6612d7abc2213b1dfd2ef5b695296808 pmc_34442034.pdf 0b5e98cba2e6ed20b3aef2f6a5877191678a4097 pmc_34442034.pdf 093179c39216ef32bd34e99f9f8cdc6b502583afd5873aaf700d8f53d3ffda67 pmc_34442034.pdf Title: Prevalence and Prognostic Value of Myocardial Injury in the Initial Presentation of SARS-CoV-2 Infection among Older Adults Subject: Myocardial involvement during SARS-CoV-2 infection has been reported in many prior publications. We aim to study the prevalence and the clinical implications of acute myocardial injury (MIN) during SARS-CoV-2 infection, particularly in older patients. The method includes a longitudinal observational study with all consecutive adult patients admitted to a COVID-19 unit between March–April 2020. Those aged 65 were considered as older adult group. MIN was defined as at least 1 high-sensitive troponin (hs-TnT) concentration above the 99th percentile upper reference limit with different sex-cutoff. Results. Among the 634 patients admitted during the period of observation, 365 (58%) had evidence of MIN, and, of them, 224 (61%) were older adults. Among older adults, MIN was associated with longer time to recovery compared to those without MIN (13 days (IQR 6-21) versus 9 days (IQR 5-17); p < 0.001, respectively. In-hospital mortality was significantly higher in older adults with MIN at admission versus those without it (71 (31%) versus 11 (12%); p < 0.001). In a logistic regression model adjusting by age, sex, severity, and Charlson Comorbidity Index, the OR for in-hospital mortality was 2.1 (95% CI: 1.02–4.42; p = 0.043) among those older adults with MIN at admission. Older adults with acute myocardial injury had greater time to clinical recovery, as well as higher odds of in-hospital mortality. Keywords: myocardial injury; older adults; prognosis; SARS-CoV-2 Author: Isabel Arnau-Barrés, Ana Pascual-Dapena, Inmaculada López-Montesinos, Silvia Gómez-Zorrilla, Luisa Sorlí, Marta Herrero, Xavier Nogués, Mila Montero, Olga Vázquez, Natalia García-Giralt, Ramón Miralles and Robert Güerri-Fernández Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Mon Aug 23 06:52:29 2021 CEST ModDate: Mon Aug 23 06:55:29 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 381036 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DDMOHK+VnURWPalladioL Type 1 Custom yes yes no 10 0 JADROU+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 JKROMP+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 RDKDKZ+URWPalladioL-BoldItal Type 1 Custom yes yes no 24 0 ZDPIAW+URWPalladioL-Roma Type 1 Custom yes yes no 28 0 ZYGMNY+CMSY10 Type 1 Builtin yes yes no 32 0 JYPLJJ+VnURWPalladioL-Bold Type 1 Custom yes yes no 36 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 44 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 47 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 69 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 73 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 77 0 JLZORU+EURM10 Type 1 Builtin yes yes no 92 0 ENAAAB+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 99 0 ENAAAD+PalatinoLinotype TrueType WinAnsi yes yes no 102 0 ENAABF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 105 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-10-21 02:36:27 CEST RepresentationInformation: pmc_34442034.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 12:14:55 CEST Size: 381036 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 233 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Patients and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Children: Item: Title: Clinical Variables, Data Source, and Study Outcomes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Ethics Considerations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Info: Title: Prevalence and Prognostic Value of Myocardial Injury in the Initial Presentation of SARS-CoV-2 Infection among Older Adults Author: Isabel Arnau-Barrés, Ana Pascual-Dapena, Inmaculada López-Montesinos, Silvia Gómez-Zorrilla, Luisa Sorlí, Marta Herrero, Xavier Nogués, Mila Montero, Olga Vázquez, Natalia García-Giralt, Ramón Miralles and Robert Güerri-Fernández Subject: Myocardial involvement during SARS-CoV-2 infection has been reported in many prior publications. We aim to study the prevalence and the clinical implications of acute myocardial injury (MIN) during SARS-CoV-2 infection, particularly in older patients. The method includes a longitudinal observational study with all consecutive adult patients admitted to a COVID-19 unit between March April 2020. Those aged 65 were considered as older adult group. MIN was defined as at least 1 high-sensitive troponin (hs-TnT) concentration above the 99th percentile upper reference limit with different sex-cutoff. Results. Among the 634 patients admitted during the period of observation, 365 (58%) had evidence of MIN, and, of them, 224 (61%) were older adults. Among older adults, MIN was associated with longer time to recovery compared to those without MIN (13 days (IQR 6-21) versus 9 days (IQR 5-17); p < 0.001, respectively. In-hospital mortality was significantly higher in older adults with MIN at admission versus those without it (71 (31%) versus 11 (12%); p < 0.001). In a logistic regression model adjusting by age, sex, severity, and Charlson Comorbidity Index, the OR for in-hospital mortality was 2.1 (95% CI: 1.02 4.42; p = 0.043) among those older adults with MIN at admission. Older adults with acute myocardial injury had greater time to clinical recovery, as well as higher odds of in-hospital mortality. 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