5a0042dc15f0fdb416a612374e03a2d0  ijms_a2022m2v23n5a2531.pdf
fd3ba72247b967a304d0924b601d209686820a17  ijms_a2022m2v23n5a2531.pdf
8608c079526a3e698c88c60c93bb0fbbef6d2ee6631795fd961808c2db793e06  ijms_a2022m2v23n5a2531.pdf

Title:          Fertility-Sparing Approaches in Atypical Endometrial Hyperplasia and Endometrial Cancer Patients: Current Evidence and Future Directions
Subject:        Endometrial cancer (EC) is the fourth most common cancer in women in developed countries. Although it is usually diagnosed in postmenopausal women, its incidence has increased in young women, as well in recent decades, with an estimated rate of 4% in those under 40 years of age. Factors involved in this increase, particularly in resource-rich countries, include delayed childbearing and the rise in obesity. The new molecular classification of EC should help to personalize treatment, through appropriate candidate selection. With the currently available evidence, the use of oral progestin either alone or in combination with other drugs such as metformin, levonorgestrel-releasing intrauterine devices and hysteroscopic resection, seems to be feasible and safe in women with early-stage EC limited to the endometrium. However, there is a lack of high-quality evidence of the efficacy and safety of conservative management in EC. Randomized clinical trials in younger women and obese patients are currently underway.
Keywords:       endometrial neoplasms; endometrial hyperplasia; fertility preservation; progestins; organ sparing treatments; meta-analysis; randomized clinical trials
Author:         Nayanar-Adela Contreras, Jordi Sabadell, Paula Verdaguer, Carla Julià and Maria-Eulalia Fernández-Montolí
Creator:        LaTeX with hyperref
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      Title: Introduction 
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     Item: 
      Title: Criteria for Fertility-Sparing Treatment in Endometrial Cancer 
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        Title: Histologic Diagnosis 
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      Title: Current Evidence on Fertility-Sparing Treatments for Endometrial Cancer and Atypical Endometrial Hyperplasia 
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        Title: Grade 2 Endometrial Cancer 
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    Title: Fertility-Sparing Approaches in Atypical Endometrial Hyperplasia and Endometrial Cancer Patients: Current Evidence and Future Directions
    Author: Nayanar-Adela Contreras, Jordi Sabadell, Paula Verdaguer, Carla Julià and Maria-Eulalia Fernández-Montolí
    Subject: Endometrial cancer (EC) is the fourth most common cancer in women in developed countries. Although it is usually diagnosed in postmenopausal women, its incidence has increased in young women, as well in recent decades, with an estimated rate of 4% in those under 40 years of age. Factors involved in this increase, particularly in resource-rich countries, include delayed childbearing and the rise in obesity. The new molecular classification of EC should help to personalize treatment, through appropriate candidate selection. With the currently available evidence, the use of oral progestin either alone or in combination with other drugs such as metformin, levonorgestrel-releasing intrauterine devices and hysteroscopic resection, seems to be feasible and safe in women with early-stage EC limited to the endometrium. However, there is a lack of high-quality evidence of the efficacy and safety of conservative management in EC. Randomized clinical trials in younger women and obese patients are currently underway.
    Keywords: endometrial neoplasms; endometrial hyperplasia; fertility preservation; progestins; organ sparing treatments; meta-analysis; randomized clinical trials
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