547318ba262553d1f2e21e5517ca5b2e diglivdis_a2022.pdf abc8b7953f0dd3596ba259be92d5f73552930d7c diglivdis_a2022.pdf d1bbd4e7ee735bca04af2c678e3c28c5f5198c015dced61a27e427254191d406 diglivdis_a2022.pdf Title: On-therapy HBsAg kinetics can predict HBsAg loss after nucleos(t)ide analogues interruption in HBeAg-negative patients. The cup is half full and half empty Subject: Digestive and Liver Disease, 54 (2022) 1044-1051. doi:10.1016/j.dld.2021.12.017 Keywords: "Antiviral"; "HBsAg"; "Hepatitis B"; "Kinetics" Author: Teresa Broquetas Creator: Elsevier Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Thu Jul 7 07:48:55 2022 CEST ModDate: Thu Jul 7 07:49:23 2022 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 595.245 x 793.92 pts Page rot: 0 File size: 1011694 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GGKMIG+Gulliver-Bold Type 1C Custom yes yes yes 435 0 GGKMHE+GulliverSCOsF Type 1C Custom yes yes yes 440 0 GGKMFD+MTSY Type 1C Custom yes yes yes 445 0 GGKMGE+Gulliver-Italic Type 1C Custom yes yes yes 450 0 GGKKCN+Gulliver Type 1C Custom yes yes yes 455 0 GGKLNF+UniversLTStd Type 1C Custom yes yes yes 460 0 GGKMHF+RMTMI Type 1C Custom yes yes yes 465 0 GGKKCO+dummy-space Type 1C WinAnsi yes yes no 470 0 GGKMOF+TimesNewRomanPSMT-00 Type 1C Custom yes yes yes 4 0 GGKOCP+MTSYB Type 1C Custom yes yes yes 50 0 GGKOCO+Gulliver-BoldItalic Type 1C Custom yes yes yes 55 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-02-21 03:14:53 CET RepresentationInformation: diglivdis_a2022.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-02-20 22:15:51 CET Size: 1011694 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 555 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: On-therapy HBsAg kinetics can predict HBsAg loss after nucleos(t)ide analogues interruption in HBeAg-negative patients. The cup is half full and half empty Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Children: Item: Title: 1 Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: 2 Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Children: Item: Title: 2.1 Patients and study design Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: 2.2 Variables and clinical definitions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: 2.3 Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: 3 Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Children: Item: Title: 3.1 Study population and baseline characteristics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: 3.2 HBsAg kinetics during therapy and after withdrawal Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: 3.3 Predictors of HBsAg loss Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: 3.4 Diagnostic accuracy of HBsAg decline to predict HBsAg loss Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: 3.5 Probability of HBsAg loss according to HBsAg kinetics during antiviral treatment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: 3.6 Response after NA withdrawal Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: 3.7 HBsAg kinetics according to HBV genotype and NA therapy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: 4 Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Conflict of interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Financial support statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Ethics approval statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Patients consent statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Guarantor of the article and final version of the manuscript Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Supplementary materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Info: Title: On-therapy HBsAg kinetics can predict HBsAg loss after nucleos(t)ide analogues interruption in HBeAg-negative patients. The cup is half full and half empty Author: Teresa Broquetas Subject: Digestive and Liver Disease, 54 (2022) 1044-1051. doi:10.1016/j.dld.2021.12.017 Keywords: "Antiviral"; "HBsAg"; "Hepatitis B"; "Kinetics" Creator: Elsevier Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Thu Jul 07 08:18:55 CEST 2022 ModDate: Thu Jul 07 08:19:23 CEST 2022 ID: 0xe1b7a8005e63228098beaf6e6ef7b990, 0x5999a77e5b3f082fa52190bf64a4b539 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 249 ImageHeight: 273 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 118 ImageHeight: 118 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 224 ImageHeight: 297 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 278 ImageHeight: 790 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 552 ImageHeight: 396 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1401 ImageHeight: 1080 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 552 ImageHeight: 396 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: GGKMHF+RMTMI FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: GGKMHF+RMTMI Flags: Symbolic, Italic FontBBox: 0, -213, 987, 680 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GGKMGE+Gulliver-Italic FontSubset: true FirstChar: 40 LastChar: 242 FontDescriptor: FontName: GGKMGE+Gulliver-Italic Flags: Serif, Symbolic, Italic FontBBox: -141, -211, 1053, 789 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GGKOCP+MTSYB FontSubset: true FirstChar: 61 LastChar: 61 FontDescriptor: FontName: GGKOCP+MTSYB Flags: Symbolic, ForceBold FontBBox: -16, -935, 1043, 896 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GGKMIG+Gulliver-Bold FontSubset: true FirstChar: 40 LastChar: 148 FontDescriptor: FontName: GGKMIG+Gulliver-Bold Flags: Serif, Symbolic, ForceBold FontBBox: -150, -211, 1131, 789 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GGKMOF+TimesNewRomanPSMT-00 FontSubset: true FirstChar: 176 LastChar: 176 FontDescriptor: FontName: GGKMOF+TimesNewRomanPSMT-00 Flags: Serif, Symbolic FontBBox: -77, -216, 936, 877 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GGKKCO+dummy-space FontSubset: true FirstChar: 32 LastChar: 32 FontDescriptor: FontName: GGKKCO+dummy-space Flags: Nonsymbolic FontBBox: 0, 0, 0, 0 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GGKKCN+Gulliver FontSubset: true FirstChar: 2 LastChar: 243 FontDescriptor: FontName: GGKKCN+Gulliver Flags: Serif, Symbolic FontBBox: -115, -211, 1042, 789 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GGKOCO+Gulliver-BoldItalic FontSubset: true FirstChar: 112 LastChar: 112 FontDescriptor: FontName: GGKOCO+Gulliver-BoldItalic Flags: Serif, Symbolic, Italic, ForceBold FontBBox: -175, -211, 1138, 789 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GGKMHE+GulliverSCOsF FontSubset: true FirstChar: 97 LastChar: 116 FontDescriptor: FontName: GGKMHE+GulliverSCOsF Flags: Serif, Symbolic FontBBox: -115, -211, 1407, 789 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GGKLNF+UniversLTStd FontSubset: true FirstChar: 46 LastChar: 119 FontDescriptor: FontName: GGKLNF+UniversLTStd Flags: Symbolic FontBBox: -168, -250, 992, 947 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GGKMFD+MTSY FontSubset: true FirstChar: 2 LastChar: 138 FontDescriptor: FontName: GGKMFD+MTSY Flags: Symbolic FontBBox: 0, -954, 1043, 796 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: 2022-07-07T11:18:55+05:30 Elsevier 2022-07-07T11:19:23+05:30 2022-07-07T11:19:23+05:30 Acrobat Distiller 10.0.0 (Windows) "Antiviral"; "HBsAg"; "Hepatitis B"; "Kinetics" application/pdf doi:10.1016/j.dld.2021.12.017 Elsevier Ltd Digestive and Liver Disease, 54 (2022) 1044-1051. doi:10.1016/j.dld.2021.12.017 Antiviral HBsAg Hepatitis B Kinetics On-therapy HBsAg kinetics can predict HBsAg loss after nucleos(t)ide analogues interruption in HBeAg-negative patients. The cup is half full and half empty Teresa Broquetas Juan-Jose Hernandez Montserrat Garcia-Retortillo Lidia Canillas Marc Puigvehí Nuria Cañete Susanna Coll Ana Viu Esther Garrido Miquel Mico Xavier Bessa José A. Carrión uuid:fd8cfc10-4791-4a8b-8025-00abb91efa0c uuid:b71d3bf4-7b3f-4055-a25e-9903f8863fe6 journal © 2022 The Authors. Published by Elsevier Ltd on behalf of Editrice Gastroenterologica Italiana S.r.l. 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