89b778d707f77a6b5000a6458fd81a9c  pmc_34322119.pdf
e60487ab6f642125cf3168b7aff29d16e4bcb618  pmc_34322119.pdf
a225bb048234cf7facc0fe983307faba83cce113e08c085360e1d32f7fcd918e  pmc_34322119.pdf

Title:           Identification of the Immunological Changes Appearing in the CSF During the Early Immunosenescence Process Occurring in Multiple Sclerosis
Subject:         Patients with multiple sclerosis (MS) suffer with age an early immunosenescence process, which influence the treatment response and increase the risk of infections
Keywords:        multiple sclerosis, aging, innate immunity, adaptive immunity, inflammation
Author:          Carmen Pic&oacute
Creator:         Arbortext Advanced Print Publisher 10.0.1306/W Unicode
Producer:        Acrobat Distiller 7.0 (Windows)
CreationDate:    Thu Jul  8 04:55:36 2021 CEST
ModDate:         Thu Jul  8 05:06:01 2021 CEST
Custom Metadata: no
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           10
Encrypted:       no
Page size:       595.276 x 779.528 pts
Page rot:        0
File size:       1713840 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
FMDFPF+AdvOT6e5d2ec0+fb              Type 1C           Custom           yes yes yes    713  0
FMDGAF+AdvOT6601a1b9.BI              Type 1C           WinAnsi          yes yes no     721  0
FMDGBG+AdvOT1deab444.I+fb            Type 1C           Custom           yes yes yes    723  0
FMDFNK+AdvOT34fe1490.B               Type 1C           WinAnsi          yes yes no     695  0
FMDFNL+AdvOT34fe1490.B+fb            Type 1C           Custom           yes yes yes    696  0
FMDFNM+AdvOT01861455.I               Type 1C           WinAnsi          yes yes no     697  0
FMDFNN+AdvPSA18C                     Type 1C           WinAnsi          yes yes no     698  0
FMDFNO+AdvOT01861455.I+20            Type 1C           WinAnsi          yes yes no     699  0
FMDFNP+AdvOT01861455.I+01            Type 1C           MacRoman         yes yes no     700  0
FMDFOA+AdvOT1deab444.I               Type 1C           WinAnsi          yes yes no     701  0
FMDFPB+AdvOT1deab444.I+20            Type 1C           WinAnsi          yes yes no     702  0
FMDFPC+AdvOT1deab444.I+01            Type 1C           MacRoman         yes yes no     703  0
FMDFPD+AdvPSA323                     Type 1C           WinAnsi          yes yes no     704  0
FMDFPE+AdvOT6e5d2ec0                 Type 1C           WinAnsi          yes yes no     714  0
FMDGEG+AdvOT1ef757c0                 Type 1C           WinAnsi          yes yes no     247  0
FMDGEH+AdvOT1ef757c0+fb              Type 1C           Custom           yes yes yes    248  0
FMDGEI+AdvOT1ef757c0+20              Type 1C           WinAnsi          yes yes no     235  0
FMDGEJ+AdvOT3f84ef53                 Type 1C           WinAnsi          yes yes no     252  0
FMDGFJ+AdvTT58d178b9+03              Type 1C           Custom           yes yes yes    237  0
FMDGFK+AdvOTb65e897d.B               Type 1C           WinAnsi          yes yes no     242  0
FMDGIK+AdvOT2f02755f.I               Type 1C           WinAnsi          yes yes no     256  0
FMDGIL+AdvOT1ef757c0+22              Type 1C           Custom           yes yes yes    257  0
HelveticaNeueLTStd-Bd                Type 1C           WinAnsi          yes no  no     265  0
FMDJGK+AdvOT6e5d2ec0+22              Type 1C           Custom           yes yes yes    266  0
FMDKIE+AdvOT34fe1490.B+20            Type 1C           WinAnsi          yes yes no     267  0
FMDMCK+AdvOTd877c31c+03              Type 1C           Custom           yes yes yes    270  0
FMDMDL+AdvOT1ef757c0+01              Type 1C           MacRoman         yes yes no     274  0
FMDMDM+AdvOT7d6df7ab.I               Type 1C           WinAnsi          yes yes no     277  0
FMDMEM+AdvTT97cacd14+20              Type 1C           Custom           yes yes yes    282  0
FMDMFN+AdvOT7d6df7ab.I+fb            Type 1C           Custom           yes yes yes    280  0
FMDMFO+AdvOTb65e897d.B+fb            Type 1C           Custom           yes yes yes    281  0
FMDMFP+AdvTT02dee1cd.I+03            Type 1C           Custom           yes yes yes    278  0
FMDMGA+AdvOT7d6df7ab.I+01            Type 1C           MacRoman         yes yes no     279  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-10-02 03:09:21 CEST
 RepresentationInformation: pmc_34322119.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2023-03-31 12:14:39 CEST
  Size: 1713840
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 796
   FreeObjects: 1
   IncrementalUpdates: 2
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Outlines: 
     Item: 
      Title: Identification of the Immunological Changes Appearing in the CSF During the Early Immunosenescence Process Occurring in Multiple Sclerosis
      Destination: bmark_-1636598527
      Children: 
       Item: 
        Title: Introduction
        Destination: s1
       Item: 
        Title: Materials and Methods
        Destination: s2
        Children: 
         Item: 
          Title: Study Approval
          Destination: s2_1
         Item: 
          Title: Patients
          Destination: s2_2
         Item: 
          Title: Samples
          Destination: s2_3
         Item: 
          Title: Immunoglobulin G and M Oligoclonal Band Detection
          Destination: s2_4
         Item: 
          Title: CSF Leukocyte Subpopulations
          Destination: s2_5
         Item: 
          Title: Flow Cytometry Analysis
          Destination: s2_6
         Item: 
          Title: Detection of Soluble Molecules in CSF
          Destination: s2_7
         Item: 
          Title: Anti-CMV IgG ELISA
          Destination: s2_8
         Item: 
          Title: Statistical Analyses
          Destination: s2_9
       Item: 
        Title: Results
        Destination: s3
        Children: 
         Item: 
          Title: Patient Characteristics
          Destination: s3_1
         Item: 
          Title: Aging Diminishes Numbers of Intrathecal Lymphocytes and NK Cells in M- Patients
          Destination: s3_2
         Item: 
          Title: Changes in Soluble Factors Associated With Immunosenescence and T Cell Exhaustion
          Destination: s3_3
         Item: 
          Title: Soluble Factors Related to Innate Immune Response
          Destination: s3_4
         Item: 
          Title: Age and Disability Progression
          Destination: s3_5
       Item: 
        Title: Discussion
        Destination: s4
       Item: 
        Title: Data Availability Statement
        Destination: s5
       Item: 
        Title: Ethics Statement
        Destination: s6
       Item: 
        Title: Author Contributions
        Destination: s7
       Item: 
        Title: Funding
        Destination: s8
       Item: 
        Title: Acknowledgments
        Destination: bmark_-366698314
       Item: 
        Title: Supplementary Material
        Destination: bmark_386646472
       Item: 
        Title: References
        Destination: bmark_2090415954
   Info: 
    Title: Identification of the Immunological Changes Appearing in the CSF During the Early Immunosenescence Process Occurring in Multiple Sclerosis
    Author: Carmen Pic&oacute
    Subject: Patients with multiple sclerosis (MS) suffer with age an early immunosenescence process, which influence the treatment response and increase the risk of infections
    Keywords: multiple sclerosis, aging, innate immunity, adaptive immunity, inflammation
    Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode
    Producer: Acrobat Distiller 7.0 (Windows)
    CreationDate: Thu Jul 08 04:55:36 CEST 2021
    ModDate: Thu Jul 08 05:06:01 CEST 2021
   ID: 0xb277ce46a4ca12545c93437148802d81, 0xf2b1ffecbfbeea448dfed45033da4175
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1538
      ImageHeight: 2000
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2362
      ImageHeight: 1499
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1355
      ImageHeight: 937
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1538
      ImageHeight: 986
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: FMDFPD+AdvPSA323
      FontSubset: true
      FirstChar: 180
      LastChar: 180
      FontDescriptor: 
       FontName: FMDFPD+AdvPSA323
       Flags: Nonsymbolic
       FontBBox: -156, -239, 1104, 770
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FMDGIK+AdvOT2f02755f.I
      FontSubset: true
      FirstChar: 103
      LastChar: 103
      FontDescriptor: 
       FontName: FMDGIK+AdvOT2f02755f.I
       Flags: Nonsymbolic
       FontBBox: -177, -291, 1281, 1000
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FMDGIL+AdvOT1ef757c0+22
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: FMDGIL+AdvOT1ef757c0+22
       Flags: Symbolic
       FontBBox: -135, -166, 697, 916
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: FMDFPF+AdvOT6e5d2ec0+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: FMDFPF+AdvOT6e5d2ec0+fb
       Flags: Symbolic
       FontBBox: 0, 0, 500, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HelveticaNeueLTStd-Bd
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaNeueLTStd-Bd
       Flags: Nonsymbolic, ForceBold
       FontBBox: -166, -218, 1078, 975
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FMDFPE+AdvOT6e5d2ec0
      FontSubset: true
      FirstChar: 37
      LastChar: 124
      FontDescriptor: 
       FontName: FMDFPE+AdvOT6e5d2ec0
       Flags: Nonsymbolic
       FontBBox: -62, -208, 895, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FMDJGK+AdvOT6e5d2ec0+22
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: FMDJGK+AdvOT6e5d2ec0+22
       Flags: Symbolic
       FontBBox: -156, -145, 718, 843
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: FMDKIE+AdvOT34fe1490.B+20
      FontSubset: true
      FirstChar: 150
      LastChar: 150
      FontDescriptor: 
       FontName: FMDKIE+AdvOT34fe1490.B+20
       Flags: Nonsymbolic
       FontBBox: -156, -166, 1072, 718
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FMDMCK+AdvOTd877c31c+03
      FontSubset: true
      FirstChar: 0
      LastChar: 0
      FontDescriptor: 
       FontName: FMDMCK+AdvOTd877c31c+03
       Flags: Symbolic
       FontBBox: 0, -364, 854, 927
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: FMDGAF+AdvOT6601a1b9.BI
      FontSubset: true
      FirstChar: 42
      LastChar: 121
      FontDescriptor: 
       FontName: FMDGAF+AdvOT6601a1b9.BI
       Flags: Nonsymbolic
       FontBBox: -125, -208, 1020, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FMDMDL+AdvOT1ef757c0+01
      FontSubset: true
      FirstChar: 245
      LastChar: 245
      FontDescriptor: 
       FontName: FMDMDL+AdvOT1ef757c0+01
       Flags: Serif, Nonsymbolic
       FontBBox: -20, -250, 947, 854
       FontFile3: true
      Encoding: MacRomanEncoding
     Font: 
      BaseFont: FMDGBG+AdvOT1deab444.I+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: FMDGBG+AdvOT1deab444.I+fb
       Flags: Symbolic
       FontBBox: 9, 0, 572, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: FMDMDM+AdvOT7d6df7ab.I
      FontSubset: true
      FirstChar: 40
      LastChar: 243
      FontDescriptor: 
       FontName: FMDMDM+AdvOT7d6df7ab.I
       Flags: Serif, Nonsymbolic
       FontBBox: -135, -250, 1000, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FMDMFP+AdvTT02dee1cd.I+03
      FontSubset: true
      FirstChar: 0
      LastChar: 0
      FontDescriptor: 
       FontName: FMDMFP+AdvTT02dee1cd.I+03
       Flags: Symbolic
       FontBBox: -416, -354, 916, 864
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: FMDMGA+AdvOT7d6df7ab.I+01
      FontSubset: true
      FirstChar: 245
      LastChar: 245
      FontDescriptor: 
       FontName: FMDMGA+AdvOT7d6df7ab.I+01
       Flags: Serif, Nonsymbolic
       FontBBox: -156, -250, 1000, 854
       FontFile3: true
      Encoding: MacRomanEncoding
     Font: 
      BaseFont: FMDMFN+AdvOT7d6df7ab.I+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: FMDMFN+AdvOT7d6df7ab.I+fb
       Flags: Symbolic
       FontBBox: -156, -250, 802, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: FMDMFO+AdvOTb65e897d.B+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: FMDMFO+AdvOTb65e897d.B+fb
       Flags: Symbolic
       FontBBox: 0, -10, 843, 697
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: FMDMEM+AdvTT97cacd14+20
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: FMDMEM+AdvTT97cacd14+20
       Flags: Symbolic
       FontBBox: -291, -197, 1343, 968
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: FMDGEI+AdvOT1ef757c0+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: FMDGEI+AdvOT1ef757c0+20
       Flags: Nonsymbolic
       FontBBox: -135, -187, 1010, 833
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FMDGFJ+AdvTT58d178b9+03
      FontSubset: true
      FirstChar: 0
      LastChar: 0
      FontDescriptor: 
       FontName: FMDGFJ+AdvTT58d178b9+03
       Flags: Symbolic
       FontBBox: -645, -354, 916, 895
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: FMDGFK+AdvOTb65e897d.B
      FontSubset: true
      FirstChar: 44
      LastChar: 121
      FontDescriptor: 
       FontName: FMDGFK+AdvOTb65e897d.B
       Flags: Serif, Nonsymbolic
       FontBBox: -20, -250, 968, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FMDFNK+AdvOT34fe1490.B
      FontSubset: true
      FirstChar: 40
      LastChar: 124
      FontDescriptor: 
       FontName: FMDFNK+AdvOT34fe1490.B
       Flags: Nonsymbolic
       FontBBox: -52, -208, 937, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FMDGEG+AdvOT1ef757c0
      FontSubset: true
      FirstChar: 34
      LastChar: 252
      FontDescriptor: 
       FontName: FMDGEG+AdvOT1ef757c0
       Flags: Serif, Nonsymbolic
       FontBBox: -20, -250, 947, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FMDFNL+AdvOT34fe1490.B+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: FMDFNL+AdvOT34fe1490.B+fb
       Flags: Symbolic
       FontBBox: 0, 0, 552, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: FMDGEH+AdvOT1ef757c0+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: FMDGEH+AdvOT1ef757c0+fb
       Flags: Symbolic
       FontBBox: 0, -10, 781, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: FMDFNM+AdvOT01861455.I
      FontSubset: true
      FirstChar: 42
      LastChar: 243
      FontDescriptor: 
       FontName: FMDFNM+AdvOT01861455.I
       Flags: Nonsymbolic
       FontBBox: -125, -208, 1000, 937
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FMDFNN+AdvPSA18C
      FontSubset: true
      FirstChar: 180
      LastChar: 180
      FontDescriptor: 
       FontName: FMDFNN+AdvPSA18C
       Flags: Nonsymbolic
       FontBBox: -156, -208, 1125, 802
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FMDFNO+AdvOT01861455.I+20
      FontSubset: true
      FirstChar: 134
      LastChar: 134
      FontDescriptor: 
       FontName: FMDFNO+AdvOT01861455.I+20
       Flags: Nonsymbolic
       FontBBox: -156, -156, 1010, 718
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FMDFNP+AdvOT01861455.I+01
      FontSubset: true
      FirstChar: 245
      LastChar: 245
      FontDescriptor: 
       FontName: FMDFNP+AdvOT01861455.I+01
       Flags: Nonsymbolic
       FontBBox: -41, -166, 1125, 927
       FontFile3: true
      Encoding: MacRomanEncoding
     Font: 
      BaseFont: FMDGEJ+AdvOT3f84ef53
      FontSubset: true
      FirstChar: 97
      LastChar: 103
      FontDescriptor: 
       FontName: FMDGEJ+AdvOT3f84ef53
       Flags: Nonsymbolic
       FontBBox: -177, -291, 1083, 1000
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FMDFOA+AdvOT1deab444.I
      FontSubset: true
      FirstChar: 37
      LastChar: 250
      FontDescriptor: 
       FontName: FMDFOA+AdvOT1deab444.I
       Flags: Nonsymbolic
       FontBBox: -135, -208, 968, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FMDFPB+AdvOT1deab444.I+20
      FontSubset: true
      FirstChar: 134
      LastChar: 146
      FontDescriptor: 
       FontName: FMDFPB+AdvOT1deab444.I+20
       Flags: Nonsymbolic
       FontBBox: -156, -145, 1000, 718
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FMDFPC+AdvOT1deab444.I+01
      FontSubset: true
      FirstChar: 245
      LastChar: 245
      FontDescriptor: 
       FontName: FMDFPC+AdvOT1deab444.I+01
       Flags: Nonsymbolic
       FontBBox: -52, -166, 1093, 906
       FontFile3: true
      Encoding: MacRomanEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="3.1-701">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>Acrobat Distiller 7.0 (Windows)</pdf:Producer>
         <pdf:Keywords>multiple sclerosis, aging, innate immunity, adaptive immunity, inflammation</pdf:Keywords>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xap="http://ns.adobe.com/xap/1.0/">
         <xap:ModifyDate>2021-07-08T11:06:01+08:00</xap:ModifyDate>
         <xap:CreateDate>2021-07-08T10:55:36+08:00</xap:CreateDate>
         <xap:CreatorTool>Arbortext Advanced Print Publisher 10.0.1306/W Unicode</xap:CreatorTool>
         <xap:MetadataDate>2021-07-08T11:06:01+08:00</xap:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Patients with multiple sclerosis (MS) suffer with age an early immunosenescence process, which influence the treatment response and increase the risk of infections</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Identification of the Immunological Changes Appearing in the CSF During the Early Immunosenescence Process Occurring in Multiple Sclerosis</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Carmen Pic&amp;oacute</rdf:li>
               <rdf:li>n</rdf:li>
               <rdf:li>Amalia Tejeda-Velarde</rdf:li>
               <rdf:li>José Ignacio Fernández-Velasco</rdf:li>
               <rdf:li>Manuel Comabella</rdf:li>
               <rdf:li>Roberto &amp;Aacute</rdf:li>
               <rdf:li>lvarez-Lafuente</rdf:li>
               <rdf:li>Ester Quintana</rdf:li>
               <rdf:li>Susana Sainz de la Maza</rdf:li>
               <rdf:li>Enric Monreal</rdf:li>
               <rdf:li>Noelia Villarrubia</rdf:li>
               <rdf:li>José Carlos &amp;Aacute</rdf:li>
               <rdf:li>lvarez-Cermeño</rdf:li>
               <rdf:li>Mar&amp;iacute</rdf:li>
               <rdf:li>a Inmaculada Dom&amp;iacute</rdf:li>
               <rdf:li>nguez-Mozo</rdf:li>
               <rdf:li>Llu&amp;iacute</rdf:li>
               <rdf:li>s Ramió-Torrentà</rdf:li>
               <rdf:li>Eulalia Rodr&amp;iacute</rdf:li>
               <rdf:li>guez-Mart&amp;iacute</rdf:li>
               <rdf:li>n</rdf:li>
               <rdf:li>Ernesto Roldán</rdf:li>
               <rdf:li>Yolanda Aladro</rdf:li>
               <rdf:li>Silvia Medina</rdf:li>
               <rdf:li>Mercedes Espiño</rdf:li>
               <rdf:li>Jaime Masjuan</rdf:li>
               <rdf:li>Clara Matute-Blanch</rdf:li>
               <rdf:li>Marta Muñoz-San Mart&amp;iacute</rdf:li>
               <rdf:li>n</rdf:li>
               <rdf:li>Carmen Espejo</rdf:li>
               <rdf:li>Carmen Guaza</rdf:li>
               <rdf:li>Alfonso Muriel</rdf:li>
               <rdf:li>Lucienne Costa-Frossard</rdf:li>
               <rdf:li>Luisa Mar&amp;iacute</rdf:li>
               <rdf:li>a Villar</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>multiple sclerosis</rdf:li>
               <rdf:li>aging</rdf:li>
               <rdf:li>innate immunity</rdf:li>
               <rdf:li>adaptive immunity</rdf:li>
               <rdf:li>inflammation</rdf:li>
            </rdf:Bag>
         </dc:subject>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapMM="http://ns.adobe.com/xap/1.0/mm/">
         <xapMM:DocumentID>uuid:65f43846-b39e-4271-a136-384ff0e939c8</xapMM:DocumentID>
         <xapMM:InstanceID>uuid:4c1e0c4b-6b73-4fdd-ba46-44c91e8f6b19</xapMM:InstanceID>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 175, 602, 521, 623
      Annotation: 
       Subtype: Link
       Rect: 175, 579, 481, 600
      Annotation: 
       Subtype: Link
       Rect: 175, 556, 541, 577
      Annotation: 
       Subtype: Link
       Rect: 175, 533, 392, 554
      Annotation: 
       Subtype: Link
       Rect: 175, 510, 352, 531
      Annotation: 
       Subtype: Link
       Rect: 45, 29, 116, 36
      Annotation: 
       Subtype: Link
       Rect: 125, 29, 183, 36
      Annotation: 
       Subtype: Link
       Rect: 428, 29, 549, 36
      Annotation: 
       Subtype: Link
       Rect: 87, 518, 158, 526
      Annotation: 
       Subtype: Link
       Rect: 58, 379, 158, 386
      Annotation: 
       Subtype: Link
       Rect: 57, 64, 158, 71
      Annotation: 
       Subtype: Link
       Rect: 475, 736, 549, 743
      Annotation: 
       Subtype: Link
       Rect: 477, 728, 549, 735
      Annotation: 
       Subtype: Link
       Rect: 448, 720, 549, 727
      Annotation: 
       Subtype: Link
       Rect: 45, 719, 160, 753
      Annotation: 
       Subtype: Link
       Rect: 521, 678, 549, 706
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 199, 517, 204, 527
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 261, 506, 266, 515
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 277, 494, 282, 504
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 172, 483, 177, 492
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 90, 471, 95, 481
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 125, 448, 129, 458
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 135, 448, 140, 458
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 187, 414, 192, 423
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 70, 356, 74, 366
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 101, 322, 110, 331
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 260, 299, 269, 308
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 48, 253, 57, 262
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 239, 218, 248, 228
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 252, 218, 262, 228
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 217, 115, 226, 124
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 230, 115, 239, 124
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 470, 471, 479, 480
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 408, 448, 436, 457
       Destination: 28
      Annotation: 
       Subtype: Link
       Rect: 395, 172, 403, 181
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 408, 172, 417, 181
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 505, 126, 513, 135
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 45, 29, 116, 36
      Annotation: 
       Subtype: Link
       Rect: 125, 29, 183, 36
      Annotation: 
       Subtype: Link
       Rect: 428, 29, 549, 36
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 45, 440, 137, 450
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 264, 177, 273, 186
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 491, 440, 549, 450
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 306, 429, 355, 438
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 45, 29, 116, 36
      Annotation: 
       Subtype: Link
       Rect: 125, 29, 183, 36
      Annotation: 
       Subtype: Link
       Rect: 428, 29, 549, 36
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 55, 558, 84, 568
       Destination: 28
      Annotation: 
       Subtype: Link
       Rect: 178, 443, 206, 452
       Destination: 38
      Annotation: 
       Subtype: Link
       Rect: 341, 650, 370, 660
       Destination: 38
      Annotation: 
       Subtype: Link
       Rect: 462, 593, 491, 602
       Destination: 38
      Annotation: 
       Subtype: Link
       Rect: 495, 524, 549, 533
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 322, 512, 411, 522
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 362, 455, 400, 464
       Destination: 67
      Annotation: 
       Subtype: Link
       Rect: 490, 443, 544, 453
       Destination: 67
      Annotation: 
       Subtype: Link
       Rect: 45, 29, 116, 36
      Annotation: 
       Subtype: Link
       Rect: 125, 29, 183, 36
      Annotation: 
       Subtype: Link
       Rect: 428, 29, 549, 36
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 510, 111, 544, 120
       Destination: 67
      Annotation: 
       Subtype: Link
       Rect: 45, 29, 116, 36
      Annotation: 
       Subtype: Link
       Rect: 125, 29, 183, 36
      Annotation: 
       Subtype: Link
       Rect: 428, 29, 549, 36
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 45, 29, 116, 36
      Annotation: 
       Subtype: Link
       Rect: 125, 29, 183, 36
      Annotation: 
       Subtype: Link
       Rect: 428, 29, 549, 36
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 130, 673, 164, 683
       Destination: 87
      Annotation: 
       Subtype: Link
       Rect: 48, 569, 76, 578
       Destination: 38
      Annotation: 
       Subtype: Link
       Rect: 159, 557, 212, 567
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 230, 557, 289, 567
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 45, 546, 77, 555
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 48, 523, 102, 532
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 122, 523, 211, 532
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 239, 418, 269, 427
       Destination: 28
      Annotation: 
       Subtype: Link
       Rect: 347, 708, 407, 717
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 432, 708, 529, 717
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 477, 685, 507, 694
       Destination: 38
      Annotation: 
       Subtype: Link
       Rect: 479, 673, 508, 683
       Destination: 28
      Annotation: 
       Subtype: Link
       Rect: 334, 581, 363, 591
       Destination: 28
      Annotation: 
       Subtype: Link
       Rect: 358, 558, 411, 568
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 431, 558, 524, 568
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 332, 463, 337, 473
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 396, 429, 405, 438
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 412, 429, 421, 438
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 309, 406, 318, 415
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 323, 406, 332, 415
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 45, 29, 116, 36
      Annotation: 
       Subtype: Link
       Rect: 125, 29, 183, 36
      Annotation: 
       Subtype: Link
       Rect: 428, 29, 549, 36
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 137, 685, 146, 694
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 136, 650, 145, 660
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 211, 616, 220, 625
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 227, 616, 236, 625
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 276, 604, 285, 614
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 236, 581, 245, 591
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 252, 581, 261, 591
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 274, 409, 283, 418
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 179, 328, 188, 338
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 193, 328, 202, 338
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 120, 294, 128, 303
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 195, 213, 203, 223
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 193, 167, 202, 177
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 104, 133, 113, 142
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 118, 133, 127, 142
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 535, 708, 544, 717
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 364, 685, 373, 694
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 378, 685, 387, 694
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 465, 593, 474, 602
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 442, 512, 451, 522
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 444, 489, 454, 499
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 468, 443, 478, 453
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 45, 29, 116, 36
      Annotation: 
       Subtype: Link
       Rect: 125, 29, 183, 36
      Annotation: 
       Subtype: Link
       Rect: 428, 29, 549, 36
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 320, 601, 549, 610
      Annotation: 
       Subtype: Link
       Rect: 306, 589, 444, 599
      Annotation: 
       Subtype: Link
       Rect: 190, 519, 274, 526
      Annotation: 
       Subtype: Link
       Rect: 263, 500, 289, 507
      Annotation: 
       Subtype: Link
       Rect: 58, 490, 108, 498
      Annotation: 
       Subtype: Link
       Rect: 128, 462, 184, 469
      Annotation: 
       Subtype: Link
       Rect: 181, 433, 272, 441
      Annotation: 
       Subtype: Link
       Rect: 72, 386, 155, 393
      Annotation: 
       Subtype: Link
       Rect: 111, 357, 164, 365
      Annotation: 
       Subtype: Link
       Rect: 162, 329, 243, 336
      Annotation: 
       Subtype: Link
       Rect: 259, 300, 289, 308
      Annotation: 
       Subtype: Link
       Rect: 58, 291, 114, 298
      Annotation: 
       Subtype: Link
       Rect: 72, 253, 157, 260
      Annotation: 
       Subtype: Link
       Rect: 82, 224, 164, 232
      Annotation: 
       Subtype: Link
       Rect: 263, 186, 289, 194
      Annotation: 
       Subtype: Link
       Rect: 57, 177, 110, 184
      Annotation: 
       Subtype: Link
       Rect: 262, 148, 289, 156
      Annotation: 
       Subtype: Link
       Rect: 58, 139, 107, 146
      Annotation: 
       Subtype: Link
       Rect: 202, 110, 281, 118
      Annotation: 
       Subtype: Link
       Rect: 153, 91, 220, 99
      Annotation: 
       Subtype: Link
       Rect: 332, 547, 385, 555
      Annotation: 
       Subtype: Link
       Rect: 426, 500, 482, 508
      Annotation: 
       Subtype: Link
       Rect: 432, 472, 530, 479
      Annotation: 
       Subtype: Link
       Rect: 472, 443, 549, 450
      Annotation: 
       Subtype: Link
       Rect: 408, 405, 491, 413
      Annotation: 
       Subtype: Link
       Rect: 384, 377, 500, 384
      Annotation: 
       Subtype: Link
       Rect: 501, 348, 549, 356
      Annotation: 
       Subtype: Link
       Rect: 318, 339, 376, 346
      Annotation: 
       Subtype: Link
       Rect: 394, 300, 485, 308
      Annotation: 
       Subtype: Link
       Rect: 430, 272, 509, 280
      Annotation: 
       Subtype: Link
       Rect: 524, 253, 549, 261
      Annotation: 
       Subtype: Link
       Rect: 318, 244, 374, 251
      Annotation: 
       Subtype: Link
       Rect: 503, 215, 549, 223
      Annotation: 
       Subtype: Link
       Rect: 318, 206, 376, 213
      Annotation: 
       Subtype: Link
       Rect: 332, 167, 387, 175
      Annotation: 
       Subtype: Link
       Rect: 332, 129, 413, 137
      Annotation: 
       Subtype: Link
       Rect: 332, 92, 429, 99
      Annotation: 
       Subtype: Link
       Rect: 524, 82, 549, 90
      Annotation: 
       Subtype: Link
       Rect: 318, 73, 340, 80
      Annotation: 
       Subtype: Link
       Rect: 45, 29, 116, 36
      Annotation: 
       Subtype: Link
       Rect: 125, 29, 183, 36
      Annotation: 
       Subtype: Link
       Rect: 428, 29, 549, 36
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 154, 681, 247, 689
      Annotation: 
       Subtype: Link
       Rect: 71, 643, 138, 651
      Annotation: 
       Subtype: Link
       Rect: 206, 624, 285, 632
      Annotation: 
       Subtype: Link
       Rect: 218, 596, 275, 603
      Annotation: 
       Subtype: Link
       Rect: 263, 567, 289, 575
      Annotation: 
       Subtype: Link
       Rect: 57, 558, 111, 565
      Annotation: 
       Subtype: Link
       Rect: 71, 520, 158, 527
      Annotation: 
       Subtype: Link
       Rect: 120, 491, 201, 499
      Annotation: 
       Subtype: Link
       Rect: 133, 453, 204, 461
      Annotation: 
       Subtype: Link
       Rect: 71, 415, 154, 423
      Annotation: 
       Subtype: Link
       Rect: 523, 691, 549, 698
      Annotation: 
       Subtype: Link
       Rect: 318, 681, 376, 689
      Annotation: 
       Subtype: Link
       Rect: 448, 653, 514, 660
      Annotation: 
       Subtype: Link
       Rect: 487, 624, 549, 632
      Annotation: 
       Subtype: Link
       Rect: 318, 615, 339, 622
      Annotation: 
       Subtype: Link
       Rect: 422, 586, 499, 594
      Annotation: 
       Subtype: Link
       Rect: 500, 567, 549, 575
      Annotation: 
       Subtype: Link
       Rect: 318, 558, 356, 565
      Annotation: 
       Subtype: Link
       Rect: 495, 463, 549, 470
      Annotation: 
       Subtype: Link
       Rect: 306, 453, 388, 461
      Annotation: 
       Subtype: Link
       Rect: 45, 29, 116, 36
      Annotation: 
       Subtype: Link
       Rect: 125, 29, 183, 36
      Annotation: 
       Subtype: Link
       Rect: 428, 29, 549, 36
  Checksum: 62db40ad
   Type: CRC32
  Checksum: 89b778d707f77a6b5000a6458fd81a9c
   Type: MD5
  Checksum: e60487ab6f642125cf3168b7aff29d16e4bcb618
   Type: SHA-1
  Checksum: a225bb048234cf7facc0fe983307faba83cce113e08c085360e1d32f7fcd918e
   Type: SHA-256