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Saura Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Tue May 24 13:40:56 2022 CEST ModDate: Tue May 24 14:29:34 2022 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 2973326 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- BEPAUG+CharisSIL CID TrueType Identity-H yes yes yes 1334 0 MEUSDR+CharisSIL-Bold CID TrueType Identity-H yes yes yes 1339 0 NAGIVC+STIX-Regular Type 1C Custom yes yes yes 1344 0 KPDLBY+CharisSIL-Italic CID TrueType Identity-H yes yes yes 1349 0 BRWWWZ+TeX_CM_Roman Type 1C Builtin yes yes yes 1354 0 FTJUMV+Univers Type 1C Builtin yes yes yes 1358 0 WRPGCJ+CharisSIL CID TrueType Identity-H yes yes yes 1314 0 UXENAT+CharisSIL-Italic CID TrueType Identity-H yes yes yes 1322 0 KCKEWV+STIX-Bold Type 1C Custom yes yes yes 623 0 HHTGDS+STIX-Italic Type 1C Custom yes yes yes 634 0 ROILQV+TeX_CM_Maths_Symbols Type 1C Builtin yes yes yes 383 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-07-28 02:32:25 CEST RepresentationInformation: 264415.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-07-27 13:29:45 CEST Size: 2973326 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 1408 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Revealing cell vulnerability in Alzheimer’s disease by single-cell transcriptomics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Children: Item: Title: 1 Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: 2 Transcriptome changes in Alzheimer’s disease brain Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: 3 Cell-specific vulnerability in Alzheimer’s disease Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: 4 Cell transcriptome changes in Alzheimer’s disease Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Children: Item: Title: 4.1 Neuronal transcriptomes in Alzheimer’s disease Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: 4.2 Astrocyte transcriptomes in Alzheimer’s disease Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: 4.3 Microglia transcriptomes in Alzheimer’s disease Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: 4.4 Oligodendrocyte transcriptomes in Alzheimer’s disease Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: 4.5 Endothelial cells transcriptomes in Alzheimer’s disease Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: 5 Conclusions and future challenges Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Funding sources Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Declaration of interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Info: Title: Revealing cell vulnerability in Alzheimer’s disease by single-cell transcriptomics Author: Carlos A. Saura Subject: Seminars in Cell and Developmental Biology, Corrected proof. doi:10.1016/j.semcdb.2022.05.007 Keywords: Alzheimer’s disease,Brain,Dementia,Inflammation,Microglia,Neurodegeneration,Pathology,RNA-Seq,Single-cell transcriptomics,Systems biology Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Tue May 24 13:40:56 CEST 2022 ModDate: Tue May 24 14:29:34 CEST 2022 ID: 0x0f4d24de5eead92fb39fb91079c75da5, 0xe96c19cb6c1601ebe6c11790055c526f Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 248 ImageHeight: 271 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 298 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: KPDLBY+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: BEPAUG+CharisSIL Encoding: Identity-H ToUnicode: true Font: BaseFont: MEUSDR+CharisSIL-Bold Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: NAGIVC+STIX-Regular FontSubset: true FirstChar: 1 LastChar: 7 FontDescriptor: FontName: NAGIVC+STIX-Regular Flags: Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: BRWWWZ+TeX_CM_Roman FontSubset: true FirstChar: 1 LastChar: 128 FontDescriptor: FontName: BRWWWZ+TeX_CM_Roman Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: HHTGDS+STIX-Italic FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: HHTGDS+STIX-Italic Flags: Nonsymbolic, Italic FontBBox: -970, -305, 1429, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: FTJUMV+Univers FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: FTJUMV+Univers Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: KCKEWV+STIX-Bold FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: KCKEWV+STIX-Bold Flags: Nonsymbolic, ForceBold FontBBox: -998, -552, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: ROILQV+TeX_CM_Maths_Symbols FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: ROILQV+TeX_CM_Maths_Symbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true CIDFontType2: Font: BaseFont: KPDLBY+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: KPDLBY+CharisSIL-Italic Flags: Nonsymbolic, Italic FontBBox: -716, -533, 1627, 1318 FontFile2: true Font: BaseFont: BEPAUG+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: BEPAUG+CharisSIL Flags: Nonsymbolic FontBBox: -692, -533, 1623, 1319 FontFile2: true Font: BaseFont: MEUSDR+CharisSIL-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: MEUSDR+CharisSIL-Bold Flags: Nonsymbolic, ForceBold FontBBox: -720, -533, 1759, 1320 FontFile2: true XMP: http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf 10.1016/j.semcdb.2022.05.007 Elsevier Ltd Seminars in Cell and Developmental Biology, Corrected proof. doi:10.1016/j.semcdb.2022.05.007 Alzheimer’s disease Brain Dementia Inflammation Microglia Neurodegeneration Pathology RNA-Seq Single-cell transcriptomics Systems biology Revealing cell vulnerability in Alzheimer’s disease by single-cell transcriptomics Carlos A. Saura Angel Deprada Maria Dolores Capilla-López Arnaldo Parra-Damas P 24th May 2022 Acrobat Distiller 8.1.0 (Windows) Alzheimer’s disease,Brain,Dementia,Inflammation,Microglia,Neurodegeneration,Pathology,RNA-Seq,Single-cell transcriptomics,Systems biology 24th May 2022 10.1016/j.semcdb.2022.05.007 noindex journal © 2022 The Author(s). 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