b7aba043d59fc96d38dc10f5db86cefd jouneu_a2022v367.pdf b4c305142daff50b55dcf78f0f81bdd9f5734fe4 jouneu_a2022v367.pdf 75ee2e368f06c1f3399899efcd4a6af1f15ba210e2bba4e1742991104e034106 jouneu_a2022v367.pdf Title: Lesion-associated microglia and macrophages mediate corralling and react with massive phagocytosis for debris clearance and wound healing after LPS-induced dopaminergic depletion Subject: Journal of Neuroimmunology, 367 (2022) 577874. doi:10.1016/j.jneuroim.2022.577874 Keywords: Parkinson's disease,Microglia,Macrophages,Lipopolysaccharide,Phagocytosis,Dopamine,Neurodegeneration,Experimental models Author: P. Heman-Bozadas Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Thu Apr 28 16:38:00 2022 CEST ModDate: Thu Apr 28 20:03:37 2022 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 15882253 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- BRWWWZ+TeX_CM_Roman Type 1C Builtin yes yes yes 897 0 KTFFTA+CharisSIL CID TrueType Identity-H yes yes yes 901 0 WPIVHZ+STIX-Regular Type 1C Custom yes yes yes 906 0 WUAWRJ+CharisSIL-Bold CID TrueType Identity-H yes yes yes 911 0 AHLOJY+TimesNewRomanPS-ItalicMT CID TrueType Identity-H yes yes yes 916 0 GBNAGF+Univers Type 1C Builtin yes yes yes 921 0 WEHUEJ+CharisSIL-Italic CID TrueType Identity-H yes yes yes 925 0 ESKPXW+CharisSIL CID TrueType Identity-H yes yes yes 888 0 VQXFPH+TeX_CM_Maths_Symbols Type 1C Builtin yes yes yes 431 0 DBGULD+CharisSIL-Italic CID TrueType Identity-H yes yes yes 424 0 KQDFAM+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 442 0 NTMBZO+TeX_CM_Maths_Italic Type 1C Builtin yes yes yes 447 0 ACCMCI+ArialMT Type 1C WinAnsi yes yes no 59 0 ACCNPO+TimesNewRomanPS-BoldMT Type 1C WinAnsi yes yes no 62 0 ACCNPP+SymbolMT Type 1C Custom yes yes no 65 0 ACGBDD+ArialMT Type 1C WinAnsi yes yes no 76 0 ACGCPJ+Arial-BoldMT Type 1C WinAnsi yes yes no 79 0 ACGDAJ+SymbolMT Type 1C Custom yes yes no 82 0 ACIOML+SymbolMT Type 1C Custom yes yes no 96 0 ACINJC+ArialMT Type 1C WinAnsi yes yes no 99 0 ACLHCD+Arial-BoldMT Type 1C WinAnsi yes yes no 131 0 ACLIOJ+ArialMT Type 1C WinAnsi yes yes no 134 0 ACLIOK+SymbolMT Type 1C Custom yes yes no 137 0 ADAOML+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 181 0 ADAOLJ+TimesNewRomanPS-BoldMT Type 1C WinAnsi yes yes no 184 0 ADAOKJ+ArialMT Type 1C WinAnsi yes yes no 187 0 ADAONM+Arial-BoldMT Type 1C WinAnsi yes yes no 190 0 ADAOMK+SymbolMT Type 1C Custom yes yes no 193 0 MLTLXC+STIX-Bold Type 1C Custom yes yes yes 234 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-05-19 02:41:56 CEST RepresentationInformation: jouneu_a2022v367.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-05-05 11:17:11 CEST Size: 15882253 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 993 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Lesion-associated microglia and macrophages mediate corralling and react with massive phagocytosis for debris clearance and ... Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Children: Item: Title: 1 Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: 2 Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: 3 Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: 4 Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Children: Item: Title: 4.1 Animals and surgeries Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Children: Item: Title: 4.1.1 Perfusion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: 4.1.2 Extraction of brain tissue Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: 4.1.3 Immunofluorescence Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: 4.2 Image capture and quantifications Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: 4.3 Confocal microscopy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: 5 Cell culture experiments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Children: Item: Title: 5.1 Cell lines Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: 5.2 Primary cultures of midbrain microglia Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: 5.3 Immunocytofluorescence Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: 5.4 Immunocytofluorescence quantification Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: 5.5 Determination of nitrites by Griess assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: 5.6 Statistics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Authors’ contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Ethics approval and consent to participate Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Availability of data and materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Declaration of Competing Interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Info: Title: Lesion-associated microglia and macrophages mediate corralling and react with massive phagocytosis for debris clearance and wound healing after LPS-induced dopaminergic depletion Author: P. Heman-Bozadas Subject: Journal of Neuroimmunology, 367 (2022) 577874. doi:10.1016/j.jneuroim.2022.577874 Keywords: Parkinson's disease,Microglia,Macrophages,Lipopolysaccharide,Phagocytosis,Dopamine,Neurodegeneration,Experimental models Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Thu Apr 28 16:38:00 CEST 2022 ModDate: Thu Apr 28 20:03:37 CEST 2022 ID: 0x6954abf1ad386482440c0bc71221468c, 0xdb0c8c876671fd9f4e39460d43d7b606 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 298 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 248 ImageHeight: 271 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: AHLOJY+TimesNewRomanPS-ItalicMT Encoding: Identity-H ToUnicode: true Font: BaseFont: KTFFTA+CharisSIL Encoding: Identity-H ToUnicode: true Font: BaseFont: KQDFAM+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Font: BaseFont: WEHUEJ+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: WUAWRJ+CharisSIL-Bold Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: BRWWWZ+TeX_CM_Roman FontSubset: true FirstChar: 1 LastChar: 128 FontDescriptor: FontName: BRWWWZ+TeX_CM_Roman Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: GBNAGF+Univers FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: GBNAGF+Univers Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: WPIVHZ+STIX-Regular FontSubset: true FirstChar: 1 LastChar: 6 FontDescriptor: FontName: WPIVHZ+STIX-Regular Flags: Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MLTLXC+STIX-Bold FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: MLTLXC+STIX-Bold Flags: Nonsymbolic, ForceBold FontBBox: -998, -552, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: VQXFPH+TeX_CM_Maths_Symbols FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: VQXFPH+TeX_CM_Maths_Symbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: NTMBZO+TeX_CM_Maths_Italic FontSubset: true FirstChar: 1 LastChar: 127 FontDescriptor: FontName: NTMBZO+TeX_CM_Maths_Italic Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true CIDFontType2: Font: BaseFont: WUAWRJ+CharisSIL-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: WUAWRJ+CharisSIL-Bold Flags: Nonsymbolic, ForceBold FontBBox: -720, -533, 1759, 1320 FontFile2: true Font: BaseFont: AHLOJY+TimesNewRomanPS-ItalicMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: AHLOJY+TimesNewRomanPS-ItalicMT Flags: Nonsymbolic, Italic FontBBox: -498, -307, 1120, 1023 FontFile2: true Font: BaseFont: KTFFTA+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: KTFFTA+CharisSIL Flags: Nonsymbolic FontBBox: -692, -533, 1623, 1319 FontFile2: true Font: BaseFont: KQDFAM+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: KQDFAM+TimesNewRomanPSMT Flags: Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile2: true Font: BaseFont: WEHUEJ+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: WEHUEJ+CharisSIL-Italic Flags: Nonsymbolic, Italic FontBBox: -716, -533, 1627, 1318 FontFile2: true XMP: application/pdf 10.1016/j.jneuroim.2022.577874 Elsevier B.V. Journal of Neuroimmunology, 367 (2022) 577874. doi:10.1016/j.jneuroim.2022.577874 Parkinson's disease Microglia Macrophages Lipopolysaccharide Phagocytosis Dopamine Neurodegeneration Experimental models Lesion-associated microglia and macrophages mediate corralling and react with massive phagocytosis for debris clearance and wound healing after LPS-induced dopaminergic depletion P. Heman-Bozadas C. Romero P. Martínez-Remedios I. Freitag A. Frías E. Saavedra-López P.V. Casanova M. Roig-Martínez G.P. Cribaro M.J. Rovirosa-Hernández D. Hernandez-Baltazar C. Barcia journal Journal of Neuroimmunology © 2022 The Authors. 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