no Page size: 612 x 792 pts (letter) Page rot: 0 File size: 1233927 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- Helvetica-Bold Type 1 Custom no no yes 11 0 Helvetica-BoldOblique Type 1 Standard no no no 12 0 Helvetica Type 1 Custom no no yes 15 0 MUCZEF+Code2000 CID TrueType Identity-H yes yes yes 45 0 Times-Bold Type 1 Standard no no no 71 0 Times-Roman Type 1 Custom no no yes 72 0 Times-BoldItalic Type 1 Standard no no no 436 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:09:32 CEST RepresentationInformation: pmc_34316017.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:14:38 CEST Size: 1233927 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 0 FreeObjects: 611 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Abstract Item: Title: INTRODUCTION Children: Item: Title: Patients and methods Item: Title: Molecular analyses Item: Title: FLT3-ITD Roche 454 next-generation sequencing analysis Item: Title: Statistical analyses Item: Title: RESULTS Children: Item: Title: Patient characteristics Item: Title: Next-generation sequencing Item: Title: Molecular characterization of FLT3-ITDs Item: Title: Analysis of the duplication of specific amino acid motives Item: Title: Mutant to wild-type FLT3-ITD allelic ratio determined by NGS (NGS-cAR) Item: Title: Characterization of co-occurring insertion sites Item: Title: Correlation of FLT3-ITD IS with clinical baseline characteristics, genetic features, and treatment Item: Title: Clinical outcome Children: Item: Title: Response to induction therapy. Item: Title: Survival analysis. Item: Title: DISCUSSION Item: Title: References Item: Title: Fig. 1 Item: Title: Fig. 2 Item: Title: Fig. 3 Item: Title: Fig. 4 Item: Title: Fig. 5 Item: Title: Table 1. Item: Title: Table 2. Item: Title: Table 3. 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Rücker, Ling Du, Tamara J. Luck, Axel Benner, Julia Krzykalla, Insa Gathmann, Maria Teresa Voso, Sergio Amadori, Thomas W. Prior, Joseph M. Brandwein, Frederick R. Appelbaum, Bruno C. Medeiros, Martin S. Tallman, Lynn Savoie, Jorge Sierra, Celine Pallaud, Miguel A. Sanz, Joop H. Jansen, Dietger Niederwieser, Thomas Fischer, Gerhard Ehninger, Michael Heuser, Arnold Ganser, Lars Bullinger, Richard A. Larson, Clara D. Bloomfield, Richard M. 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