97b8d0b1cf2ba36aeaf74080e0ce00c2  JouHazMat_a2022v239p129593.pdf
55ae2f7b17c6cfb8a78f29fd12c92472775241aa  JouHazMat_a2022v239p129593.pdf
cd3fea467c3f69de741e5afd7f39f11d5b48b56fafbc5f8f2f92f740e0ea37e2  JouHazMat_a2022v239p129593.pdf

Title:          A new source of representative secondary PET nanoplastics. Obtention, characterization, and hazard evaluation
Subject:        Journal of Hazardous Materials, 439 (2022) 129593. doi:10.1016/j.jhazmat.2022.129593
Keywords:       Nanoplastics,Polyethylene terephthalate,Physicochemical characterization,Cell uptake,Cytotoxicity
Author:         Aliro Villacorta
Creator:        Elsevier
Producer:       Acrobat Distiller 8.1.0 (Windows)
CreationDate:   Thu Jul 14 16:08:16 2022 CEST
ModDate:        Thu Jul 14 16:26:25 2022 CEST
Tagged:         yes
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          12
Encrypted:      no
Page size:      595.276 x 793.701 pts
Page rot:       0
File size:      6405786 bytes
Optimized:      yes
PDF version:    1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
DKPPYQ+TeX_CM_Maths_Symbols          Type 1C           Builtin          yes yes yes    748  0
XWDQDO+CharisSIL                     CID TrueType      Identity-H       yes yes yes    752  0
NNLAUQ+TeX_CM_Roman                  Type 1C           Builtin          yes yes yes    757  0
PFNGJQ+Univers                       Type 1C           Builtin          yes yes yes    761  0
JBKTEO+CharisSIL-Italic              CID TrueType      Identity-H       yes yes yes    765  0
PMFQCR+CharisSIL                     CID TrueType      Identity-H       yes yes yes    739  0
LXWKOD+STIX-Regular                  Type 1C           Custom           yes yes yes    314  0
EMMUZV+CharisSIL-Bold                CID TrueType      Identity-H       yes yes yes    319  0
KPMOAG+TimesNewRomanPSMT             CID TrueType      Identity-H       yes yes yes    324  0
LAYAUF+CharisSIL-Italic              CID TrueType      Identity-H       yes yes yes    307  0
NTMBZO+TeX_CM_Maths_Italic           Type 1C           Builtin          yes yes yes    331  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2022-09-02 02:31:09 CEST
 RepresentationInformation: JouHazMat_a2022v239p129593.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2022-09-01 16:48:27 CEST
  Size: 6405786
  Format: PDF
  Version: 1.7
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'sec0165' cannot be found
   Offset: 6363990
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'sec0165' cannot be found
   Offset: 6363990
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'sec0165' cannot be found
   Offset: 6363990
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'sec0165' cannot be found
   Offset: 6363990
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'sec0165' cannot be found
   Offset: 6363990
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'sec0165' cannot be found
   Offset: 6363990
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'sec0165' cannot be found
   Offset: 6363990
  MIMEtype: application/pdf
  Profile: Linearized PDF, Tagged PDF
  PDFMetadata: 
   Objects: 843
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en
    Outlines: 
     Item: 
      Title: A new source of representative secondary PET nanoplastics. Obtention, characterization, and hazard evaluation
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78
      Children: 
       Item: 
        Title: 1 Introduction
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee
       Item: 
        Title: 2 Materials and methods
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f
        Children: 
         Item: 
          Title: 2.1 PET-NPLs obtention
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1
         Item: 
          Title: 2.2 Characterization of particle suspension
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d
          Children: 
           Item: 
            Title: 2.2.1 Scanning electron microscopy/Energy dispersive X-ray microscopy (SEM-EDS)
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89
           Item: 
            Title: 2.2.2 Transmission electron microscopy (TEM)
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9
           Item: 
            Title: 2.2.3 Fourier transform infrared spectroscopy (FTIR)
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e
           Item: 
            Title: 2.2.4 Multi angle and dynamic light scattering (DLS-MADLS) and zeta potential
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b
           Item: 
            Title: 2.2.5 Asymmetric flow field flow fractionation (AF4)
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b
         Item: 
          Title: 2.3 Cell culture
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31
         Item: 
          Title: 2.4 Cell uptake determination
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107
          Children: 
           Item: 
            Title: 2.4.1 Internal complexity
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e
           Item: 
            Title: 2.4.2 TEM analysis
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7
         Item: 
          Title: 2.5 Cell viability assay
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e
         Item: 
          Title: 2.6 Reactive oxygen species (ROS) quantification
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247
         Item: 
          Title: 2.7 DNA damage detection: The comet assay
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9
       Item: 
        Title: 3 Results and discussion
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36
        Children: 
         Item: 
          Title: 3.1 Characterization of the obtained PET-NPL samples
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a
          Children: 
           Item: 
            Title: 3.1.1 Morphology and composition
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30
           Item: 
            Title: 3.1.2 Dry state size distribution and shape
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c
           Item: 
            Title: 3.1.3 Chemical composition
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88
           Item: 
            Title: 3.1.4 Aqueous solution size distribution and zeta potential
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6
         Item: 
          Title: 3.2 Cell uptake of PET-NPLs
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e
          Children: 
           Item: 
            Title: 3.2.1 Internalization of PET-NPLs stained by Nile red by confocal microscopy
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20
           Item: 
            Title: 3.2.2 Cell complexity as detected by flow cytometry
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743
           Item: 
            Title: 3.2.3 Cell uptake detection by TEM
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858
         Item: 
          Title: 3.3 Cytotoxicity
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71
         Item: 
          Title: 3.4 ROS induction by PET-NPLs
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3
         Item: 
          Title: 3.5 Genotoxic evaluation of PET-NPLs by using the comet assay
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca
       Item: 
        Title: CRediT authorship contribution statement
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207
       Item: 
        Title: Declaration of Competing Interest
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d371b2d
       Item: 
        Title: Data availability
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@543c6f6d
       Item: 
        Title: Acknowledgments
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13eb8acf
       Item: 
        Title: Environmental Implication
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@51c8530f
       Item: 
        Title: Appendix A Supporting information
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7403c468
       Item: 
        Title: References
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43738a82
   Info: 
    Title: A new source of representative secondary PET nanoplastics. Obtention, characterization, and hazard evaluation
    Author: Aliro Villacorta
    Subject: Journal of Hazardous Materials, 439 (2022) 129593. doi:10.1016/j.jhazmat.2022.129593
    Keywords: Nanoplastics,Polyethylene terephthalate,Physicochemical characterization,Cell uptake,Cytotoxicity
    Creator: Elsevier
    Producer: Acrobat Distiller 8.1.0 (Windows)
    CreationDate: Thu Jul 14 16:08:16 CEST 2022
    ModDate: Thu Jul 14 16:26:25 CEST 2022
   ID: 0x06c5ad9e6782d1a3faf552907b39f8de, 0xca3ea762b3cd01e3e4a6378342364312
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 248
      ImageHeight: 271
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 236
      ImageHeight: 298
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type0: 
     Font: 
      BaseFont: XWDQDO+CharisSIL
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: KPMOAG+TimesNewRomanPSMT
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: JBKTEO+CharisSIL-Italic
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: EMMUZV+CharisSIL-Bold
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: NNLAUQ+TeX_CM_Roman
      FontSubset: true
      FirstChar: 1
      LastChar: 128
      FontDescriptor: 
       FontName: NNLAUQ+TeX_CM_Roman
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: PFNGJQ+Univers
      FontSubset: true
      FirstChar: 32
      LastChar: 251
      FontDescriptor: 
       FontName: PFNGJQ+Univers
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: LXWKOD+STIX-Regular
      FontSubset: true
      FirstChar: 1
      LastChar: 6
      FontDescriptor: 
       FontName: LXWKOD+STIX-Regular
       Flags: Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: NTMBZO+TeX_CM_Maths_Italic
      FontSubset: true
      FirstChar: 1
      LastChar: 127
      FontDescriptor: 
       FontName: NTMBZO+TeX_CM_Maths_Italic
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: DKPPYQ+TeX_CM_Maths_Symbols
      FontSubset: true
      FirstChar: 1
      LastChar: 138
      FontDescriptor: 
       FontName: DKPPYQ+TeX_CM_Maths_Symbols
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: EMMUZV+CharisSIL-Bold
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: EMMUZV+CharisSIL-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -720, -533, 1759, 1320
       FontFile2: true
     Font: 
      BaseFont: XWDQDO+CharisSIL
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: XWDQDO+CharisSIL
       Flags: Nonsymbolic
       FontBBox: -692, -533, 1623, 1319
       FontFile2: true
     Font: 
      BaseFont: KPMOAG+TimesNewRomanPSMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: KPMOAG+TimesNewRomanPSMT
       Flags: Nonsymbolic
       FontBBox: -568, -307, 2000, 1007
       FontFile2: true
     Font: 
      BaseFont: JBKTEO+CharisSIL-Italic
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: JBKTEO+CharisSIL-Italic
       Flags: Nonsymbolic, Italic
       FontBBox: -716, -533, 1627, 1318
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="XMP Core 5.1.2">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>10.1016/j.jhazmat.2022.129593</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Elsevier B.V.</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Journal of Hazardous Materials, 439 (2022) 129593. doi:10.1016/j.jhazmat.2022.129593</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Nanoplastics</rdf:li>
               <rdf:li>Polyethylene terephthalate</rdf:li>
               <rdf:li>Physicochemical characterization</rdf:li>
               <rdf:li>Cell uptake</rdf:li>
               <rdf:li>Cytotoxicity</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">A new source of representative secondary PET nanoplastics. Obtention, characterization, and hazard evaluation</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Aliro Villacorta</rdf:li>
               <rdf:li>Laura Rubio</rdf:li>
               <rdf:li>Mohamed Alaraby</rdf:li>
               <rdf:li>Montserrat López-Mesas</rdf:li>
               <rdf:li>Victor Fuentes-Cebrian</rdf:li>
               <rdf:li>Oscar H. Moriones</rdf:li>
               <rdf:li>Ricard Marcos</rdf:li>
               <rdf:li>Alba Hernández</rdf:li>
            </rdf:Seq>
         </dc:creator>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Journal of Hazardous Materials</prism:publicationName>
         <prism:copyright>© 2022 The Author(s). Published by Elsevier B.V.</prism:copyright>
         <prism:issn>0304-3894</prism:issn>
         <prism:volume>439</prism:volume>
         <prism:coverDisplayDate>5 October 2022</prism:coverDisplayDate>
         <prism:coverDate>2022-10-05</prism:coverDate>
         <prism:pageRange>129593</prism:pageRange>
         <prism:startingPage>129593</prism:startingPage>
         <prism:doi>10.1016/j.jhazmat.2022.129593</prism:doi>
         <prism:url>https://doi.org/10.1016/j.jhazmat.2022.129593</prism:url>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1016/j.jhazmat.2022.129593</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
         <ali:license_ref>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <ali:uri>http://creativecommons.org/licenses/by/4.0/</ali:uri>
               </rdf:li>
            </rdf:Bag>
         </ali:license_ref>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <FCi27n9z8ndySyM2GyMiQz8NNnteQlt-Nm9iGy.mLndj-odaQnMuQo9ePn9iJndmPntiTma/>
         <pdfx:doi>10.1016/j.jhazmat.2022.129593</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:CreationDate--Text>14th July 2022</pdfx:CreationDate--Text>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreatorTool>Elsevier</xmp:CreatorTool>
         <xmp:ModifyDate>2022-07-14T14:26:25</xmp:ModifyDate>
         <xmp:CreateDate>2022-07-14T14:08:16</xmp:CreateDate>
         <xmp:MetadataDate>2022-07-14T14:26:25</xmp:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:CreationDate--Text>14th July 2022</pdf:CreationDate--Text>
         <pdf:Producer>Acrobat Distiller 8.1.0 (Windows)</pdf:Producer>
         <pdf:Keywords>Nanoplastics,Polyethylene terephthalate,Physicochemical characterization,Cell uptake,Cytotoxicity</pdf:Keywords>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:1b499bed-4ce8-4c0c-b682-0d58baae1cbe</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:b6ed5266-03cb-4855-90c0-636283357f42</xmpMM:InstanceID>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 111, 576, 118, 587
       Flags: Print
       Destination: 720
      Annotation: 
       Subtype: Link
       Rect: 118, 571, 189, 582
       Flags: Print
       Destination: 720
      Annotation: 
       Subtype: Link
       Rect: 189, 576, 195, 587
       Flags: Print
       Destination: 720
      Annotation: 
       Subtype: Link
       Rect: 196, 571, 294, 582
       Flags: Print
       Destination: 720
      Annotation: 
       Subtype: Link
       Rect: 294, 576, 300, 587
       Flags: Print
       Destination: 720
      Annotation: 
       Subtype: Link
       Rect: 301, 571, 428, 582
       Flags: Print
       Destination: 720
      Annotation: 
       Subtype: Link
       Rect: 428, 571, 434, 582
       Flags: Print
       Destination: 720
      Annotation: 
       Subtype: Link
       Rect: 147, 558, 246, 569
       Flags: Print
       Destination: 720
      Annotation: 
       Subtype: Link
       Rect: 246, 563, 251, 574
       Flags: Print
       Destination: 720
      Annotation: 
       Subtype: Link
       Rect: 252, 558, 332, 569
       Flags: Print
       Destination: 720
      Annotation: 
       Subtype: Link
       Rect: 332, 563, 338, 574
       Flags: Print
       Destination: 720
      Annotation: 
       Subtype: Link
       Rect: 339, 566, 343, 571
       Flags: Print
       Destination: 720
      Annotation: 
       Subtype: Link
       Rect: 339, 558, 427, 569
       Flags: Print
       Destination: 720
      Annotation: 
       Subtype: Link
       Rect: 427, 563, 433, 574
       Flags: Print
       Destination: 720
      Annotation: 
       Subtype: Link
       Rect: 434, 566, 438, 571
       Flags: Print
       Destination: 720
      Annotation: 
       Subtype: Link
       Rect: 434, 558, 438, 569
       Flags: Print
       Destination: 720
      Annotation: 
       Subtype: Link
       Rect: 103, 104, 177, 111
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 221, 104, 299, 111
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 321, 722, 369, 730
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 272, 667, 399, 675
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 37, 87, 192, 94
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 297, 749, 300, 757
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 215, 748, 379, 760
      Annotation: 
       Subtype: Link
       Rect: 499, 616, 528, 645
      Annotation: 
       Subtype: Link
       Rect: 406, 57, 552, 69
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 236, 571, 288, 579
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 37, 560, 55, 568
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 108, 529, 166, 537
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 101, 487, 252, 495
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 153, 403, 288, 411
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 37, 393, 114, 401
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 128, 246, 173, 254
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 71, 184, 142, 191
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 147, 184, 204, 191
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 442, 633, 506, 641
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 399, 591, 464, 599
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 473, 581, 552, 589
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 346, 560, 465, 568
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 483, 487, 552, 495
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 309, 424, 377, 432
       Flags: Print
       Destination: 289
      Annotation: 
       Subtype: Link
       Rect: 379, 393, 469, 401
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 481, 246, 557, 254
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 306, 236, 351, 244
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 306, 225, 326, 233
       Flags: Print
       Destination: 26
    Page: 
     Label: 3
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 64, 709, 130, 717
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 190, 228, 255, 236
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 266, 144, 288, 152
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 37, 133, 148, 141
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 472, 343, 557, 351
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 306, 333, 324, 341
       Flags: Print
       Destination: 191
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 124, 668, 148, 676
       Flags: Print
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 173, 668, 178, 676
       Flags: Print
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 240, 668, 266, 676
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 235, 553, 257, 561
       Flags: Print
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 277, 553, 281, 561
       Flags: Print
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 189, 542, 208, 550
       Flags: Print
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 265, 479, 288, 487
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 37, 469, 288, 477
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 37, 458, 55, 466
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 81, 437, 105, 445
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 69, 354, 155, 362
       Flags: Print
       Destination: 289
      Annotation: 
       Subtype: Link
       Rect: 359, 689, 379, 696
       Flags: Print
       Destination: 76
      Annotation: 
       Subtype: Link
       Rect: 500, 532, 557, 540
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 306, 521, 330, 529
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 370, 417, 390, 425
       Flags: Print
       Destination: 76
      Annotation: 
       Subtype: Link
       Rect: 331, 406, 355, 414
       Flags: Print
       Destination: 76
      Annotation: 
       Subtype: Link
       Rect: 363, 406, 368, 414
       Flags: Print
       Destination: 76
      Annotation: 
       Subtype: Link
       Rect: 463, 406, 483, 414
       Flags: Print
       Destination: 76
      Annotation: 
       Subtype: Link
       Rect: 309, 396, 329, 404
       Flags: Print
       Destination: 76
      Annotation: 
       Subtype: Link
       Rect: 394, 396, 414, 404
       Flags: Print
       Destination: 76
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 375, 344, 557, 352
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 306, 334, 383, 342
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 521, 334, 542, 342
       Flags: Print
       Destination: 76
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 272, 678, 288, 686
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 37, 668, 105, 676
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 214, 626, 285, 634
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 91, 615, 115, 623
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 196, 542, 217, 550
       Flags: Print
       Destination: 92
      Annotation: 
       Subtype: Link
       Rect: 207, 532, 227, 540
       Flags: Print
       Destination: 92
      Annotation: 
       Subtype: Link
       Rect: 48, 479, 67, 487
       Flags: Print
       Destination: 92
      Annotation: 
       Subtype: Link
       Rect: 137, 417, 159, 425
       Flags: Print
       Destination: 92
      Annotation: 
       Subtype: Link
       Rect: 37, 375, 122, 383
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 127, 375, 179, 383
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 40, 354, 60, 362
       Flags: Print
       Destination: 92
      Annotation: 
       Subtype: Link
       Rect: 225, 312, 245, 320
       Flags: Print
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 124, 270, 144, 278
       Flags: Print
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 104, 260, 124, 268
       Flags: Print
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 370, 517, 431, 525
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 337, 496, 401, 504
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 485, 465, 505, 473
       Flags: Print
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 432, 444, 451, 452
       Flags: Print
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 309, 413, 428, 421
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 306, 319, 327, 327
       Flags: Print
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 431, 308, 488, 316
       Flags: Print
       Destination: 289
      Annotation: 
       Subtype: Link
       Rect: 531, 287, 550, 295
       Flags: Print
       Destination: 123
    Page: 
     Label: 8
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 160, 678, 283, 686
       Flags: Print
       Destination: 289
      Annotation: 
       Subtype: Link
       Rect: 133, 657, 154, 665
       Flags: Print
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 176, 636, 241, 644
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 72, 605, 200, 613
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 167, 584, 288, 592
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 37, 573, 55, 581
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 258, 496, 277, 504
       Flags: Print
       Destination: 136
      Annotation: 
       Subtype: Link
       Rect: 142, 402, 209, 410
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 214, 402, 283, 410
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 160, 350, 223, 358
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 82, 221, 103, 229
       Flags: Print
       Destination: 136
      Annotation: 
       Subtype: Link
       Rect: 501, 504, 557, 512
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 306, 494, 324, 502
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 328, 473, 393, 481
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 368, 442, 450, 449
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 309, 431, 397, 439
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 326, 400, 390, 408
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 545, 400, 557, 408
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 306, 389, 346, 397
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 335, 315, 411, 323
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 412, 252, 516, 260
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 453, 231, 477, 239
       Flags: Print
       Destination: 173
      Annotation: 
       Subtype: Link
       Rect: 389, 221, 413, 229
       Flags: Print
       Destination: 173
      Annotation: 
       Subtype: Link
       Rect: 437, 210, 461, 218
       Flags: Print
       Destination: 173
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 185, 489, 250, 497
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 40, 457, 119, 465
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 229, 457, 288, 465
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 37, 447, 55, 455
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 78, 405, 142, 413
       Flags: Print
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 371, 531, 433, 539
       Flags: Print
       Destination: 191
    Page: 
     Label: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 99, 626, 227, 634
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 200, 563, 275, 569
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 555, 114, 561
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 169, 523, 245, 530
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 515, 114, 522
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 78, 491, 198, 498
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 253, 467, 286, 474
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 459, 155, 466
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 261, 435, 283, 442
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 427, 136, 434
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 253, 404, 286, 410
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 396, 125, 402
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 127, 372, 267, 378
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 206, 332, 278, 338
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 324, 96, 330
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 253, 260, 286, 266
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 252, 138, 259
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 78, 220, 188, 227
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 188, 180, 195
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 106, 164, 237, 171
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 156, 141, 270, 147
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 270, 125, 286, 131
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 117, 278, 123
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 154, 93, 284, 99
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 162, 69, 273, 75
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 370, 716, 496, 722
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 436, 676, 553, 682
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 417, 604, 527, 611
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 342, 565, 482, 571
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 448, 541, 520, 547
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 533, 359, 539
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 336, 509, 455, 515
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 347, 485, 471, 491
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 533, 461, 555, 467
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 453, 430, 459
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 533, 421, 555, 427
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 413, 417, 419
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 425, 389, 548, 396
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 381, 397, 388
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 408, 349, 546, 356
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 317, 453, 324
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 363, 301, 555, 308
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 294, 370, 300
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 510, 270, 555, 276
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 262, 411, 268
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 453, 238, 528, 244
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 230, 380, 236
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 499, 206, 545, 212
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 198, 379, 204
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 400, 174, 527, 180
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 522, 150, 555, 156
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 142, 423, 148
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 396, 118, 533, 125
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 420, 94, 543, 101
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 423, 70, 546, 77
       Flags: Print
    Page: 
     Label: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 194, 724, 270, 730
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 716, 106, 722
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 175, 692, 247, 698
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 684, 121, 690
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 468, 700, 544, 706
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 692, 380, 698
       Flags: Print
  Checksum: 3d140842
   Type: CRC32
  Checksum: 97b8d0b1cf2ba36aeaf74080e0ce00c2
   Type: MD5
  Checksum: 55ae2f7b17c6cfb8a78f29fd12c92472775241aa
   Type: SHA-1