ec27310c351d70da93433b57b16515e6  265291.pdf
6dc63069bd885859fd0b51340972a2749edb0e2f  265291.pdf
807042ee3bbda03fefa508ece6f1e7ec6a28c634df185122510375b13666db01  265291.pdf

Title:          The Genetic Landscape of Complex Childhood‐Onset Hyperkinetic Movement Disorders
Subject:        Movement Disorders 2021.0
Creator:        Arbortext Advanced Print Publisher 9.1.520/W Unicode
Producer:       Acrobat Distiller 11.0 (Windows); modified using iText 4.2.0 by 1T3XT
CreationDate:   Mon Aug 22 09:39:27 2022 CEST
ModDate:        Thu Sep 29 16:53:37 2022 CEST
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          14
Encrypted:      no
Page size:      595.276 x 790.866 pts
Page rot:       0
File size:      1527537 bytes
Optimized:      no
PDF version:    1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
OFJNGD+AdvOT5bf56204.B               Type 1C           WinAnsi          yes yes no     384  0
OFJNFA+AdvOTff94f252.I+fb            Type 1C           Custom           yes yes yes    385  0
OFJNGE+AdvOT47eb9df8+20              Type 1C           WinAnsi          yes yes no     386  0
OFJNFB+AdvOT34fe1490.B               Type 1C           WinAnsi          yes yes no      19  0
OFJNFC+AdvOT8608a8d1                 Type 1C           WinAnsi          yes yes no     174  0
OFJNGF+AdvOT5bf56204.B+fb            Type 1C           Custom           yes yes yes    387  0
OFJNGG+AdvOT47eb9df8+fb              Type 1C           Custom           yes yes yes    388  0
OFJLOD+AdvOTf0129623                 Type 1C           WinAnsi          yes yes no      27  0
OFJLPD+AdvOTf94803d4                 Type 1C           WinAnsi          yes yes no      28  0
OFJLPE+AdvOT47eb9df8                 Type 1C           WinAnsi          yes yes no      29  0
OFJNDN+AdvOTff94f252.I               Type 1C           WinAnsi          yes yes no      30  0
OFJNEO+AdvOTff94f252.I+20            Type 1C           WinAnsi          yes yes no     389  0
OFJNEP+AdvP4C4E59                    Type 1C           Custom           yes yes yes     31  0
OFJNKM+AdvOTda51268d                 Type 1C           WinAnsi          yes yes no      18  0
OFJNJL+AdvOTbc475f09+20              Type 1C           WinAnsi          yes yes no      20  0
OFJNIK+AdvOTbc475f09+fb              Type 1C           Custom           yes yes yes     21  0
OFJNJK+AdvOT638a931c.I               Type 1C           WinAnsi          yes yes no      22  0
OFJNII+AdvP4C4E74                    Type 1C           Custom           yes yes yes     23  0
OFJNIJ+AdvOTbc475f09                 Type 1C           WinAnsi          yes yes no      24  0
OFJNIG+AdvOT3a037357.I               Type 1C           WinAnsi          yes yes no      25  0
OFJNIH+AdvOTf0129623+fb              Type 1C           Custom           yes yes yes     26  0
OFJNLN+AdvOTf94803d4+fb              Type 1C           Custom           yes yes yes     47  0
OFKFFP+AdvOT8608a8d1+03              Type 1C           Custom           yes yes yes     61  0
OFKFIP+HelveticaLTStd-Bold           Type 1C           WinAnsi          yes yes no      62  0
OFKGBM+AdvOT6601a1b9.BI              Type 1C           WinAnsi          yes yes no      81  0
OFKKDI+AdvOT2f17b3c6+20              Type 1C           WinAnsi          yes yes no      88  0
OFKKEJ+AdvOT2f17b3c6+fb              Type 1C           Custom           yes yes yes     89  0
OFKKDH+AdvOT2f17b3c6                 Type 1C           WinAnsi          yes yes no      90  0
OFKKDF+AdvOTecfccdcf_I               Type 1C           WinAnsi          yes yes no      91  0
OFKKDG+AdvOTecfccdcf_I+fb            Type 1C           Custom           yes yes yes     92  0
OFKKDE+AdvOT5bd620f6.B               Type 1C           WinAnsi          yes yes no      93  0
OFKKMH+AdvOT8608a8d1+20              Type 1C           WinAnsi          yes yes no     119  0
OFKLBG+AdvOT66af078c.B               Type 1C           WinAnsi          yes yes no     173  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2022-09-30 02:33:05 CEST
 RepresentationInformation: 265291.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2022-09-29 16:54:39 CEST
  Size: 1527537
  Format: PDF
  Version: 1.7
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 0
   FreeObjects: 2
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseNone
    Outlines: 
     Item: 
      Title:  The Genetic Landscape of Complex Childhood-Onset Hyperkinetic Movement Disorders
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9
      Children: 
       Item: 
        Title: Patients and Methods
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f
        Children: 
         Item: 
          Title: Study Design
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78
         Item: 
          Title: Ethical Approval and Consent
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee
         Item: 
          Title: Study Inclusion Criteria
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f
         Item: 
          Title: Data Acquisition
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1
         Item: 
          Title: Genetic Analysis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d
         Item: 
          Title: Statistical Analysis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89
       Item: 
        Title: Results
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9
        Children: 
         Item: 
          Title: Molecular Genetic Findings
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e
         Item: 
          Title: HMD Classification and Body Distribution
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b
          Children: 
           Item: 
            Title: Abnormal Eye Movements
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b
           Item: 
            Title: Hyperkinetic Facial Movements
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31
           Item: 
            Title: Dystonia
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107
           Item: 
            Title: Chorea
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e
           Item: 
            Title: Myoclonus
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7
           Item: 
            Title: Tremor
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e
           Item: 
            Title: Stereotypies
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247
         Item: 
          Title: Other Neurological and Systemic Features
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9
         Item: 
          Title: Functional Impairment of HMDs and Impact on DLAs
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36
         Item: 
          Title: Paroxysmal Fluctuation
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a
         Item: 
          Title: Treatment and Disease Course
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30
       Item: 
        Title: Discussion
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c
       Item: 
        Title: Acknowledgments
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88
        Children: 
         Item: 
          Title: Data Availability Statement
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6
       Item: 
        Title: References
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 228
      ImageHeight: 45
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1278
      ImageHeight: 164
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: Separation
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 228
      ImageHeight: 45
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1890
      ImageHeight: 1036
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: OFJNGD+AdvOT5bf56204.B
      FontSubset: true
      FirstChar: 47
      LastChar: 118
      FontDescriptor: 
       FontName: OFJNGD+AdvOT5bf56204.B
       Flags: Nonsymbolic
       FontBBox: -41, -218, 947, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OFJNFA+AdvOTff94f252.I+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: OFJNFA+AdvOTff94f252.I+fb
       Flags: Symbolic
       FontBBox: 82, 0, 645, 729
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OFJNGE+AdvOT47eb9df8+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: OFJNGE+AdvOT47eb9df8+20
       Flags: Nonsymbolic
       FontBBox: -156, -156, 1000, 718
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OFJNGF+AdvOT5bf56204.B+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: OFJNGF+AdvOT5bf56204.B+fb
       Flags: Symbolic
       FontBBox: 0, 0, 541, 718
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OFJNGG+AdvOT47eb9df8+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: OFJNGG+AdvOT47eb9df8+fb
       Flags: Symbolic
       FontBBox: 0, 0, 500, 729
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OFJNEO+AdvOTff94f252.I+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: OFJNEO+AdvOTff94f252.I+20
       Flags: Nonsymbolic
       FontBBox: -166, -156, 1052, 718
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OFKGBM+AdvOT6601a1b9.BI
      FontSubset: true
      FirstChar: 65
      LastChar: 121
      FontDescriptor: 
       FontName: OFKGBM+AdvOT6601a1b9.BI
       Flags: Nonsymbolic
       FontBBox: -125, -208, 1020, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OFJNKM+AdvOTda51268d
      FontSubset: true
      FirstChar: 45
      LastChar: 209
      FontDescriptor: 
       FontName: OFJNKM+AdvOTda51268d
       Flags: Nonsymbolic
       FontBBox: -10, -218, 947, 927
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OFJNFB+AdvOT34fe1490.B
      FontSubset: true
      FirstChar: 46
      LastChar: 118
      FontDescriptor: 
       FontName: OFJNFB+AdvOT34fe1490.B
       Flags: Nonsymbolic
       FontBBox: -52, -208, 937, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OFJNJL+AdvOTbc475f09+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: OFJNJL+AdvOTbc475f09+20
       Flags: Nonsymbolic
       FontBBox: -156, -177, 1000, 708
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OFJNIK+AdvOTbc475f09+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: OFJNIK+AdvOTbc475f09+fb
       Flags: Symbolic
       FontBBox: 0, 0, 531, 760
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OFJNJK+AdvOT638a931c.I
      FontSubset: true
      FirstChar: 45
      LastChar: 120
      FontDescriptor: 
       FontName: OFJNJK+AdvOT638a931c.I
       Flags: Nonsymbolic
       FontBBox: -62, -229, 1052, 916
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OFJNII+AdvP4C4E74
      FontSubset: true
      FirstChar: 1
      LastChar: 48
      FontDescriptor: 
       FontName: OFJNII+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OFJNIJ+AdvOTbc475f09
      FontSubset: true
      FirstChar: 37
      LastChar: 252
      FontDescriptor: 
       FontName: OFJNIJ+AdvOTbc475f09
       Flags: Serif, Nonsymbolic
       FontBBox: -31, -218, 989, 937
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OFKKDI+AdvOT2f17b3c6+20
      FontSubset: true
      FirstChar: 150
      LastChar: 150
      FontDescriptor: 
       FontName: OFKKDI+AdvOT2f17b3c6+20
       Flags: Nonsymbolic
       FontBBox: -197, -208, 1000, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OFJNIG+AdvOT3a037357.I
      FontSubset: true
      FirstChar: 48
      LastChar: 118
      FontDescriptor: 
       FontName: OFJNIG+AdvOT3a037357.I
       Flags: Nonsymbolic
       FontBBox: -125, -208, 979, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OFKKEJ+AdvOT2f17b3c6+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: OFKKEJ+AdvOT2f17b3c6+fb
       Flags: Symbolic
       FontBBox: 0, 0, 760, 697
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OFJNIH+AdvOTf0129623+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: OFJNIH+AdvOTf0129623+fb
       Flags: Symbolic
       FontBBox: 0, 0, 500, 718
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OFKKDH+AdvOT2f17b3c6
      FontSubset: true
      FirstChar: 37
      LastChar: 122
      FontDescriptor: 
       FontName: OFKKDH+AdvOT2f17b3c6
       Flags: Serif, Nonsymbolic
       FontBBox: -104, -229, 989, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OFJLOD+AdvOTf0129623
      FontSubset: true
      FirstChar: 37
      LastChar: 169
      FontDescriptor: 
       FontName: OFJLOD+AdvOTf0129623
       Flags: Nonsymbolic
       FontBBox: -52, -208, 906, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OFKKDF+AdvOTecfccdcf_I
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: OFKKDF+AdvOTecfccdcf_I
       Flags: Nonsymbolic
       FontBBox: -187, -229, 1083, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OFJLPD+AdvOTf94803d4
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: OFJLPD+AdvOTf94803d4
       Flags: Nonsymbolic
       FontBBox: -41, -218, 937, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OFKKDG+AdvOTecfccdcf_I+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: OFKKDG+AdvOTecfccdcf_I+fb
       Flags: Symbolic
       FontBBox: -177, -229, 729, 697
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OFJLPE+AdvOT47eb9df8
      FontSubset: true
      FirstChar: 40
      LastChar: 241
      FontDescriptor: 
       FontName: OFJLPE+AdvOT47eb9df8
       Flags: Nonsymbolic
       FontBBox: -41, -250, 958, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OFKKDE+AdvOT5bd620f6.B
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: OFKKDE+AdvOT5bd620f6.B
       Flags: Serif, Nonsymbolic
       FontBBox: -114, -229, 989, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OFJNDN+AdvOTff94f252.I
      FontSubset: true
      FirstChar: 40
      LastChar: 242
      FontDescriptor: 
       FontName: OFJNDN+AdvOTff94f252.I
       Flags: Nonsymbolic
       FontBBox: -31, -270, 1093, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OFJNEP+AdvP4C4E59
      FontSubset: true
      FirstChar: 1
      LastChar: 95
      FontDescriptor: 
       FontName: OFJNEP+AdvP4C4E59
       Flags: Symbolic
       FontBBox: -31, -250, 1000, 750
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OFKLBG+AdvOT66af078c.B
      FontSubset: true
      FirstChar: 58
      LastChar: 119
      FontDescriptor: 
       FontName: OFKLBG+AdvOT66af078c.B
       Flags: Serif, Nonsymbolic
       FontBBox: -41, -218, 989, 937
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OFJNFC+AdvOT8608a8d1
      FontSubset: true
      FirstChar: 45
      LastChar: 174
      FontDescriptor: 
       FontName: OFJNFC+AdvOT8608a8d1
       Flags: Nonsymbolic
       FontBBox: -62, -208, 927, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OFJNLN+AdvOTf94803d4+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: OFJNLN+AdvOTf94803d4+fb
       Flags: Symbolic
       FontBBox: 0, 0, 500, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OFKKMH+AdvOT8608a8d1+20
      FontSubset: true
      FirstChar: 147
      LastChar: 148
      FontDescriptor: 
       FontName: OFKKMH+AdvOT8608a8d1+20
       Flags: Nonsymbolic
       FontBBox: -968, -333, 2000, 1020
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OFKFFP+AdvOT8608a8d1+03
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: OFKFFP+AdvOT8608a8d1+03
       Flags: Symbolic
       FontBBox: -479, -364, 854, 927
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OFKFIP+HelveticaLTStd-Bold
      FontSubset: true
      FirstChar: 110
      LastChar: 110
      FontDescriptor: 
       FontName: OFKFIP+HelveticaLTStd-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/"><dc:format>application/pdf</dc:format><dc:identifier>doi:10.1002/mds.29182</dc:identifier></rdf:Description>
<rdf:Description rdf:about="" xmlns:prism="http://prismstandard.org/namespaces/basic/2.1/"><prism:doi>10.1002/mds.29182</prism:doi><prism:url>https://doi.org/10.1002/mds.29182</prism:url></rdf:Description>
<rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/"><crossmark:MajorVersionDate>2022-08-25</crossmark:MajorVersionDate><crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive><crossmark:CrossMarkDomains><rdf:Seq><rdf:li>movementdisorders.onlinelibrary.wiley.com</rdf:li></rdf:Seq></crossmark:CrossMarkDomains><crossmark:DOI>10.1002/mds.29182</crossmark:DOI></rdf:Description>
<rdf:Description rdf:about="" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"><pdfx:CrossMarkDomains><rdf:Seq><rdf:li>movementdisorders.onlinelibrary.wiley.com</rdf:li></rdf:Seq></pdfx:CrossMarkDomains><pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive><pdfx:doi>10.1002/mds.29182</pdfx:doi><pdfx:CrossmarkMajorVersionDate>2022-08-25</pdfx:CrossmarkMajorVersionDate></rdf:Description>
<rdf:Description rdf:about="" xmlns:jav="http://www.niso.org/schemas/jav/1.0/"><jav:journal_article_version>VoR</jav:journal_article_version></rdf:Description>
</rdf:RDF></x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 246, 636, 261, 645
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 261, 632, 264, 641
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 266, 634, 275, 642
      Annotation: 
       Subtype: Link
       Rect: 369, 636, 378, 645
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 476, 636, 480, 645
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 482, 634, 490, 642
      Annotation: 
       Subtype: Link
       Rect: 227, 625, 231, 634
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 336, 625, 351, 634
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 444, 625, 448, 634
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 527, 625, 531, 634
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 178, 614, 188, 623
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 189, 612, 198, 620
      Annotation: 
       Subtype: Link
       Rect: 288, 614, 291, 623
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 371, 614, 375, 623
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 531, 614, 535, 623
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 537, 612, 545, 620
      Annotation: 
       Subtype: Link
       Rect: 183, 603, 190, 612
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 312, 603, 322, 612
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 392, 603, 396, 612
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 514, 603, 521, 612
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 182, 592, 190, 601
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 287, 592, 294, 601
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 406, 592, 413, 601
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 508, 592, 516, 601
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 174, 581, 181, 590
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 294, 581, 302, 590
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 409, 581, 416, 590
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 508, 581, 515, 590
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 218, 570, 225, 579
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 227, 568, 236, 576
      Annotation: 
       Subtype: Link
       Rect: 347, 570, 350, 579
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 475, 570, 485, 579
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 485, 566, 488, 575
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 490, 568, 499, 576
      Annotation: 
       Subtype: Link
       Rect: 224, 149, 286, 157
      Annotation: 
       Subtype: Link
       Rect: 54, 141, 86, 148
      Annotation: 
       Subtype: Link
       Rect: 120, 92, 190, 100
      Annotation: 
       Subtype: Link
       Rect: 54, 59, 132, 66
      Annotation: 
       Subtype: Link
       Rect: 320, 77, 396, 85
      Annotation: 
       Subtype: Link
       Rect: 519, 790, 595, 775
     Thumb: true
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 188, 415, 192, 425
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 449, 110, 453, 120
       Destination: 157
     Thumb: true
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 243, 510, 248, 520
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 125, 250, 129, 260
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 542, 303, 547, 313
       Destination: 52
      Annotation: 
       Subtype: Link
       Rect: 361, 262, 367, 272
       Destination: 52
      Annotation: 
       Subtype: Link
       Rect: 390, 262, 396, 272
       Destination: 72
      Annotation: 
       Subtype: Link
       Rect: 429, 238, 435, 248
       Destination: 52
      Annotation: 
       Subtype: Link
       Rect: 340, 202, 346, 212
       Destination: 72
      Annotation: 
       Subtype: Link
       Rect: 396, 130, 401, 140
       Destination: 84
      Annotation: 
       Subtype: Link
       Rect: 425, 130, 431, 140
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 552, 70, 557, 80
       Destination: 84
      Annotation: 
       Subtype: Link
       Rect: 336, 58, 342, 68
       Destination: 107
     Thumb: true
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 134, 70, 140, 80
       Destination: 84
      Annotation: 
       Subtype: Link
       Rect: 171, 70, 177, 80
       Destination: 52
      Annotation: 
       Subtype: Link
       Rect: 434, 390, 508, 397
      Annotation: 
       Subtype: Link
       Rect: 108, 108, 182, 115
     Thumb: true
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 282, 82, 288, 92
       Destination: 52
      Annotation: 
       Subtype: Link
       Rect: 340, 412, 346, 422
       Destination: 52
      Annotation: 
       Subtype: Link
       Rect: 380, 412, 386, 422
       Destination: 84
      Annotation: 
       Subtype: Link
       Rect: 340, 58, 345, 68
       Destination: 52
      Annotation: 
       Subtype: Link
       Rect: 88, 447, 161, 454
     Thumb: true
    Page: 
     Label: 6
     Thumb: true
    Page: 
     Label: 7
     Thumb: true
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 507, 532, 512, 542
       Destination: 52
      Annotation: 
       Subtype: Link
       Rect: 323, 405, 328, 415
       Destination: 52
     Thumb: true
    Page: 
     Label: 9
     Thumb: true
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 473, 694, 479, 704
       Destination: 84
      Annotation: 
       Subtype: Link
       Rect: 403, 542, 413, 552
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 416, 338, 426, 348
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 448, 310, 454, 320
       Destination: 52
     Thumb: true
    Page: 
     Label: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 283, 662, 294, 672
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 129, 554, 139, 564
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 135, 506, 150, 516
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 267, 482, 275, 492
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 219, 470, 227, 480
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 275, 470, 294, 480
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 92, 458, 100, 468
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 146, 458, 154, 468
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 197, 458, 201, 468
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 166, 446, 185, 456
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 285, 422, 294, 432
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 275, 374, 294, 384
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 285, 326, 294, 336
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 203, 266, 238, 276
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 90, 134, 130, 144
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 171, 110, 190, 120
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 366, 698, 374, 708
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 343, 650, 351, 660
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 454, 602, 468, 612
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 362, 578, 381, 588
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 549, 566, 557, 576
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 533, 542, 557, 552
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 347, 506, 356, 516
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 509, 506, 518, 516
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 469, 482, 483, 492
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 516, 458, 520, 468
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 370, 338, 388, 348
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 348, 158, 367, 168
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 490, 146, 494, 156
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 458, 86, 466, 96
       Destination: 177
     Thumb: true
    Page: 
     Label: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 249, 718, 255, 728
       Destination: 52
      Annotation: 
       Subtype: Link
       Rect: 140, 650, 148, 660
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 197, 638, 205, 648
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 124, 578, 132, 588
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 105, 542, 114, 552
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 130, 518, 138, 528
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 195, 482, 203, 492
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 132, 446, 140, 456
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 141, 314, 150, 324
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 239, 278, 247, 288
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 195, 254, 218, 264
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 249, 206, 253, 216
       Destination: 177
     Thumb: true
    Page: 
     Label: 13
     Thumb: true
    Page: 
     Label: 14
     Thumb: true
  Checksum: 51cc0776
   Type: CRC32
  Checksum: ec27310c351d70da93433b57b16515e6
   Type: MD5
  Checksum: 6dc63069bd885859fd0b51340972a2749edb0e2f
   Type: SHA-1