54da6f75f4581f9ba0f225bb7cc27bc3 THE_a2022n184p110.pdf e8d118904193e05c498f2889817a911b97f7e504 THE_a2022n184p110.pdf e58933270c76b9c82043504b281f154ee88e6d46140a3cad657a5f29a29d3214 THE_a2022n184p110.pdf Title: Impact of equilibration duration combined with temperature on the outcome of bovine oocyte vitrification Subject: Theriogenology, 184 (2022) 110-123. doi:10.1016/j.theriogenology.2022.02.024 Author: Tania García-Martínez Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Sat Apr 9 11:20:49 2022 CEST ModDate: Sat Apr 9 11:21:37 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 1854366 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GBCDPF+AdvOT863180fb Type 1C WinAnsi yes yes no 1085 0 GBCDPG+AdvOT863180fb+fb Type 1C Custom yes yes yes 1090 0 GBCDPH+AdvP4C4E59 Type 1C Custom yes yes yes 1095 0 GBCDPI+AdvTT5843c571 Type 1C WinAnsi yes yes no 1098 0 GBCDPJ+AdvOTb92eb7df.I Type 1C WinAnsi yes yes no 1100 0 GBCDPK+AdvOTc4d0b532 Type 1C WinAnsi yes yes no 1102 0 GBCDPL+AdvP4C4E74 Type 1C Custom yes yes yes 1108 0 GBCEAM+AdvOTb0c9bf5d Type 1C WinAnsi yes yes no 1110 0 GBCEAN+AdvOTb83ee1dd.B Type 1C WinAnsi yes yes no 1112 0 GBCEDN+AdvPSA35D Type 1C WinAnsi yes yes no 1120 0 GBCEEN+AdvPS44A44B Type 1C WinAnsi yes yes no 1118 0 GBCEFO+AdvP3F4C13 Type 1C WinAnsi yes yes no 743 0 GBCEGO+AdvOTb92eb7df.I+fb Type 1C Custom yes yes yes 751 0 GBCEGP+AdvP4721B4 Type 1C WinAnsi yes yes no 747 0 GBCEIA+AdvOTb0c9bf5d+21 Type 1C WinAnsi yes yes no 757 0 GBCIMH+AdvOTb83ee1dd.B+fb Type 1C Custom yes yes yes 759 0 GBCLFI+AdvOT404f8e91.BI Type 1C WinAnsi yes yes no 765 0 GBCLFJ+AdvOTb0c9bf5d+22 Type 1C Custom yes yes yes 768 0 GBDFOJ+AdvOT863180fb+20 Type 1C WinAnsi yes yes no 781 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-05-06 02:23:56 CEST RepresentationInformation: THE_a2022n184p110.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-05-05 12:20:34 CEST Size: 1854366 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: 2. Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: 2.1. Chemicals and suppliers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: 2.2. Oocyte collection and in vitro maturation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: 2.3. Modeling the membrane permeability of bovine MII oocytes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Children: Item: Title: 2.3.1. Measurement of oocyte volumetric changes following CPA exposure at 25 °C and 38.5 °C Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: 2.3.2. Membrane permeability parameters Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: 2.3.3. Prediction of cell volume changes during exposure of bovine oocytes to the equilibration solution at 25 °C and 38.5 °C Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: 2.4. In vitro osmotic behavior following ES exposure at 25°C and 38.5°C Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: 2.5. Oocyte vitrification and warming Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: 2.6. In vitro fertilization and embryo culture Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: 2.7. Spindle configuration Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: 2.8. TUNEL detection of fragmented oocyte DNA Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: 2.9. Differential staining of blastocysts and DNA fragmentation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: 2.10. Experimental design Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: 2.11. Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: 3. Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Children: Item: Title: 3.1. Modeling membrane permeability of bovine MII oocytes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Children: Item: Title: 3.1.1. Membrane permeability parameters Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: 3.1.2. In silico versus in vitro results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: 3.2. Spindle configurations observed in IVM bovine oocytes vitrified/warmed in the 25°C or 38.5°C equilibration protocols Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: 3.3. Percentages of TUNEL-positive oocytes observed in IVM bovine oocytes vitrified/warmed in the 25°C or 38.5°C equilibration 瀀 ⸀⸀⸩㸾൥湤潢樍ㄱ㠵‰扪഼㰯偡牥湴‱ㄶ㔠〠刯乥硴‱ㄸ㐠〠刯䑥獴⣾＀猀氀椀渀欀㄀㠩⽐牥瘠ㄱ㘶‰⁒⽔楴汥⣾＀㌀⸀㈀⸀ 匀瀀椀渀搀氀攀 挀漀渀昀椀最甀爀愀琀椀漀渀猀 漀戀猀攀爀瘀攀搀 椀渀 䤀嘀䴀 戀漀瘀椀渀攀 漀漀挀礀琀攀猀 瘀椀琀爀椀昀椀攀搀⼀眀愀爀洀攀搀 椀渀 琀栀攀 ㈀㔀뀀䌀 漀爀 ㌀㠀⸀㔀뀀䌀 攀焀甀椀氀椀戀爀愀琀椀漀渀 瀀爀漀琀漀挀漀氀猩㸾൥湤潢樍ㄱ㠶‰扪഼㰯偡牥湴‱ㄶ㘠〠刯乥硴‱ㄸ㜠〠刯䑥獴⣾＀琀氀椀渀欀㄀㘩⽔楴汥⣾＀㌀⸀㄀⸀㄀⸀ 䴀攀洀戀爀愀渀攀 瀀攀爀洀攀愀戀椀氀椀琀礀 瀀愀爀愀洀攀琀攀爀猩㸾൥湤潢樍ㄱ㠷‰扪഼㰯偡牥湴‱ㄶ㘠〠刯䑥獴⣾＀琀氀椀渀欀㄀㜩⽐牥瘠ㄱ㠶‰⁒⽔楴汥⣾＀㌀⸀㄀⸀㈀⸀ 䤀渀 猀椀氀椀挀漀 瘀攀爀猀甀猀 椀渀 瘀椀琀爀漀 爀攀猀甀氀琀猩㸾൥湤潢樍ㄠ〠潢樍㰼⽃牯灂潸嬰‰‵㤵⸲㜶‷㤳⸷〱崯䅮湯瑳嬲‰⁒″‰⁒‴‰⁒‵‰⁒‶‰⁒‷‰⁒‸‰⁒‹‰⁒‱〠〠删ㄱ‰⁒‱㈠〠删ㄳ‰⁒‱㐠〠删ㄵ‰⁒‱㘠〠删ㄷ‰⁒崯偡牥湴‱〰㘠〠刯䉛㄰㘹‰⁒‱〶㠠〠删㄰㘷‰⁒‱〶㘠〠删㄰㘵‰⁒崯䍯湴敮瑳′〠〠刯副瑡瑥‰⽍敤楡䉯硛〠〠㔹㔮㈷㘠㜹㌮㜰ㅝ⽒敳潵牣敳‱㠠〠刯呹灥⽐慧放㸍敮摯扪ല‰扪഼㰯剥捴嬲㜹⸰㤹‷ㄹ⸰㤳′㠳⸸㘱‷㈷⸰㠶崯卵扴祰支䱩湫⽂潲摥牛〠〠そ⽄敳琨bib1 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: 3.4. Embryo development in IVM bovine oocytes vitrified/warmed in the 25°C or 38.5°C equilibration protocols Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: 3.5. Differential staining of blastocysts and DNA fragmentation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: 4. Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: 5. Conclusion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Availability of data and materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: CRediT authorship contribution statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: Declaration of competing interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Info: Title: Impact of equilibration duration combined with temperature on the outcome of bovine oocyte vitrification Author: Tania García-Martínez Subject: Theriogenology, 184 (2022) 110-123. doi:10.1016/j.theriogenology.2022.02.024 Creator: 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322, 609, 458, 615 Annotation: Subtype: Link Rect: 463, 609, 471, 615 Annotation: Subtype: Link Rect: 322, 601, 557, 607 Annotation: Subtype: Link Rect: 322, 593, 557, 599 Annotation: Subtype: Link Rect: 322, 585, 455, 591 Annotation: Subtype: Link Rect: 460, 585, 468, 591 Annotation: Subtype: Link Rect: 322, 577, 557, 583 Annotation: Subtype: Link Rect: 322, 569, 557, 575 Annotation: Subtype: Link Rect: 322, 561, 420, 567 Annotation: Subtype: Link Rect: 425, 561, 437, 567 Annotation: Subtype: Link Rect: 322, 553, 557, 559 Annotation: Subtype: Link Rect: 322, 545, 557, 551 Annotation: Subtype: Link Rect: 322, 537, 334, 543 Annotation: Subtype: Link Rect: 339, 537, 346, 543 Annotation: Subtype: Link Rect: 322, 529, 557, 535 Annotation: Subtype: Link Rect: 322, 521, 557, 527 Annotation: Subtype: Link Rect: 322, 513, 557, 519 Annotation: Subtype: Link Rect: 322, 505, 369, 511 Annotation: Subtype: Link Rect: 374, 505, 381, 511 Annotation: Subtype: Link Rect: 322, 497, 557, 503 Annotation: Subtype: Link Rect: 322, 489, 383, 495 Annotation: Subtype: Link Rect: 388, 489, 396, 495 Annotation: Subtype: Link Rect: 322, 481, 557, 487 Annotation: Subtype: Link Rect: 322, 473, 557, 479 Annotation: Subtype: Link Rect: 322, 465, 380, 472 Annotation: Subtype: Link Rect: 385, 465, 393, 472 Annotation: Subtype: Link Rect: 322, 457, 557, 464 Annotation: Subtype: Link Rect: 322, 449, 540, 456 Annotation: Subtype: Link Rect: 545, 449, 553, 456 Annotation: Subtype: Link Rect: 322, 441, 557, 448 Annotation: Subtype: Link Rect: 322, 433, 557, 440 Annotation: Subtype: Link Rect: 322, 425, 457, 432 Annotation: Subtype: Link Rect: 462, 425, 465, 432 Annotation: Subtype: Link Rect: 322, 417, 557, 424 Annotation: Subtype: Link Rect: 322, 409, 557, 416 Annotation: Subtype: Link Rect: 322, 401, 557, 408 Annotation: Subtype: Link Rect: 322, 393, 377, 400 Annotation: Subtype: Link Rect: 382, 393, 386, 400 Annotation: Subtype: Link Rect: 322, 385, 557, 392 Annotation: Subtype: Link Rect: 322, 377, 557, 384 Annotation: Subtype: Link Rect: 322, 369, 419, 376 Annotation: Subtype: Link Rect: 424, 369, 428, 376 Annotation: Subtype: Link Rect: 322, 362, 557, 368 Annotation: Subtype: Link Rect: 322, 354, 557, 360 Annotation: Subtype: Link Rect: 322, 346, 430, 352 Annotation: Subtype: Link Rect: 435, 346, 443, 352 Annotation: Subtype: Link Rect: 322, 338, 557, 344 Annotation: Subtype: Link Rect: 322, 330, 361, 336 Annotation: Subtype: Link Rect: 366, 330, 374, 336 Annotation: Subtype: Link Rect: 322, 322, 557, 328 Annotation: Subtype: Link Rect: 322, 314, 557, 320 Annotation: Subtype: Link Rect: 322, 306, 369, 312 Annotation: Subtype: Link Rect: 374, 306, 381, 312 Annotation: Subtype: Link Rect: 322, 298, 557, 304 Annotation: Subtype: Link Rect: 322, 290, 557, 296 Annotation: Subtype: Link Rect: 322, 282, 425, 288 Annotation: Subtype: Link Rect: 430, 282, 434, 288 Annotation: Subtype: Link Rect: 322, 274, 557, 280 Annotation: Subtype: Link Rect: 322, 266, 557, 272 Annotation: Subtype: Link Rect: 322, 258, 357, 264 Annotation: Subtype: Link Rect: 362, 258, 370, 264 Annotation: Subtype: Link Rect: 322, 250, 557, 256 Annotation: Subtype: Link Rect: 322, 242, 512, 248 Annotation: Subtype: Link Rect: 517, 242, 521, 248 Annotation: Subtype: Link Rect: 322, 234, 557, 240 Annotation: Subtype: Link Rect: 322, 226, 557, 232 Annotation: Subtype: Link Rect: 322, 218, 464, 224 Annotation: Subtype: Link Rect: 322, 210, 557, 216 Annotation: Subtype: Link Rect: 322, 202, 557, 208 Annotation: Subtype: Link Rect: 322, 194, 436, 201 Annotation: Subtype: Link Rect: 441, 194, 448, 201 Annotation: Subtype: Link Rect: 322, 186, 557, 193 Annotation: Subtype: Link Rect: 322, 178, 557, 185 Annotation: Subtype: Link Rect: 322, 170, 523, 177 Annotation: Subtype: Link Rect: 528, 170, 535, 177 Annotation: Subtype: Link Rect: 322, 162, 557, 169 Annotation: Subtype: Link Rect: 322, 154, 557, 161 Annotation: Subtype: Link Rect: 322, 146, 408, 153 Annotation: Subtype: Link Rect: 413, 146, 424, 153 Annotation: Subtype: Link Rect: 322, 138, 557, 145 Annotation: Subtype: Link Rect: 322, 130, 557, 137 Annotation: Subtype: Link Rect: 322, 122, 385, 129 Annotation: Subtype: Link Rect: 322, 114, 331, 121 Annotation: Subtype: Link Rect: 335, 114, 366, 121 Annotation: Subtype: Link Rect: 370, 114, 557, 121 Annotation: Subtype: Link Rect: 322, 106, 557, 113 Annotation: Subtype: Link Rect: 322, 98, 557, 105 Annotation: Subtype: Link Rect: 322, 91, 408, 97 Annotation: Subtype: Link Rect: 413, 91, 421, 97 Annotation: Subtype: Link Rect: 322, 83, 557, 89 Annotation: Subtype: Link Rect: 322, 75, 557, 81 Annotation: Subtype: Link Rect: 322, 67, 523, 73 Annotation: Subtype: Link Rect: 528, 67, 536, 73 Annotation: Subtype: Link Rect: 322, 59, 557, 65 Annotation: Subtype: Link Rect: 322, 51, 557, 57 Page: Label: 123 Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 53, 720, 200, 727 Annotation: Subtype: Link Rect: 205, 720, 255, 727 Annotation: Subtype: Link Rect: 53, 712, 288, 719 Annotation: Subtype: Link Rect: 53, 704, 288, 711 Annotation: Subtype: Link Rect: 53, 696, 288, 703 Annotation: Subtype: Link Rect: 53, 688, 271, 695 Annotation: Subtype: Link Rect: 276, 688, 284, 695 Annotation: Subtype: Link Rect: 53, 680, 288, 687 Annotation: Subtype: Link Rect: 53, 672, 160, 679 Annotation: Subtype: Link Rect: 53, 664, 288, 671 Annotation: Subtype: Link Rect: 53, 656, 288, 663 Annotation: Subtype: Link Rect: 53, 648, 288, 655 Annotation: Subtype: Link Rect: 53, 640, 69, 647 Annotation: Subtype: Link Rect: 53, 632, 288, 639 Annotation: Subtype: Link Rect: 322, 720, 557, 727 Annotation: Subtype: Link Rect: 322, 712, 330, 719 Annotation: Subtype: Link Rect: 335, 712, 343, 719 Annotation: Subtype: Link Rect: 322, 704, 557, 711 Annotation: Subtype: Link Rect: 322, 696, 557, 703 Annotation: Subtype: Link Rect: 322, 688, 365, 695 Annotation: Subtype: Link Rect: 322, 680, 557, 687 Annotation: Subtype: Link Rect: 322, 672, 557, 679 Annotation: Subtype: Link Rect: 322, 664, 557, 671 Annotation: Subtype: Link Rect: 322, 656, 393, 663 Annotation: Subtype: Link Rect: 322, 648, 557, 655 Annotation: Subtype: Link Rect: 322, 640, 557, 647 Annotation: Subtype: Link Rect: 322, 632, 396, 639 Annotation: Subtype: Link Rect: 401, 632, 408, 639 Checksum: 92fd59a0 Type: CRC32 Checksum: 54da6f75f4581f9ba0f225bb7cc27bc3 Type: MD5 Checksum: e8d118904193e05c498f2889817a911b97f7e504 Type: SHA-1