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Title:           Disease-associated mutations impacting BC-loop flexibility trigger long-range transthyretin tetramer destabilization and aggregation
Subject:         Journal of Biological Chemistry, 297 (2021) 101039. doi:10.1016/j.jbc.2021.101039
Author:          Sebastián A. Esperante
Creator:         Elsevier
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     Item: 
      Title: Disease-associated mutations impacting BC-loop flexibility trigger long-range transthyretin tetramer destabilization and ag ...
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       Item: 
        Title: Results
        Destination: flink1
        Children: 
         Item: 
          Title: pH-induced amyloidogenicity of missense mutations at residues 34 and 35 of TTR
          Destination: slink1
         Item: 
          Title: Conformational stability of TTR variants
          Destination: slink2
         Item: 
          Title: Quaternary structure of TTR urea denaturation intermediates
          Destination: slink3
         Item: 
          Title: Effect of R34G and K35T mutations in the context of a kinetically stabilized T119M-TTR tetramer
          Destination: slink4
         Item: 
          Title: Molecular dynamic simulations of the TTR variants involving residues 34 and 35
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         Item: 
          Title: Structural basis for TTR destabilization induced by variants at residues 34 and 35
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        Title: Discussion
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        Title: Experimental procedures
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         Item: 
          Title: Protein expression and purification
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         Item: 
          Title: Aggregation and fibril formation assays
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         Item: 
          Title: Transmission electron microscopy (TEM)
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         Item: 
          Title: Chemical equilibrium denaturation of TTR variants
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         Item: 
          Title: Sedimentation velocity assays (SV)
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          Title: Crystallography and structure determination
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          Title: Molecular dynamics (MD) simulations
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        Title: Data availability
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   Info: 
    Title: Disease-associated mutations impacting BC-loop flexibility trigger long-range transthyretin tetramer destabilization and aggregation
    Author: Sebastián A. Esperante
    Subject: Journal of Biological Chemistry, 297 (2021) 101039. doi:10.1016/j.jbc.2021.101039
    Creator: Elsevier
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       Subtype: Link
       Rect: 316, 357, 553, 365
      Annotation: 
       Subtype: Link
       Rect: 316, 347, 553, 355
      Annotation: 
       Subtype: Link
       Rect: 316, 337, 553, 345
      Annotation: 
       Subtype: Link
       Rect: 316, 327, 394, 335
  Checksum: 84bb7f93
   Type: CRC32
  Checksum: 8afbfdc8af6672a80eb43fd0ae6208be
   Type: MD5
  Checksum: 09e4671843ab1032071ec24c43bb8670fb518c41
   Type: SHA-1
  Checksum: 8c3b58ffe79b65c3f2b9aad7b9eb033e6f2e2f4db0c2f36e20b491966c5e52f1
   Type: SHA-256