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Title:           Validation of nasospheroids to assay CFTR functionality and modulator responses in cystic fibrosis
Subject:         Scientific Reports, https://doi.org/10.1038/s41598-021-94798-x
Author:          Maite Calucho 
Creator:         Springer
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     Item: 
      Title: Validation of nasospheroids to assay CFTR functionality and modulator responses in cystic fibrosis
      Children: 
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Participants. 
         Item: 
          Title: Nasal epithelial cell sampling. 
         Item: 
          Title: Growth and expansion of nasal epithelial cells. 
         Item: 
          Title: Confocal live-cell microscopy image. 
         Item: 
          Title: Equipment and settings. 
         Item: 
          Title: Image analysis. 
         Item: 
          Title: GraphPad statistics. 
         Item: 
          Title: Development of a specific mixed-level model for analysis of nasospheroids. 
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Formation and embedding of nasospheroids for in vivo imaging analysis. 
         Item: 
          Title: Comparison of GraphPad Prism statistical results with a newly developed logarithmic model. 
         Item: 
          Title: Time and response variability after CFTR activation in WT nasospheroids. 
         Item: 
          Title: Potentially all spheres are suitable for analysis independently of their baseline size and condition. 
         Item: 
          Title: Analysis of inner fluid reservoir areas as an effective indicator to study CFTR functionality. 
         Item: 
          Title: Differential responses of nasospheroids from CF patients after combinatorial treatment of CFTR modulators. 
       Item: 
        Title: Discussion
       Item: 
        Title: References
       Item: 
        Title: Acknowledgements
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