e019b6aa06e1dabf68f6b3aaad8aaa80 genes_a2022m1v13a280.pdf 8f9616eaef7f7cde7a7c70a03cfe598d77a5a7ec genes_a2022m1v13a280.pdf 3c8ed8620236fca882445a1d636f567a9d6ee353409a1296d1e7a7d5f366eb35 genes_a2022m1v13a280.pdf Title: Behavior Problems and Social Competence in Fragile X Syndrome: A Systematic Review Subject: Fragile X syndrome (FXS) causes intellectual disability and is the known leading cause of autism. Common problems in FXS include behavior and social problems. Along with syndromic characteristics and autism comorbidity, environmental factors might influence these difficulties. This systematic review focuses on the last 20 years of studies concerning behavior and social problems in FXS, considering environmental and personal variables that might influence both problems. Three databases were reviewed, leading to fifty-one studies meeting the inclusion criteria. Attention deficit hyperactivity disorder (ADHD) problems remain the greatest behavior problems, with behavioral problems and social competence being stable during the 20 years. Some developmental trajectories might have changed due to higher methodological control, such as aggressive behavior and attention problems. The socialization trajectory from childhood to adolescence remains unclear. Comorbidity with autism in individuals with FXS increased behavior problems and worsened social competence profiles. At the same time, comparisons between individuals with comorbid FXS and autism and individuals with autism might help define the comorbid phenotype. Environmental factors and parental characteristics influenced behavior problems and social competence. Higher methodological control is needed in studies including autism symptomatology and parental characteristics. More studies comparing autism in FXS with idiopathic autism are needed to discern differences between conditions. Keywords: behavior problems; social competence; fragile X syndrome; autism; anxiety; aggressive; socialization; attention; withdrawn Author: Olga Cregenzán-Royo, Carme Brun-Gasca and Albert Fornieles-Deu Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Mon Feb 7 10:13:23 2022 CET ModDate: Mon Feb 7 10:27:56 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 32 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1144952 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LJHJSH+VnURWPalladioL Type 1 Custom yes yes no 10 0 YMJCDS+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 VIHFNY+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 BLHJWB+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 AIQCCL+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 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1.12.1 (2019-04-17) LastModified: 2022-03-07 16:38:23 CET Size: 1144952 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 1000 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Comorbidities Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Behavior Problems Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Social Skills and Social Competence Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Environmental Factors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Current Study Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Children: Item: Title: Researched Profile in Behavior Problems Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Researched Profile in Social Competence Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Differences in Behavior Problems and Social Competence, Comparing Individuals with Fragile X Syndrome with Individuals with TD and Individuals with Other IDs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Children: Item: Title: Comparison of Behavior Problems between Individuals with FXS and Individuals with TD Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Comparisons of Behavior Problems between Individuals with FXS and Individuals with Other IDs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Comparisons of Social Competence between Individuals with FXS and Individuals with TD Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: Comparisons of Social Competence between Individuals with FXS and Individuals with Other IDs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: Differences in Behavior Problems and Social Competence between Individuals with FXS Only and Those with Comorbid ASD Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Children: Item: Title: Differences in Behavior Problems Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Item: Title: Differences in Social Competence Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Item: Title: Environmental Factors Affecting Behavior and Social Problems in FXS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Children: Item: Title: Environmental Factors Affecting Behavior Problems Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: Environmental Factors Affecting Social Competence Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Appendix A Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Info: Title: Behavior Problems and Social Competence in Fragile X Syndrome: A Systematic Review Author: Olga Cregenzán-Royo, Carme Brun-Gasca and Albert Fornieles-Deu Subject: Fragile X syndrome (FXS) causes intellectual disability and is the known leading cause of autism. Common problems in FXS include behavior and social problems. Along with syndromic characteristics and autism comorbidity, environmental factors might influence these difficulties. This systematic review focuses on the last 20 years of studies concerning behavior and social problems in FXS, considering environmental and personal variables that might influence both problems. Three databases were reviewed, leading to fifty-one studies meeting the inclusion criteria. Attention deficit hyperactivity disorder (ADHD) problems remain the greatest behavior problems, with behavioral problems and social competence being stable during the 20 years. Some developmental trajectories might have changed due to higher methodological control, such as aggressive behavior and attention problems. The socialization trajectory from childhood to adolescence remains unclear. Comorbidity with autism in individuals with FXS increased behavior problems and worsened social competence profiles. At the same time, comparisons between individuals with comorbid FXS and autism and individuals with autism might help define the comorbid phenotype. Environmental factors and parental characteristics influenced behavior problems and social competence. Higher methodological control is needed in studies including autism symptomatology and parental characteristics. More studies comparing autism in FXS with idiopathic autism are needed to discern differences between conditions. Keywords: behavior problems; social competence; fragile X syndrome; autism; anxiety; aggressive; socialization; attention; withdrawn Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Mon Feb 07 10:13:23 CET 2022 ModDate: Mon Feb 07 10:27:56 CET 2022 ID: 0xf4424c1cb03c388683ba050ebde1bb08, 0xf4424c1cb03c388683ba050ebde1bb08 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: VIHFNY+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 246 FontDescriptor: FontName: VIHFNY+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: BLHJWB+URWPalladioL-Ital FontSubset: true FirstChar: 2 LastChar: 151 FontDescriptor: FontName: BLHJWB+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: UJUUJI+PazoMath FontSubset: true FirstChar: 160 LastChar: 160 FontDescriptor: FontName: UJUUJI+PazoMath Flags: 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