0c83960dd8f6c826c36d6183d32ad18a 254984.pdf 0402060f3b73bfe5089da19a2915e384d84a2687 254984.pdf e4076efe09029791ade50d8ba96a8517a994bfcf55ca8e91e891e18fbe6f3b3e 254984.pdf Title: Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders Subject: Cell Metabolism, 34 (2022) 269-293. doi:10.1016/j.cmet.2021.12.023 Author: Sara Ramírez Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Mon Jan 24 22:40:10 2022 CET ModDate: Tue Jan 25 06:01:08 2022 CET Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 26 Encrypted: no Page size: 602.986 x 782.986 pts Page rot: 0 File size: 5552691 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ACOKOP+AdvPSHN-H Type 1C WinAnsi yes yes no 1265 0 ACOKPP+AdvPSHN-M Type 1C MacRoman yes yes no 1269 0 ACOLAA+AdvPSMPi6 Type 1C WinAnsi yes yes no 1271 0 ACOMBL+AdvPSHN-MI Type 1C WinAnsi yes yes no 1274 0 ACOMBM+AdvPSSym Type 1C WinAnsi yes yes no 1276 0 ACOMCM+Helvetica-Bold Type 1C WinAnsi yes yes no 1279 0 ACOKOP+AdvPSHN-H Type 1C MacRoman yes yes no 1083 0 ACGMBL+AdvPSA189 Type 1C MacRoman yes yes no 1068 0 ACOKPP+AdvPSHN-M Type 1C MacRoman yes yes no 1076 0 ACGMCN+Advhelvneue-italic Type 1C MacRoman yes yes no 1084 0 ACOMBL+AdvPSHN-MI Type 1C WinAnsi yes yes no 1079 0 ACGMCP+AdvPSA183 Type 1C Custom yes yes no 1082 0 ACGMDA+AdvP4C4E59 Type 1C WinAnsi yes yes no 1091 0 ACOMBM+AdvPSSym Type 1C WinAnsi yes yes no 1072 0 ACOMCM+Helvetica-Bold Type 1C WinAnsi yes yes no 1114 0 ACHANG+AdvP4C4E74 Type 1C Custom yes yes no 1123 0 ACHHFP+Advhelvneue-bi Type 1C WinAnsi yes yes no 1131 0 ACHONC+AdvPS3F4C13 Type 1C WinAnsi yes yes no 1142 0 ACIEKP+AdvPS480274 Type 1C WinAnsi yes yes no 1155 0 ACOLAA+AdvPSMPi6 Type 1C WinAnsi yes yes no 1153 0 ACIELB+AdvP41CBCA Type 1C WinAnsi yes yes no 1151 0 ACIFFO+AdvPSHN-HI Type 1C WinAnsi yes yes no 1174 0 ACIFGP+AdvPS4721B4 Type 1C WinAnsi yes yes no 1170 0 ACIFIP+AdvPS4731B1 Type 1C WinAnsi yes yes no 1178 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-02-18 02:29:17 CET RepresentationInformation: 254984.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-02-17 09:43:49 CET Size: 5552691 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fn1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'cor1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff2' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff3' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff4' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff5' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff6' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff7' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff8' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff9' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff10' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff11' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff12' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib44' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib40' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib44' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib16' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib33' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib42' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib42' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib43' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib3' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib32' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib23' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib23' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib49' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib10' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib10' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib44' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib12' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib21' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff13' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff14' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff6' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff7' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff8' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff15' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff12' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff16' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff17' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff17' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff9' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff11' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff18' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff19' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff20' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff4' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff5' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff21' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff3' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff16' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff22' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff6' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff7' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff8' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff15' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff23' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff24' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fn1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fn2' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'cor2' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib32' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib23' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib23' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib11' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib11' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib50' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib55' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib55' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib44' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib44' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib25' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib25' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib33' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib33' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib42' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib43' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib44' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib24' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib24' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib48' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib48' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib27' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib27' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib50' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib50' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib18' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib29' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib19' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib20' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib30' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib30' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib26' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib41' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib54' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib54' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib56' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib56' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib56' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'sec5.1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'sec5.2' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'sec5.3' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'sec5.4' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib51' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib46' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib47' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib25' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib47' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib51' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib46' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib25' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib25' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib31' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib61' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib31' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib31' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'sec5.1' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib45' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib52' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib52' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib28' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib62' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib62' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib15' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib17' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib14' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib14' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib14' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib14' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib14' cannot be found Offset: 5517525 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib13' cannot be found Offset: 5517525 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1368 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: Cognitive impairment caused by short-term obesogenic diet, in the absence of overt metabolic disturbances, is reversed by c ..⸩㸾൥湤潢樍ㄳ㈸‰扪഼㰯偡牥湴‱㌲㘠〠刯䑥獴⣾＀猀氀椀渀欀㘩⽐牥瘠ㄳ㈹‰⁒⽔楴汥⣾＀倀爀攀最渀攀渀漀氀漀渀攀 挀漀渀挀攀渀琀爀愀琀椀漀渀 椀渀 琀栀攀 挀攀爀攀戀爀漀猀瀀椀渀愀氀 昀氀甀椀搀 漀昀 洀攀琀愀戀漀氀椀挀愀氀氀礀 甀渀栀攀愀氀琀栀礀 瀀愀琀椀攀渀琀猀 眀椀琀栀 漀戀攀猀椀琀礀 瀀漀猀椀琀椀瘀攀氀礀 挀漀爀爀攀氀愀琀攀 ⸀⸀ Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Method details Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Insulin signaling in POMC neurons does not mediate cognitive performance Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: POMC neuron-derived pregnenolone mediates cognitive performance likely via autocrine mechanisms Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Obesity-related metabolic complications associate with impaired cognitive function and reduced hypothalamic neurosteroid co ..⸩㸾൥湤潢樍ㄳ㌰‰扪഼㰯偡牥湴‱㌲㘠〠刯乥硴‱㌲㤠〠刯䑥獴⣾＀猀氀椀渀欀㐩⽐牥瘠ㄳ㌱‰⁒⽔楴汥⣾＀倀伀䴀䌀 渀攀甀爀漀渀ⴀ搀攀爀椀瘀攀搀 瀀爀攀最渀攀渀漀氀漀渀攀 洀攀搀椀愀琀攀猀 挀漀最渀椀琀椀瘀攀 瀀攀爀昀漀爀洀愀渀挀攀 氀椀欀攀氀礀 瘀椀愀 愀甀琀漀挀爀椀渀攀 洀攀挀栀愀渀椀猀洀猩㸾൥湤潢樍ㄳ㌱‰扪഼㰯偡牥湴‱㌲㘠〠刯乥硴‱㌳〠〠刯䑥獴⣾＀猀氀椀渀欀㌩⽐牥瘠ㄳ㌲‰⁒⽔楴汥⣾＀䤀渀猀甀氀椀渀 猀椀最渀愀氀椀渀最 椀渀 倀伀䴀䌀 渀攀甀爀漀渀猀 搀漀攀猀 渀漀琀 洀攀搀椀愀琀攀 挀漀最渀椀琀椀瘀攀 瀀攀爀昀漀爀洀愀渀挀攩㸾൥湤潢樍ㄳ㌲‰扪഼㰯偡牥湴‱㌲㘠〠刯乥硴‱㌳ㄠ〠刯䑥獴⣾＀猀氀椀渀欀㈩⽐牥瘠ㄳ㈷‰⁒⽔楴汥⣾＀䤀渀琀攀爀昀攀爀攀渀挀攀 眀椀琀栀 瀀爀攀最渀攀渀漀氀漀渀攀 戀椀漀猀礀渀琀栀攀猀椀猀 椀渀 栀礀瀀漀琀栀愀氀愀洀椀挀 倀伀䴀䌀 渀攀甀爀漀渀猀Ⰰ 戀甀琀 渀漀琀 䄀最刀倀 渀攀甀爀漀渀猀Ⰰ 爀攀猀甀氀琀猀 椀渀 挀漀最渀椀琀椀瘀攀 搀礀猀昀甀渀 ⸀⸀ Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Pregnenolone concentration in the cerebrospinal fluid of metabolically unhealthy patients with obesity positively correlate ..⸩㸾൥湤潢樍ㄳ㈹‰扪഼㰯偡牥湴‱㌲㘠〠刯乥硴‱㌲㠠〠刯䑥獴⣾＀猀氀椀渀欀㔩⽐牥瘠ㄳ㌰‰⁒⽔楴汥⣾＀伀戀攀猀椀琀礀ⴀ爀攀氀愀琀攀搀 洀攀琀愀戀漀氀椀挀 挀漀洀瀀氀椀挀愀琀椀漀渀猀 愀猀猀漀挀椀愀琀攀 眀椀琀栀 椀洀瀀愀椀爀攀搀 挀漀最渀椀琀椀瘀攀 昀甀渀挀琀椀漀渀 愀渀搀 爀攀搀甀挀攀搀 栀礀瀀漀琀栀愀氀愀洀椀挀 渀攀甀爀漀猀琀攀爀漀椀搀 挀漀 ⸀⸀ Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Children: Item: Title: Limitations of study Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Supplemental information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Declaration of interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: STAR★Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Children: Item: Title: Key resources table Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Resource availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Children: Item: Title: Lead contact Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Materials availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Data and code availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Experimental model and subject details Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Children: Item: Title: Animal care and diets Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Mouse lines Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Human subjects and cerebrospinal fluid samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Method details Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Children: Item: Title: Physiological tests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Intracerebroventricular (i.c.v.) surgery and cannulation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: ARC surgery and cannulation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Corticosterone measurements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Pregnenolone extraction and quantitative analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: In vivo insulin signaling analysis by immunoblot Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Quantitative polymerase chain reaction (qPCR) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: Fluorescent in situ hybridization and quantification Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: Double POMC and FOS immunofluorescence after pregnenolone delivery Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: POMC and AgRP neuron count Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: pCREB analysis by immunofluorescence Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: General behavioral procedures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: Neurosensory screen Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Item: Title: Barnes maze test Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca Item: Title: Novel object recognition test (NORT) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207 Item: Title: Novel odor recognition test (NODR) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d371b2d Item: Title: Open field test Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@543c6f6d Item: Title: Light–Dark box test Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13eb8acf Item: Title: Elevated plus maze test Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@51c8530f Item: Title: Tail suspension test Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7403c468 Item: Title: Marble burying test Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43738a82 Item: Title: NORT performance after i.c.v. or intra-ARC administration of pregnenolone Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@c81cdd1 Item: Title: NORT performance after chemogenetic modulation of POMC neuron activity and i.c.v pregnenolone administration Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1fc2b765 Item: Title: Synaptophysin studies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@75881071 Item: Title: Electrophysiological studies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2a70a3d8 Item: Title: Quantification and statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@289d1c02 Info: Title: Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders Author: Sara Ramírez Subject: Cell Metabolism, 34 (2022) 269-293. doi:10.1016/j.cmet.2021.12.023 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Mon Jan 24 23:10:10 CET 2022 ModDate: Tue Jan 25 06:31:08 CET 2022 ID: 0xd3ba715196ef73a05198a6d918afabaf, 0xac44483915105a44abeb8ba105209707 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1191 ImageHeight: 1191 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 68 ImageHeight: 68 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 68 ImageHeight: 68 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1843 ImageHeight: 2488 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1980 ImageHeight: 2491 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1818 ImageHeight: 2432 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1744 ImageHeight: 2451 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1694 ImageHeight: 2310 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1694 ImageHeight: 1348 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Fonts: Type1: Font: BaseFont: ACOLAA+AdvPSMPi6 FontSubset: true FirstChar: 100 LastChar: 100 FontDescriptor: FontName: ACOLAA+AdvPSMPi6 Flags: Nonsymbolic FontBBox: 0, -177, 989, 739 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ACGMDA+AdvP4C4E59 FontSubset: true FirstChar: 128 LastChar: 128 FontDescriptor: FontName: ACGMDA+AdvP4C4E59 Flags: Nonsymbolic FontBBox: -31, -250, 1000, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ACHANG+AdvP4C4E74 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: ACHANG+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: ACIEKP+AdvPS480274 FontSubset: true FirstChar: 43 LastChar: 66 FontDescriptor: FontName: ACIEKP+AdvPS480274 Flags: Nonsymbolic FontBBox: 0, -208, 1354, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ACHHFP+Advhelvneue-bi FontSubset: true FirstChar: 67 LastChar: 116 FontDescriptor: FontName: ACHHFP+Advhelvneue-bi Flags: Nonsymbolic FontBBox: -156, -208, 1125, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ACGMBL+AdvPSA189 FontSubset: true FirstChar: 45 LastChar: 223 FontDescriptor: FontName: ACGMBL+AdvPSA189 Flags: Nonsymbolic FontBBox: -156, -208, 1072, 802 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: ACOMBM+AdvPSSym FontSubset: true FirstChar: 170 LastChar: 170 FontDescriptor: FontName: ACOMBM+AdvPSSym Flags: Nonsymbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ACOKOP+AdvPSHN-H FontSubset: true FirstChar: 65 LastChar: 121 FontDescriptor: FontName: ACOKOP+AdvPSHN-H Flags: Nonsymbolic FontBBox: -166, -229, 1093, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ACIFGP+AdvPS4721B4 FontSubset: true FirstChar: 98 LastChar: 98 FontDescriptor: FontName: ACIFGP+AdvPS4721B4 Flags: Nonsymbolic FontBBox: 0, -208, 843, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ACOKPP+AdvPSHN-M FontSubset: true FirstChar: 42 LastChar: 247 FontDescriptor: FontName: ACOKPP+AdvPSHN-M Flags: Nonsymbolic FontBBox: -156, -218, 1062, 802 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: ACOKPP+AdvPSHN-M FontSubset: true FirstChar: 40 LastChar: 245 FontDescriptor: FontName: ACOKPP+AdvPSHN-M Flags: Nonsymbolic FontBBox: -156, -218, 1062, 802 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: ACHONC+AdvPS3F4C13 FontSubset: true FirstChar: 97 LastChar: 109 FontDescriptor: FontName: ACHONC+AdvPS3F4C13 Flags: Nonsymbolic FontBBox: 0, -291, 875, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ACIFFO+AdvPSHN-HI FontSubset: true FirstChar: 67 LastChar: 118 FontDescriptor: FontName: ACIFFO+AdvPSHN-HI Flags: Nonsymbolic FontBBox: -156, -218, 1135, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ACOLAA+AdvPSMPi6 FontSubset: true FirstChar: 100 LastChar: 100 FontDescriptor: FontName: ACOLAA+AdvPSMPi6 Flags: Nonsymbolic FontBBox: 0, -177, 989, 739 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ACOMBL+AdvPSHN-MI FontSubset: true FirstChar: 83 LastChar: 116 FontDescriptor: FontName: ACOMBL+AdvPSHN-MI Flags: Nonsymbolic FontBBox: -156, -208, 1125, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ACOMBL+AdvPSHN-MI FontSubset: true FirstChar: 51 LastChar: 52 FontDescriptor: FontName: ACOMBL+AdvPSHN-MI Flags: Nonsymbolic FontBBox: -156, -208, 1125, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ACGMCP+AdvPSA183 FontSubset: true FirstChar: 25 LastChar: 216 FontDescriptor: FontName: ACGMCP+AdvPSA183 Flags: Nonsymbolic FontBBox: -156, -208, 1072, 791 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: ACOMCM+Helvetica-Bold FontSubset: true FirstChar: 108 LastChar: 108 FontDescriptor: FontName: ACOMCM+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ACIFIP+AdvPS4731B1 FontSubset: true FirstChar: 82 LastChar: 82 FontDescriptor: FontName: ACIFIP+AdvPS4731B1 Flags: Nonsymbolic FontBBox: 0, -208, 1572, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ACOKOP+AdvPSHN-H FontSubset: true FirstChar: 40 LastChar: 223 FontDescriptor: FontName: ACOKOP+AdvPSHN-H Flags: Nonsymbolic FontBBox: -166, -229, 1093, 812 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: ACOMBM+AdvPSSym FontSubset: true FirstChar: 170 LastChar: 170 FontDescriptor: FontName: ACOMBM+AdvPSSym Flags: Nonsymbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ACGMCN+Advhelvneue-italic FontSubset: true FirstChar: 40 LastChar: 223 FontDescriptor: FontName: ACGMCN+Advhelvneue-italic Flags: Nonsymbolic FontBBox: -156, -208, 1104, 791 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: ACOMCM+Helvetica-Bold FontSubset: true FirstChar: 108 LastChar: 108 FontDescriptor: FontName: ACOMCM+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ACIELB+AdvP41CBCA FontSubset: true FirstChar: 49 LastChar: 49 FontDescriptor: FontName: ACIELB+AdvP41CBCA Flags: Nonsymbolic FontBBox: -20, -229, 927, 895 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.cmet.2021.12.023 Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders Sara Ramírez Roberta Haddad-Tóvolli Marija Radosevic Miriam Toledo Adriana Pané Daniel Alcolea Vicent Ribas Maria Milà-Guasch Macarena Pozo Arnaud Obri Elena Eyre Alicia G. Gómez-Valadés Iñigo Chivite Tomas Van Eeckhout Ioannis Zalachoras Jordi Altirriba Corinna Bauder Mónica Imbernón Gloria Garrabou Carmen Garcia-Ruiz Rubén Nogueiras David Soto Xavier Gasull Carmen Sandi Jens C. Brüning Juan Fortea Amanda Jiménez José C. Fernández-Checa Marc Claret hypothalamus obesity diabetes cognitive function recognition memory neurosteroids POMC neurons pregnenolone Stard1 mitochondria Cell Metabolism, 34 (2022) 269-293. doi:10.1016/j.cmet.2021.12.023 The Authors journal Cell Metabolism © 2022 The Authors. Published by Elsevier Inc. 1550-4131 34 2 1 February 2022 2022-02-01 269-284.e9 269 284.e9 10.1016/j.cmet.2021.12.023 https://doi.org/10.1016/j.cmet.2021.12.023 2010-04-23 true 10.1016/j.cmet.2021.12.023 elsevier.com sciencedirect.com VoR 10.1016/j.cmet.2021.12.023 noindex true 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2022-01-25T03:10:10+05:30 2022-01-25T10:31:08+05:30 2022-01-25T10:31:08+05:30 True Acrobat Distiller 8.1.0 (Windows) uuid:62b2f314-cb36-4968-95c6-c51b27661bbd uuid:18e7557a-781c-4f6b-a8a7-99975992d8b8 http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 269 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 354, 517, 438, 527 Annotation: Subtype: Link Rect: 354, 505, 438, 515 Annotation: Subtype: Link Rect: 104, 48, 270, 56 Annotation: Subtype: Link Rect: 53, 56, 69, 72 Page: Label: 270 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 110, 605, 116, 614 Destination: null Annotation: Subtype: Link Rect: 116, 605, 125, 614 Destination: null Annotation: Subtype: Link Rect: 125, 605, 129, 614 Destination: null Annotation: Subtype: Link Rect: 233, 605, 237, 614 Destination: null Annotation: Subtype: Link Rect: 313, 605, 317, 614 Destination: null Annotation: Subtype: Link Rect: 381, 605, 385, 614 Destination: null Annotation: Subtype: Link Rect: 445, 605, 449, 614 Destination: null Annotation: Subtype: Link Rect: 513, 605, 518, 614 Destination: null Annotation: Subtype: Link Rect: 518, 605, 522, 614 Destination: null Annotation: Subtype: Link Rect: 107, 595, 113, 604 Destination: null Annotation: Subtype: Link Rect: 113, 595, 118, 604 Destination: null Annotation: Subtype: Link Rect: 118, 595, 122, 604 Destination: null Annotation: Subtype: Link Rect: 205, 595, 209, 604 Destination: null Annotation: Subtype: Link Rect: 278, 595, 282, 604 Destination: null Annotation: Subtype: Link Rect: 337, 595, 341, 604 Destination: null Annotation: Subtype: Link Rect: 389, 595, 393, 604 Destination: null Annotation: Subtype: Link Rect: 500, 595, 504, 604 Destination: null Annotation: Subtype: Link Rect: 107, 585, 110, 594 Destination: null Annotation: Subtype: Link Rect: 203, 585, 207, 594 Destination: null Annotation: Subtype: Link Rect: 290, 585, 294, 594 Destination: null Annotation: Subtype: Link Rect: 354, 585, 362, 594 Destination: null Annotation: Subtype: Link Rect: 432, 585, 439, 594 Destination: null Annotation: Subtype: Link Rect: 517, 585, 524, 594 Destination: null Annotation: Subtype: Link Rect: 306, 70, 314, 78 Destination: 464 Annotation: Subtype: Link Rect: 318, 70, 354, 78 Destination: 464 Annotation: Subtype: Link Rect: 53, 16, 69, 32 Annotation: Subtype: Link Rect: 356, 9, 538, 17 Page: Label: 271 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 89, 497, 188, 506 Destination: 464 Annotation: Subtype: Link Rect: 193, 497, 264, 506 Destination: null Annotation: Subtype: Link Rect: 90, 464, 187, 473 Destination: 464 Annotation: Subtype: Link Rect: 191, 464, 296, 473 Destination: null Annotation: Subtype: Link Rect: 59, 453, 134, 462 Destination: null Annotation: Subtype: Link Rect: 279, 432, 298, 440 Destination: 464 Annotation: Subtype: Link Rect: 59, 421, 145, 429 Destination: 464 Annotation: Subtype: Link Rect: 151, 421, 230, 429 Destination: null Annotation: Subtype: Link Rect: 166, 311, 267, 319 Destination: null Annotation: Subtype: Link Rect: 273, 311, 298, 319 Destination: null Annotation: Subtype: Link Rect: 59, 300, 101, 308 Destination: null Annotation: Subtype: Link Rect: 105, 300, 124, 308 Destination: null Annotation: Subtype: Link Rect: 226, 256, 294, 265 Destination: null Annotation: Subtype: Link Rect: 116, 190, 186, 199 Destination: 464 Annotation: Subtype: Link Rect: 190, 190, 259, 199 Destination: null Annotation: Subtype: Link Rect: 214, 136, 294, 144 Destination: 707 Annotation: Subtype: Link Rect: 61, 81, 131, 89 Destination: 707 Annotation: Subtype: Link Rect: 136, 81, 205, 89 Destination: 707 Annotation: Subtype: Link Rect: 417, 497, 463, 506 Destination: null Annotation: Subtype: Link Rect: 468, 497, 509, 506 Destination: null Annotation: Subtype: Link Rect: 366, 475, 453, 484 Destination: null Annotation: Subtype: Link Rect: 430, 453, 549, 462 Destination: null Annotation: Subtype: Link Rect: 310, 442, 329, 451 Destination: null Annotation: Subtype: Link Rect: 447, 256, 547, 265 Destination: 464 Annotation: Subtype: Link Rect: 310, 245, 381, 254 Destination: null Annotation: Subtype: Link Rect: 310, 212, 346, 221 Destination: null Annotation: Subtype: Link Rect: 388, 201, 429, 210 Destination: null Annotation: Subtype: Link Rect: 422, 168, 452, 177 Destination: 152 Annotation: Subtype: Link Rect: 388, 158, 421, 166 Destination: 152 Annotation: Subtype: Link Rect: 456, 147, 494, 155 Destination: null Annotation: Subtype: Link Rect: 467, 136, 502, 144 Destination: 152 Annotation: Subtype: Link Rect: 466, 114, 502, 122 Destination: 152 Annotation: Subtype: Link Rect: 522, 103, 549, 111 Destination: null Annotation: Subtype: Link Rect: 310, 92, 320, 100 Destination: null Annotation: Subtype: Link Rect: 388, 37, 457, 45 Destination: null Annotation: Subtype: Link Rect: 463, 37, 545, 45 Destination: null Annotation: Subtype: Link Rect: 128, 672, 135, 681 Destination: null Annotation: Subtype: Link Rect: 137, 672, 145, 681 Destination: null Annotation: Subtype: Link Rect: 233, 672, 237, 681 Destination: null Annotation: Subtype: Link Rect: 239, 672, 243, 681 Destination: null Annotation: Subtype: Link Rect: 244, 672, 248, 681 Destination: null Annotation: Subtype: Link Rect: 250, 672, 258, 681 Destination: null Annotation: Subtype: Link Rect: 334, 672, 342, 681 Destination: null Annotation: Subtype: Link Rect: 344, 672, 351, 681 Destination: null Annotation: Subtype: Link Rect: 402, 672, 409, 681 Destination: null Annotation: Subtype: Link Rect: 468, 672, 476, 681 Destination: null Annotation: Subtype: Link Rect: 539, 672, 543, 681 Destination: null Annotation: Subtype: Link Rect: 128, 662, 135, 671 Destination: null Annotation: Subtype: Link Rect: 137, 662, 145, 671 Destination: null Annotation: Subtype: Link Rect: 146, 662, 154, 671 Destination: null Annotation: Subtype: Link Rect: 156, 662, 163, 671 Destination: null Annotation: Subtype: Link Rect: 218, 662, 221, 671 Destination: null Annotation: Subtype: Link Rect: 223, 662, 227, 671 Destination: null Annotation: Subtype: Link Rect: 229, 662, 236, 671 Destination: null Annotation: Subtype: Link Rect: 313, 662, 316, 671 Destination: null Annotation: Subtype: Link Rect: 318, 662, 326, 671 Destination: null Annotation: Subtype: Link Rect: 327, 662, 335, 671 Destination: null Annotation: Subtype: Link Rect: 447, 662, 451, 671 Destination: null Annotation: Subtype: Link Rect: 453, 662, 457, 671 Destination: null Annotation: Subtype: Link Rect: 458, 662, 462, 671 Destination: null Annotation: Subtype: Link Rect: 464, 662, 471, 671 Destination: null Annotation: Subtype: Link Rect: 107, 652, 111, 661 Destination: null Annotation: Subtype: Link Rect: 113, 652, 120, 661 Destination: null Annotation: Subtype: Link Rect: 122, 652, 130, 661 Destination: null Annotation: Subtype: Link Rect: 132, 652, 139, 661 Destination: null Annotation: Subtype: Link Rect: 141, 652, 148, 661 Destination: null Annotation: Subtype: Link Rect: 150, 652, 154, 661 Destination: null Annotation: Subtype: Link Rect: 126, 561, 190, 569 Annotation: Subtype: Link Rect: 216, 561, 281, 569 Annotation: Subtype: Link Rect: 59, 551, 212, 559 Page: Label: 272 Sequence: 4 Page: Label: 273 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 201, 651, 232, 659 Destination: 152 Annotation: Subtype: Link Rect: 205, 629, 241, 637 Destination: null Annotation: Subtype: Link Rect: 127, 618, 164, 626 Destination: null Annotation: Subtype: Link Rect: 166, 552, 201, 561 Destination: 152 Annotation: Subtype: Link Rect: 151, 530, 228, 539 Destination: 707 Annotation: Subtype: Link Rect: 147, 497, 185, 506 Destination: null Annotation: Subtype: Link Rect: 153, 421, 188, 429 Destination: 152 Annotation: Subtype: Link Rect: 61, 322, 96, 330 Destination: 152 Annotation: Subtype: Link Rect: 122, 322, 132, 330 Destination: null Annotation: Subtype: Link Rect: 284, 223, 298, 232 Destination: 209 Annotation: Subtype: Link Rect: 310, 673, 336, 681 Destination: 209 Annotation: Subtype: Link Rect: 523, 640, 549, 648 Destination: 464 Annotation: Subtype: Link Rect: 310, 629, 352, 637 Destination: 464 Annotation: Subtype: Link Rect: 357, 629, 427, 637 Destination: null Annotation: Subtype: Link Rect: 434, 629, 470, 637 Destination: null Annotation: Subtype: Link Rect: 445, 607, 485, 615 Destination: null Annotation: Subtype: Link Rect: 420, 596, 461, 604 Destination: null Annotation: Subtype: Link Rect: 313, 585, 350, 593 Destination: null Annotation: Subtype: Link Rect: 313, 552, 349, 561 Destination: null Annotation: Subtype: Link Rect: 334, 541, 375, 550 Destination: null Annotation: Subtype: Link Rect: 500, 475, 539, 484 Destination: null Annotation: Subtype: Link Rect: 362, 432, 403, 440 Destination: null Annotation: Subtype: Link Rect: 389, 377, 431, 385 Destination: null Annotation: Subtype: Link Rect: 435, 377, 474, 385 Destination: null Annotation: Subtype: Link Rect: 359, 333, 399, 341 Destination: null Annotation: Subtype: Link Rect: 334, 278, 369, 287 Destination: 209 Annotation: Subtype: Link Rect: 346, 256, 384, 265 Destination: 209 Annotation: Subtype: Link Rect: 433, 256, 443, 265 Destination: null Annotation: Subtype: Link Rect: 461, 245, 493, 254 Destination: 209 Page: Label: 274 Sequence: 6 Page: Label: 275 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 262, 673, 298, 681 Destination: null Annotation: Subtype: Link Rect: 59, 662, 101, 670 Destination: null Annotation: Subtype: Link Rect: 108, 662, 145, 670 Destination: null Annotation: Subtype: Link Rect: 202, 651, 238, 659 Destination: 209 Annotation: Subtype: Link Rect: 276, 651, 286, 659 Destination: null Annotation: Subtype: Link Rect: 284, 640, 298, 648 Destination: 209 Annotation: Subtype: Link Rect: 59, 629, 85, 637 Destination: 209 Annotation: Subtype: Link Rect: 129, 629, 139, 637 Destination: null Annotation: Subtype: Link Rect: 141, 618, 176, 626 Destination: 209 Annotation: Subtype: Link Rect: 61, 596, 102, 604 Destination: null Annotation: Subtype: Link Rect: 284, 596, 298, 604 Destination: null Annotation: Subtype: Link Rect: 59, 585, 90, 593 Destination: null Annotation: Subtype: Link Rect: 88, 574, 130, 582 Destination: null Annotation: Subtype: Link Rect: 195, 541, 262, 550 Destination: null Annotation: Subtype: Link Rect: 178, 530, 216, 539 Destination: null Annotation: Subtype: Link Rect: 144, 519, 185, 528 Destination: null Annotation: Subtype: Link Rect: 134, 508, 175, 517 Destination: null Annotation: Subtype: Link Rect: 180, 464, 219, 473 Destination: null Annotation: Subtype: Link Rect: 105, 453, 148, 462 Destination: null Annotation: Subtype: Link Rect: 113, 432, 149, 440 Destination: 209 Annotation: Subtype: Link Rect: 242, 399, 298, 407 Destination: null Annotation: Subtype: Link Rect: 59, 388, 129, 396 Destination: null Annotation: Subtype: Link Rect: 250, 366, 292, 374 Destination: null Annotation: Subtype: Link Rect: 162, 267, 264, 276 Destination: 464 Annotation: Subtype: Link Rect: 271, 267, 298, 276 Destination: null Annotation: Subtype: Link Rect: 59, 256, 101, 265 Destination: null Annotation: Subtype: Link Rect: 363, 651, 398, 659 Destination: 276 Annotation: Subtype: Link Rect: 474, 618, 508, 626 Destination: 276 Annotation: Subtype: Link Rect: 522, 618, 549, 626 Destination: null Annotation: Subtype: Link Rect: 310, 607, 351, 615 Destination: null Annotation: Subtype: Link Rect: 418, 596, 454, 604 Destination: 276 Annotation: Subtype: Link Rect: 313, 563, 350, 572 Destination: 276 Annotation: Subtype: Link Rect: 390, 453, 421, 462 Destination: 332 Annotation: Subtype: Link Rect: 491, 442, 527, 451 Destination: 332 Annotation: Subtype: Link Rect: 504, 432, 540, 440 Destination: 332 Annotation: Subtype: Link Rect: 497, 410, 540, 418 Destination: null Annotation: Subtype: Link Rect: 482, 333, 512, 341 Destination: 332 Annotation: Subtype: Link Rect: 459, 300, 495, 309 Destination: 332 Annotation: Subtype: Link Rect: 442, 278, 474, 287 Destination: 332 Page: Label: 276 Sequence: 8 Page: Label: 277 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 258, 640, 294, 648 Destination: 332 Annotation: Subtype: Link Rect: 79, 629, 89, 637 Destination: null Annotation: Subtype: Link Rect: 284, 618, 298, 626 Destination: null Annotation: Subtype: Link Rect: 59, 607, 84, 615 Destination: null Annotation: Subtype: Link Rect: 270, 585, 298, 593 Destination: 332 Annotation: Subtype: Link Rect: 59, 574, 64, 582 Destination: 332 Annotation: Subtype: Link Rect: 108, 574, 118, 582 Destination: null Annotation: Subtype: Link Rect: 240, 541, 275, 550 Destination: 152 Annotation: Subtype: Link Rect: 286, 541, 290, 550 Destination: 332 Annotation: Subtype: Link Rect: 61, 497, 92, 506 Destination: 332 Annotation: Subtype: Link Rect: 126, 475, 161, 484 Destination: 332 Annotation: Subtype: Link Rect: 172, 475, 182, 484 Destination: null Annotation: Subtype: Link Rect: 188, 453, 260, 462 Destination: 707 Annotation: Subtype: Link Rect: 120, 432, 155, 440 Destination: 332 Annotation: Subtype: Link Rect: 92, 355, 128, 363 Destination: 332 Annotation: Subtype: Link Rect: 172, 355, 182, 363 Destination: null Annotation: Subtype: Link Rect: 350, 607, 380, 615 Destination: 373 Annotation: Subtype: Link Rect: 313, 585, 343, 593 Destination: 373 Annotation: Subtype: Link Rect: 489, 585, 525, 593 Destination: 373 Annotation: Subtype: Link Rect: 492, 563, 527, 572 Destination: 373 Annotation: Subtype: Link Rect: 508, 541, 539, 550 Destination: 373 Annotation: Subtype: Link Rect: 346, 508, 380, 517 Destination: 373 Annotation: Subtype: Link Rect: 405, 497, 436, 506 Destination: 373 Annotation: Subtype: Link Rect: 508, 475, 539, 484 Destination: 373 Annotation: Subtype: Link Rect: 355, 442, 390, 451 Destination: 373 Annotation: Subtype: Link Rect: 382, 377, 418, 385 Destination: 373 Annotation: Subtype: Link Rect: 345, 223, 376, 232 Destination: 419 Annotation: Subtype: Link Rect: 387, 223, 420, 232 Destination: null Page: Label: 278 Sequence: 10 Page: Label: 279 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 256, 662, 288, 670 Destination: 419 Annotation: Subtype: Link Rect: 111, 629, 147, 637 Destination: 419 Annotation: Subtype: Link Rect: 271, 552, 298, 561 Destination: null Annotation: Subtype: Link Rect: 59, 541, 134, 550 Destination: null Annotation: Subtype: Link Rect: 139, 541, 212, 550 Destination: null Annotation: Subtype: Link Rect: 218, 541, 237, 550 Destination: null Annotation: Subtype: Link Rect: 221, 442, 298, 451 Destination: 464 Annotation: Subtype: Link Rect: 59, 432, 78, 440 Destination: 464 Annotation: Subtype: Link Rect: 84, 432, 158, 440 Destination: null Annotation: Subtype: Link Rect: 416, 640, 489, 648 Destination: 464 Annotation: Subtype: Link Rect: 494, 640, 549, 648 Destination: 464 Annotation: Subtype: Link Rect: 310, 629, 329, 637 Destination: 464 Annotation: Subtype: Link Rect: 417, 421, 507, 429 Destination: 707 Page: Label: 280 Sequence: 12 Page: Label: 281 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 88, 541, 174, 550 Destination: null Annotation: Subtype: Link Rect: 206, 519, 294, 528 Destination: null Annotation: Subtype: Link Rect: 432, 563, 504, 572 Destination: 707 Annotation: Subtype: Link Rect: 487, 541, 549, 550 Destination: null Annotation: Subtype: Link Rect: 310, 530, 329, 539 Destination: null Annotation: Subtype: Link Rect: 505, 519, 549, 528 Destination: null Annotation: Subtype: Link Rect: 310, 508, 329, 517 Destination: null Annotation: Subtype: Link Rect: 527, 442, 549, 451 Destination: null Annotation: Subtype: Link Rect: 310, 432, 352, 440 Destination: null Annotation: Subtype: Link Rect: 357, 432, 393, 440 Destination: null Annotation: Subtype: Link Rect: 347, 333, 421, 341 Destination: null Annotation: Subtype: Link Rect: 428, 333, 491, 341 Destination: null Annotation: Subtype: Link Rect: 313, 289, 387, 298 Destination: null Annotation: Subtype: Link Rect: 392, 289, 474, 298 Destination: null Annotation: Subtype: Link Rect: 479, 289, 549, 298 Destination: null Annotation: Subtype: Link Rect: 310, 278, 329, 287 Destination: null Annotation: Subtype: Link Rect: 334, 278, 397, 287 Destination: 707 Annotation: Subtype: Link Rect: 423, 212, 519, 221 Destination: null Page: Label: 282 Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 55, 223, 158, 232 Destination: null Annotation: Subtype: Link Rect: 163, 223, 234, 232 Destination: null Annotation: Subtype: Link Rect: 239, 223, 292, 232 Destination: null Annotation: Subtype: Link Rect: 53, 212, 71, 221 Destination: null Annotation: Subtype: Link Rect: 203, 136, 292, 144 Destination: null Annotation: Subtype: Link Rect: 53, 125, 292, 133 Destination: null Annotation: Subtype: Link Rect: 53, 114, 88, 122 Destination: null Page: Label: 283 Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 221, 552, 294, 561 Destination: 707 Annotation: Subtype: Link Rect: 81, 377, 180, 385 Destination: null Annotation: Subtype: Link Rect: 81, 366, 183, 374 Destination: null Annotation: Subtype: Link Rect: 81, 322, 272, 330 Destination: null Annotation: Subtype: Link Rect: 81, 278, 153, 287 Destination: null Annotation: Subtype: Link Rect: 332, 597, 518, 605 Destination: 1047 Annotation: Subtype: Link Rect: 472, 557, 549, 564 Annotation: Subtype: Link Rect: 310, 547, 367, 554 Page: Label: 284 Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 53, 569, 292, 576 Annotation: Subtype: Link Rect: 53, 560, 292, 567 Annotation: Subtype: Link Rect: 53, 550, 292, 557 Annotation: Subtype: Link Rect: 53, 541, 292, 548 Annotation: Subtype: Link Rect: 53, 532, 87, 539 Annotation: Subtype: Link Rect: 53, 519, 292, 526 Annotation: Subtype: Link Rect: 53, 510, 292, 517 Annotation: Subtype: Link Rect: 53, 501, 108, 508 Annotation: Subtype: Link Rect: 53, 488, 292, 495 Annotation: Subtype: Link Rect: 53, 479, 292, 486 Annotation: Subtype: Link Rect: 53, 469, 87, 476 Annotation: Subtype: Link Rect: 53, 457, 292, 464 Annotation: Subtype: Link Rect: 53, 448, 292, 455 Annotation: Subtype: Link Rect: 53, 438, 292, 445 Annotation: Subtype: Link Rect: 53, 429, 284, 436 Annotation: Subtype: Link Rect: 53, 417, 292, 424 Annotation: Subtype: Link Rect: 53, 407, 292, 414 Annotation: Subtype: Link Rect: 53, 398, 292, 405 Annotation: Subtype: Link Rect: 53, 388, 79, 395 Annotation: Subtype: Link Rect: 53, 376, 292, 383 Annotation: Subtype: Link Rect: 53, 367, 292, 374 Annotation: Subtype: Link Rect: 53, 357, 87, 364 Annotation: Subtype: Link Rect: 53, 345, 292, 352 Annotation: Subtype: Link Rect: 53, 336, 292, 343 Annotation: Subtype: Link Rect: 53, 326, 292, 333 Annotation: Subtype: Link Rect: 53, 317, 95, 324 Annotation: Subtype: Link Rect: 53, 305, 292, 312 Annotation: Subtype: Link Rect: 53, 295, 292, 302 Annotation: Subtype: Link Rect: 53, 286, 157, 293 Annotation: Subtype: Link Rect: 53, 274, 292, 281 Annotation: Subtype: Link Rect: 53, 264, 292, 271 Annotation: Subtype: Link Rect: 53, 255, 91, 262 Annotation: Subtype: Link Rect: 53, 243, 59, 250 Annotation: Subtype: Link Rect: 63, 243, 292, 250 Annotation: Subtype: Link Rect: 53, 233, 128, 240 Annotation: Subtype: Link Rect: 53, 221, 292, 228 Annotation: Subtype: Link Rect: 53, 212, 292, 219 Annotation: Subtype: Link Rect: 53, 202, 292, 209 Annotation: Subtype: Link Rect: 53, 193, 210, 200 Annotation: Subtype: Link Rect: 53, 180, 292, 187 Annotation: Subtype: Link Rect: 53, 171, 246, 178 Annotation: Subtype: Link Rect: 53, 159, 292, 166 Annotation: Subtype: Link Rect: 53, 149, 292, 156 Annotation: Subtype: Link Rect: 53, 140, 292, 147 Annotation: Subtype: Link Rect: 53, 131, 203, 137 Annotation: Subtype: Link Rect: 53, 118, 292, 125 Annotation: Subtype: Link Rect: 53, 109, 292, 116 Annotation: Subtype: Link Rect: 53, 99, 290, 106 Annotation: Subtype: Link Rect: 53, 87, 292, 94 Annotation: Subtype: Link Rect: 53, 78, 269, 85 Annotation: Subtype: Link Rect: 53, 66, 292, 73 Annotation: Subtype: Link Rect: 53, 56, 292, 63 Annotation: Subtype: Link Rect: 53, 47, 292, 54 Annotation: Subtype: Link Rect: 53, 37, 93, 44 Annotation: Subtype: Link Rect: 304, 674, 543, 681 Annotation: Subtype: Link Rect: 304, 665, 543, 672 Annotation: Subtype: Link Rect: 304, 655, 518, 662 Annotation: Subtype: Link Rect: 304, 643, 543, 650 Annotation: Subtype: Link Rect: 304, 633, 543, 640 Annotation: Subtype: Link Rect: 304, 624, 430, 631 Annotation: Subtype: Link Rect: 304, 612, 543, 619 Annotation: Subtype: Link Rect: 304, 602, 543, 609 Annotation: Subtype: Link Rect: 304, 593, 380, 600 Annotation: Subtype: Link Rect: 304, 581, 543, 588 Annotation: Subtype: Link Rect: 304, 571, 543, 578 Annotation: Subtype: Link Rect: 304, 562, 527, 569 Annotation: Subtype: Link Rect: 304, 549, 543, 556 Annotation: Subtype: Link Rect: 304, 540, 543, 547 Annotation: Subtype: Link Rect: 304, 530, 543, 537 Annotation: Subtype: Link Rect: 304, 521, 479, 528 Annotation: Subtype: Link Rect: 304, 509, 543, 516 Annotation: Subtype: Link Rect: 304, 499, 543, 506 Annotation: Subtype: Link Rect: 304, 490, 492, 497 Annotation: Subtype: Link Rect: 304, 478, 543, 485 Annotation: Subtype: Link Rect: 304, 468, 543, 475 Annotation: Subtype: Link Rect: 304, 459, 543, 466 Annotation: Subtype: Link Rect: 304, 449, 459, 456 Annotation: Subtype: Link Rect: 304, 437, 543, 444 Annotation: Subtype: Link Rect: 304, 428, 543, 435 Annotation: Subtype: Link Rect: 304, 418, 543, 425 Annotation: Subtype: Link Rect: 304, 409, 429, 416 Annotation: Subtype: Link Rect: 304, 396, 543, 403 Annotation: Subtype: Link Rect: 304, 387, 501, 394 Annotation: Subtype: Link Rect: 445, 356, 543, 363 Annotation: Subtype: Link Rect: 304, 346, 331, 353 Annotation: Subtype: Link Rect: 304, 334, 543, 341 Annotation: Subtype: Link Rect: 304, 325, 543, 332 Annotation: Subtype: Link Rect: 304, 315, 364, 322 Annotation: Subtype: Link Rect: 304, 303, 543, 310 Annotation: Subtype: Link Rect: 304, 293, 543, 300 Annotation: Subtype: Link Rect: 304, 284, 543, 291 Annotation: Subtype: Link Rect: 304, 274, 374, 281 Annotation: Subtype: Link Rect: 304, 262, 543, 269 Annotation: Subtype: Link Rect: 304, 253, 472, 260 Annotation: Subtype: Link Rect: 304, 241, 543, 247 Annotation: Subtype: Link Rect: 304, 231, 543, 238 Annotation: Subtype: Link Rect: 304, 222, 543, 229 Annotation: Subtype: Link Rect: 304, 212, 499, 219 Annotation: Subtype: Link Rect: 304, 200, 543, 207 Annotation: Subtype: Link Rect: 304, 190, 543, 197 Annotation: Subtype: Link Rect: 304, 181, 421, 188 Annotation: Subtype: Link Rect: 304, 169, 543, 176 Annotation: Subtype: Link Rect: 304, 159, 543, 166 Annotation: Subtype: Link Rect: 304, 150, 338, 157 Annotation: Subtype: Link Rect: 304, 138, 543, 145 Annotation: Subtype: Link Rect: 304, 128, 543, 135 Annotation: Subtype: Link Rect: 304, 119, 543, 126 Annotation: Subtype: Link Rect: 304, 109, 400, 116 Annotation: Subtype: Link Rect: 304, 97, 543, 104 Annotation: Subtype: Link Rect: 304, 87, 543, 94 Annotation: Subtype: Link Rect: 304, 78, 543, 85 Annotation: Subtype: Link Rect: 304, 68, 389, 75 Annotation: Subtype: Link Rect: 304, 56, 543, 63 Annotation: Subtype: Link Rect: 304, 47, 543, 54 Annotation: Subtype: Link Rect: 304, 37, 408, 44 Page: Label: 285 Sequence: 17 Annotations: Annotation: Subtype: Link Rect: 59, 674, 298, 681 Annotation: Subtype: Link Rect: 59, 665, 298, 672 Annotation: Subtype: Link Rect: 59, 655, 298, 662 Annotation: Subtype: Link Rect: 59, 646, 277, 653 Annotation: Subtype: Link Rect: 59, 633, 298, 640 Annotation: Subtype: Link Rect: 59, 624, 298, 631 Annotation: Subtype: Link Rect: 59, 614, 233, 621 Annotation: Subtype: Link Rect: 59, 601, 298, 608 Annotation: Subtype: Link Rect: 59, 592, 298, 599 Annotation: Subtype: Link Rect: 59, 582, 86, 589 Annotation: Subtype: Link Rect: 59, 570, 298, 577 Annotation: Subtype: Link Rect: 59, 560, 298, 567 Annotation: Subtype: Link Rect: 59, 551, 298, 558 Annotation: Subtype: Link Rect: 59, 541, 298, 548 Annotation: Subtype: Link Rect: 59, 532, 128, 539 Annotation: Subtype: Link Rect: 59, 519, 298, 526 Annotation: Subtype: Link Rect: 59, 510, 239, 517 Annotation: Subtype: Link Rect: 59, 497, 298, 504 Annotation: Subtype: Link Rect: 59, 488, 298, 495 Annotation: Subtype: Link Rect: 59, 478, 257, 485 Annotation: Subtype: Link Rect: 59, 466, 298, 472 Annotation: Subtype: Link Rect: 59, 456, 298, 463 Annotation: Subtype: Link Rect: 59, 447, 298, 454 Annotation: Subtype: Link Rect: 59, 437, 298, 444 Annotation: Subtype: Link Rect: 59, 428, 151, 435 Annotation: Subtype: Link Rect: 59, 415, 298, 422 Annotation: Subtype: Link Rect: 59, 406, 298, 413 Annotation: Subtype: Link Rect: 59, 396, 82, 403 Annotation: Subtype: Link Rect: 59, 383, 298, 390 Annotation: Subtype: Link Rect: 59, 374, 298, 381 Annotation: Subtype: Link Rect: 59, 364, 298, 371 Annotation: Subtype: Link Rect: 59, 355, 148, 362 Annotation: Subtype: Link Rect: 59, 342, 298, 349 Annotation: Subtype: Link Rect: 59, 333, 298, 340 Annotation: Subtype: Link Rect: 59, 323, 298, 330 Annotation: Subtype: Link Rect: 59, 314, 252, 321 Annotation: Subtype: Link Rect: 59, 301, 298, 308 Annotation: Subtype: Link Rect: 59, 292, 298, 299 Annotation: Subtype: Link Rect: 59, 282, 131, 289 Annotation: Subtype: Link Rect: 59, 270, 298, 277 Annotation: Subtype: Link Rect: 59, 260, 298, 267 Annotation: Subtype: Link Rect: 59, 251, 265, 258 Annotation: Subtype: Link Rect: 310, 674, 549, 681 Annotation: Subtype: Link Rect: 310, 665, 549, 672 Annotation: Subtype: Link Rect: 310, 655, 449, 662 Annotation: Subtype: Link Rect: 310, 644, 549, 651 Annotation: Subtype: Link Rect: 310, 634, 549, 641 Annotation: Subtype: Link Rect: 310, 625, 468, 632 Annotation: Subtype: Link Rect: 310, 613, 549, 620 Annotation: Subtype: Link Rect: 310, 604, 549, 611 Annotation: Subtype: Link Rect: 310, 594, 461, 601 Annotation: Subtype: Link Rect: 310, 583, 549, 590 Annotation: Subtype: Link Rect: 310, 573, 549, 580 Annotation: Subtype: Link Rect: 310, 564, 549, 571 Annotation: Subtype: Link Rect: 310, 555, 341, 561 Annotation: Subtype: Link Rect: 310, 543, 549, 550 Annotation: Subtype: Link Rect: 310, 534, 549, 541 Annotation: Subtype: Link Rect: 310, 524, 417, 531 Annotation: Subtype: Link Rect: 310, 513, 549, 520 Annotation: Subtype: Link Rect: 310, 503, 549, 510 Annotation: Subtype: Link Rect: 310, 494, 549, 501 Annotation: Subtype: Link Rect: 310, 484, 537, 491 Annotation: Subtype: Link Rect: 310, 473, 549, 480 Annotation: Subtype: Link Rect: 310, 463, 549, 470 Annotation: Subtype: Link Rect: 310, 454, 459, 461 Annotation: Subtype: Link Rect: 310, 442, 549, 449 Annotation: Subtype: Link Rect: 310, 433, 549, 440 Annotation: Subtype: Link Rect: 310, 424, 549, 431 Annotation: Subtype: Link Rect: 310, 414, 543, 421 Annotation: Subtype: Link Rect: 310, 403, 549, 410 Annotation: Subtype: Link Rect: 310, 393, 424, 400 Annotation: Subtype: Link Rect: 310, 382, 549, 389 Annotation: Subtype: Link Rect: 310, 372, 549, 379 Annotation: Subtype: Link Rect: 310, 363, 488, 370 Annotation: Subtype: Link Rect: 310, 351, 549, 358 Annotation: Subtype: Link Rect: 310, 342, 549, 349 Annotation: Subtype: Link Rect: 310, 332, 502, 339 Annotation: Subtype: Link Rect: 310, 321, 549, 328 Annotation: Subtype: Link Rect: 310, 311, 549, 318 Annotation: Subtype: Link Rect: 310, 302, 416, 309 Annotation: Subtype: Link Rect: 310, 291, 549, 298 Annotation: Subtype: Link Rect: 310, 281, 478, 288 Annotation: Subtype: Link Rect: 310, 270, 549, 277 Annotation: Subtype: Link Rect: 310, 260, 549, 267 Annotation: Subtype: Link Rect: 310, 251, 352, 258 Page: Label: 284.e1 Sequence: 18 Page: Label: 284.e2 Sequence: 19 Annotations: Annotation: Subtype: Link Rect: 86, 55, 155, 64 Annotation: Subtype: Link Rect: 248, 571, 295, 578 Destination: null Annotation: Subtype: Link Rect: 248, 559, 304, 566 Destination: null Annotation: Subtype: Link Rect: 248, 547, 308, 554 Destination: null Annotation: Subtype: Link Rect: 248, 535, 311, 542 Destination: null Annotation: Subtype: Link Rect: 394, 338, 512, 345 Annotation: Subtype: Link Rect: 394, 326, 518, 333 Annotation: Subtype: Link Rect: 394, 316, 447, 323 Annotation: Subtype: Link Rect: 394, 303, 515, 311 Annotation: Subtype: Link Rect: 394, 293, 518, 301 Annotation: Subtype: Link Rect: 394, 283, 537, 291 Annotation: Subtype: Link Rect: 394, 273, 459, 281 Annotation: Subtype: Link Rect: 394, 261, 522, 269 Annotation: Subtype: Link Rect: 394, 251, 521, 259 Page: Label: 284.e3 Sequence: 20 Annotations: Annotation: Subtype: Link Rect: 419, 457, 487, 465 Destination: null Annotation: Subtype: Link Rect: 117, 446, 169, 454 Destination: null Annotation: Subtype: Link Rect: 226, 446, 288, 454 Destination: null Annotation: Subtype: Link Rect: 492, 435, 543, 444 Destination: null Annotation: Subtype: Link Rect: 53, 424, 71, 433 Destination: null Annotation: Subtype: Link Rect: 130, 314, 203, 323 Destination: null Annotation: Subtype: Link Rect: 366, 304, 466, 312 Destination: 464 Annotation: Subtype: Link Rect: 213, 84, 309, 93 Destination: null Page: Label: 284.e4 Sequence: 21 Annotations: Annotation: Subtype: Link Rect: 521, 355, 549, 363 Destination: null Annotation: Subtype: Link Rect: 59, 344, 101, 352 Destination: null Annotation: Subtype: Link Rect: 73, 81, 145, 89 Destination: null Page: Label: 284.e5 Sequence: 22 Annotations: Annotation: Subtype: Link Rect: 283, 355, 352, 363 Destination: null Annotation: Subtype: Link Rect: 258, 169, 331, 177 Destination: 707 Page: Label: 284.e6 Sequence: 23 Annotations: Annotation: Subtype: Link Rect: 382, 497, 453, 506 Destination: 707 Annotation: Subtype: Link Rect: 477, 300, 549, 309 Destination: null Annotation: Subtype: Link Rect: 59, 289, 78, 298 Destination: null Annotation: Subtype: Link Rect: 163, 190, 230, 199 Destination: 464 Annotation: Subtype: Link Rect: 236, 190, 288, 199 Destination: 464 Page: Label: 284.e7 Sequence: 24 Annotations: Annotation: Subtype: Link Rect: 106, 596, 170, 604 Destination: null Annotation: Subtype: Link Rect: 495, 519, 543, 528 Destination: null Annotation: Subtype: Link Rect: 53, 508, 95, 517 Destination: null Annotation: Subtype: Link Rect: 239, 410, 316, 418 Destination: null Annotation: Subtype: Link Rect: 320, 410, 423, 418 Destination: null Annotation: Subtype: Link Rect: 118, 223, 174, 232 Destination: null Annotation: Subtype: Link Rect: 191, 147, 248, 155 Destination: null Annotation: Subtype: Link Rect: 316, 48, 373, 56 Destination: null Page: Label: 284.e8 Sequence: 25 Annotations: Annotation: Subtype: Link Rect: 512, 607, 549, 615 Destination: null Annotation: Subtype: Link Rect: 59, 596, 78, 604 Destination: null Annotation: Subtype: Link Rect: 403, 541, 455, 550 Destination: null Page: Label: 284.e9 Sequence: 26 Checksum: 7860bc8e Type: CRC32 Checksum: 0c83960dd8f6c826c36d6183d32ad18a Type: MD5 Checksum: 0402060f3b73bfe5089da19a2915e384d84a2687 Type: SHA-1