37360d069897785f80ac1f4972f67b30 jouclimed_a2022v11n7p1831.pdf d2d4811caba5073ae6a804f2093ccb423084b624 jouclimed_a2022v11n7p1831.pdf 7ac9ad843231aefb21d4190b12e879607c11826b494f5f7b587292e101776e93 jouclimed_a2022v11n7p1831.pdf Title: One Year of Recombinant Human Growth Hormone Treatment in Adults with Prader–Willi Syndrome Improves Body Composition, Motor Skills and Brain Functional Activity in the Cerebellum Subject: We compared body composition, biochemical parameters, motor function, and brain neural activation in 27 adults with Prader–Willi syndrome and growth-hormone deficiency versus age-and sex-matched controls and baseline versus posttreatment values of these parameters after one year of recombinant human growth hormone (rhGH) treatment. To study body composition, we analyzed percentage of fat mass, percentage of lean mass, and muscle-mass surrogate variables from dual X-ray absorptiometry. Biochemical parameters analyzed included IGF-I, glucose metabolism, and myokines (myostatin, irisin, and IL6). To explore muscle function, we used dynamometer-measured handgrip strength, the Timed Up and Go (TUG) test, and the Berg Balance Scale (BBS). To study brain activation, we acquired functional magnetic resonance images during three motor tasks of varying complexity. After one year of treatment, we observed an increase in lean mass and its surrogates, a decrease in fat mass, improvements in TUG test and BBS scores, and increased neural activation in certain cerebellar areas. The treatment did not significantly worsen glucose metabolism, and no side-effects were reported. Our findings support the benefits of rhGH treatment in adults with Prader–Willi syndrome and growth-hormone deficiency on body composition and suggest that it may also improve balance and brain neural activation. Keywords: Prader–Willi syndrome; growth hormone; hypotonia; motor function; fMRI; myokines Author: Laia Casamitjana, Laura Blanco-Hinojo, Olga Giménez-Palop, Jesús Pujol, Gerard Martínez-Vilavella, Susanna Esteba-Castillo, Rocío Pareja, Valentín Freijo, Laura Vigil, Joan Deus and Assumpta Caixàs Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Sat Mar 26 11:39:21 2022 CET ModDate: Sat Mar 26 11:43:35 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1058689 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- APSDON+VnURWPalladioL Type 1 Custom yes yes no 10 0 DRINBN+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 ZXULKL+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 IHSJWR+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 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Polysomnography Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Statistical Analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Children: Item: Title: Comparison of Baseline Measurements in the PWS and Control Groups Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Comparison between Parameters Measured at Baseline and 12 Months after the Initiation of rhGH Treatment in the PWS Group Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Correlations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Children: Item: Title: Body Composition Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Item: Title: Motor Performance Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Item: Title: fMRI Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Item: Title: Myokines Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Info: Title: One Year of Recombinant Human Growth Hormone Treatment in Adults with Prader Willi Syndrome Improves Body Composition, Motor Skills and Brain Functional Activity in the Cerebellum Author: Laia Casamitjana, Laura Blanco-Hinojo, Olga Giménez-Palop, Jesús Pujol, Gerard Martínez-Vilavella, Susanna Esteba-Castillo, Rocío Pareja, Valentín Freijo, Laura Vigil, Joan Deus and Assumpta Caixàs Subject: We compared body composition, biochemical parameters, motor function, and brain neural activation in 27 adults with Prader Willi syndrome and growth-hormone deficiency versus age-and sex-matched controls and baseline versus posttreatment values of these parameters after one year of recombinant human growth hormone (rhGH) treatment. To study body composition, we analyzed percentage of fat mass, percentage of lean mass, and muscle-mass surrogate variables from dual X-ray absorptiometry. Biochemical parameters analyzed included IGF-I, glucose metabolism, and myokines (myostatin, irisin, and IL6). To explore muscle function, we used dynamometer-measured handgrip strength, the Timed Up and Go (TUG) test, and the Berg Balance Scale (BBS). To study brain activation, we acquired functional magnetic resonance images during three motor tasks of varying complexity. After one year of treatment, we observed an increase in lean mass and its surrogates, a decrease in fat mass, improvements in TUG test and BBS scores, and increased neural activation in certain cerebellar areas. The treatment did not significantly worsen glucose metabolism, and no side-effects were reported. Our findings support the benefits of rhGH treatment in adults with Prader Willi syndrome and growth-hormone deficiency on body composition and suggest that it may also improve balance and brain neural activation. 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