4e2a9cace4bcc1fe0ea49ccdbae508f8 VET_a2022v9p427.pdf 1adab27507fc3cc26919a0b2fa263a55cfd9ec8b VET_a2022v9p427.pdf 555b98652eff3bc0ebbdc0a915f81398aeb1ced07230135253a69888ba0fdb2c VET_a2022v9p427.pdf Title: Survival Time after Surgical Debulking and Temozolomide Adjuvant Chemotherapy in Canine Intracranial Gliomas Subject: Intracranial gliomas are associated with a poor prognosis, and the most appropriate treatment is yet to be defined. The objectives of this retrospective study are to report the time to progression and survival times of a group of dogs with histologically confirmed intracranial gliomas treated with surgical debulking and adjuvant temozolomide chemotherapy. All cases treated in a single referral veterinary hospital from 2014 to 2021 were reviewed. Inclusion criteria comprised a histopathological diagnosis of intracranial glioma, adjunctive chemotherapy, and follow-up until death. Cases were excluded if the owner declined chemotherapy or there was insufficient follow-up information in the clinical records. Fourteen client-owned dogs were included with a median time to progression (MTP) of 156 days (95% CI 133–320 days) and median survival time (MST) of 240 days (95% CI 149–465 days). Temozolomide was the first-line adjuvant chemotherapy but changed to another chemotherapy agent (lomustine, toceranib phosphate, or melphalan) when tumour relapse was either suspected by clinical signs or confirmed by advanced imaging. Of the fourteen dogs, three underwent two surgical resections and one, three surgeries. Survival times (ST) were 241, 428, and 468 days for three dogs treated twice surgically and 780 days for the dog treated surgically three times. Survival times for dogs operated once was 181 days. One case was euthanized after developing aspiration pneumonia, and all other cases after progression of clinical signs due to suspected or confirmed tumour relapse. In conclusion, the results of this study suggest that debulking surgery and adjuvant chemotherapy are well-tolerated options in dogs with intracranial gliomas in which surgery is a possibility and should be considered a potential treatment option. Repeated surgery may be considered for selected cases. Keywords: chemotherapy; glioma; intracranial tumour; surgery; survival time; treatment Author: Emma Hidalgo Crespo, Alba Farré Mariné, Martí Pumarola i Battle, Juan Francisco Borrego Massó and Alejandro Luján Feliu-Pascual Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Aug 12 11:35:05 2022 CEST ModDate: Fri Aug 12 11:41:02 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1468740 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AUFDZX+VnURWPalladioL Type 1 Custom yes yes no 10 0 OHHEKB+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 QROLQP+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 TOSKTV+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 OJYKSJ+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 CTCXDQ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 46 0 HHEOCP+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 89 0 HHFALJ+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 95 0 HHEOFP+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 98 0 HHEOOO+TimesNewRomanPS-ItalicMT TrueType WinAnsi yes yes no 104 0 HHEPHM+TimesNewRomanPS-BoldMT CID TrueType Identity-H yes yes yes 107 0 HHFAKH+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 113 0 HHFAKI+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 116 0 HHEOCP+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 137 0 HHFALJ+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 143 0 HHFKMM+Calibri-Light CID TrueType Identity-H yes yes yes 146 0 HHEOFP+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 152 0 HHEOOO+TimesNewRomanPS-ItalicMT TrueType WinAnsi yes yes no 158 0 HHEPHM+TimesNewRomanPS-BoldMT CID TrueType Identity-H yes yes yes 161 0 HHFAKH+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 167 0 HHFAKI+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 170 0 HHEOCP+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 185 0 HHFALJ+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 191 0 HHFKMM+Calibri-Light CID TrueType Identity-H yes yes yes 194 0 HHEOFP+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 200 0 HHEOOO+TimesNewRomanPS-ItalicMT TrueType WinAnsi yes yes no 206 0 HHEPHM+TimesNewRomanPS-BoldMT CID TrueType Identity-H yes yes yes 209 0 HHFAKH+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 215 0 HHFAKI+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 218 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-09-16 02:28:30 CEST RepresentationInformation: VET_a2022v9p427.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-09-15 12:40:48 CEST Size: 1468740 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 492 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4923ab24 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Children: Item: Title: Case Selection and Data Collection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: Medical Records Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Info: Title: Survival Time after Surgical Debulking and Temozolomide Adjuvant Chemotherapy in Canine Intracranial Gliomas Author: Emma Hidalgo Crespo, Alba Farré Mariné, Martí Pumarola i Battle, Juan Francisco Borrego Massó and Alejandro Luján Feliu-Pascual Subject: Intracranial gliomas are associated with a poor prognosis, and the most appropriate treatment is yet to be defined. The objectives of this retrospective study are to report the time to progression and survival times of a group of dogs with histologically confirmed intracranial gliomas treated with surgical debulking and adjuvant temozolomide chemotherapy. All cases treated in a single referral veterinary hospital from 2014 to 2021 were reviewed. Inclusion criteria comprised a histopathological diagnosis of intracranial glioma, adjunctive chemotherapy, and follow-up until death. Cases were excluded if the owner declined chemotherapy or there was insufficient follow-up information in the clinical records. Fourteen client-owned dogs were included with a median time to progression (MTP) of 156 days (95% CI 133 320 days) and median survival time (MST) of 240 days (95% CI 149 465 days). Temozolomide was the first-line adjuvant chemotherapy but changed to another chemotherapy agent (lomustine, toceranib phosphate, or melphalan) when tumour relapse was either suspected by clinical signs or confirmed by advanced imaging. Of the fourteen dogs, three underwent two surgical resections and one, three surgeries. Survival times (ST) were 241, 428, and 468 days for three dogs treated twice surgically and 780 days for the dog treated surgically three times. Survival times for dogs operated once was 181 days. One case was euthanized after developing aspiration pneumonia, and all other cases after progression of clinical signs due to suspected or confirmed tumour relapse. In conclusion, the results of this study suggest that debulking surgery and adjuvant chemotherapy are well-tolerated options in dogs with intracranial gliomas in which surgery is a possibility and should be considered a potential treatment option. Repeated surgery may be considered for selected cases. 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