d642c0afa9b801a674df33f696402021 254985.pdf 7bb7243f0db667bc64c0ee71b3389ffee99f7060 254985.pdf 0da277069536d1edc05e797dfaa9aab985bf9dd9145ce502cece17fb8000c223 254985.pdf Title: Ascites and resistance to immune checkpoint inhibition in dMMR/MSI-H metastatic colorectal and gastric cancers Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Wed Feb 2 05:34:26 2022 CET ModDate: Fri Apr 1 09:19:48 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 1703299 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GUSMRG+ArialMT CID TrueType Identity-H yes yes yes 296 0 GHQGBG+HelveticaNeueLTStd-BdCn Type 1C Custom yes yes yes 13 0 KPYUVY+HelveticaNeueLTStd-Bd Type 1C WinAnsi yes yes yes 12 0 AYXCLS+HelveticaNeueLTStd-Roman Type 1C Custom yes yes yes 52 0 ZZIWXU+HelveticaLTStd-BoldCond Type 1C WinAnsi yes yes yes 298 0 IKPSDC+HelveticaNeueLTStd-Cn Type 1C Custom yes yes yes 109 0 HGAMPE+HelveticaNeueLTStd-CnO Type 1C Custom yes yes yes 297 0 CJUONO+NewBaskerville-Roman Type 1C WinAnsi yes yes yes 11 0 Helvetica Type 1 WinAnsi no no no 396 0 QBUZBM+BookAntiqua-Bold TrueType WinAnsi yes yes yes 299 0 IKPSDC+HelveticaNeueLTStd-Cn Type 1C Custom yes yes yes 387 0 HGAMPE+HelveticaNeueLTStd-CnO Type 1C Custom yes yes yes 389 0 GHQGBG+HelveticaNeueLTStd-BdCn Type 1C WinAnsi yes yes yes 391 0 IFUYTC+SymbolMT CID TrueType Identity-H yes yes yes 8 0 EZRVPK+NewBaskerville-Italic Type 1C WinAnsi yes yes yes 10 0 ATTXLS+Symbol Type 1C Custom yes yes yes 9 0 IKPSDC+HelveticaNeueLTStd-Cn Type 1C Custom yes yes yes 241 0 HGAMPE+HelveticaNeueLTStd-CnO Type 1C Custom yes yes yes 245 0 GHQGBG+HelveticaNeueLTStd-BdCn Type 1C WinAnsi yes yes yes 243 0 ATTXLS+HelveticaNeueLTStd-It Type 1C Custom yes yes yes 51 0 IKPSDC+HelveticaNeueLTStd-Cn Type 1C Custom yes yes yes 55 0 HGAMPE+HelveticaNeueLTStd-CnO Type 1C Custom yes yes yes 59 0 GHQGBG+HelveticaNeueLTStd-BdCn Type 1C WinAnsi yes yes yes 62 0 IKPSDC+HelveticaNeueLTStd-Cn Type 1C Custom yes yes yes 254 0 HGAMPE+HelveticaNeueLTStd-CnO Type 1C Custom yes yes yes 250 0 GHQGBG+HelveticaNeueLTStd-BdCn Type 1C WinAnsi yes yes yes 255 0 WIQZHA+ArialUnicodeMS CID TrueType Identity-H yes yes yes 139 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-04-02 02:23:25 CEST RepresentationInformation: 254985.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-04-01 09:20:28 CEST Size: 1703299 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 479 FreeObjects: 23 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: Ascites and resistance to immune checkpoint inhibition in dMMR/MSI-­H metastatic colorectal and gastric cancers Children: Item: Title: Abstract Item: Title: Introduction Item: Title: Methods Children: Item: Title: Patients’ population Item: Title: Statistical analyses Item: Title: Results Children: Item: Title: Patients’ characteristics Item: Title: Survival outcomes according to the presence of peritoneal involvement and ascites Item: Title: Discussion Item: Title: References Info: Title: Ascites and resistance to immune checkpoint inhibition in dMMR/MSI-H metastatic colorectal and gastric cancers Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Wed Feb 02 06:04:26 CET 2022 ModDate: Fri Apr 01 02:19:48 CEST 2022 ID: 0x8b4a332b7ac45d4fa94c9c432f3439f5, 0xd3c3f622d21db2110a00130910000000 Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2143 ImageHeight: 2052 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2143 ImageHeight: 1200 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: GUSMRG+ArialMT Encoding: Identity-H ToUnicode: true Font: BaseFont: IFUYTC+SymbolMT Encoding: Identity-H ToUnicode: true Font: BaseFont: WIQZHA+ArialUnicodeMS Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: ATTXLS+HelveticaNeueLTStd-It FontSubset: true FirstChar: 31 LastChar: 121 FontDescriptor: FontName: ATTXLS+HelveticaNeueLTStd-It Flags: Nonsymbolic, Italic FontBBox: -166, -214, 1106, 957 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: AYXCLS+HelveticaNeueLTStd-Roman FontSubset: true FirstChar: 28 LastChar: 252 FontDescriptor: FontName: AYXCLS+HelveticaNeueLTStd-Roman Flags: Nonsymbolic FontBBox: -166, -214, 1076, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: HGAMPE+HelveticaNeueLTStd-CnO FontSubset: true FirstChar: 31 LastChar: 121 FontDescriptor: FontName: HGAMPE+HelveticaNeueLTStd-CnO Flags: Nonsymbolic, Italic FontBBox: -171, -272, 1068, 932 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: ATTXLS+Symbol FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: ATTXLS+Symbol Flags: Symbolic FontBBox: -180, -293, 1090, 1010 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: ZZIWXU+HelveticaLTStd-BoldCond FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: ZZIWXU+HelveticaLTStd-BoldCond Flags: Nonsymbolic FontBBox: -169, -250, 1091, 991 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: EZRVPK+NewBaskerville-Italic FontSubset: true FirstChar: 65 LastChar: 83 FontDescriptor: FontName: EZRVPK+NewBaskerville-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -138, -274, 1347, 906 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: CJUONO+NewBaskerville-Roman FontSubset: true FirstChar: 32 LastChar: 177 FontDescriptor: FontName: CJUONO+NewBaskerville-Roman Flags: Serif, Nonsymbolic FontBBox: -205, -272, 1207, 906 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: Helvetica Encoding: WinAnsiEncoding Font: BaseFont: KPYUVY+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 32 LastChar: 118 FontDescriptor: FontName: KPYUVY+HelveticaNeueLTStd-Bd Flags: Nonsymbolic FontBBox: -166, -218, 1078, 975 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: IKPSDC+HelveticaNeueLTStd-Cn FontSubset: true FirstChar: 29 LastChar: 244 FontDescriptor: FontName: IKPSDC+HelveticaNeueLTStd-Cn Flags: Nonsymbolic FontBBox: -164, -212, 1000, 932 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: GHQGBG+HelveticaNeueLTStd-BdCn FontSubset: true FirstChar: 31 LastChar: 146 FontDescriptor: FontName: GHQGBG+HelveticaNeueLTStd-BdCn Flags: Nonsymbolic FontBBox: -164, -224, 1066, 961 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true TrueType: Font: BaseFont: QBUZBM+BookAntiqua-Bold FontSubset: true FirstChar: 32 LastChar: 117 FontDescriptor: FontName: QBUZBM+BookAntiqua-Bold Flags: Serif, Nonsymbolic FontBBox: -134, -337, 1193, 1021 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: GUSMRG+ArialMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: GUSMRG+ArialMT Flags: Symbolic FontBBox: -665, -325, 2000, 1006 FontFile2: true Font: BaseFont: WIQZHA+ArialUnicodeMS CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: WIQZHA+ArialUnicodeMS Flags: Symbolic FontBBox: -1011, -330, 2260, 1078 FontFile2: true Font: BaseFont: IFUYTC+SymbolMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: IFUYTC+SymbolMT Flags: Symbolic FontBBox: 0, -220, 1113, 1005 FontFile2: true XMP: doi:jitc-2021-004001 application/pdf 2022-02-02T10:04:26+05:30 2022-04-01T00:19:48-07:00 2022-04-01T00:19:48-07:00 Adobe InDesign 15.1 (Windows) uuid:22f6c4e6-1dd2-11b2-0a00-d3001840b6ff xmp.did:B2C59A163194E611BD009A7CB80B8EC7 xmp.id:ff49987f-462a-7e4f-8cef-a93f3c4f16d5 proof:pdf xmp.iid:5142c1cd-0b88-f24d-bd86-1c9a829e6018 xmp.did:1a9f061a-e91f-254c-a96d-178f4fbdef1d xmp.did:B2C59A163194E611BD009A7CB80B8EC7 default converted from application/x-indesign to application/pdf Adobe InDesign 15.1 (Windows) / 2022-02-02T10:04:26+05:30 b1534c39-8c98-4f60-adba-46b238a932a8 Adobe PDF Library 15.0 False Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 38, 34, 63, 18 Annotation: Subtype: Link Rect: 222, 648, 231, 635 Annotation: Subtype: Link Rect: 323, 648, 332, 635 Annotation: Subtype: Link Rect: 414, 648, 423, 635 Annotation: Subtype: Link Rect: 388, 635, 397, 622 Annotation: Subtype: Link Rect: 424, 557, 433, 544 Annotation: Subtype: Link Rect: 247, 544, 256, 531 Annotation: Subtype: Link Rect: 62, 364, 121, 354 Annotation: Subtype: Link Rect: 40, 354, 110, 344 Annotation: Subtype: Link Rect: 38, 207, 134, 184 Annotation: Subtype: Link Rect: 551, 303, 554, 291 ActionDest: 138 Annotation: Subtype: Link Rect: 480, 255, 491, 243 ActionDest: 138 Annotation: Subtype: Link Rect: 443, 195, 452, 183 ActionDest: 138 Annotation: Subtype: Link Rect: 458, 183, 461, 171 ActionDest: 138 Annotation: Subtype: Link Rect: 417, 147, 427, 135 ActionDest: 138 Annotation: Subtype: Link Rect: 443, 99, 450, 87 ActionDest: 138 Annotation: Subtype: Link Rect: 468, 87, 475, 75 ActionDest: 138 Annotation: Subtype: Link Rect: 576, 247, 587, 321 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 105, 735, 123, 723 ActionDest: 138 Annotation: Subtype: Link Rect: 259, 735, 266, 723 ActionDest: 138 Annotation: Subtype: Link Rect: 119, 711, 126, 699 ActionDest: 138 Annotation: Subtype: Link Rect: 164, 627, 181, 615 ActionDest: 138 Annotation: Subtype: Link Rect: 218, 591, 225, 579 ActionDest: 199 Annotation: Subtype: Link Rect: 60, 303, 67, 291 ActionDest: 199 Annotation: Subtype: Link Rect: 398, 195, 518, 183 Annotation: Subtype: Link Rect: 520, 159, 552, 147 ActionDest: 46 Annotation: Subtype: Link Rect: 378, 87, 507, 75 Annotation: Subtype: Link Rect: 576, 247, 587, 321 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 576, 247, 587, 321 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 156, 516, 281, 504 Annotation: Subtype: Link Rect: 53, 468, 84, 456 ActionDest: 87 Annotation: Subtype: Link Rect: 116, 339, 260, 327 Annotation: Subtype: Link Rect: 125, 303, 175, 291 ActionDest: 90 Annotation: Subtype: Link Rect: 139, 207, 169, 195 ActionDest: 98 Annotation: Subtype: Link Rect: 403, 552, 453, 540 ActionDest: 90 Annotation: Subtype: Link Rect: 406, 516, 533, 504 Annotation: Subtype: Link Rect: 384, 492, 527, 480 Annotation: Subtype: Link Rect: 424, 456, 474, 444 ActionDest: 100 Annotation: Subtype: Link Rect: 428, 360, 459, 348 ActionDest: 104 Annotation: Subtype: Link Rect: 576, 247, 587, 321 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 576, 247, 587, 321 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 490, 135, 497, 123 ActionDest: 199 Annotation: Subtype: Link Rect: 576, 247, 587, 321 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 576, 247, 587, 321 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 576, 247, 587, 321 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 576, 247, 587, 321 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 576, 247, 587, 321 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 108, 711, 111, 699 ActionDest: 138 Annotation: Subtype: Link Rect: 150, 675, 165, 663 ActionDest: 199 Annotation: Subtype: Link Rect: 252, 639, 288, 627 ActionDest: 138 Annotation: Subtype: Link Rect: 121, 543, 138, 531 ActionDest: 138 Annotation: Subtype: Link Rect: 155, 495, 162, 483 ActionDest: 199 Annotation: Subtype: Link Rect: 265, 483, 272, 471 ActionDest: 199 Annotation: Subtype: Link Rect: 160, 327, 167, 315 ActionDest: 199 Annotation: Subtype: Link Rect: 73, 303, 89, 291 ActionDest: 199 Annotation: Subtype: Link Rect: 223, 255, 230, 243 ActionDest: 199 Annotation: Subtype: Link Rect: 89, 195, 92, 183 ActionDest: 138 Annotation: Subtype: Link Rect: 368, 591, 393, 579 ActionDest: 138 Annotation: Subtype: Link Rect: 492, 507, 508, 495 ActionDest: 199 Annotation: Subtype: Link Rect: 536, 375, 554, 363 ActionDest: 138 Annotation: Subtype: Link Rect: 576, 247, 587, 321 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 378, 666, 520, 656 Annotation: Subtype: Link Rect: 350, 625, 466, 616 Annotation: Subtype: Link Rect: 351, 615, 467, 606 Annotation: Subtype: Link Rect: 346, 606, 462, 596 Annotation: Subtype: Link Rect: 346, 596, 463, 587 Annotation: Subtype: Link Rect: 348, 586, 465, 577 Annotation: Subtype: Link Rect: 365, 577, 481, 568 Annotation: Subtype: Link Rect: 500, 529, 526, 520 Annotation: Subtype: Link Rect: 469, 503, 515, 494 Annotation: Subtype: Link Rect: 519, 461, 541, 452 Annotation: Subtype: Link Rect: 524, 427, 548, 418 Annotation: Subtype: Link Rect: 322, 418, 341, 409 Annotation: Subtype: Link Rect: 415, 384, 459, 375 Annotation: Subtype: Link Rect: 376, 350, 417, 341 Annotation: Subtype: Link Rect: 524, 325, 539, 316 Annotation: Subtype: Link Rect: 526, 282, 548, 273 Annotation: Subtype: Link Rect: 322, 274, 342, 265 Annotation: Subtype: Link Rect: 425, 240, 448, 231 Annotation: Subtype: Link Rect: 349, 206, 392, 197 Annotation: Subtype: Link Rect: 383, 172, 425, 163 Annotation: Subtype: Link Rect: 421, 146, 456, 137 Annotation: Subtype: Link Rect: 373, 121, 422, 112 Annotation: Subtype: Link Rect: 496, 95, 539, 86 Annotation: Subtype: Link Rect: 545, 70, 551, 61 Annotation: Subtype: Link Rect: 322, 61, 389, 52 Annotation: Subtype: Link Rect: 576, 247, 587, 321 Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 225, 730, 256, 721 Annotation: Subtype: Link Rect: 239, 704, 278, 695 Annotation: Subtype: Link Rect: 249, 662, 284, 653 Annotation: Subtype: Link Rect: 166, 636, 233, 627 Annotation: Subtype: Link Rect: 141, 611, 177, 602 Annotation: Subtype: Link Rect: 172, 585, 204, 576 Annotation: Subtype: Link Rect: 146, 560, 183, 551 Annotation: Subtype: Link Rect: 210, 543, 249, 534 Annotation: Subtype: Link Rect: 83, 500, 165, 491 Annotation: Subtype: Link Rect: 450, 730, 493, 721 Annotation: Subtype: Link Rect: 428, 696, 464, 687 Annotation: Subtype: Link Rect: 396, 662, 469, 653 Annotation: Subtype: Link Rect: 517, 636, 523, 627 Annotation: Subtype: Link Rect: 322, 628, 389, 619 Annotation: Subtype: Link Rect: 476, 611, 516, 602 Annotation: Subtype: Link Rect: 476, 585, 536, 576 Annotation: Subtype: Link Rect: 514, 551, 527, 542 Annotation: Subtype: Link Rect: 322, 500, 365, 491 Annotation: Subtype: Link Rect: 576, 247, 587, 321 Checksum: 99c79576 Type: CRC32 Checksum: d642c0afa9b801a674df33f696402021 Type: MD5 Checksum: 7bb7243f0db667bc64c0ee71b3389ffee99f7060 Type: SHA-1