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Title:          Microglial response promotes neurodegeneration in the Ndufs4 KO mouse model of Leigh syndrome
Subject:        Glia 2022.70:2032-2044
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      Title: Microglial response promotes neurodegeneration in the Ndufs4 KO mouse model of Leigh syndrome
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       Item: 
        Title: 1  INTRODUCTION
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        Title: 2  MATERIAL AND METHODS
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         Item: 
          Title: 2.1  Animals
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          Title: 2.2  Mice generation
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          Title: 2.3  Genotyping
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          Title: 2.4  Microglial depletion with the colony-stimulating factor 1 receptor (CSF1R) inhibitor, PLX3397
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          Title: 2.5  Disease staging and clinical evaluation
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          Title: 2.6  Behavioral tests
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            Title: 2.6.1  Rotarod
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            Title: 2.6.2  Open field
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            Title: 2.6.3  Whole-body plethysmography
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          Title: 2.7  Tissue preparation
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          Title: 2.8  Multiplex
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          Title: 2.9  Histology
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          Title: 2.10  In situ hybridization using RNAscope
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          Title: 2.11  Microscopy and image quantification
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          Title: 2.12  Statistics
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        Title: 3  RESULTS
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          Title: 3.1  Microglia depletion increases lifespan and improves the motor performance of Ndufs4 KO mice
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          Title: 3.2  PLX3397 treatment protects against IBA-1+ cell accumulation and proliferation in brain regions associated with neurode...
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          Title: 3.3  Microglial response promotes both glutamatergic and GABAergic neuronal loss in Ndufs4 KO mice
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          Title: 3.4  Lack of evidence of infiltrating CD3+ cells in motor-related neurodegenerative regions of Ndufs4 KO mice
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          Title: 3.5  IL-6 levels are increased in Ndufs4 KO mice brains, but IL-6 deficiency does not protect against Ndufs4 KO clinical si...
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        Title: 4  DISCUSSION
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        Title: AUTHOR CONTRIBUTIONS
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        Title: ACKNOWLEDGMENTS
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        Title: CONFLICT OF INTEREST
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          Title: DATA AVAILABILITY STATEMENT
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        Title: REFERENCES
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