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Brandts Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Mon Dec 12 14:10:41 2022 CET ModDate: Mon Dec 12 15:03:45 2022 CET Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 8270523 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GBNAGF+Univers Type 1C Builtin yes yes yes 1007 0 LPIFRR+CharisSIL CID TrueType Identity-H yes yes yes 1011 0 UHQTGH+TeX_CM_Roman Type 1C Builtin yes yes yes 1016 0 IOXKEB+CharisSIL-Bold CID TrueType Identity-H yes yes yes 1020 0 BXDSIB+CharisSIL-Italic CID TrueType Identity-H yes yes yes 1025 0 LWZQZY+CharisSIL CID TrueType Identity-H yes yes yes 998 0 HRRCNB+STIX-Regular Type 1C Custom yes yes yes 459 0 HRURGZ+TeX_CM_Maths_Symbols Type 1C Builtin yes yes yes 464 0 FSOLTI+TeX_CM_Maths_Italic Type 1C Builtin yes yes yes 468 0 BIUAXI+CharisSIL-Italic CID TrueType Identity-H yes yes yes 452 0 YVXNKA+STIX-BoldItalic Type 1C Custom yes yes yes 472 0 TFTPWM+TeX_CM_Maths_Extension Type 1C Builtin yes yes yes 54 0 EXMJVJ+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 86 0 CAIZSP+ArialUnicodeMS CID TrueType Identity-H yes yes yes 91 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-03-01 02:35:50 CET RepresentationInformation: EnvRes_a2022v212p113433.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-02-28 17:35:49 CET Size: 8270523 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 1091 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Nanoplastics are bioaccumulated in fish liver and muscle and cause DNA damage after a chronic exposure Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Children: Item: Title: 1 Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: 2 Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Children: Item: Title: 2.1 1. Fish maintenance, bioassay and sampling Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: 2.2 Polystyrene nanoplastics characterization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: 2.3 Extraction of polystyrene nanoplastics from biological samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: 2.4 Analysis and quantification of polystyrene nanoplastics using size exclusion chromatography coupled to high-resolution ... Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: 2.5 Fitness indicators Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: 2.6 Hematological profile Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: 2.7 Erythrocytic nuclear abnormalities Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: 2.8 Cortisol and glucose Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: 2.9 Data analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: 3 Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Children: Item: Title: 3.1 Polystyrene nanoplastics characterization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: 3.2 Polystyrene nanoplastics concentration levels in muscle, liver and gastrointestinal tract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: 3.3 Biological effects of polystyrene nanoplastics in goldfish Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: 4 Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Children: Item: Title: 4.1 Polystyrene nanoplastics bioaccumulate in liver and muscle of goldfish Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: 4.2 Polystyrene nanoplastics do not alter fish morphological nor hematological indices but induces DNA damage Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: 4.3 Polystyrene nanoplastics do not affect goldfish response to stress Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: 5 Concluding remarks Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Credit author statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Declaration of competing interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Info: Title: Nanoplastics are bioaccumulated in fish liver and muscle and cause DNA damage after a chronic exposure Author: I. 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Environmental Research, 212 (2022) 113433. doi:10.1016/j.envres.2022.113433 Nanoplastics Quantification Chronic Genotoxicity Liver Muscle Nanoplastics are bioaccumulated in fish liver and muscle and cause DNA damage after a chronic exposure I. Brandts M. Cánovas A. Tvarijonaviciute M. Llorca A. Vega M. Farré J. Pastor N. Roher M. Teles journal Environmental Research © 2022 The Authors. Published by Elsevier Inc. 0013-9351 212 PA 1 September 2022 2022-09-01 113433 113433 10.1016/j.envres.2022.113433 https://doi.org/10.1016/j.envres.2022.113433 2010-04-23 true 10.1016/j.envres.2022.113433 elsevier.com sciencedirect.com http://creativecommons.org/licenses/by-nc-nd/4.0/ VoR 10.1016/j.envres.2022.113433 noindex 2010-04-23 true 12th December 2022 sciencedirect.com elsevier.com Elsevier 2022-12-12T14:03:45 2022-12-12T13:10:41 2022-12-12T14:03:45 True 12th December 2022 Acrobat Distiller 8.1.0 (Windows) Nanoplastics,Quantification,Chronic,Genotoxicity,Liver,Muscle uuid:1b499bed-4ce8-4c0c-b682-0d58baae1cbe uuid:b6ed5266-03cb-4855-90c0-636283357f42 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 84, 576, 91, 587 Flags: Print Destination: 983 Annotation: Subtype: Link Rect: 91, 571, 159, 582 Flags: Print Destination: 983 Annotation: Subtype: Link Rect: 159, 571, 261, 582 Flags: Print Destination: 983 Annotation: Subtype: Link Rect: 261, 571, 318, 582 Flags: 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