96dd28fd46f70bcf4f783dd90397eb65 pmc_34354580.pdf 32dc99ab58afe2f2deebcb7c81e27d89d0cc4673 pmc_34354580.pdf 0dbb0db71d5b57f18f7ef68cf2d39a6ae5f4c9fc594b5d287107a314a08c4a5c pmc_34354580.pdf Title: Preserved Thermal Pain in 3xTg-AD Mice With Increased Sensory-Discriminative Pain Sensitivity in Females but Affective-Emotional Dimension in Males as Early Sex-Specific AD-Phenotype Biomarkers Subject: The increase of the aging population, where quite chronic comorbid conditions are associated with pain, draws growing interest across its investigation and the underlying nociceptive mechanisms. Keywords: pain, plantar test, biomarkers, nociception, sensory-discriminative, affective-emotional, translational research, gender medicine Author: Toni Cañete and Lydia Giménez-Llort Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.12 CreationDate: Wed Jul 14 13:48:59 2021 CEST ModDate: Wed Jul 14 14:19:52 2021 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 1517651 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AQRCOC+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 405 0 ZYFEJR+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 406 0 YQLHNJ+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 407 0 LUQGYQ+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 408 0 BEOBFT+HelveticaNeueLTStd-MdIt Type 1 Custom yes yes no 409 0 AQPVJT+MTSYN Type 1 Builtin yes yes no 252 0 TQRQBJ+MinionPro-It Type 1 Custom yes yes no 243 0 EWYLZG+MTGU Type 1 Builtin yes yes no 247 0 NBHSKH+MinionPro-Regular Type 1 Custom yes yes no 258 0 LTZATI+MTSY Type 1 Builtin yes yes no 271 0 CRACEU+MinionPro-Bold Type 1 Custom yes yes no 270 0 WTUXLH+RMTMI Type 1 Builtin yes yes no 267 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:08:31 CEST RepresentationInformation: pmc_34354580.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:14:43 CEST Size: 1517651 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 519 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Preserved Thermal Pain in 3xTg-AD Mice With Increased Sensory-Discriminative Pain Sensitivity in Females but Affective-Emotional Dimension in Males as Early Sex-Specific AD-Phenotype Biomarkers Children: Item: Title: INTRODUCTION Item: Title: MATERIALS AND METHODS Children: Item: Title: Subjects Item: Title: Plantar Test—Hargreaves Test Item: Title: Statistics Item: Title: RESULTS Item: Title: DISCUSSION Item: Title: DATA AVAILABILITY STATEMENT Item: Title: ETHICS STATEMENT Item: Title: AUTHOR CONTRIBUTIONS Item: Title: FUNDING Item: Title: ACKNOWLEDGMENTS Item: Title: REFERENCES Info: Title: Preserved Thermal Pain in 3xTg-AD Mice With Increased Sensory-Discriminative Pain Sensitivity in Females but Affective-Emotional Dimension in Males as Early Sex-Specific AD-Phenotype Biomarkers Author: Toni Cañete and Lydia Giménez-Llort Subject: The increase of the aging population, where quite chronic comorbid conditions are associated with pain, draws growing interest across its investigation and the underlying nociceptive mechanisms. Keywords: pain, plantar test, biomarkers, nociception, sensory-discriminative, affective-emotional, translational research, gender medicine Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.12 CreationDate: Wed Jul 14 14:18:59 CEST 2021 ModDate: Wed Jul 14 14:49:52 CEST 2021 ID: 0x401a8fe37ec0625ee95529c434099e24, 0x7bd8eefc3ca95846bdf9e922b57a696d Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: NBHSKH+MinionPro-Regular FontSubset: true FirstChar: 35 LastChar: 246 FontDescriptor: FontName: NBHSKH+MinionPro-Regular Flags: Symbolic FontBBox: -288, -358, 1684, 989 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: TQRQBJ+MinionPro-It FontSubset: true FirstChar: 39 LastChar: 241 FontDescriptor: FontName: TQRQBJ+MinionPro-It Flags: Symbolic FontBBox: -199, -358, 1684, 1002 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: AQRCOC+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 2 LastChar: 151 FontDescriptor: FontName: AQRCOC+HelveticaNeueLTStd-Bd Flags: Symbolic FontBBox: -164, -216, 1078, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: ZYFEJR+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 2 LastChar: 241 FontDescriptor: FontName: ZYFEJR+HelveticaNeueLTStd-Lt Flags: Symbolic FontBBox: -164, -212, 1050, 967 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: YQLHNJ+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: YQLHNJ+HelveticaNeueLTStd-BdIt Flags: Symbolic FontBBox: -164, -216, 1129, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: EWYLZG+MTGU FontSubset: true FirstChar: 98 LastChar: 109 FontDescriptor: FontName: EWYLZG+MTGU Flags: Symbolic FontBBox: 25, -213, 839, 683 FontFile: true Font: BaseFont: LUQGYQ+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 2 LastChar: 241 FontDescriptor: FontName: LUQGYQ+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -163, -212, 1099, 951 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: BEOBFT+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 241 FontDescriptor: FontName: BEOBFT+HelveticaNeueLTStd-MdIt Flags: Symbolic FontBBox: -163, -216, 1125, 947 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: WTUXLH+RMTMI FontSubset: true FirstChar: 60 LastChar: 60 FontDescriptor: FontName: WTUXLH+RMTMI Flags: Symbolic FontBBox: 0, -213, 987, 680 FontFile: true Font: BaseFont: AQPVJT+MTSYN FontSubset: true FirstChar: 0 LastChar: 14 FontDescriptor: FontName: AQPVJT+MTSYN Flags: Symbolic FontBBox: 0, -954, 1043, 900 FontFile: true Font: BaseFont: CRACEU+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 150 FontDescriptor: FontName: CRACEU+MinionPro-Bold Flags: Symbolic FontBBox: -317, -358, 1684, 1024 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: LTZATI+MTSY FontSubset: true FirstChar: 6 LastChar: 6 FontDescriptor: FontName: LTZATI+MTSY Flags: Symbolic FontBBox: 0, -954, 1043, 796 FontFile: true XMP: 2021-07-14T17:18:59+05:30 LaTeX with hyperref package 2021-07-14T17:49:52+05:30 2021-07-14T17:49:52+05:30 application/pdf The increase of the aging population, where quite chronic comorbid conditions are associated with pain, draws growing interest across its investigation and the underlying nociceptive mechanisms. 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