dd70815962292cc3bb0a223fcef6434d pmc_34362312.pdf a1bc652a8ab55542c7b424a19af0a1cad67365b2 pmc_34362312.pdf f3e6c9fca17631e0cad886428f4e1685b8e1dae2613e2b7559ba17de6048463f pmc_34362312.pdf Title: Opportunities and limits of combining microbiome and genome data for complex trait prediction Subject: Genetics Selection Evolution, https://doi.org/10.1186/s12711-021-00658-7 Author: Miguel Pérez-Enciso Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Tue Aug 3 18:02:33 2021 CEST ModDate: Fri Aug 6 08:51:14 2021 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 20 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 4054458 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-Regular Type 1C Custom yes no yes 75 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CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Opportunities and limits of combining microbiome and genome data for complex trait prediction Children: Item: Title: Abstract Children: Item: Title: Background: Item: Title: Methods: Item: Title: Results: Item: Title: Conclusions: Item: Title: Background Item: Title: Methods Children: Item: Title: Causative scenarios considered Item: Title: A novel data-driven strategy to simulate microbiome-genome-phenotype experiments Item: Title: Simulation details Item: Title: Box 1 Finding a permutation of vectors and  such that the correlation between permuted vectors is a predetermined value . Item: Title: Parameter fitting Item: Title: Data analysis Item: Title: Results Children: Item: Title: How useful can the microbiome be for prediction of complex traits? Item: Title: Are microbiability estimates reliable? Item: Title: Can the underlying biological scenario and causative OTU be recovered? Item: Title: Discussion Children: Item: Title: Given the uncertainty with the true scenario, a flexible simulation approach is proposed Item: Title: There is room for methodological developments Item: Title: Final remarks: on using microbiome for prediction of complex traits Item: Title: Conclusions Item: Title: Acknowledgements Item: Title: References Info: Title: Opportunities and limits of combining microbiome and genome data for complex trait prediction Author: Miguel Pérez-Enciso Subject: Genetics Selection Evolution, https://doi.org/10.1186/s12711-021-00658-7 Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Tue Aug 03 18:32:33 CEST 2021 ModDate: Fri Aug 06 08:51:14 CEST 2021 ID: 0x3f946f2325ce42e73cebbc58e5612a43, 0x1cadc4985b2d3a1e7d524f33cde2d590 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 39 ImageHeight: 39 BitsPerSample: 8 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EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MyriadPro-SemiboldIt FontSubset: true FirstChar: 29 LastChar: 32 FontDescriptor: FontName: SCEBHJ+MyriadPro-SemiboldIt Flags: Symbolic FontBBox: 0, -209, 676, 710 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MTSYN11 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MTSYN11 Flags: Symbolic FontBBox: 0, -133, 724, 736 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SCEBHJ+MyriadPro-SemiboldIt4 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MyriadPro-SemiboldIt4 Flags: Symbolic FontBBox: 0, -209, 676, 710 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SGRCHJ+WarnockPro-Bold17 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: 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true FirstChar: 22 LastChar: 33 FontDescriptor: FontName: IBOSCD+WarnockPro-Regular13 Flags: Symbolic FontBBox: 0, -226, 700, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MyriadPro-SemiboldIt2 FontSubset: true FirstChar: 28 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MyriadPro-SemiboldIt2 Flags: Symbolic FontBBox: 0, -209, 676, 710 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MTMI16 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MTMI16 Flags: Symbolic FontBBox: 0, -207, 644, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SCEBHJ+MyriadPro-LightIt FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MyriadPro-LightIt Flags: Symbolic, SmallCap FontBBox: 0, 0, 500, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SGRCHJ+WarnockPro-Bold15 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SGRCHJ+WarnockPro-Bold15 Flags: Symbolic FontBBox: -6, -232, 1053, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MyriadPro-Semibold2 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MyriadPro-Semibold2 Flags: Symbolic, AllCap FontBBox: 0, 0, 500, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: IBOSCD+WarnockPro-Regular14 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: IBOSCD+WarnockPro-Regular14 Flags: Symbolic FontBBox: 0, -226, 700, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MyriadPro-SemiboldIt5 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MyriadPro-SemiboldIt5 Flags: Symbolic FontBBox: 0, 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SCEBHJ+MyriadPro-Regular3 Flags: Symbolic, AllCap FontBBox: 0, 0, 500, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MTSYN10 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MTSYN10 Flags: Symbolic FontBBox: 0, -133, 724, 736 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SCEBHJ+CMEX102 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SCEBHJ+CMEX102 Flags: Symbolic FontBBox: 0, -1759, 1387, 40 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MTMI15 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MTMI15 Flags: Symbolic FontBBox: 0, -207, 644, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SCEBHJ+MyriadPro-It6 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MyriadPro-It6 Flags: Symbolic FontBBox: 0, -209, 657, 710 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SGRCHJ+WarnockPro-Bold24 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: SGRCHJ+WarnockPro-Bold24 Flags: Symbolic FontBBox: -6, -232, 1053, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MTMI9 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MTMI9 Flags: Symbolic FontBBox: 0, -207, 644, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: IBOSCD+WarnockPro-It32 FontSubset: true FirstChar: 27 LastChar: 33 FontDescriptor: FontName: IBOSCD+WarnockPro-It32 Flags: Symbolic FontBBox: -102, -240, 821, 708 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MyriadPro-It5 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MyriadPro-It5 Flags: Symbolic FontBBox: 0, -209, 657, 710 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SGRCHJ+WarnockPro-Bold25 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SGRCHJ+WarnockPro-Bold25 Flags: Symbolic FontBBox: -6, -232, 1053, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: IBOSCD+WarnockPro-It18 FontSubset: true FirstChar: 25 LastChar: 33 FontDescriptor: FontName: IBOSCD+WarnockPro-It18 Flags: Symbolic FontBBox: -102, -240, 821, 708 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MTSYN16 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MTSYN16 Flags: Symbolic FontBBox: 0, -133, 724, 736 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: IBOSCD+WarnockPro-It17 FontSubset: true FirstChar: 26 LastChar: 33 FontDescriptor: FontName: IBOSCD+WarnockPro-It17 Flags: Symbolic FontBBox: -102, -240, 821, 708 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: IBOSCD+WarnockPro-It45 FontSubset: true FirstChar: 26 LastChar: 33 FontDescriptor: FontName: IBOSCD+WarnockPro-It45 Flags: Symbolic FontBBox: -102, -240, 821, 708 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MyriadPro-It8 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MyriadPro-It8 Flags: Symbolic FontBBox: 0, -209, 657, 710 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MTMI20 FontSubset: true FirstChar: 29 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MTMI20 Flags: Symbolic FontBBox: 0, -207, 644, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SCEBHJ+MTSYN FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: SCEBHJ+MTSYN Flags: Symbolic FontBBox: 0, -133, 724, 736 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: IBOSCD+WarnockPro-Regular21 FontSubset: true FirstChar: 26 LastChar: 33 FontDescriptor: FontName: IBOSCD+WarnockPro-Regular21 Flags: Symbolic FontBBox: 0, -226, 700, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: IBOSCD+WarnockPro-Regular4 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: IBOSCD+WarnockPro-Regular4 Flags: Symbolic FontBBox: 0, -226, 700, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SGRCHJ+WarnockPro-Bold34 FontSubset: true FirstChar: 29 LastChar: 33 FontDescriptor: FontName: SGRCHJ+WarnockPro-Bold34 Flags: Symbolic FontBBox: -6, -232, 1053, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MyriadPro-It7 FontSubset: true FirstChar: 29 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MyriadPro-It7 Flags: Symbolic FontBBox: 0, -209, 657, 710 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MTSYN17 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MTSYN17 Flags: Symbolic FontBBox: 0, -133, 724, 736 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SCEBHJ+MTSYN2 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MTSYN2 Flags: Symbolic FontBBox: 0, -133, 724, 736 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SGRCHJ+WarnockPro-Bold33 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: SGRCHJ+WarnockPro-Bold33 Flags: Symbolic FontBBox: -6, -232, 1053, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MTMI8 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MTMI8 Flags: Symbolic, AllCap FontBBox: 0, -177, 344, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MyriadPro-It4 FontSubset: true FirstChar: 27 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MyriadPro-It4 Flags: Symbolic FontBBox: 0, -209, 657, 710 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MTMI7 FontSubset: true FirstChar: 28 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MTMI7 Flags: Symbolic FontBBox: 0, -207, 644, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SCEBHJ+MyriadPro-It2 FontSubset: true FirstChar: 29 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MyriadPro-It2 Flags: Symbolic FontBBox: 0, -209, 657, 710 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: IBOSCD+WarnockPro-It16 FontSubset: true FirstChar: 24 LastChar: 33 FontDescriptor: FontName: IBOSCD+WarnockPro-It16 Flags: Symbolic FontBBox: -102, -240, 821, 708 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MTMI6 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MTMI6 Flags: Symbolic FontBBox: 0, -207, 644, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: IBOSCD+WarnockPro-It15 FontSubset: true FirstChar: 28 LastChar: 33 FontDescriptor: FontName: IBOSCD+WarnockPro-It15 Flags: Symbolic FontBBox: -102, -240, 821, 708 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MyriadPro-SemiboldIt7 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MyriadPro-SemiboldIt7 Flags: Symbolic FontBBox: 0, -209, 676, 710 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: CCWZRP+Calibri FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: CCWZRP+Calibri Flags: Nonsymbolic FontBBox: -503, -307, 1240, 964 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CCWZRP+Calibri-Bold FontSubset: true FirstChar: 32 LastChar: 71 FontDescriptor: FontName: CCWZRP+Calibri-Bold Flags: Nonsymbolic FontBBox: -519, -306, 1240, 971 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IBOSCD+WarnockPro-It14 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: IBOSCD+WarnockPro-It14 Flags: Symbolic FontBBox: -102, -240, 821, 708 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MTMI5 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MTMI5 Flags: Symbolic FontBBox: 0, -207, 644, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SCEBHJ+MyriadPro-Semibold4 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MyriadPro-Semibold4 Flags: Symbolic, AllCap FontBBox: 0, 0, 500, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MyriadPro-Semibold3 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MyriadPro-Semibold3 Flags: Symbolic, AllCap FontBBox: 0, 0, 500, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: IBOSCD+WarnockPro-It13 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: IBOSCD+WarnockPro-It13 Flags: Symbolic FontBBox: -102, -240, 821, 708 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MTMI FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: SCEBHJ+MTMI Flags: Symbolic FontBBox: 0, -207, 644, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: CECJRP+MyriadPro-Light2 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: CECJRP+MyriadPro-Light2 Flags: Symbolic, AllCap FontBBox: 0, 0, 500, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MyriadPro-SemiboldIt6 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MyriadPro-SemiboldIt6 Flags: Symbolic FontBBox: 0, -209, 676, 710 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: MyriadPro-LightIt2 FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-LightIt2 Flags: Nonsymbolic, Italic FontBBox: -121, -250, 1007, 863 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: SGRCHJ+WarnockPro-Bold32 FontSubset: true FirstChar: 29 LastChar: 33 FontDescriptor: FontName: SGRCHJ+WarnockPro-Bold32 Flags: Symbolic FontBBox: -6, -232, 1053, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+WarnockPro-Regular18 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SCEBHJ+WarnockPro-Regular18 Flags: Symbolic, AllCap FontBBox: 0, -99, 500, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MTSYN14 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MTSYN14 Flags: Symbolic FontBBox: 0, -133, 724, 736 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+CMEX108 FontSubset: true FirstChar: 28 LastChar: 33 FontDescriptor: FontName: SCEBHJ+CMEX108 Flags: Symbolic FontBBox: 0, -1759, 1387, 40 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SGRCHJ+WarnockPro-Bold31 FontSubset: true FirstChar: 29 LastChar: 33 FontDescriptor: FontName: SGRCHJ+WarnockPro-Bold31 Flags: Symbolic FontBBox: -6, -232, 1053, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SGRCHJ+WarnockPro-Bold30 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SGRCHJ+WarnockPro-Bold30 Flags: Symbolic FontBBox: -6, -232, 1053, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SGRCHJ+WarnockPro-Bold29 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SGRCHJ+WarnockPro-Bold29 Flags: Symbolic FontBBox: -6, -232, 1053, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: IBOSCD+WarnockPro-It39 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: IBOSCD+WarnockPro-It39 Flags: Symbolic FontBBox: -102, -240, 821, 708 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: IBOSCD+WarnockPro-It38 FontSubset: true FirstChar: 29 LastChar: 33 FontDescriptor: FontName: IBOSCD+WarnockPro-It38 Flags: Symbolic FontBBox: -102, -240, 821, 708 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SGRCHJ+WarnockPro-Bold27 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: SGRCHJ+WarnockPro-Bold27 Flags: Symbolic FontBBox: -6, -232, 1053, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SGRCHJ+WarnockPro-Bold28 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: SGRCHJ+WarnockPro-Bold28 Flags: Symbolic FontBBox: -6, -232, 1053, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MyriadPro-It10 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MyriadPro-It10 Flags: Symbolic FontBBox: 0, -209, 657, 710 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MyriadPro-SemiboldIt9 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MyriadPro-SemiboldIt9 Flags: Symbolic FontBBox: 0, -209, 676, 710 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MyriadPro-SemiboldIt8 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MyriadPro-SemiboldIt8 Flags: Symbolic FontBBox: 0, -209, 676, 710 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MTSYN15 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MTSYN15 Flags: Symbolic FontBBox: 0, -133, 724, 736 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MTSYN13 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MTSYN13 Flags: Symbolic FontBBox: 0, -133, 724, 736 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: XGAGZZ+MTSYB FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: XGAGZZ+MTSYB Flags: Symbolic FontBBox: 0, 0, 654, 461 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: IBOSCD+WarnockPro-It2 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: IBOSCD+WarnockPro-It2 Flags: Symbolic FontBBox: -102, -240, 821, 708 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MyriadPro-It9 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MyriadPro-It9 Flags: Symbolic FontBBox: 0, -209, 657, 710 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: IBOSCD+WarnockPro-It41 FontSubset: true FirstChar: 29 LastChar: 33 FontDescriptor: FontName: IBOSCD+WarnockPro-It41 Flags: Symbolic FontBBox: -102, -240, 821, 708 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+WarnockPro-Regular19 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: SCEBHJ+WarnockPro-Regular19 Flags: Symbolic, AllCap FontBBox: 0, -99, 500, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: IBOSCD+WarnockPro-It40 FontSubset: true FirstChar: 21 LastChar: 33 FontDescriptor: FontName: IBOSCD+WarnockPro-It40 Flags: Symbolic FontBBox: -102, -240, 821, 708 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SGRCHJ+WarnockPro-Bold35 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: SGRCHJ+WarnockPro-Bold35 Flags: Symbolic FontBBox: -6, -232, 1053, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: MFNSBV+WarnockPro-BoldIt2 FontSubset: true FirstChar: 29 LastChar: 33 FontDescriptor: FontName: MFNSBV+WarnockPro-BoldIt2 Flags: Symbolic, SmallCap FontBBox: -34, -227, 575, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: IBOSCD+WarnockPro-Regular5 FontSubset: true FirstChar: 28 LastChar: 33 FontDescriptor: FontName: IBOSCD+WarnockPro-Regular5 Flags: Symbolic FontBBox: 0, -226, 700, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SGRCHJ+WarnockPro-Bold FontSubset: true FirstChar: 31 LastChar: 32 FontDescriptor: FontName: SGRCHJ+WarnockPro-Bold Flags: Symbolic FontBBox: -6, -232, 1053, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SGRCHJ+WarnockPro-BoldIt FontSubset: true FirstChar: 28 LastChar: 32 FontDescriptor: FontName: SGRCHJ+WarnockPro-BoldIt Flags: Symbolic FontBBox: -34, -227, 575, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SGRCHJ+WarnockPro-Bold7 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: SGRCHJ+WarnockPro-Bold7 Flags: Symbolic FontBBox: -6, -232, 1053, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MTMI14 FontSubset: true FirstChar: 29 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MTMI14 Flags: Symbolic FontBBox: 0, -207, 644, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: IBOSCD+WarnockPro-It25 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: IBOSCD+WarnockPro-It25 Flags: Symbolic FontBBox: -102, -240, 821, 708 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SGRCHJ+WarnockPro-Bold2 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SGRCHJ+WarnockPro-Bold2 Flags: Symbolic FontBBox: -6, -232, 1053, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MTMI11 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MTMI11 Flags: Symbolic FontBBox: 0, -207, 644, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: IBOSCD+WarnockPro-It28 FontSubset: true FirstChar: 24 LastChar: 33 FontDescriptor: FontName: IBOSCD+WarnockPro-It28 Flags: Symbolic FontBBox: -102, -240, 821, 708 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: CCWZRP+MTGUB FontSubset: true FirstChar: 31 LastChar: 32 FontDescriptor: FontName: CCWZRP+MTGUB Flags: Symbolic FontBBox: 0, -206, 514, 462 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: EFFYUS+WarnockPro-Bold6 FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: EFFYUS+WarnockPro-Bold6 Flags: Serif, Nonsymbolic FontBBox: -183, -599, 1614, 1030 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: IBOSCD+WarnockPro-It23 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: IBOSCD+WarnockPro-It23 Flags: Symbolic FontBBox: -102, -240, 821, 708 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MTSYN4 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MTSYN4 Flags: Symbolic FontBBox: 0, -133, 724, 736 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: IBOSCD+WarnockPro-It21 FontSubset: true FirstChar: 29 LastChar: 33 FontDescriptor: FontName: IBOSCD+WarnockPro-It21 Flags: Symbolic FontBBox: -102, -240, 821, 708 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+WarnockPro-Regular6 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: SCEBHJ+WarnockPro-Regular6 Flags: Symbolic, AllCap FontBBox: 0, -99, 500, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: IBOSCD+WarnockPro-It24 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: IBOSCD+WarnockPro-It24 Flags: Symbolic FontBBox: -102, -240, 821, 708 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: CCWZRP+RMTMIB2 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: CCWZRP+RMTMIB2 Flags: Symbolic FontBBox: 0, -205, 534, 462 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: CCWZRP+MyriadPro-Semibold6 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: CCWZRP+MyriadPro-Semibold6 Flags: Symbolic, SmallCap FontBBox: 0, -220, 500, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: IBOSCD+WarnockPro-It19 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: IBOSCD+WarnockPro-It19 Flags: Symbolic FontBBox: -102, -240, 821, 708 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SGRCHJ+WarnockPro-Bold3 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SGRCHJ+WarnockPro-Bold3 Flags: Symbolic FontBBox: -6, -232, 1053, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: CCWZRP+MyriadPro-Semibold5 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: CCWZRP+MyriadPro-Semibold5 Flags: Symbolic, SmallCap FontBBox: 0, -220, 500, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: IBOSCD+WarnockPro-It22 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: IBOSCD+WarnockPro-It22 Flags: Symbolic FontBBox: -102, -240, 821, 708 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MTMI13 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MTMI13 Flags: Symbolic FontBBox: 0, -207, 644, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SGRCHJ+WarnockPro-Bold4 FontSubset: true FirstChar: 29 LastChar: 33 FontDescriptor: FontName: SGRCHJ+WarnockPro-Bold4 Flags: Symbolic FontBBox: -6, -232, 1053, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MTSYN3 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MTSYN3 Flags: Symbolic FontBBox: 0, -133, 724, 736 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SGRCHJ+WarnockPro-Bold5 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: SGRCHJ+WarnockPro-Bold5 Flags: Symbolic FontBBox: -6, -232, 1053, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+CMEX104 FontSubset: true FirstChar: 28 LastChar: 33 FontDescriptor: FontName: SCEBHJ+CMEX104 Flags: Symbolic FontBBox: 0, -1759, 1387, 40 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: IBOSCD+WarnockPro-It29 FontSubset: true FirstChar: 28 LastChar: 33 FontDescriptor: FontName: IBOSCD+WarnockPro-It29 Flags: Symbolic FontBBox: -102, -240, 821, 708 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MTSYN8 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MTSYN8 Flags: Symbolic FontBBox: 0, -133, 724, 736 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SCEBHJ+MTMI10 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MTMI10 Flags: Symbolic FontBBox: 0, -207, 644, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: IBOSCD+WarnockPro-Regular9 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: IBOSCD+WarnockPro-Regular9 Flags: Symbolic FontBBox: 0, -226, 700, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+CMEX105 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: SCEBHJ+CMEX105 Flags: Symbolic FontBBox: 0, -1759, 1387, 40 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: IBOSCD+WarnockPro-Regular2 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: IBOSCD+WarnockPro-Regular2 Flags: Symbolic FontBBox: 0, -226, 700, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MTMI22 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MTMI22 Flags: Symbolic FontBBox: 0, -207, 644, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: IBOSCD+WarnockPro-Regular10 FontSubset: true FirstChar: 26 LastChar: 33 FontDescriptor: FontName: IBOSCD+WarnockPro-Regular10 Flags: Symbolic FontBBox: 0, -226, 700, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SCEBHJ+MTMI21 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SCEBHJ+MTMI21 Flags: Symbolic FontBBox: 0, -207, 644, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SCEBHJ+CMEX103 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SCEBHJ+CMEX103 Flags: Symbolic FontBBox: 0, -1759, 1387, 40 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: HIDJJF+STIXMath-Regular FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: HIDJJF+STIXMath-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -524, 3238, 2566 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SGRCHJ+WarnockPro-Bold14 FontSubset: true FirstChar: 29 LastChar: 33 FontDescriptor: FontName: SGRCHJ+WarnockPro-Bold14 Flags: Symbolic FontBBox: -6, -232, 1053, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SGRCHJ+WarnockPro-Bold12 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: SGRCHJ+WarnockPro-Bold12 Flags: Symbolic FontBBox: -6, -232, 1053, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: IBOSCD+WarnockPro-It20 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: 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https://doi.org/10.1186/s12711-021-00658-7 Opportunities and limits of combining microbiome and genome data for complex trait prediction Miguel Pérez-Enciso Laura M. 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