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Title:          All-in-one biofabrication and loading of recombinant vaults in human cells
Subject:        Biofabrication, 14 (2022) 025018 doi: 10.1088/1758-5090/ac584d
Keywords:       vault particles,protein nanocages,drug delivery systems,self-assembling protein nanoparticles,eukaryotic cell factories
Author:         Fernando Martn,Aida Carreño,Rosa Mendoza,Pablo Caruana,Francisco Rodriguez,Marlon Bravo,Antoni Benito,Neus Ferrer-Miralles,M Virtudes Céspedes,José Luis Corchero
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      Title: All-in-one biofabrication and loading of recombinant vaults in human cells
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       Item: 
        Title: 1. Introduction
       Item: 
        Title: 2. Material and methods
        Children: 
         Item: 
          Title: 2.1. Design, synthesis and cloning of recombinant genes
         Item: 
          Title: 2.2. Recombinant protein expression
         Item: 
          Title: 2.3. Cell fractionation
         Item: 
          Title: 2.4. SDS-PAGE and western blot analyses
         Item: 
          Title: 2.5. Protein purification
         Item: 
          Title: 2.6. Physico-chemical characterization of recombinant vaults
         Item: 
          Title: 2.7. GFP-INT protein expression and spontaneous encapsulation
         Item: 
          Title: 2.8. GFP-INT cell internalization mediated by recombinant vaults
         Item: 
          Title: 2.9. Cytotoxicity of recombinant vaults
         Item: 
          Title: 2.10. MVP-H6 protein stability in human serum
         Item: 
          Title: 2.11. Statistical analysis
       Item: 
        Title: 3. Results
        Children: 
         Item: 
          Title: 3.1. MVP-H6 protein expression and solubility
         Item: 
          Title: 3.2. MVP-H6 protein purification
         Item: 
          Title: 3.3. Physico-chemical characterization of recombinant vaults
         Item: 
          Title: 3.4. GFP-INT protein expression
         Item: 
          Title: 3.5. Encapsulation and co-purification of GFP-INT protein
         Item: 
          Title: 3.6. GFP-INT cell internalization mediated by recombinant vaults
         Item: 
          Title: 3.7. Cytotoxicity of recombinant vaults
         Item: 
          Title: 3.8. Stability of recombinant vaults in human serum
       Item: 
        Title: 4. Discussion
       Item: 
        Title: 5. Conclusions
       Item: 
        Title: Acknowledgments
       Item: 
        Title: References
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    Keywords: vault particles,protein nanocages,drug delivery systems,self-assembling protein nanoparticles,eukaryotic cell factories
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