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PageMode: UseOutlines Language: EN Outlines: Item: Title: Controlling oncogenic KRAS signaling pathways with a Palladium-responsive peptide Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Children: Item: Title: Design and synthesis of the metal-responsive KRAS peptide inhibitor Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Addition of Pd(II) increases the α-helical content of the peptide αH-His2 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: NMR spectroscopy demonstrates that the αH-His2 core sequence partially folds into an α-helical conformation upon metal chelation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Molecular modeling provides further insight into the conformational dynamics and metal coordination of the peptide αH-His2 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: The metallopeptide αH-His2[Pd] binds KRASwt Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: The metallopeptide αH-His2[Pd] inhibits KRASwt GTP exchange Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: The metallopeptide αH-His2[Pd] inhibits the ERK1/2’signaling pathway in cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Children: Item: Title: Peptide synthesis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Circular Dichroism Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Fluorescence Anisotropy and switch experiments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: High-resolution NMR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Computational methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Protein Expression and Purification Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Nucleotide Release assays Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Cell internalization and inhibition of ERK1/2 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Fluorescence microscopy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Reporting summary Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Data availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Additional information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Info: Title: Controlling oncogenic KRAS signaling pathways with a Palladium-responsive peptide Author: Soraya Learte-Aymamí Subject: Communications Chemistry, doi:10.1038/s42004-022-00691-7 Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Thu Jun 23 14:17:49 CEST 2022 ModDate: Thu Jun 23 16:11:58 CEST 2022 ID: 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Couceiro Jean-Didier Maréchal Maria J. Macias José L. Mascareñas M. Eugenio Vázquez Springer US Communications Chemistry, doi:10.1038/s42004-022-00691-7 Springer 2022-06-23T16:11:58+02:00 2022-06-23T17:17:49+05:30 2022-06-23T16:11:58+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) uuid:6df1de34-769d-4085-8ea2-980551f56fae uuid:22e875af-bfcf-47c2-b4c5-9099af793fa9 default 1 converted uuid:910d65d5-8053-4d08-bccb-2b71f825bcd0 converted to PDF/A-2b pdfToolbox 2022-06-23T17:18:48+05:30 2 B http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. 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