4327c7e9b5482a93bb2618939a2e44f1 nutrients_a2022v14n4p851.pdf 821545654fe8f3ef6bd666e7fb60ded20d9d2405 nutrients_a2022v14n4p851.pdf 911cbf778cb447ace5ead578e2f78da16b96f6ea9d0cbf6ae67127e6b99b9425 nutrients_a2022v14n4p851.pdf Title: Lipid Metabolism and Epigenetics Crosstalk in Prostate Cancer Subject: Prostate cancer (PCa) is the most commonly diagnosed malignant neoplasm in men in the Western world. Localized low-risk PCa has an excellent prognosis thanks to effective local treatments; however, despite the incorporation of new therapeutic strategies, metastatic PCa remains incurable mainly due to disease heterogeneity and the development of resistance to therapy. The mechanisms underlying PCa progression and therapy resistance are multiple and include metabolic reprogramming, especially in relation to lipid metabolism, as well as epigenetic remodelling, both of which enable cancer cells to adapt to dynamic changes in the tumour. Interestingly, metabolism and epigenetics are interconnected. Metabolism can regulate epigenetics through the direct influence of metabolites on epigenetic processes, while epigenetics can control metabolism by directly or indirectly regulating the expression of metabolic genes. Moreover, epidemiological studies suggest an association between a high-fat diet, which can alter the availability of metabolites, and PCa progression. Here, we review the alterations of lipid metabolism and epigenetics in PCa, before focusing on the mechanisms that connect them. We also discuss the influence of diet in this scenario. This information may help to identify prognostic and predictive biomarkers as well as targetable vulnerabilities. Keywords: prostate cancer; lipid metabolism; epigenetics; diet; fatty acid; cholesterol; DNA methylation; histone modifications; predictive biomarkers; therapeutic vulnerabilities Author: Juan C. Pardo, Vicenç Ruiz de Porras, Joan Gil, Albert Font, Manel Puig-Domingo and Mireia Jordà Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Feb 18 06:55:33 2022 CET ModDate: Fri Feb 18 07:01:25 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 29 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1418256 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- BCDWAK+VnURWPalladioL Type 1 Custom yes yes no 10 0 HKKCDU+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 WOLOAL+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 RIVHWD+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 GYREAE+CMSY10 Type 1 Builtin yes yes no 28 0 WNWTFR+VnURWPalladioL-Bold Type 1 Custom yes yes no 32 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 40 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 44 0 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UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: Lipid Metabolism Alterations: A Hallmark of PCa Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Children: Item: Title: Alterations of FA Metabolism in PCa Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Children: Item: Title: De Novo FA Synthesis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: FA Uptake Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: FA Oxidation (FAO) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: FA Storage and Release Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Alterations of Cholesterol Metabolism in PCa Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Alterations of Phospholipid Metabolism in PCa Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Targeting Metabolic Vulnerabilities in PCa Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: The Epigenome of PCa Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Children: Item: Title: Alterations of DNA Methylation in PCa Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Alterations of Histone Modifications in PCa Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Influence of Diet on PCa, Lipid Metabolism and the Epigenome Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: Interaction between Lipid Metabolism and Epigenetics in PCa Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Children: Item: Title: Impact of Lipid Metabolism on Epigenetics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Children: Item: Title: FAs, Acetyl-CoA, and Histone Acetylation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Item: Title: SCFAs, Non-Acetyl Acyl-CoAs, and Histone Acylation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Item: Title: SCFAs and Histone Deacetylases Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: FAs and Sirtuins Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: Phospholipids, SAM, and Histone Methylation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Nuclear Lipogenic Enzymes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Impact of Epigenetics on Lipid Metabolism Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Concluding Remarks and Future Directions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Info: Title: Lipid Metabolism and Epigenetics Crosstalk in Prostate Cancer Author: Juan C. Pardo, Vicenç Ruiz de Porras, Joan Gil, Albert Font, Manel Puig-Domingo and Mireia Jordà Subject: Prostate cancer (PCa) is the most commonly diagnosed malignant neoplasm in men in the Western world. Localized low-risk PCa has an excellent prognosis thanks to effective local treatments; however, despite the incorporation of new therapeutic strategies, metastatic PCa remains incurable mainly due to disease heterogeneity and the development of resistance to therapy. The mechanisms underlying PCa progression and therapy resistance are multiple and include metabolic reprogramming, especially in relation to lipid metabolism, as well as epigenetic remodelling, both of which enable cancer cells to adapt to dynamic changes in the tumour. Interestingly, metabolism and epigenetics are interconnected. Metabolism can regulate epigenetics through the direct influence of metabolites on epigenetic processes, while epigenetics can control metabolism by directly or indirectly regulating the expression of metabolic genes. Moreover, epidemiological studies suggest an association between a high-fat diet, which can alter the availability of metabolites, and PCa progression. Here, we review the alterations of lipid metabolism and epigenetics in PCa, before focusing on the mechanisms that connect them. We also discuss the influence of diet in this scenario. This information may help to identify prognostic and predictive biomarkers as well as targetable vulnerabilities. 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