db756adb234c6ddbf8e5e4ee0f4306f7 pmc_34441790.pdf 81bd87954950f3654a8046b9693417324ae976bd pmc_34441790.pdf 175f02af25c648644cd8b1e828e910028efbdb2c1aab9c94ac84924b35214843 pmc_34441790.pdf Title: Cataract Surgery in Elderly Subjects with Heterozygous Familial Hypercholesterolemia in Prolonged Treatment with Statins Subject: Background: Cataracts are the main cause of blindness and represent one fifth of visual problems worldwide. It is still unknown whether prolonged statin treatment favors the development of cataracts. We aimed to ascertain the prevalence of cataract surgery in elderly subjects with genetically diagnosed heterozygous familial hypercholesterolemia (HeFH) receiving statin treatment for 5 years, and compare this with controls. Methods: This is an observational, multicenter, case–control study from five lipid clinics in Spain. We collected data with the following inclusion criteria: age 65 years, LDL cholesterol levels 220 mg/dL without lipid-lowering drugs, a pathogenic mutation in a candidate gene for HeFH (LDLR, APOB, or PCSK9) and statin treatment for 5 years. Controls were selected from relatives of HeFH patients without hypercholesterolemia. Linear and logistic regressions based on generalized linear models and generalized estimating equations (GEE) were used. Cataract surgery was used as a proxy for cataract development. Results: We analyzed 205 subjects, 112 HeFH, and 93 controls, with a mean age of 71.8 (6.5) and 70.0 (7.3) years, respectively. HeFH subjects presented no difference in clinical characteristics, including smoking, hypertension, and type 2 diabetes mellitus, compared with controls. The mean duration of lipid-lowering treatment in HeFH was 22.5 (8.7) years. Cataract surgery prevalence was not significantly different between cases and controls. The presence of cataracts was associated neither with LDLc nor with the length of the statin therapy. Conclusion: In the present study, HeFH was not a risk factor for cataract surgery and prolonged statin treatment did not favor it either. These findings suggest that statin treatment is not related with cataracts. Keywords: cataracts; heterozygous familial hypercholesterolemia; statins; lipid-lowering treatment Author: Victoria Marco-Benedí, Martín Laclaustra, Rosa M. Sánchez-Hernández, Emilio Ortega-Martínez de Victoria, Juan Pedro-Botet, Jose Puzo and Fernando Civeira Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Sun Aug 8 09:29:35 2021 CEST ModDate: Sun Aug 8 09:34:46 2021 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 5 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 236299 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- PSUYZB+VnURWPalladioL Type 1 Custom yes yes no 10 0 FGRJJM+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 LSDUEJ+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 HEYHDA+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 PDTLUH+CMSY10 Type 1 Builtin yes yes no 28 0 SSNIUI+VnURWPalladioL-Bold Type 1 Custom yes yes no 32 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 40 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 43 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 65 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 69 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 73 0 FAECIJ+URWPalladioL-BoldItal Type 1 Custom yes yes no 88 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:06:12 CEST RepresentationInformation: pmc_34441790.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:14:55 CEST Size: 236299 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 163 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Methods Destination: section.2 Children: Item: Title: Study Characteristics Destination: subsection.2.1 Item: Title: Assessments Destination: subsection.2.2 Item: Title: Statistical Analyses Destination: subsection.2.3 Item: Title: Results Destination: section.3 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.5 Info: Title: Cataract Surgery in Elderly Subjects with Heterozygous Familial Hypercholesterolemia in Prolonged Treatment with Statins Author: Victoria Marco-Benedí, Martín Laclaustra, Rosa M. Sánchez-Hernández, Emilio Ortega-Martínez de Victoria, Juan Pedro-Botet, Jose Puzo and Fernando Civeira Subject: Background: Cataracts are the main cause of blindness and represent one fifth of visual problems worldwide. It is still unknown whether prolonged statin treatment favors the development of cataracts. We aimed to ascertain the prevalence of cataract surgery in elderly subjects with genetically diagnosed heterozygous familial hypercholesterolemia (HeFH) receiving statin treatment for 5 years, and compare this with controls. Methods: This is an observational, multicenter, case control study from five lipid clinics in Spain. We collected data with the following inclusion criteria: age 65 years, LDL cholesterol levels 220 mg/dL without lipid-lowering drugs, a pathogenic mutation in a candidate gene for HeFH (LDLR, APOB, or PCSK9) and statin treatment for 5 years. Controls were selected from relatives of HeFH patients without hypercholesterolemia. Linear and logistic regressions based on generalized linear models and generalized estimating equations (GEE) were used. Cataract surgery was used as a proxy for cataract development. Results: We analyzed 205 subjects, 112 HeFH, and 93 controls, with a mean age of 71.8 (6.5) and 70.0 (7.3) years, respectively. HeFH subjects presented no difference in clinical characteristics, including smoking, hypertension, and type 2 diabetes mellitus, compared with controls. The mean duration of lipid-lowering treatment in HeFH was 22.5 (8.7) years. Cataract surgery prevalence was not significantly different between cases and controls. The presence of cataracts was associated neither with LDLc nor with the length of the statin therapy. Conclusion: In the present study, HeFH was not a risk factor for cataract surgery and prolonged statin treatment did not favor it either. These findings suggest that statin treatment is not related with cataracts. Keywords: cataracts; heterozygous familial hypercholesterolemia; statins; lipid-lowering treatment Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Sun Aug 08 09:29:35 CEST 2021 ModDate: Sun Aug 08 09:34:46 CEST 2021 ID: 0xddbe6c6628230fce323b03f05a202ef9, 0xddbe6c6628230fce323b03f05a202ef9 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: SSNIUI+VnURWPalladioL-Bold FontSubset: true FirstChar: 161 LastChar: 189 FontDescriptor: FontName: SSNIUI+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: LSDUEJ+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 122 FontDescriptor: FontName: LSDUEJ+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: HEYHDA+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 237 FontDescriptor: FontName: HEYHDA+URWPalladioL-Roma Flags: Symbolic 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