1cc51e85809d83bb60ba3bac1c0152fa jouclimed_a2022v11n5p1431.pdf e0af931a4c8e950d83ec3aa4e4b30b9af639b356 jouclimed_a2022v11n5p1431.pdf 5fe63af89436a3e12213848ac66d97b15a685d00dfb1fa2688f61fc6768f2963 jouclimed_a2022v11n5p1431.pdf Title: The GenoDiabMar Registry: A Collaborative Research Platform of Type 2 Diabetes Patients Subject: The GenoDiabMar registry is a prospective study that aims to provide data on demographic, biochemical, and clinical changes in type 2 diabetic (T2D) patients attending real medical outpatient consultations. This registry is also used to find new biomarkers related to the micro- and macrovascular complications of T2D, with a particular focus on diabetic nephropathy. With this purpose, longitudinal serum and urine samples, DNA banking, and data on 227 metabolomics profiles, 77 immunoglobulin G glycomics traits, and other emerging biomarkers were recorded in this cohort. In this study, we show a detailed longitudinal description of the clinical and analytical parameters of this registry, with a special focus on the progress of renal function and cardiovascular events. The main objective is to analyze whether there are differential risk factors for renal function deterioration between sexes, as well as to analyze cardiovascular events and mortality in this population. In total, 650 patients with a median age of 69 (14) with different grades of chronic kidney disease—G1–G2 (eGFR > 90–60 mL/min/1.73 m2) 50.3%, G3 (eGFR; 59–30 mL/min/1.73 m2) 31.4%, G4 (eGFR; 29–15 mL/min/1.73 m2) 10.8%, and G5 (eGFR < 15 mL/min/1.73 m2) 7.5%—were followed up for 4.7 (0.65) years. Regardless of albuminuria, women lost 0.93 (0.40–1.46) fewer glomerular filtration units per year than men. A total of 17% of the participants experienced rapid deterioration of renal function, 75.2% of whom were men, with differential risk factors between sexes—severe macroalbuminuria > 300 mg/g for men OR [IQ] 2.40 [1.29:4.44] and concomitant peripheral vascular disease 3.32 [1.10:9.57] for women. Overall mortality of 23% was detected (38% of which was due to cardiovascular etiology). We showed that kidney function declined faster in men, with different risk factors compared to women. Patients with T2D and kidney involvement have very high mortality and an important cardiovascular burden. This cohort is proposed as a great tool for scientific collaboration for studies, whether they are focused on T2D, or whether they are interested in comparing differential markers between diabetic and non-diabetic populations. Keywords: type 2 diabetes; real-world patient registry; epidemiology; diabetes complication; renal function; sex differences; multiomic collaborative platform Author: Adriana Sierra, Sol Otero, Eva Rodríguez, Anna Faura, María Vera, Marta Riera, Vanesa Palau, Xavier Durán, Anna Costa-Garrido, Laia Sans, Eva Márquez, Vladimir Poposki, Josep Franch-Nadal, Xavier Mundet, Anna Oliveras, Marta Crespo, Julio Pascual and Clara Barrios Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Sat Mar 5 10:36:09 2022 CET ModDate: Tue Mar 8 08:42:43 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1278603 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DUFXDP+VnURWPalladioL Type 1 Custom yes yes no 10 0 EOUHQE+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 RCEHTP+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 FGMUUD+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 SSNIUI+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 36 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 40 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 44 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 56 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 59 0 WABLSD+SFRM1000 Type 1 Custom yes yes no 84 0 FNTSBS+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 94 0 FNTSBS+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 100 0 FNTSBS+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 106 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes no 118 0 EILUJF+CMSY10 Type 1 Builtin yes yes no 125 0 FNTSBS+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 134 0 FNTSBS+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 140 0 FNTSBS+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 146 0 FNTSBS+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 160 0 FNTSBS+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 166 0 FNTSBS+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 172 0 FNTSBS+PalatinoLinotype-BoldItalic CID TrueType Identity-H yes yes yes 178 0 FNTSBS+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 190 0 FNTSBS+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 196 0 FNTSBS+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 202 0 FNTSBS+Calibri CID TrueType Identity-H yes yes yes 208 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-07-12 02:32:40 CEST RepresentationInformation: jouclimed_a2022v11n5p1431.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-03-21 11:44:17 CET Size: 1278603 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 368 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Study Design Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Data Registry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Laboratory Data and Sample Management Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Children: Item: Title: General Characteristics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Patient Follow-Up: Renal Deterioration by Sex and Mortality Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Info: Title: The GenoDiabMar Registry: A Collaborative Research Platform of Type 2 Diabetes Patients Author: Adriana Sierra, Sol Otero, Eva Rodríguez, Anna Faura, María Vera, Marta Riera, Vanesa Palau, Xavier Durán, Anna Costa-Garrido, Laia Sans, Eva Márquez, Vladimir Poposki, Josep Franch-Nadal, Xavier Mundet, Anna Oliveras, Marta Crespo, Julio Pascual and Clara Barrios Subject: The GenoDiabMar registry is a prospective study that aims to provide data on demographic, biochemical, and clinical changes in type 2 diabetic (T2D) patients attending real medical outpatient consultations. This registry is also used to find new biomarkers related to the micro- and macrovascular complications of T2D, with a particular focus on diabetic nephropathy. With this purpose, longitudinal serum and urine samples, DNA banking, and data on 227 metabolomics profiles, 77 immunoglobulin G glycomics traits, and other emerging biomarkers were recorded in this cohort. In this study, we show a detailed longitudinal description of the clinical and analytical parameters of this registry, with a special focus on the progress of renal function and cardiovascular events. The main objective is to analyze whether there are differential risk factors for renal function deterioration between sexes, as well as to analyze cardiovascular events and mortality in this population. In total, 650 patients with a median age of 69 (14) with different grades of chronic kidney disease G1 G2 (eGFR > 90 60 mL/min/1.73 m2) 50.3%, G3 (eGFR; 59 30 mL/min/1.73 m2) 31.4%, G4 (eGFR; 29 15 mL/min/1.73 m2) 10.8%, and G5 (eGFR < 15 mL/min/1.73 m2) 7.5% were followed up for 4.7 (0.65) years. Regardless of albuminuria, women lost 0.93 (0.40 1.46) fewer glomerular filtration units per year than men. A total of 17% of the participants experienced rapid deterioration of renal function, 75.2% of whom were men, with differential risk factors between sexes severe macroalbuminuria > 300 mg/g for men OR [IQ] 2.40 [1.29:4.44] and concomitant peripheral vascular disease 3.32 [1.10:9.57] for women. Overall mortality of 23% was detected (38% of which was due to cardiovascular etiology). We showed that kidney function declined faster in men, with different risk factors compared to women. Patients with T2D and kidney involvement have very high mortality and an important cardiovascular burden. This cohort is proposed as a great tool for scientific collaboration for studies, whether they are focused on T2D, or whether they are interested in comparing differential markers between diabetic and non-diabetic populations. 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