f0709b4197bd637acf402690d5bfc0c1 neudis_a2022m10v173p105841.pdf 354b1651cfa347014ce15898290ebaf2f9afa431 neudis_a2022m10v173p105841.pdf 6ae663dec7ad4a9f5d3dc60c865f5118ce299e8bbe561dd5d2e0474513f1b55a neudis_a2022m10v173p105841.pdf Title: Postnatal environmental enrichment enhances memory through distinct neural mechanisms in healthy and trisomic female mice Subject: Neurobiology of Disease, 173 (2022) 105841. doi:10.1016/j.nbd.2022.105841 Keywords: Intellectual disability,Down syndrome,Prefrontal cortex,Hippocampus,Functional connectivity,Cognitive stimulation,Neural synchrony,Ts65Dn Genetic mouse model,Memory impairment,REM sleep Author: Maria Alemany-González Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Mon Sep 19 14:22:19 2022 CEST ModDate: Mon Sep 19 20:46:20 2022 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 7228777 bytes Optimized: yes PDF 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yes yes yes 243 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-10-28 02:29:19 CEST RepresentationInformation: neudis_a2022m10v173p105841.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-10-27 11:37:56 CEST Size: 7228777 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 1025 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Postnatal environmental enrichment enhances memory through distinct neural mechanisms in healthy and trisomic female mice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Children: Item: Title: 1 Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: 2 Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Children: Item: Title: 2.1 Animals Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: 2.2 Environmental enrichment protocol Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: 2.3 Stereotaxic surgeries Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: 2.4 Behavioral and neurophysiological characterization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Children: Item: Title: 2.4.1 Quiet wakefulness, NREM and REM sleep Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: 2.4.2 Novel object recognition test Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: 2.5 Data analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Children: Item: Title: 2.5.1 Power spectral analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: 2.5.2 Phase-amplitude modulation index Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: 2.5.3 Phase slope index (PSI) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: 2.5.4 Analysis of ripples during NREM sleep Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: 2.5.5 Analyses of entropy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: 2.6 Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: 3 Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Children: Item: Title: 3.1 Female mice reared in enriched environments exhibit increased gamma synchrony in the hippocampus during rest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: 3.2 Environmental enrichment entrains hippocampal gamma oscillations and hippocampal-prefrontal gamma connectivity during m ... Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: 3.3 Environmental enrichment enhances hippocampal gamma synchrony and sharp wave ripples during sleep Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: 3.4 Environmental enrichment reduces aberrant spiking and theta/gamma hypersynchrony in the HPC and PFC of Ts65Dn female mi ... Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: 3.5 Environmental enrichment reduces aberrant theta-gamma hypersynchrony in the HPC and PFC of Ts65Dn female mice during me ... Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: 3.6 Environmental enrichment attenuates aberrant hippocampal-prefrontal gamma synchrony and ripple activity in Ts65Dn mice ... Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: 4 Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: 5 Concluding remarks Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: CRediT authorship contribution statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: Declaration of Competing Interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: Data availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Info: Title: Postnatal environmental enrichment enhances memory through distinct neural mechanisms in healthy and trisomic female mice Author: Maria Alemany-González Subject: Neurobiology of Disease, 173 (2022) 105841. doi:10.1016/j.nbd.2022.105841 Keywords: Intellectual disability,Down syndrome,Prefrontal cortex,Hippocampus,Functional connectivity,Cognitive stimulation,Neural synchrony,Ts65Dn Genetic mouse model,Memory impairment,REM sleep Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Mon Sep 19 14:22:19 CEST 2022 ModDate: Mon Sep 19 20:46:20 CEST 2022 ID: 0x48317d1ca3116e4b723898b81f47c6a7, 0x4fdffa5dffdbe9ebaea6e99e4d96830c Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 298 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 248 ImageHeight: 271 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: SZLZJN+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Font: BaseFont: ONXTQH+CharisSIL-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: WNOSGI+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: IEEWBB+CharisSIL Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: NNLAUQ+TeX_CM_Roman FontSubset: true FirstChar: 1 LastChar: 128 FontDescriptor: FontName: NNLAUQ+TeX_CM_Roman Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: CTKRFM+TeX_CM_Maths_Symbols FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: CTKRFM+TeX_CM_Maths_Symbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: IZQYQY+Univers FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: IZQYQY+Univers Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: HLZUXR+STIX-Regular FontSubset: true FirstChar: 1 LastChar: 9 FontDescriptor: FontName: HLZUXR+STIX-Regular Flags: Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: VVCCGG+TeX_CM_Maths_Italic FontSubset: true FirstChar: 1 LastChar: 127 FontDescriptor: FontName: VVCCGG+TeX_CM_Maths_Italic Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true CIDFontType2: Font: BaseFont: SZLZJN+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: SZLZJN+TimesNewRomanPSMT Flags: Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile2: true Font: BaseFont: ONXTQH+CharisSIL-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: ONXTQH+CharisSIL-Bold Flags: Nonsymbolic, ForceBold FontBBox: -720, -533, 1759, 1320 FontFile2: true Font: BaseFont: WNOSGI+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: WNOSGI+CharisSIL-Italic Flags: Nonsymbolic, Italic FontBBox: -716, -533, 1627, 1318 FontFile2: true Font: BaseFont: IEEWBB+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: IEEWBB+CharisSIL Flags: Nonsymbolic FontBBox: -692, -533, 1623, 1319 FontFile2: true XMP: application/pdf 10.1016/j.nbd.2022.105841 Elsevier Inc. Neurobiology of Disease, 173 (2022) 105841. doi:10.1016/j.nbd.2022.105841 Intellectual disability Down syndrome Prefrontal cortex Hippocampus Functional connectivity Cognitive stimulation Neural synchrony Ts65Dn Genetic mouse model Memory impairment REM sleep Postnatal environmental enrichment enhances memory through distinct neural mechanisms in healthy and trisomic female mice Maria Alemany-González Marta Vilademunt Thomas Gener M. Victoria Puig journal Neurobiology of Disease © 2022 The Authors. Published by Elsevier Inc. 0969-9961 173 15 October 2022 2022-10-15 105841 105841 10.1016/j.nbd.2022.105841 https://doi.org/10.1016/j.nbd.2022.105841 2010-04-23 true 10.1016/j.nbd.2022.105841 elsevier.com sciencedirect.com http://creativecommons.org/licenses/by-nc-nd/4.0/ VoR 10.1016/j.nbd.2022.105841 noindex 2010-04-23 true 20th September 2022 sciencedirect.com elsevier.com Elsevier 2022-09-19T18:46:20 2022-09-19T12:22:19 2022-09-19T18:46:20 True 20th September 2022 Acrobat Distiller 8.1.0 (Windows) Intellectual disability,Down syndrome,Prefrontal cortex,Hippocampus,Functional connectivity,Cognitive stimulation,Neural synchrony,Ts65Dn Genetic mouse model,Memory impairment,REM sleep uuid:1b499bed-4ce8-4c0c-b682-0d58baae1cbe uuid:b6ed5266-03cb-4855-90c0-636283357f42 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 157, 576, 341, 587 Flags: Print Destination: 897 Annotation: Subtype: Link Rect: 342, 576, 349, 587 Flags: Print Destination: 897 Annotation: Subtype: Link 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