6faf1b242c8a4c142dd5619a2556803f bio_a2022m6v12n6p784.pdf 8afbf9a6126a5279e18c2bf84f59845453ac49d4 bio_a2022m6v12n6p784.pdf ab5d1e2f6ef6515dceb59b9335f56cf0a331b81b4b1c9c97b15b69f8dac7fac8 bio_a2022m6v12n6p784.pdf Title: Nano-Based Approved Pharmaceuticals for Cancer Treatment: Present and Future Challenges Subject: Cancer is one of the main causes of death worldwide. To date, and despite the advances in conventional treatment options, therapy in cancer is still far from optimal due to the non-specific systemic biodistribution of antitumor agents. The inadequate drug concentrations at the tumor site led to an increased incidence of multiple drug resistance and the appearance of many severe undesirable side effects. Nanotechnology, through the development of nanoscale-based pharmaceuticals, has emerged to provide new and innovative drugs to overcome these limitations. In this review, we provide an overview of the approved nanomedicine for cancer treatment and the rationale behind their designs and applications. We also highlight the new approaches that are currently under investigation and the perspectives and challenges for nanopharmaceuticals, focusing on the tumor microenvironment and tumor disseminate cells as the most attractive and effective strategies for cancer treatments. Keywords: nanomedicine; cancer therapy; nanotechnology; approved nanopharmaceuticals; targeted therapy Author: Francisco Rodríguez, Pablo Caruana, Noa De la Fuente, Pía Español, María Gámez, Josep Balart, Elisa Llurba, Ramón Rovira, Raúl Ruiz, Cristina Martín-Lorente, José Luis Corchero and María Virtudes Céspedes Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Thu Jun 16 02:53:30 2022 CEST ModDate: Thu Jun 16 02:56:17 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 27 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2216027 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ARIQJE+VnURWPalladioL Type 1 Custom yes yes no 10 0 MWOPIL+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 SBNNAU+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 QMVIIU+URWPalladioL-Ital Type 1 Custom yes yes no 24 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Item: Title: Drug Chemoresistance Targets Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Disseminated Tumor Cell Targets Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Modes of Targeting: From Size to Multicomplexity DDSs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Approved Nanopharmaceuticals for Clinical Uses in Cancer Therapy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Children: Item: Title: Lipid-Based Approved Nanopharmaceuticals Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Protein-Based Approved Nanopharmaceuticals Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Metallic-Based Approved Nanopharmaceuticals Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Nanopharmaceuticals in Clinical Trials for Cancer Therapy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Future Perspectives of Nanopharmaceuticals Targeting TME Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Challenges in the Clinical Translation of Nanopharmaceuticals Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Children: Item: Title: Costs, Production, and Toxicology Limitations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: Clinical Translation of Nanopharmaceuticals Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Item: Title: FDA and EMA Regulatory Guidelines Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Info: Title: Nano-Based Approved Pharmaceuticals for Cancer Treatment: Present and Future Challenges Author: Francisco Rodríguez, Pablo Caruana, Noa De la Fuente, Pía Español, María Gámez, Josep Balart, Elisa Llurba, Ramón Rovira, Raúl Ruiz, Cristina Martín-Lorente, José Luis Corchero and María Virtudes Céspedes Subject: Cancer is one of the main causes of death worldwide. To date, and despite the advances in conventional treatment options, therapy in cancer is still far from optimal due to the non-specific systemic biodistribution of antitumor agents. The inadequate drug concentrations at the tumor site led to an increased incidence of multiple drug resistance and the appearance of many severe undesirable side effects. Nanotechnology, through the development of nanoscale-based pharmaceuticals, has emerged to provide new and innovative drugs to overcome these limitations. In this review, we provide an overview of the approved nanomedicine for cancer treatment and the rationale behind their designs and applications. We also highlight the new approaches that are currently under investigation and the perspectives and challenges for nanopharmaceuticals, focusing on the tumor microenvironment and tumor disseminate cells as the most attractive and effective strategies for cancer treatments. 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382, 654 Annotation: Subtype: Link Rect: 317, 608, 354, 619 Annotation: Subtype: Link Rect: 361, 608, 397, 619 Annotation: Subtype: Link Rect: 135, 563, 173, 573 Annotation: Subtype: Link Rect: 153, 540, 191, 550 Annotation: Subtype: Link Rect: 400, 505, 437, 516 Annotation: Subtype: Link Rect: 435, 470, 473, 481 Annotation: Subtype: Link Rect: 246, 425, 283, 435 Annotation: Subtype: Link Rect: 59, 391, 96, 401 Annotation: Subtype: Link Rect: 102, 391, 138, 401 Annotation: Subtype: Link Rect: 519, 367, 557, 378 Annotation: Subtype: Link Rect: 59, 356, 95, 366 Annotation: Subtype: Link Rect: 218, 333, 256, 343 Annotation: Subtype: Link Rect: 262, 333, 298, 343 Annotation: Subtype: Link Rect: 301, 298, 338, 309 Annotation: Subtype: Link Rect: 345, 298, 381, 309 Checksum: 0b15bf55 Type: CRC32 Checksum: 6faf1b242c8a4c142dd5619a2556803f Type: MD5 Checksum: 8afbf9a6126a5279e18c2bf84f59845453ac49d4 Type: SHA-1